Andrew R Reynolds
Affiliation: Institute of Cancer Research
Reynolds A, Hart I, Watson A, Welti J, Silva R, Robinson S, et al
. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med. 2009;15:392-400 pubmed publisher
..The proangiogenic effects of low concentrations of RGD-mimetic integrin inhibitors could compromise their efficacy as anticancer agents and have major implications for the use of RGD-mimetic compounds in humans...
Bridgeman V, Wan E, Foo S, Nathan M, Welti J, Frentzas S, et al
. Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma. Mol Cancer Ther. 2016;15:172-83 pubmed publisher
..In conclusion, we provide preclinical evidence that combining a TKI, such as sunitinib or pazopanib, with a MEKI, such as trametinib, is a rational and efficacious treatment regimen for RCC. ..
Clarke C, Berg T, Birch J, Ennis D, Mitchell L, Cloix C, et al
. The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis. Curr Biol. 2016;26:755-65 pubmed publisher