Arthur Thompson

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc An incomplete TCA cycle increases survival of Salmonella Typhimurium during infection of resting and activated murine macrophages
    Steven D Bowden
    Institute of Food Research, Norwich, United Kingdom
    PLoS ONE 5:e13871. 2010
  2. pmc Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses
    M H Karavolos
    Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle NE2 4HH, UK
    BMC Genomics 9:458. 2008
  3. ncbi request reprint It's easy to build your own microarrayer!
    A Thompson
    Molecular Microbiology, Institute of Food Research, Colney, NR4 7UA, Norwich, UK
    Trends Microbiol 9:154-6. 2001
  4. ncbi request reprint The bacterial signal molecule, ppGpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of Salmonella
    Arthur Thompson
    Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom
    J Biol Chem 281:30112-21. 2006
  5. ncbi request reprint Salmonella transcriptomics: relating regulons, stimulons and regulatory networks to the process of infection
    Arthur Thompson
    Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK
    Curr Opin Microbiol 9:109-16. 2006
  6. pmc Location effects of a reporter gene on expression levels and on native protein synthesis in Lactococcus lactis and Saccharomyces cerevisiae
    A Thompson
    Institute of Food Research, Colney, Norwich NR4 7UA, United Kingdom
    Appl Environ Microbiol 67:3434-9. 2001
  7. ncbi request reprint Characterization of an alanine racemase gene from Lactobacillus reuteri
    Arthur Thompson
    Institute of Food Research, Colney Lane, Colney, Norwich, NR4 7UA, UK
    Curr Microbiol 44:246-50. 2002
  8. pmc Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium
    Steven D Bowden
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Infect Immun 77:3117-26. 2009
  9. doi request reprint The H-NS-like protein StpA represses the RpoS (sigma 38) regulon during exponential growth of Salmonella Typhimurium
    Sacha Lucchini
    Institute of Food Research, Colney Lane, Norwich, NR4 7UA, UK
    Mol Microbiol 74:1169-86. 2009
  10. ncbi request reprint Benefits and pitfalls of using microarrays to monitor bacterial gene expression during infection
    Jay C D Hinton
    Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, United Kingdom
    Curr Opin Microbiol 7:277-82. 2004

Collaborators

Detail Information

Publications22

  1. pmc An incomplete TCA cycle increases survival of Salmonella Typhimurium during infection of resting and activated murine macrophages
    Steven D Bowden
    Institute of Food Research, Norwich, United Kingdom
    PLoS ONE 5:e13871. 2010
    ..We investigated the role of the tricarboxylic acid (TCA) cycle in the intracellular replication of Salmonella Typhimurium in resting and activated macrophages, epithelial cells, and during infection of mice...
  2. pmc Adrenaline modulates the global transcriptional profile of Salmonella revealing a role in the antimicrobial peptide and oxidative stress resistance responses
    M H Karavolos
    Institute for Cell and Molecular Biosciences, The Medical School, University of Newcastle, Newcastle NE2 4HH, UK
    BMC Genomics 9:458. 2008
    ..We wished to investigate the impact of adrenaline on the biology of Salmonella spp...
  3. ncbi request reprint It's easy to build your own microarrayer!
    A Thompson
    Molecular Microbiology, Institute of Food Research, Colney, NR4 7UA, Norwich, UK
    Trends Microbiol 9:154-6. 2001
    ..Having built our own robot, we want to dispel some of the myths that might be associated with such a project, as well as provide practical advice for potential builders in the UK and Europe...
  4. ncbi request reprint The bacterial signal molecule, ppGpp, mediates the environmental regulation of both the invasion and intracellular virulence gene programs of Salmonella
    Arthur Thompson
    Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, United Kingdom
    J Biol Chem 281:30112-21. 2006
    ..This is the first demonstration that this highly conserved regulatory system is involved in bacterial virulence gene expression on a global scale...
  5. ncbi request reprint Salmonella transcriptomics: relating regulons, stimulons and regulatory networks to the process of infection
    Arthur Thompson
    Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK
    Curr Opin Microbiol 9:109-16. 2006
    ..This task has highlighted the need for sophisticated computational techniques to describe regulatory interactions...
  6. pmc Location effects of a reporter gene on expression levels and on native protein synthesis in Lactococcus lactis and Saccharomyces cerevisiae
    A Thompson
    Institute of Food Research, Colney, Norwich NR4 7UA, United Kingdom
    Appl Environ Microbiol 67:3434-9. 2001
    ..Analysis of the protein composition of the yeast and lactococcal integrant strains by separation on one-dimensional (1D) and 2D gels showed no significant variations in position beyond those observed in control samples...
  7. ncbi request reprint Characterization of an alanine racemase gene from Lactobacillus reuteri
    Arthur Thompson
    Institute of Food Research, Colney Lane, Colney, Norwich, NR4 7UA, UK
    Curr Microbiol 44:246-50. 2002
    ..6% homology to the Lb. plantarum alanine racemase. Unlike the single alanine racemase activity found in Lb. plantarum, deletion of the Lb. reuteri alanine racemase reveals a second activity, which is inhibited by beta-chloro- D-alanine...
  8. pmc Glucose and glycolysis are required for the successful infection of macrophages and mice by Salmonella enterica serovar typhimurium
    Steven D Bowden
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Infect Immun 77:3117-26. 2009
    ..7 macrophages. This study proves that S. Typhimurium requires glycolysis for infection of mice and macrophages and that transport of glucose is required for replication within macrophages...
  9. doi request reprint The H-NS-like protein StpA represses the RpoS (sigma 38) regulon during exponential growth of Salmonella Typhimurium
    Sacha Lucchini
    Institute of Food Research, Colney Lane, Norwich, NR4 7UA, UK
    Mol Microbiol 74:1169-86. 2009
    ..Our findings identify StpA as a novel growth phase-specific regulator that plays an important physiological role by linking sigma(38) levels to nutrient availability...
  10. ncbi request reprint Benefits and pitfalls of using microarrays to monitor bacterial gene expression during infection
    Jay C D Hinton
    Molecular Microbiology Group, Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, United Kingdom
    Curr Opin Microbiol 7:277-82. 2004
    ..Here, we review the methods used to produce microarray data for defining the bacterial intracellular transcriptome, and examine the pitfalls in extracting bacterial RNA from the infected host compartment...
  11. pmc Lag phase is a distinct growth phase that prepares bacteria for exponential growth and involves transient metal accumulation
    Matthew D Rolfe
    Institute of Food Research, Norwich Research Park, Norwich, UK
    J Bacteriol 194:686-701. 2012
    ..The study of lag phase promises to identify the physiological and regulatory processes responsible for adaptation to new environments...
  12. pmc The architecture and ppGpp-dependent expression of the primary transcriptome of Salmonella Typhimurium during invasion gene expression
    Vinoy K Ramachandran
    Institute of Food Research, Norwich, UK, University of Wurzburg, Josef Schneider Str, 2 Bau D15, 97080 Wurzburg, Germany
    BMC Genomics 13:25. 2012
    ..Typhimurium and a ppGpp null strain under growth conditions which model ST(EX). In doing so we show that ppGpp plays a much wider role in regulating the S. Typhimurium ST(EX) primary transcriptome than previously recognised...
  13. doi request reprint Salicylidene acylhydrazide-mediated inhibition of type III secretion system-1 in Salmonella enterica serovar Typhimurium is associated with iron restriction and can be reversed by free iron
    Abigail N Layton
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire, UK
    FEMS Microbiol Lett 302:114-22. 2010
    ..We show that INP0403 restricts iron availability to Salmonella, and that inhibition of T3S system-1 by INP0403 is, at least in part, reversible by exogenous iron and independent of the iron response regulator Fur...
  14. pmc During infection of epithelial cells Salmonella enterica serovar Typhimurium undergoes a time-dependent transcriptional adaptation that results in simultaneous expression of three type 3 secretion systems
    I Hautefort
    Molecular Microbiology Group, Institute of Food Research, Norwich NR4 7UA, UK
    Cell Microbiol 10:958-84. 2008
    ....
  15. pmc Nutritional and Metabolic Requirements for the Infection of HeLa Cells by Salmonella enterica Serovar Typhimurium
    Steven D Bowden
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan
    PLoS ONE 9:e96266. 2014
    ..Typhimurium within HeLa cells. ..
  16. pmc SseL, a Salmonella deubiquitinase required for macrophage killing and virulence
    Anne Rytkonen
    Department of Infectious Diseases, Centre for Molecular Microbiology and Infection and Division of Molecular Biosciences, Imperial College London, Flowers Building, Armstrong Road, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 104:3502-7. 2007
    ..Salmonella sseL mutant strains did not show a replication defect or induce altered levels of cytokine production upon infection of macrophages but were defective for a delayed cytotoxic effect and were attenuated for virulence in mice...
  17. pmc Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica
    Mark O Clements
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, 171 77 Stockholm, Sweden
    Proc Natl Acad Sci U S A 99:8784-9. 2002
    ..The results demonstrate a connection between PNPase and Salmonella virulence and show that alterations in PNPase activity could represent a strategy for the establishment of persistency...
  18. pmc Polynucleotide phosphorylase negatively controls spv virulence gene expression in Salmonella enterica
    Sofia Eriksson Ygberg
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, 171 77 Stockholm, Sweden
    Infect Immun 74:1243-54. 2006
    ..Combined, our results support the idea that in S. enterica PNPase, apart from being a regulator of the cold shock response, also functions in tuning the expression of virulence genes and bacterial fitness during infection...
  19. ncbi request reprint Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
    Sofia Eriksson
    Microbiology and Tumor Biology Center, Karolinska Institute, Nobels vag 16, 171 77 Stockholm, Sweden
    Mol Microbiol 47:103-18. 2003
    ..This is the first report that identifies the whole set of in vivo-regulated genes for any bacterial pathogen during infection of mammalian cells...
  20. ncbi request reprint Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG)
    Louise J Lloyd
    Department of Biological Sciences, Sir Alexander Fleming Building, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom
    J Biol Chem 279:55707-14. 2004
    ..Because yjbO is co-conserved and co-regulated with the psp operon and is a member of the phage shock protein F regulon, we propose that yjbO be renamed pspG...
  21. pmc Transcriptional profiling of colicin-induced cell death of Escherichia coli MG1655 identifies potential mechanisms by which bacteriocins promote bacterial diversity
    Daniel Walker
    Department of Biology, University of York, Heslington, York YO10 5YW, United Kingdom
    J Bacteriol 186:866-9. 2004
    ..coli populations, pointing to a more general role for colicins in adaptive bacterial physiology than has hitherto been realized...
  22. pmc Comparative genomic indexing reveals the phylogenomics of Escherichia coli pathogens
    Muna F Anjum
    Department of Bacterial Diseases, Veterinary Laboratories Agency Weybridge, New Haw, Addlestone, Surrey KT15 3NB, United Kingdom
    Infect Immun 71:4674-83. 2003
    ..Using this approach, we established the core genes which are central to the E. coli species and identified regions of variation from the E. coli K-12 chromosomal backbone...