Genomes and Genes


Andrew R Reynolds


Affiliation: Institute of Cancer Research
Country: UK


  1. Reynolds A, Hart I, Watson A, Welti J, Silva R, Robinson S, et al. Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med. 2009;15:392-400 pubmed publisher
    ..The proangiogenic effects of low concentrations of RGD-mimetic integrin inhibitors could compromise their efficacy as anticancer agents and have major implications for the use of RGD-mimetic compounds in humans...
  2. Bridgeman V, Wan E, Foo S, Nathan M, Welti J, Frentzas S, et al. Preclinical Evidence That Trametinib Enhances the Response to Antiangiogenic Tyrosine Kinase Inhibitors in Renal Cell Carcinoma. Mol Cancer Ther. 2016;15:172-83 pubmed publisher
    ..In conclusion, we provide preclinical evidence that combining a TKI, such as sunitinib or pazopanib, with a MEKI, such as trametinib, is a rational and efficacious treatment regimen for RCC. ..
  3. Clarke C, Berg T, Birch J, Ennis D, Mitchell L, Cloix C, et al. The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis. Curr Biol. 2016;26:755-65 pubmed publisher