Katrina Tatton-Brown

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. doi request reprint The NSD1 and EZH2 overgrowth genes, similarities and differences
    Katrina Tatton-Brown
    Institute of Cancer Research, St George s University of London and the Royal Marsden Hospital, London, UK
    Am J Med Genet C Semin Med Genet 163:86-91. 2013
  2. doi request reprint Molecular mechanisms of childhood overgrowth
    Katrina Tatton-Brown
    Institute of Cancer Research, St George s University of London and the Royal Marsden Hospital, London, UK
    Am J Med Genet C Semin Med Genet 163:71-5. 2013
  3. pmc Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability
    Katrina Tatton-Brown
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK 2 Cancer Genetics Unit, Royal Marsden Hospital, London, UK 3 Medical Genetics, St George s University of London, London, UK
    Nat Genet 46:385-8. 2014
  4. ncbi request reprint Clinical features of NSD1-positive Sotos syndrome
    Katrina Tatton-Brown
    Section of Cancer Genetics, Brookes Lawley Building, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Clin Dysmorphol 13:199-204. 2004
  5. ncbi request reprint Weaver syndrome and EZH2 mutations: Clarifying the clinical phenotype
    Katrina Tatton-Brown
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Am J Med Genet A 161:2972-80. 2013
  6. ncbi request reprint Sotos syndrome
    Katrina Tatton-Brown
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Eur J Hum Genet 15:264-71. 2007
  7. ncbi request reprint Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth
    Jenny Douglas
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Nat Genet 39:963-5. 2007
  8. pmc Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height
    Katrina Tatton-Brown
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Oncotarget 2:1127-33. 2011
  9. ncbi request reprint Evaluation of NSD2 and NSD3 in overgrowth syndromes
    Jenny Douglas
    Section of Cancer Genetics, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Eur J Hum Genet 13:150-3. 2005

Collaborators

Detail Information

Publications9

  1. doi request reprint The NSD1 and EZH2 overgrowth genes, similarities and differences
    Katrina Tatton-Brown
    Institute of Cancer Research, St George s University of London and the Royal Marsden Hospital, London, UK
    Am J Med Genet C Semin Med Genet 163:86-91. 2013
    ..However, studies are underway to address these and, as more cases are ascertained and technology improves, it is hoped that these will, in time, be answered...
  2. doi request reprint Molecular mechanisms of childhood overgrowth
    Katrina Tatton-Brown
    Institute of Cancer Research, St George s University of London and the Royal Marsden Hospital, London, UK
    Am J Med Genet C Semin Med Genet 163:71-5. 2013
    ..We hope that some of the work reviewed in this issue will facilitate the next decade's discoveries and we look forward to a 10 years as productive as the last...
  3. pmc Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability
    Katrina Tatton-Brown
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK 2 Cancer Genetics Unit, Royal Marsden Hospital, London, UK 3 Medical Genetics, St George s University of London, London, UK
    Nat Genet 46:385-8. 2014
    ..Thus, DNMT3A joins an emerging group of epigenetic DNA- and histone-modifying genes associated with both developmental growth disorders and hematological malignancies. ..
  4. ncbi request reprint Clinical features of NSD1-positive Sotos syndrome
    Katrina Tatton-Brown
    Section of Cancer Genetics, Brookes Lawley Building, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Clin Dysmorphol 13:199-204. 2004
    ..A mutation or microdeletion of NSD1 is diagnostic of Sotos syndrome...
  5. ncbi request reprint Weaver syndrome and EZH2 mutations: Clarifying the clinical phenotype
    Katrina Tatton-Brown
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Am J Med Genet A 161:2972-80. 2013
    ..As mutation testing becomes increasingly accessible and larger numbers of EZH2 mutation-positive individuals are identified, knowledge of the clinical spectrum and prognostic implications of EZH2 mutations should improve...
  6. ncbi request reprint Sotos syndrome
    Katrina Tatton-Brown
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Eur J Hum Genet 15:264-71. 2007
    ..More recently, the NSD1 mutational spectrum has been defined, the phenotype of Sotos syndrome clarified and diagnostic and management guidelines developed...
  7. ncbi request reprint Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth
    Jenny Douglas
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Nat Genet 39:963-5. 2007
    ..These data identify RNF135 as causative of a new overgrowth syndrome and demonstrate that RNF135 haploinsufficiency contributes to the phenotype of NF1 microdeletion cases...
  8. pmc Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height
    Katrina Tatton-Brown
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Oncotarget 2:1127-33. 2011
    ..Our data establish EZH2 mutations as the cause of Weaver syndrome and provide further links between histone modifications and regulation of human growth...
  9. ncbi request reprint Evaluation of NSD2 and NSD3 in overgrowth syndromes
    Jenny Douglas
    Section of Cancer Genetics, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
    Eur J Hum Genet 13:150-3. 2005
    ....