M Turner

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint VAV proteins as signal integrators for multi-subunit immune-recognition receptors
    Martin Turner
    Lymphocyte Signalling and Development Laboratory, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Immunol 2:476-86. 2002
  2. ncbi request reprint The role of Vav proteins in B cell responses
    Martin Turner
    Laboratory of Lymphocyte Signaling and Development Molecular Immunology Programme, The Babraham Institute Cambridge, UK
    Adv Exp Med Biol 512:29-34. 2002
  3. pmc A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
    Elizabeth Clayton
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    J Exp Med 196:753-63. 2002
  4. pmc Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals
    Grahame McKenzie
    Lorantis Ltd, Cambridge, CB4 0PE, UK
    BMC Cell Biol 7:10. 2006
  5. doi request reprint Is transcription the dominant force during dynamic changes in gene expression?
    Martin Turner
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Adv Exp Med Biol 780:1-13. 2011
  6. ncbi request reprint Tyrosine kinase SYK: essential functions for immunoreceptor signalling
    M Turner
    Molecular Immunology Programme, The Babraham Institute, Cambridge, UK CB2 4AT
    Immunol Today 21:148-54. 2000
  7. doi request reprint Regulation of B- and T-cell differentiation by a single microRNA
    Martin Turner
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK
    Biochem Soc Trans 36:531-3. 2008
  8. ncbi request reprint B-cell development and antigen receptor signalling
    M Turner
    Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem Soc Trans 30:812-5. 2002
  9. ncbi request reprint Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation
    G M Doody
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Immunol 2:542-7. 2001
  10. ncbi request reprint Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation
    F Colucci
    Babraham Institute, Cambridge, UK
    J Immunol 163:1769-74. 1999

Detail Information

Publications62

  1. ncbi request reprint VAV proteins as signal integrators for multi-subunit immune-recognition receptors
    Martin Turner
    Lymphocyte Signalling and Development Laboratory, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Immunol 2:476-86. 2002
    ..This review focuses on the role of VAV proteins in the regulation of lymphocyte development and function, and emphasizes the regulatory roles that these proteins have through both GEF-dependent and -independent mechanisms...
  2. ncbi request reprint The role of Vav proteins in B cell responses
    Martin Turner
    Laboratory of Lymphocyte Signaling and Development Molecular Immunology Programme, The Babraham Institute Cambridge, UK
    Adv Exp Med Biol 512:29-34. 2002
  3. pmc A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation
    Elizabeth Clayton
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    J Exp Med 196:753-63. 2002
    ..p110delta function is required for BCR-mediated calcium flux, activation of phosphlipaseCgamma2, and Bruton's tyrosine kinase. Thus, p110delta plays a critical role in B cell homeostasis and function...
  4. pmc Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals
    Grahame McKenzie
    Lorantis Ltd, Cambridge, CB4 0PE, UK
    BMC Cell Biol 7:10. 2006
    ..Mice with disrupted Notch and PI3K signalling show phenotypic similarities during haematopoietic cell development, suggesting functional interaction between these pathways...
  5. doi request reprint Is transcription the dominant force during dynamic changes in gene expression?
    Martin Turner
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Adv Exp Med Biol 780:1-13. 2011
    ..Developing a more "RNA centric" view of gene expression will allow a more systematic understanding of how gene expression and cell function are integrated...
  6. ncbi request reprint Tyrosine kinase SYK: essential functions for immunoreceptor signalling
    M Turner
    Molecular Immunology Programme, The Babraham Institute, Cambridge, UK CB2 4AT
    Immunol Today 21:148-54. 2000
    ..There is also evidence of a role for SYK in non-immune cells and in the maintenance of vascular integrity...
  7. doi request reprint Regulation of B- and T-cell differentiation by a single microRNA
    Martin Turner
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK
    Biochem Soc Trans 36:531-3. 2008
    ..Microarray analysis of bic-deficient B- and T-cells under different conditions has revealed a wide spectrum of targets regulated by an miR-155 and suggested mechanisms for the regulation of lymphocyte differentiation by a single miR...
  8. ncbi request reprint B-cell development and antigen receptor signalling
    M Turner
    Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem Soc Trans 30:812-5. 2002
    ..At the molecular level, Vav proteins regulate small-molecular-mass GTPases, phosphoinositide 3-kinase, TEC family tyrosine kinases and intracellular calcium flux...
  9. ncbi request reprint Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation
    G M Doody
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Immunol 2:542-7. 2001
    ..B cells from Vav-1(-/-)Vav-2(-/-) mice respond poorly to antigen receptor triggering, both in terms of proliferation and calcium release. These studies show the importance of Vav-2 in humoral immune responses and B cell maturation...
  10. ncbi request reprint Redundant role of the Syk protein tyrosine kinase in mouse NK cell differentiation
    F Colucci
    Babraham Institute, Cambridge, UK
    J Immunol 163:1769-74. 1999
    ....
  11. ncbi request reprint The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells
    Michelle L Janas
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 180:739-46. 2008
    ..These results demonstrate an epistatic relationship between p110delta and PTEN. In addition, they also suggest that additional PI3K catalytic subunits contribute to B cell development and function...
  12. ncbi request reprint BCR activation of PI3K is Vav-independent in murine B cells
    E Vigorito
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem Soc Trans 32:781-4. 2004
    ....
  13. ncbi request reprint Vav proteins are required for B-lymphocyte responses to LPS
    Barbara Hebeis
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Blood 106:635-40. 2005
    ..These data provide evidence for the function for the Vav proteins in regulating the responses of B cells to LPS...
  14. doi request reprint Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
    Susan Kohlhaas
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 182:2578-82. 2009
    ..However, we found no evidence for defective suppressor activity of miR-155-deficient Tregs, either in vitro or in vivo. Our results indicate that miR-155 contributes to Treg development, but that additional miRNAs control Treg function...
  15. pmc Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice
    M Baker
    Laboratory of Lymphocyte Signalling and Development, Programme of Molecular Immunology, The Babraham Institute, Cambridge CB2 4AT, UK
    EMBO J 19:4644-54. 2000
    ..Our findings represent the first example in which a tyrosine phosphatase in situ prevents the oncogenic actions of a SRC: family tyrosine kinase...
  16. ncbi request reprint The p110delta subunit of phosphoinositide 3-kinase is required for the lipopolysaccharide response of mouse B cells
    B J Hebeis
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Biochem Soc Trans 32:789-91. 2004
    ..This demonstrates that the p110delta subunit of PI3K is involved in the LPS response in B cells and may represent a link between the innate and the adaptive immune system...
  17. doi request reprint Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes
    Amy Saunders
    Immunology Programme, The Babraham Institute, Cambridge, UK
    Blood 115:3249-57. 2010
    ..These findings show a vital requirement for GIMAP1 in mature lymphocyte development/survival and draw attention to the nonredundant roles of members of the GIMAP GTPase family in these processes...
  18. ncbi request reprint Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils
    Sabine Suire
    The Babraham Institute, Babraham, Cambs CB22 3AT, UK
    Nat Cell Biol 8:1303-9. 2006
    ..We conclude that Gbetagammas, p101 and the Ras-RBD interaction all have important roles in the regulation of PI(3)Kgamma in vivo and that they can simultaneously, but differentially, control distinct PI(3)Kgamma effectors...
  19. pmc Vav-2 controls NFAT-dependent transcription in B- but not T-lymphocytes
    G M Doody
    Lymphocyte Signaling and Development Laboratory, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    EMBO J 19:6173-84. 2000
    ..These data suggest a role for Vav-2 in transducing BCR signals to the transcription factor NFAT and implicate Vav-2 in the integration of BCR and CD19 signaling...
  20. ncbi request reprint The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
    Nayoung Kim
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    Blood 110:3202-8. 2007
    ..These results provide genetic evidence that p110delta is the dominant PI3K isoform for cytokine secretion by NK cells and suggest that PI3Ks cooperate during NK-cell development and cytotoxicity...
  21. ncbi request reprint The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
    Miriam Llorian
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, United Kingdom
    J Immunol 178:1981-5. 2007
    ..These results demonstrate a role for p110delta in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion...
  22. ncbi request reprint The tyrosine kinase Lyn is required for B cell development beyond the T1 stage in the spleen: rescue by over-expression of Bcl-2
    Josephine Meade
    The Laboratory of Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Cambridge, GB
    Eur J Immunol 32:1029-34. 2002
    ..The results indicate that Lyn plays a positive role in the selection and survival of mature B cells in addition to its previously documented negative role in tolerance and B cell activation...
  23. pmc Deletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemia
    Daniel J Hodson
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK
    Nat Immunol 11:717-24. 2010
    ..Our data establish a role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation...
  24. doi request reprint Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    Julia Rolf
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 185:4042-52. 2010
    ..Our findings support a model in which the magnitude of the GC reaction is controlled by the activity of the PI3K pathway in T(FH) cells...
  25. ncbi request reprint Structural organization of the mouse phosphatidylinositol 3-kinase p110d gene
    E Clayton
    Lymphocyte Signaling and Development Laboratory, Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom
    Biochem Biophys Res Commun 280:1328-32. 2001
    ..Comparison of the genomic structure with that of p110alpha, beta, and gamma demonstrates that the p110delta gene shares its exon structure with p110beta, the most closely related PI3K at the amino acid level...
  26. ncbi request reprint The CD45 tyrosine phosphatase regulates CD3-induced signal transduction and T cell development in recombinase-deficient mice: restoration of pre-TCR function by active p56(lck)
    S Pingel
    Laboratory of Lymphocyte Signalling and Development Programme of Molecular Immunology, The Babraham Institute, Cambridge, GB
    Eur J Immunol 29:2376-84. 1999
    ..Our results are consistent with a model in which CD45-activated p56(lck) is critical for pre-TCR signal transduction...
  27. doi request reprint B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta
    Thomas Henley
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK
    Eur J Immunol 38:3543-8. 2008
    ..Our findings reveal an important role for p110delta in regulating B-cell responses to BAFF...
  28. ncbi request reprint RhoG regulates the neutrophil NADPH oxidase
    Alison M Condliffe
    Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge, UK
    J Immunol 176:5314-20. 2006
    ....
  29. ncbi request reprint Differential requirements of PI3K subunits for BCR or BCR/CD19-induced ERK activation
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Adv Exp Med Biol 584:43-52. 2006
  30. ncbi request reprint The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression
    Sarah E Bell
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Babraham, Cambridge, United Kingdom
    Dev Dyn 235:3144-55. 2006
    ..These data implicate Zfp36l1as a negative regulator of Vegf-a gene activity during development...
  31. doi request reprint Detection of protein-protein interactions by ribosome display and protein in situ immobilisation
    Mingyue He
    The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, UK
    N Biotechnol 26:277-81. 2009
    ..The method has promise for library screening of pairwise protein interactions, down to the analytical level of individual domain or motif mapping...
  32. doi request reprint Stromal cell-derived factor 1α and CXCR4: newly defined requirements for efficient thymic β-selection
    Michelle L Janas
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham, Cambridge CB223AT, UK
    Trends Immunol 31:370-6. 2010
    ..Recent reports have identified a role for the chemokine stromal cell-derived factor 1α and its receptor CXC chemokine receptor 4 in β-selection. This review explores these findings in detail...
  33. ncbi request reprint microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    Elena Vigorito
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK
    Immunity 27:847-59. 2007
    ..1 regulation is a contributing factor to the miR-155-deficient phenotype. Our results implicate post-transcriptional regulation of gene expression for establishing the terminal differentiation program of B cells...
  34. ncbi request reprint RhoG regulates gene expression and the actin cytoskeleton in lymphocytes
    Elena Vigorito
    Laboratory for Lymphocyte Signalling and Development, Molecular Immunology Programme, The Babraham Institute, Cambridge, UK
    Oncogene 22:330-42. 2003
    ..Hence, these results implicate RhoG in leukocyte trafficking and the control of gene expression induced in response to antigen encounter...
  35. doi request reprint Regulation of B-cell differentiation by microRNAs and RNA-binding proteins
    Alexander Ademokun
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, UK
    Biochem Soc Trans 36:1191-3. 2008
    ....
  36. pmc Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4
    Michelle L Janas
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham, Cambridge, CB22 3AT England, UK
    J Exp Med 207:247-61. 2010
    ..These findings establish a role for CXCR4-mediated PI3K signaling that, together with signals from Notch and the preTCR, contributes to continued T cell development beyond beta-selection...
  37. ncbi request reprint Synergistic activation of PKD by the B cell antigen receptor and CD19 requires PI3K, Vav1 and PLCgamma
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Cell Signal 18:1455-60. 2006
    ..These findings show that Vav proteins and PI3K regulation of PLCgamma contributes to the activation of PKD in response to BCR and or CD19 cross-linking...
  38. ncbi request reprint PLCgamma2 regulates Bcl-2 levels and is required for survival rather than differentiation of marginal zone and follicular B cells
    Sarah E Bell
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge CB2 4AT, GB
    Eur J Immunol 34:2237-47. 2004
    ..These data suggest that PLCgamma2 performs a critical role in B cell development through regulation of survival rather than differentiation...
  39. ncbi request reprint Vav proteins regulate peripheral B-cell survival
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    Blood 106:2391-8. 2005
    ..Vav proteins thus regulate an NF-kappaB-dependent survival signal in naive B cells and are required for NF-kappaB function after BCR cross-linking...
  40. ncbi request reprint The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells
    Josephine Meade
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Cambridge, GB
    Eur J Immunol 34:1102-10. 2004
    ..Thus signaling events that mediate negative selection can still occur in the absence of Syk. This may be due to redundancy with zeta-associated protein 70 (ZAP-70), which we demonstrate to be expressed in immature B cells...
  41. ncbi request reprint Vav-dependent and vav-independent phosphatidylinositol 3-kinase activation in murine B cells determined by the nature of the stimulus
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 173:3209-14. 2004
    ..Our results indicate that the strong signals delivered by multivalent cross-linking agents activate B cells in a qualitatively different manner from those triggered by coreceptor recruitment...
  42. pmc Immunological function in mice lacking the Rac-related GTPase RhoG
    Elena Vigorito
    Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Mol Cell Biol 24:719-29. 2004
    ..The lack of a strong phenotype could indicate a functional redundancy of RhoG with other Rac proteins in lymphocytes...
  43. ncbi request reprint Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase
    Louise M C Webb
    Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham, Cambridge, United Kingdom
    J Immunol 175:2783-7. 2005
    ..This work demonstrates that PI3K activity is critical for T cell development and depends on the combined function of p110gamma and p110delta...
  44. ncbi request reprint Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
    Alison M Condliffe
    The Inositide Laboratory, Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Blood 106:1432-40. 2005
    ..These results start to define which PI3K isoforms are responsible for modulating neutrophil responsiveness to infection and inflammation...
  45. ncbi request reprint The role of PI3K signalling in the B cell response to antigen
    Daniel J Hodson
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK
    Adv Exp Med Biol 633:43-53. 2009
    ..PI3K activity has been shown to be inhibitory to CSR. The effects on immunoglobulin production and ASC differentiation are harder to disentangle from the developmental effects on cell populations and at present remain uncertain...
  46. doi request reprint Signaling pathways in T follicular helper cells
    Julia Rolf
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 184:6563-8. 2010
    ..In this review, the molecular mechanisms constituting the signaling network in TFH cells will be explored...
  47. pmc Differential regulation of TCR-mediated gene transcription by Vav family members
    Shaheen Zakaria
    Division of Oncology Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 199:429-34. 2004
    ..These data indicate that, although both Vav proteins are biochemically coupled to the TCR, they regulate distinct molecular pathways leading to defined gene transcriptional events...
  48. ncbi request reprint Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK
    Sachiko Johmura
    Department of Molecular Genetics, Institute for Liver Research, Kansai Medical University, 10 15 Fumizono cho, Moriguchi 570 8506, Japan
    Immunity 18:777-87. 2003
    ..Hence, our findings suggest that Grb2 and BLNK cooperate to localize Vav into membrane rafts, thereby contributing to optimal activation of Vav in B cells...
  49. ncbi request reprint Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases
    Francesco Colucci
    Laboratory for Cytokines and Lymphoid Development, The Pasteur Institute, Paris, France
    Nat Immunol 3:288-94. 2002
    ..This suggests that distinct and redundant signaling pathways act synergistically to trigger natural cytotoxicity...
  50. ncbi request reprint Vav1, but not Vav2, contributes to platelet aggregation by CRP and thrombin, but neither is required for regulation of phospholipase C
    Andrew C Pearce
    Department of Pharmacology, University of Oxford, United Kingdom
    Blood 100:3561-9. 2002
    ..The present study has provided evidence for a possible role of Vav1 but not Vav2 in the later stages of platelet aggregation...
  51. ncbi request reprint Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue
    Kamal D Puri
    ICOS, Bothell, WA 98021, USA
    Blood 103:3448-56. 2004
    ..Thus, PI3K delta may be a reasonable therapeutic target in specific inflammatory conditions as blockade of its activity reduces neutrophil influx into tissues by diminishing their attachment to and migration across vascular endothelium...
  52. ncbi request reprint Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen
    Andrew C Pearce
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    J Biol Chem 279:53955-62. 2004
    ..This is the first time that absolute redundancy between two protein isoforms has been observed with respect to the regulation of PLC gamma 2 in platelets...
  53. ncbi request reprint Phospholipase C-gamma2 is essential for NK cell cytotoxicity and innate immunity to malignant and virally infected cells
    Anouk Caraux
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    Blood 107:994-1002. 2006
    ..In vivo, PLC-gamma2 regulates selective facets of innate immunity because it is essential for NK cell responses to malignant and virally infected cells but not to bacterial infections...
  54. ncbi request reprint Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization
    Claire M Wells
    Ludwig Institute for Cancer Research, Royal Free and University College Medical School Branch, 91 Riding House Street, London W1W 7BS, UK
    Exp Cell Res 310:303-10. 2005
    ..Our results suggest that the migration speed of macrophages is regulated independently of spread area or membrane ruffling and that Vav1 is selectively required to maintain a normal migration speed...
  55. ncbi request reprint Syk and Slp-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development
    Eric Sebzda
    Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Dev Cell 11:349-61. 2006
    ..These studies provide genetic evidence for hematopoietic contribution to vascular development and suggest that hematopoietic tissue can provide a source of vascular endothelial progenitor cells throughout life...
  56. ncbi request reprint Phosphatidylinositol 3-kinase is required for the transcriptional activation of cyclin D2 in BCR activated primary mouse B lymphocytes
    Janet Glassford
    Cancer Research UK Laboratories, Department of Cancer Medicine, MRC Cyclotron Building, Imperial College London, Hammersmith Hospital, London, UK
    Eur J Immunol 35:2748-61. 2005
    ....
  57. pmc Vav family proteins are required for optimal regulation of PLCgamma2 by integrin alphaIIbbeta3
    Andrew C Pearce
    Centre for Cardiovascular Sciences, Institute of Biomedical Research, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Biochem J 401:753-61. 2007
    ..These results demonstrate that Vav1 and Vav3 are required for optimal spreading and regulation of PLCgamma2 by integrin alphaIIbbeta3, but that their requirement is by-passed upon G-protein receptor activation...
  58. pmc Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets
    Yotis A Senis
    Centre for Cardiovascular Sciences, Division of Medical Sciences, Institute of Biomedical Research, Wolfson Drive, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK
    Platelets 16:191-202. 2005
    ..The more pronounced inhibitory effect of LY294002 and wortmannin indicates that other isoforms of PI 3-kinase play a more significant role in signalling by the two platelet glycoprotein receptors...
  59. pmc The 3BP2 adapter protein is required for optimal B-cell activation and thymus-independent type 2 humoral response
    Grace Chen
    Princess Margaret Hospital Ontario Cancer Institute, Room 10 105, University Ave, Toronto, ON, Canada
    Mol Cell Biol 27:3109-22. 2007
    ..We show that 3BP2 binds via its SH2 domain to the CD19 signaling complex and is required for optimum Syk phosphorylation and calcium flux...
  60. pmc Requirement of bic/microRNA-155 for normal immune function
    Antony Rodriguez
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Science 316:608-11. 2007
    ..Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system...
  61. pmc The role of endothelial PI3Kgamma activity in neutrophil trafficking
    Kamal D Puri
    ICOS Corporation, Bothell, WA, USA
    Blood 106:150-7. 2005
    ....
  62. doi request reprint Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation
    Eloisa Arana
    Lymphocyte Interaction Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Immunity 28:88-99. 2008
    ..We postulate that this critical role for Rac2 in mediating B cell adhesion and IS formation might apply in all lymphocytes...