Genomes and Genes
B E Shaw
Affiliation: Institute of Cancer Research
- Donor safety: the role of the WMDA in ensuring the safety of volunteer unrelated donors: clinical and ethical considerationsB E Shaw
Department of Haematology, Anthony Nolan Trust, Royal Free Hospital, London, UK
Bone Marrow Transplant 45:832-8. 2010..One of the principal goals leading to the formation of the World Marrow Donor Association (WMDA) was to establish internationally acceptable standards for all aspects of unrelated donor care...
- Diverging effects of HLA-DPB1 matching status on outcome following unrelated donor transplantation depending on disease stage and the degree of matching for other HLA allelesB E Shaw
Research Department, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
Leukemia 24:58-65. 2010..Conversely, our results suggest that in patients receiving an HLA-mismatched graft, the outcome is significantly better if they are also mismatched for DPB1. We recommend validation of these results in independent datasets...
- Outcome of second allogeneic transplants using reduced-intensity conditioning following relapse of haematological malignancy after an initial allogeneic transplantB E Shaw
Department of Haematology, Royal Marsden Hospital, Institute of Cancer Research, London, UK
Bone Marrow Transplant 42:783-9. 2008..014). These data support our hypothesis that the second RIC allograft results in a lower TRM than using MA. A proportion of patients achieved a sustained remission even when relapsing after a previous MA transplant...
- Impact of extracorporeal photopheresis on skin scores and quality of life in patients with steroid-refractory chronic GVHDF L Dignan
1 St John s Institute of Dermatology, St Thomas Hospital, London, UK 2 Section of Haemato oncology, The Royal Marsden Hospital, Sutton, UK 3 University College London, Cancer Institute, London, UK
Bone Marrow Transplant 49:704-8. 2014..012 and 3.4 compared with 6.9, P=0.009, respectively). This study confirms that ECP can lead to objective clinical responses and, in addition, may lead to an improvement in QoL in cGVHD. ..
- The clinical implications of HLA mismatches in unrelated donor haematopoietic cell transplantationB E Shaw
Anthony Nolan Research Institute, Royal Free Hospital, Hampstead, UK
Int J Immunogenet 35:367-74. 2008..The findings of this study have made it possible to offer advice concerning the choice of the most appropriate unrelated donor to select in order to achieve the best patient outcomes...
- Evidence for a GVL effect following reduced-intensity allo-SCT in ALL: a British Society of Blood and Marrow Transplantation studyP G Medd
Department of Haematology, Oxford University Hospitals NHS Trust, Oxford, UK
Bone Marrow Transplant 48:982-7. 2013..035 and HR = 0.52, P = 0.025, respectively). Long-term ALL-free survival is achievable following fludarabine-based RIC allo-SCT. The association between GVHD and decreased RI suggests the presence of a GVL effect...
- Topical issues in unrelated donor haematopoietic stem cell transplants: a report from a workshop convened by the Anthony Nolan Trust in London - 2005R F Duarte
The Anthony Nolan Trust, Royal Free Hospital, London, UK
Bone Marrow Transplant 37:901-8. 2006....
- Unrelated adult stem cell donor medical suitability: recommendations from the World Marrow Donor Association Clinical Working Group CommitteeR N Lown
1 Anthony Nolan Research Institute, UCL Cancer Institute, London, UK 2 Royal Marsden NHS Foundation Trust, London, UK
Bone Marrow Transplant 49:880-6. 2014..Guidance from the WMDA is intended to complement, not supersede, guidance from national competent authorities and international regulatory bodies. ..
- Ethnicity, length of time on the register and sex predict donor availability at the confirmatory typing stageR N Lown
1 Anthony Nolan Research Institute, Royal Free Hospital, London, UK 2 UCL Cancer Institute, University College London, London, UK
Bone Marrow Transplant 49:525-31. 2014..99, 2.52, 3.4 and 5.53, respectively, for 1, 2, 3 and 4 risk factors, P<0.001). Donor registries must develop evidence-driven strategies to recruit and retain the most reliable donors. ..
- Towards a global system of vigilance and surveillance in unrelated donors of haematopoietic progenitor cells for transplantationB E Shaw
1 Anthony Nolan Research Institute, Royal Free Hospital, UCL Cancer Centre, London, UK 2 Royal Marsden NHS Foundation Trust, London, UK
Bone Marrow Transplant 48:1506-9. 2013..The system has a robust governance structure, formal feedback to the WMDA membership and transparent information flows to other agencies, specialist physicians and transplant programs and the general public. ..
- Beating the odds: factors implicated in the speed and availability of unrelated haematopoietic cell donor provisionR N Lown
Anthony Nolan, London, UK
Bone Marrow Transplant 48:210-9. 2013....
- Efficacy of bimonthly extracorporeal photopheresis in refractory chronic mucocutaneous GVHDF L Dignan
St John s Institute of Dermatology, St Thomas Hospital, London, UK
Bone Marrow Transplant 47:824-30. 2012..OS at 3 years from the start of ECP was 69%. This study reports the largest series of patients receiving bimonthly ECP treatment for cGVHD, and confirms that ECP allows successful reduction of immunosuppression...
- Transforming growth factor-β1 polymorphisms and the outcome of hematopoietic stem cell transplantationE Arrieta-Bolaños
The Anthony Nolan Research Institute, Royal Free and University College Medical School, Pond Street, Hampstead, London, UK
Int J Immunogenet 39:192-202. 2012..The present review will focus on the current knowledge surrounding the effect of polymorphisms within TGFB1 on the outcome of HSCT...
- A review of the haematopoietic stem cell donation experience: is there room for improvement?A Billen
1 UCL Cancer Institute, London, UK 2 Anthony Nolan, London, UK
Bone Marrow Transplant 49:729-36. 2014..Owing to the relative rarity of donation in each country, a global effort to collect donor outcome data is needed. ..
- Clinical importance of HLA-DPB1 in haematopoietic cell transplantationB E Shaw
Department of Haematology, Nottingham City Hospital, Nottingham, UK
Tissue Antigens 69:36-41. 2007..33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus...
- Polymorphisms in the TNFA gene promoter region show evidence of strong linkage disequilibrium with HLA and are associated with delayed neutrophil engraftment in unrelated donor hematopoietic stem cell transplantationB E Shaw
Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK
Tissue Antigens 63:401-11. 2004..Our results suggest a functional effect of TNFA polymorphisms on myeloid engraftment in unrelated HSCT...
- The degree of matching at HLA-DPB1 predicts for acute graft-versus-host disease and disease relapse following haematopoietic stem cell transplantationB E Shaw
Anthony Nolan Research Institute, Royal Free Hospital, London, UK
Bone Marrow Transplant 31:1001-8. 2003..This study provides further evidence for an immunogenic role of HLA-DPB1 in HSC transplants...