Khin Thway

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. doi request reprint Two-stage phase I dose-escalation study of intratumoral reovirus type 3 dearing and palliative radiotherapy in patients with advanced cancers
    Kevin J Harrington
    The Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Clin Cancer Res 16:3067-77. 2010
  2. doi request reprint Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck
    Kevin J Harrington
    Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
    Clin Cancer Res 16:4005-15. 2010
  3. doi request reprint Immunohistochemical detection of glypican-5 in paraffin-embedded material: an optimized method for a novel research antibody
    Khin Thway
    Sarcoma Molecular Pathology Team, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK
    Appl Immunohistochem Mol Morphol 20:189-95. 2012
  4. doi request reprint Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases
    Khin Thway
    Sarcoma Unit, Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:470-7. 2012
  5. doi request reprint Glypican-3 is expressed in rhabdomyosarcomas but not adult spindle cell and pleomorphic sarcomas
    Khin Thway
    Sarcoma Molecular Pathology Team, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK
    J Clin Pathol 64:587-91. 2011
  6. doi request reprint Role of palliative chemotherapy in advanced epithelioid sarcoma
    Robin L Jones
    Sarcoma Unit, Royal Marsden Hospital, London, UK
    Am J Clin Oncol 35:351-7. 2012
  7. doi request reprint Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors
    Khin Thway
    Sarcoma Unit, Department of Histopathology, Drug Development and Medical Oncology Units, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:462-9. 2012
  8. doi request reprint Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 35:1722-32. 2011
  9. doi request reprint Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, SW3 6JJ London, UK
    Hum Pathol 44:289-93. 2013
  10. doi request reprint Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 36:e1-e11. 2012

Collaborators

Detail Information

Publications26

  1. doi request reprint Two-stage phase I dose-escalation study of intratumoral reovirus type 3 dearing and palliative radiotherapy in patients with advanced cancers
    Kevin J Harrington
    The Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Clin Cancer Res 16:3067-77. 2010
    ..To determine the safety and feasibility of combining intratumoral reovirus and radiotherapy in patients with advanced cancer and to assess viral biodistribution, reoviral replication in tumors, and antiviral immune responses...
  2. doi request reprint Phase I/II study of oncolytic HSV GM-CSF in combination with radiotherapy and cisplatin in untreated stage III/IV squamous cell cancer of the head and neck
    Kevin J Harrington
    Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
    Clin Cancer Res 16:4005-15. 2010
    ....
  3. doi request reprint Immunohistochemical detection of glypican-5 in paraffin-embedded material: an optimized method for a novel research antibody
    Khin Thway
    Sarcoma Molecular Pathology Team, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK
    Appl Immunohistochem Mol Morphol 20:189-95. 2012
    ..We demonstrate that anti-human GPC5 antibody is amenable to use in FFPE tissue and with the optimized protocol we describe shows specific cellular localization and good staining intensity with minimal background staining...
  4. doi request reprint Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases
    Khin Thway
    Sarcoma Unit, Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:470-7. 2012
    ..Here, we discuss the clinical, radiologic, and pathologic findings and review the literature on adrenal cortical carcinosarcomas...
  5. doi request reprint Glypican-3 is expressed in rhabdomyosarcomas but not adult spindle cell and pleomorphic sarcomas
    Khin Thway
    Sarcoma Molecular Pathology Team, Division of Molecular Pathology, The Institute of Cancer Research, Sutton, Surrey, UK
    J Clin Pathol 64:587-91. 2011
    ..Immunohistochemistry was performed on tissue microarrays to study GPC3 expression in paediatric RMS and a variety of the more common spindle cell and pleomorphic adult sarcomas...
  6. doi request reprint Role of palliative chemotherapy in advanced epithelioid sarcoma
    Robin L Jones
    Sarcoma Unit, Royal Marsden Hospital, London, UK
    Am J Clin Oncol 35:351-7. 2012
    ..The aim of this study was to investigate the response rate and progression-free survival in a series of epithelioid sarcoma patients treated with chemotherapy at a single referral center...
  7. doi request reprint Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors
    Khin Thway
    Sarcoma Unit, Department of Histopathology, Drug Development and Medical Oncology Units, The Royal Marsden NHS Foundation Trust, London, UK
    Am J Surg Pathol 36:462-9. 2012
    ..p16 was the most sensitive and specific marker for detecting WDL/DDL, and the combination of CDK4 and p16 is of more discriminatory value than the combination of either with MDM2, the least sensitive and specific of the 3 markers...
  8. doi request reprint Primary pulmonary myxoid sarcoma with EWSR1-CREB1 fusion: a new tumor entity
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 35:1722-32. 2011
    ....
  9. doi request reprint Metastatic angiomatoid fibrous histiocytoma of the scalp, with EWSR1-CREB1 gene fusions in primary tumor and nodal metastasis
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, SW3 6JJ London, UK
    Hum Pathol 44:289-93. 2013
    ..Angiomatoid fibrous histiocytoma can mimic both benign and malignant lesions, and although most behave indolently, it is important to recognize their metastatic potential...
  10. doi request reprint Tumors with EWSR1-CREB1 and EWSR1-ATF1 fusions: the current status
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Am J Surg Pathol 36:e1-e11. 2012
    ..We review the clinicopathologic and molecular features of this group of neoplasms unified by the presence of EWSR1-CREB1 and EWSR1-ATF1 genetic fusions...
  11. doi request reprint PAX3/FOXO1 fusion gene status is the key prognostic molecular marker in rhabdomyosarcoma and significantly improves current risk stratification
    Edoardo Missiaglia
    The Institute of Cancer Research, Sutton, Surrey, UK
    J Clin Oncol 30:1670-7. 2012
    ..To improve the risk stratification of patients with rhabdomyosarcoma (RMS) through the use of clinical and molecular biologic data...
  12. doi request reprint Endobronchial pulmonary angiomatoid fibrous histiocytoma: two cases with EWSR1-CREB1 and EWSR1-ATF1 fusions
    Khin Thway
    Department of Histopathology, Royal Marsden NHS Foundation Trust, 203 Fulham Road, London, UK
    Am J Surg Pathol 36:883-8. 2012
    ..It is likely that cases of AFH in the lung may have been previously missed because of their morphologic and genetic overlap with other pulmonary lesions...
  13. doi request reprint Clinical benefit of early phase clinical trial participation for advanced sarcoma patients
    Robin L Jones
    Royal Marsden Hospital, London, SW3 6JJ, UK
    Cancer Chemother Pharmacol 68:423-9. 2011
    ..The aim of this study was to evaluate the clinical benefit for sarcoma patients treated within the Phase I Unit of a single referral centre...
  14. doi request reprint Primary cardiac sarcomas may develop from resident or bone marrow-derived mesenchymal stem cells: use of immunohistochemistry including CD44 and octamer binding protein 3/4
    Laszlo Hegyi
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Histopathology 61:966-73. 2012
    ..To provide evidence that cardiac sarcomas 'not otherwise specified' express markers that might indicate their cellular origin or identify any lines of differentiation...
  15. doi request reprint Primary cutaneous epithelioid angiosarcoma: a clinicopathologic study of 13 cases of a rare neoplasm occurring outside the setting of conventional angiosarcomas and with predilection for the limbs
    Ravi Suchak
    Department of Dermatopathology, St John s Institute of Dermatology, St Thomas Hospital, London, UK
    Am J Surg Pathol 35:60-9. 2011
    ..These findings suggest that primary cutaneous epithelioid angiosarcoma occurring outside the conventional settings of angiosarcoma is a highly aggressive malignant tumor with mortality rates in excess of 55% after 3 years...
  16. doi request reprint Utility of sarcoma-specific fusion gene analysis in paraffin-embedded material for routine diagnosis at a specialist centre
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    J Clin Pathol 63:508-12. 2010
    ..It can be aided by detection of specific genetic aberrations in many cases. This study assessed the utility of a molecular genetics/cytogenetics service as part of the routine diagnostic service at the Royal Marsden Hospital...
  17. doi request reprint Chemotherapy in clear cell sarcoma
    Robin L Jones
    Royal Marsden Hospital, London, UK
    Med Oncol 28:859-63. 2011
    ..These data provide a reference for response and outcome in the assessment of novel agents in this histological subtype...
  18. doi request reprint Metastatic renal mucinous tubular and spindle cell carcinoma. Atypical behavior of a rare, morphologically bland tumor
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Ann Diagn Pathol 16:407-10. 2012
    ....
  19. doi request reprint Chondroid lipoma: an update and review
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London, UK
    Ann Diagn Pathol 16:230-4. 2012
    ..We review the literature on chondroid lipoma, discussing tumor histology, immunohistochemistry, ultrastructure, and differential diagnosis, and summarize the molecular genetic features so far known...
  20. doi request reprint Anatomic distribution of cervical lymph node spread in parotid carcinoma
    Edward J Chisholm
    Head and Neck Unit, Royal Marsden Hospital, London, UK
    Head Neck 33:513-5. 2011
    ..The pattern of distribution of cervical nodal involvement from primary parotid carcinomas has not been extensively described...
  21. doi request reprint Dedifferentiated liposarcoma with meningothelial-like whorls, metaplastic bone formation, and CDK4, MDM2, and p16 expression: a morphologic and immunohistochemical study
    Khin Thway
    Department of Histopathology, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, London, UK
    Am J Surg Pathol 35:356-63. 2011
    ..The CDK4, MDM2, and p16 expression in the whorls suggests that they share a similar genetic background to well-differentiated and dedifferentiated liposarcoma, and that additional genetic events are causal to their distinct morphology...
  22. doi request reprint Pediatric fibroblastic and myofibroblastic lesions
    Khin Thway
    Department of Histopathology, The Royal Marsden NHS Foundation Trust, London, UK
    Adv Anat Pathol 19:54-65. 2012
    ..In this review, we discuss the clinicopathologic spectrum of fibroblastic and myofibroblastic lesions of childhood and adolescence...
  23. doi request reprint The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial
    Shahneen K Sandhu
    The Institute of Cancer Research, Sutton, Surrey, UK
    Lancet Oncol 14:882-92. 2013
    ..We investigated the safety, tolerability, maximum tolerated dose, pharmacokinetic and pharmacodynamic profiles, and preliminary antitumour activity of niraparib...
  24. doi request reprint Heterologous osteosarcomatous and rhabdomyosarcomatous elements in dedifferentiated solitary fibrous tumor: further support for the concept of dedifferentiation in solitary fibrous tumor
    Khin Thway
    Sarcoma Unit, Department of Histopathology, Royal Marsden Hospital, London UK Electronic address
    Ann Diagn Pathol 17:457-63. 2013
    ..This expands the range of histopathology of this rare, newly characterized type of malignant progression in solitary fibrous tumor. ..
  25. doi request reprint Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant
    Yassar A Qureshi
    The Royal Marsden Hospital, Soft Tissue Sarcoma Unit, London, UK
    J Surg Oncol 101:520-3. 2010
    ..We describe a further case and review the relevant literature with specific emphasis on a possible mechanism for the development of angiosarcoma in the post-transplant patient...
  26. doi request reprint Claudin-1 is expressed in perineurioma-like low-grade fibromyxoid sarcoma
    Khin Thway
    Department of Histopathology, Royal Marsden Hospital, London SW3 6JJ, UK
    Hum Pathol 40:1586-90. 2009
    ..Although positivity for claudin-1 remains useful as an adjunct marker for perineurioma, it should be taken in context with clinical findings, morphology, and the additional immunoprofile...