M W Shirley

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi Eimeria tenella: infection with a single sporocyst gives a clonal population
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Nr Newbury, Berks, UK
    Parasitology 112:523-8. 1996
  2. ncbi The genome of Eimeria spp., with special reference to Eimeria tenella--a coccidium from the chicken
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Newbury, UK
    Int J Parasitol 30:485-93. 2000
  3. pmc A genetic linkage map of the apicomplexan protozoan parasite Eimeria tenella
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Near Newbury, Berkshire, RG20 7NN UK
    Genome Res 10:1587-93. 2000
  4. ncbi The biology of avian Eimeria with an emphasis on their control by vaccination
    Martin W Shirley
    Institute for Animal Health, Compton Laboratory, Compton Nr Newbury, Berks RG20 7NN, UK
    Adv Parasitol 60:285-330. 2005
  5. ncbi The Eimeria genome projects: a sequence of events
    Martin W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Nr Newbury, Berkshire RG20 7NN, UK
    Trends Parasitol 20:199-201. 2004
  6. ncbi Integrating genetics and genomics to identify new leads for the control of Eimeria spp
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Nr Newbury, Berks, UK
    Parasitology 128:S33-42. 2004
  7. ncbi Genetic identification of antigens protective against coccidia
    D P Blake
    Enteric Immunology Group, Institute for Animal Health, Compton, Nr Newbury, Berkshire, UK
    Parasite Immunol 28:305-14. 2006
  8. ncbi Parasite genetics and the immune host: a novel strategy in the search for a vaccine against Eimeria spp
    D P Blake
    Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN
    Br Poult Sci 45:S16-7. 2004
  9. ncbi Modelling host cell availability and the crowding effect in Eimeria infections
    W T Johnston
    Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, Newbury, UK
    Int J Parasitol 31:1070-81. 2001
  10. ncbi Mapping the genome of Eimeria tenella: use of a yeast artificial chromosome library as the basis for a physical map
    B Hoogendoorn
    Institute for Animal Health, Compton, Berkshire, UK
    Parasitol Res 84:13-6. 1998

Detail Information

Publications17

  1. ncbi Eimeria tenella: infection with a single sporocyst gives a clonal population
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Nr Newbury, Berks, UK
    Parasitology 112:523-8. 1996
    ..EAch of the 5 polymorphic DNA markers used segregated independently within the "recombinant' parasites and only 1 of the parental forms was inherited in 22 of the populations aimed to have been established from a single sporocyst...
  2. ncbi The genome of Eimeria spp., with special reference to Eimeria tenella--a coccidium from the chicken
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Newbury, UK
    Int J Parasitol 30:485-93. 2000
    ..No large-scale genomic DNA sequencing projects have been reported...
  3. pmc A genetic linkage map of the apicomplexan protozoan parasite Eimeria tenella
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Near Newbury, Berkshire, RG20 7NN UK
    Genome Res 10:1587-93. 2000
    ..A table with the segregation data is available as an online supplement at http://www.genome.org.]..
  4. ncbi The biology of avian Eimeria with an emphasis on their control by vaccination
    Martin W Shirley
    Institute for Animal Health, Compton Laboratory, Compton Nr Newbury, Berks RG20 7NN, UK
    Adv Parasitol 60:285-330. 2005
    ..Although Eimeria are effective immunogens, it is probable that to date none of the antigens that induce potent protective immune responses during the course of natural infection has been isolated...
  5. ncbi The Eimeria genome projects: a sequence of events
    Martin W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Nr Newbury, Berkshire RG20 7NN, UK
    Trends Parasitol 20:199-201. 2004
  6. ncbi Integrating genetics and genomics to identify new leads for the control of Eimeria spp
    M W Shirley
    Institute for Animal Health, Compton Laboratory, Compton, Nr Newbury, Berks, UK
    Parasitology 128:S33-42. 2004
    ..Such a finding opens the way forward for genetic mapping of the loci responsible for the induction of protective immunity and integration with the genome sequencing efforts...
  7. ncbi Genetic identification of antigens protective against coccidia
    D P Blake
    Enteric Immunology Group, Institute for Animal Health, Compton, Nr Newbury, Berkshire, UK
    Parasite Immunol 28:305-14. 2006
    ..maxima genome linked to escape from a protective immune response. These regions now form the basis of detailed study to identify antigens as candidates for inclusion in future vaccination strategies...
  8. ncbi Parasite genetics and the immune host: a novel strategy in the search for a vaccine against Eimeria spp
    D P Blake
    Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN
    Br Poult Sci 45:S16-7. 2004
  9. ncbi Modelling host cell availability and the crowding effect in Eimeria infections
    W T Johnston
    Institute for Animal Health, Compton Laboratory, Berkshire RG20 7NN, Newbury, UK
    Int J Parasitol 31:1070-81. 2001
    ..Alternative factors such as the influence of the primary immune response to the parasite may also be explored using within-host models and other applications of these models are discussed...
  10. ncbi Mapping the genome of Eimeria tenella: use of a yeast artificial chromosome library as the basis for a physical map
    B Hoogendoorn
    Institute for Animal Health, Compton, Berkshire, UK
    Parasitol Res 84:13-6. 1998
    ..A probe representing the whole of the 1.2-Mb chromosome 2, excised from a preparative gel following pulsed-field gel electrophoresis, revealed between 80 and 100 positive clones...
  11. ncbi Amplified fragment length polymorphism analyses of Eimeria spp.: an improved process for genetic studies of recombinant parasites
    D P Blake
    Institute for Animal Health, Compton near Newbury, Berkshire RG20 7NN, UK
    Parasitol Res 90:473-5. 2003
    ..Our new method should also be useful for genetic analyses of other coccidial parasites and for the recovery of AFLP-quality DNA from other pathogens...
  12. ncbi Parasite genetics and the immune host: recombination between antigenic types of Eimeria maxima as an entrée to the identification of protective antigens
    Damer P Blake
    Eimerian Genomics Group, Institute for Animal Health, Compton, Nr Newbury, Berkshire RG20 7NN, UK
    Mol Biochem Parasitol 138:143-52. 2004
    ..Consideration of the numbers of parasites recombinant for the two traits implicates very few antigen-encoding loci. Our data provide a potential strategy to identify putative antigen-encoding loci in other parasites...
  13. pmc Antigenic diversity in Eimeria maxima and the influence of host genetics and immunization schedule on cross-protective immunity
    Adrian L Smith
    Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berks RG20 7NN, United Kingdom
    Infect Immun 70:2472-9. 2002
    ..These results are discussed in relation to the number of protective antigens presented by complex pathogens and the development of immunoprotective responses in hosts of different genetic backgrounds...
  14. ncbi Eimeria maxima: the influence of host genotype on parasite reproduction as revealed by quantitative real-time PCR
    Damer P Blake
    Enteric Immunology Group, Institute for Animal Health, Compton, Nr Newbury, Berkshire RG20 7NN, UK
    Int J Parasitol 36:97-105. 2006
    ..Parasite DNA remained detectable up to 20 days post-infection; 11 days after the last oocysts had been detected leaving the host...
  15. ncbi The influence of immunizing dose size and schedule on immunity to subsequent challenge with antigenically distinct strains of Eimeria maxima
    Damer P Blake
    Enteric Immunology Group, Institute for Animal Health, Compton, Nr Newbury, Berkshire, RG20 7NN, UK
    Avian Pathol 34:489-94. 2005
    ..These antigens supplement a separate restricted pool of antigens that are capable of stimulating stronger, but strain-specific, protective immune responses...
  16. ncbi Challenges in the successful control of the avian coccidia
    Martin W Shirley
    Molecular Parasitology, Institute for Animal Health, Compton, Nr Newbury, Berkshire RG20 7NN, United Kingdom
    Vaccine 25:5540-7. 2007
    ..Some past and present methods of controlling avian coccidia are discussed briefly and we describe progress with a novel approach to identify immunoprotective antigens as vaccine candidates...
  17. pmc metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella
    John W Pinney
    Faculty of Biological Sciences, University of Leeds, LS2 9JT, UK
    Nucleic Acids Res 33:1399-409. 2005
    ..5x to 7.5x. Lastly, as an example of how metaSHARK can be used to evaluate the genomic evidence for specific metabolic pathways, we present a study of coenzyme A biosynthesis in P.falciparum and E.tenella...