Jorge S Reis-Filho

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
  2. pmc Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement
    Alan Mackay
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, UK
    J Natl Cancer Inst 103:662-73. 2011
  3. pmc Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype
    S E Elsheikh
    Department of Histopathology, School of Molecular Medical Sciences, Nottingham, UK
    Br J Cancer 99:327-34. 2008
  4. pmc Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
    Mohammed A Aleskandarany
    Department of Histopathology, School of Molecular Medical Sciences, Queens Medical Centre, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK
    Breast Cancer Res 14:R3. 2012
  5. pmc Molecular characterisation of cell line models for triple-negative breast cancers
    Anita Grigoriadis
    Breakthrough Breast Cancer Research Unit, Guy s Hospital, King s Health Partners AHSC, King s College London School of Medicine, London SE1 9RT, UK
    BMC Genomics 13:619. 2012
  6. pmc Prognostic signatures in breast cancer: correlation does not imply causation
    Charlotte Ng
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    Breast Cancer Res 14:313. 2012
  7. pmc Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction
    Pierre Emmanuel Colombo
    Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 13:212. 2011
  8. pmc Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment
    Olivia Wansbury
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Breast Cancer Res 13:R79. 2011
  9. pmc Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers
    Huiling Xu
    Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006, Australia
    Breast Cancer Res 13:R9. 2011
  10. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010

Detail Information

Publications138 found, 100 shown here

  1. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
    ..To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients...
  2. pmc Microarray-based class discovery for molecular classification of breast cancer: analysis of interobserver agreement
    Alan Mackay
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Rd, London SW3 6JB, UK
    J Natl Cancer Inst 103:662-73. 2011
    ..The aim of this study was to determine the objectivity and interobserver reproducibility of the assignment of molecular subtype classes by hierarchical cluster analysis...
  3. pmc Caveolin 1 and Caveolin 2 are associated with breast cancer basal-like and triple-negative immunophenotype
    S E Elsheikh
    Department of Histopathology, School of Molecular Medical Sciences, Nottingham, UK
    Br J Cancer 99:327-34. 2008
    ..Further studies are warranted to determine whether they play an oncogenic role in basal-like/triple-negative breast cancer development or are just surrogate markers for this subgroup...
  4. pmc Prognostic value of proliferation assay in the luminal, HER2-positive, and triple-negative biologic classes of breast cancer
    Mohammed A Aleskandarany
    Department of Histopathology, School of Molecular Medical Sciences, Queens Medical Centre, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK
    Breast Cancer Res 14:R3. 2012
    ..This study aimed to assess the prognostic value of a proliferation assay by using Ki-67 immunohistochemistry as compared with mitotic count scores...
  5. pmc Molecular characterisation of cell line models for triple-negative breast cancers
    Anita Grigoriadis
    Breakthrough Breast Cancer Research Unit, Guy s Hospital, King s Health Partners AHSC, King s College London School of Medicine, London SE1 9RT, UK
    BMC Genomics 13:619. 2012
    ..Target validation studies for all BC subtypes have largely employed established BC cell lines, which have proven to be effective tools for drug discovery...
  6. pmc Prognostic signatures in breast cancer: correlation does not imply causation
    Charlotte Ng
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    Breast Cancer Res 14:313. 2012
    ..These findings demonstrate that a statistical association between a gene signature and disease outcome does not necessarily imply biological significance...
  7. pmc Microarrays in the 2010s: the contribution of microarray-based gene expression profiling to breast cancer classification, prognostication and prediction
    Pierre Emmanuel Colombo
    Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 13:212. 2011
    ..Here, we review the clinical relevance of microarray-based profiling of breast cancer and discuss its impact on patient management...
  8. pmc Transcriptome analysis of embryonic mammary cells reveals insights into mammary lineage establishment
    Olivia Wansbury
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Breast Cancer Res 13:R79. 2011
    ..Despite these exciting properties, the molecular identity of embryonic mammary cells remains to be fully characterised...
  9. pmc Enhanced RAD21 cohesin expression confers poor prognosis and resistance to chemotherapy in high grade luminal, basal and HER2 breast cancers
    Huiling Xu
    Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A Beckett Street, Melbourne, VIC 8006, Australia
    Breast Cancer Res 13:R9. 2011
    ..We assessed its prognostic and predictive power in a cohort of in situ and invasive breast cancers, and its effect on chemosensitivity in vitro...
  10. pmc Breast cancer prognostic classification in the molecular era: the role of histological grade
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK
    Breast Cancer Res 12:207. 2010
    ....
  11. pmc Are triple-negative tumours and basal-like breast cancer synonymous?
    Emad A Rakha
    Breast Cancer Res 9:404; author reply 405. 2007
  12. pmc Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
    Laura G Fulford
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 9:R4. 2007
    ..Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas...
  13. pmc Identification of gene fusion transcripts by transcriptome sequencing in BRCA1-mutated breast cancers and cell lines
    Kevin C H Ha
    Department of Human Genetics, McGill University, Montreal, Quebec, H3A 1B1, Canada
    BMC Med Genomics 4:75. 2011
    ..We sought to identify putative gene fusions in the transcriptomes of these cancers using high-throughput RNA sequencing (RNA-Seq)...
  14. pmc Revisiting the technical validation of tumour biomarker assays: how to open a Pandora's box
    Caterina Marchio
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    BMC Med 9:41. 2011
    ..Here we discuss the challenges for the technical validation of immunohistochemical and gene expression assays to detect tumour biomarkers and provide suggestions of pragmatic solutions to address these challenges...
  15. pmc Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue
    David Robertson
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    BMC Cell Biol 9:13. 2008
    ..Consequently, there is a demand in the research community to be able to perform routine, high quality immunofluorescence labelling of FFPE tissues...
  16. ncbi request reprint Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma
    Jorge S Reis-Filho
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Arch Pathol Lab Med 127:e396-8. 2003
  17. ncbi request reprint Cyclin D1 protein overexpression and CCND1 amplification in breast carcinomas: an immunohistochemical and chromogenic in situ hybridisation analysis
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 19:999-1009. 2006
    ..The results of this study confirm the association between cyclin D1 overexpression and positivity for hormone receptors and the lack of CCND1 amplification in basal-like breast carcinomas...
  18. doi request reprint Molecular profiling: moving away from tumor philately
    Jorge S Reis-Filho
    Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, SW3 6JB, UK
    Sci Transl Med 2:47ps43. 2010
    ..On the wave of recent scientific advances and clinical findings, new cutting-edge technologies are poised to deliver an array of diverse molecular data that are expected to dramatically alter breast cancer diagnosis and treatment...
  19. doi request reprint Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using ETV6'split apart' probes
    J S Reis-Filho
    Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Histopathology 52:840-6. 2008
    ..It has been demonstrated that SCs of the breast consistently harbour the t(12;15)ETV6-NTRK3 translocation. The aim was to determine whether ACCs also harbour ETV6 gene rearrangements and are thus variants of SCs...
  20. pmc Next-generation sequencing
    Jorge S Reis-Filho
    Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Breast Cancer Res 11:S12. 2009
    ..Here, I discuss the potential impact of this technology on breast cancer research and the challenges that come with this technological breakthrough...
  21. pmc Non-operative breast pathology: lobular neoplasia
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Clin Pathol 60:1321-7. 2007
    ..Furthermore, the current recommendations for the management of lobular neoplasia diagnosed on core needle biopsies proposed in the National Health Service Breast Cancer Screening guidelines are discussed...
  22. doi request reprint Triple negative tumours: a critical review
    J S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Histopathology 52:108-18. 2008
    ..In addition, the possible mechanisms are discussed leading to BRCA1 pathway dysfunction in sporadic triple-negative and basal-like cancers and animal models for these tumour types...
  23. doi request reprint Breast cancer special types: why bother?
    J S Reis-Filho
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    J Pathol 216:394-8. 2008
    ..Here we review the molecular characteristics of special types of breast cancer, with special emphasis on their microarray-based expression profiles and their impact on our understanding of breast cancer...
  24. ncbi request reprint Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    J Pathol 207:1-13. 2005
    ..Taken together, these data suggest that at least some PLCs may evolve from the same precursor or through the same genetic pathway as classic lobular carcinomas...
  25. ncbi request reprint Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer
    Edurne Arriola
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Breast Cancer Res Treat 106:181-9. 2007
    ....
  26. doi request reprint Functional characterization of EMSY gene amplification in human cancers
    Paul M Wilkerson
    Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 225:29-42. 2011
    ..Taken together, this suggests that EMSY is unlikely to be a driver of the 11q13-q14 amplicon and does not have a dominant role in modulating the response to agents targeting cells with defective homologous recombination...
  27. doi request reprint Molecular analysis reveals a genetic basis for the phenotypic diversity of metaplastic breast carcinomas
    Felipe C Geyer
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 220:562-73. 2010
    ..This proof-of-principle study provides direct evidence of intra-tumour genetic heterogeneity in breast cancers, and shows that in some cases morphological diversity may be underpinned by distinct genetic aberrations...
  28. doi request reprint Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines
    Edurne Arriola
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lab Invest 88:491-503. 2008
    ..The 17q12 amplicon is complex and harbours multiple genes that may be associated with breast cancer development and progression, and potentially exploitable as therapeutic targets...
  29. ncbi request reprint DNA amplifications in breast cancer: genotypic-phenotypic correlations
    Kai Keen Shiu
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW36JB, UK
    Future Oncol 6:967-84. 2010
    ....
  30. ncbi request reprint Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis
    Kay Savage
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 13:90-101. 2007
    ....
  31. ncbi request reprint Distribution and significance of nerve growth factor receptor (NGFR/p75NTR) in normal, benign and malignant breast tissue
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 19:307-19. 2006
    ..Furthermore, provisional data in a small number of basal-like breast carcinomas suggest that NGFR may identify a subgroup of basal-like breast carcinomas with good prognosis...
  32. doi request reprint Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type
    Magali Lacroix-Triki
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 222:282-98. 2010
    ..Both components of mixed mucinous tumours are remarkably similar at the molecular level to pure mucinous cancers, suggesting that mixed mucinous carcinomas may be best classified as variants of mucinous cancers rather than of IDC-NSTs...
  33. doi request reprint Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family
    Tarek M A Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences and Nottingham University Hospitals Trust, University of Nottingham, Nottingham, UK
    Am J Surg Pathol 32:513-23. 2008
    ..Our findings support the concept that progression of LNGBC to HNGBC (basal-like or HER2+) phenotype is an unlikely biologic phenomenon...
  34. ncbi request reprint High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma
    Tarek M A Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, London, UK
    Am J Surg Pathol 31:417-26. 2007
    ..Molecular studies are being performed to substantiate the hypothesis that tubular and lobular carcinomas have direct evolutionary links to CCLs and flat epithelial atypia...
  35. ncbi request reprint Evaluation of Phi29-based whole-genome amplification for microarray-based comparative genomic hybridisation
    Edurne Arriola
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lab Invest 87:75-83. 2007
    ..For accurate results using Phi29 amplification, samples subjected to aCGH analysis should be combined with reference DNA amplified with the same method, using similar amounts of starting template...
  36. doi request reprint Cortactin gene amplification and expression in breast cancer: a chromogenic in situ hybridisation and immunohistochemical study
    Konstantin J Dedes
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, SW3 6JB, UK
    Breast Cancer Res Treat 124:653-66. 2010
    ..CTTN expression is not associated with the outcome of breast cancer patients treated with anthracycline-based chemotherapy...
  37. doi request reprint PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization study
    Maryou B Lambros
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 23:1334-45. 2010
    ..Co-amplification of PPM1D and HER2/TOP2A and CCND1 are not random events and may suggest the presence of a 'firestorm' genetic profile...
  38. doi request reprint Breast cancer molecular profiling with single sample predictors: a retrospective analysis
    Britta Weigelt
    Cancer Research UK, London Research Institute, London, UK
    Lancet Oncol 11:339-49. 2010
    ..Three microarray-based single sample predictors (SSPs) have been used to define molecular classification of individual samples. We aimed to establish agreement between these SSPs for identification of breast cancer molecular subtypes...
  39. doi request reprint Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components
    Caterina Marchio
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 218:301-15. 2009
    ....
  40. pmc Characterization of the genomic features and expressed fusion genes in micropapillary carcinomas of the breast
    Rachael Natrajan
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    J Pathol 232:553-65. 2014
    ..Although seemingly private genetic events, some of the fusion transcripts found in MPCs may play a role in maintenance of a malignant phenotype and potentially offer therapeutic opportunities...
  41. doi request reprint Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers
    Daniel Wetterskog
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    J Pathol 226:84-96. 2012
    ..Breast AdCCs constitute an entity distinct from grade-matched and triple-negative and basal-like IDC-NSTs, emphasizing the importance of histological subtyping of triple-negative and basal-like breast carcinomas...
  42. doi request reprint PPM1D is a potential therapeutic target in ovarian clear cell carcinomas
    David S P Tan
    Department of Histopathology and Gynecologic Oncology, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom
    Clin Cancer Res 15:2269-80. 2009
    ..To identify therapeutic targets in ovarian clear cell carcinomas, a chemoresistant and aggressive type of ovarian cancer...
  43. doi request reprint A high-resolution integrated analysis of genetic and expression profiles of breast cancer cell lines
    Alan Mackay
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res Treat 118:481-98. 2009
    ..e., gains of 1q, 8q and 20q), basal-like and luminal cell lines are characterised by distinct genomic aberrations...
  44. doi request reprint CD44 is overexpressed in basal-like breast cancers but is not a driver of 11p13 amplification
    Pamela Klingbeil
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res Treat 120:95-109. 2010
    ..Given that expression of CD44 is not an absolute requirement for the survival of cells harbouring CD44 gene amplification, CD44 is unlikely to be a driver of the 11p13 amplicon...
  45. ncbi request reprint Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients
    David S P Tan
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res Treat 111:27-44. 2008
    ....
  46. doi request reprint Breast cancer precursors revisited: molecular features and progression pathways
    Maria A Lopez-Garcia
    Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, UK
    Histopathology 57:171-92. 2010
    ....
  47. pmc FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer
    Nicholas Turner
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 70:2085-94. 2010
    ..Our data suggest that amplification and overexpression of FGFR1 may be a major contributor to poor prognosis in luminal-type breast cancers, driving anchorage-independent proliferation and endocrine therapy resistance...
  48. doi request reprint Transcriptomic analysis of tubular carcinomas of the breast reveals similarities and differences with molecular subtype-matched ductal and lobular carcinomas
    Maria A Lopez-Garcia
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 222:64-75. 2010
    ....
  49. doi request reprint β-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
    Felipe C Geyer
    Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 24:209-31. 2011
    ..In conclusion, β-catenin/Wnt pathway activation is preferentially found in triple-negative/basal-like breast carcinomas, is associated with poor clinical outcome and is unlikely to be driven by CTNNB1 mutations in breast cancer...
  50. pmc Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer
    Elise Ruark
    Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton SM2 5NG, UK
    Nature 493:406-10. 2013
    ..More generally, these data provide new insights into the role of rare and of mosaic genetic variants in common conditions, and the use of sequencing in their identification...
  51. doi request reprint A whole-genome massively parallel sequencing analysis of BRCA1 mutant oestrogen receptor-negative and -positive breast cancers
    Rachael Natrajan
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK
    J Pathol 227:29-41. 2012
    ....
  52. pmc MYC amplification in breast cancer: a chromogenic in situ hybridisation study
    S Maria Rodriguez-Pinilla
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Clin Pathol 60:1017-23. 2007
    ....
  53. doi request reprint Loss of 16q in high grade breast cancer is associated with estrogen receptor status: Evidence for progression in tumors with a luminal phenotype?
    Rachael Natrajan
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    Genes Chromosomes Cancer 48:351-65. 2009
    ..Given that GI breast cancers harbor a luminal phenotype, our results suggest that if progression from GI to GIII breast cancer does happen, it may preferentially occur in breast cancers of luminal phenotype...
  54. doi request reprint The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers
    Tarek M Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, UK
    J Pathol 220:419-34. 2010
    ....
  55. ncbi request reprint Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization
    Maryou B K Lambros
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lab Invest 86:398-408. 2006
    ..In summary, this protocol enables the generation of probes mapping to any gene of interest that can be applied to FFPETS, allowing correlation of morphological features with gene copy number...
  56. doi request reprint Tiling path genomic profiling of grade 3 invasive ductal breast cancers
    Rachael Natrajan
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Clin Cancer Res 15:2711-22. 2009
    ....
  57. pmc Functional characterization of the 19q12 amplicon in grade III breast cancers
    Rachael Natrajan
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 14:R53. 2012
    ..The aim of this study was to identify the genes within the 19q12 amplicon whose expression is required for the survival of cancer cells harbouring their amplification...
  58. doi request reprint Non-existence of caveolin-1 gene mutations in human breast cancer
    Neill Patani
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Breast Cancer Res Treat 131:307-10. 2012
    ..Taken together with other studies, which have also failed to identify CAV1 mutations, our data call into question the existence and biological and clinical relevance of CAV1 gene mutations in human breast cancer...
  59. ncbi request reprint Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis
    Peter T Simpson
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Am J Surg Pathol 29:734-46. 2005
    ..These data further support the hypothesis that CCLs are a nonobligate, intermediary step in the development of some forms of low grade in situ and invasive carcinoma...
  60. doi request reprint Genomic and mutational profiling of ductal carcinomas in situ and matched adjacent invasive breast cancers reveals intra-tumour genetic heterogeneity and clonal selection
    Lucia Hernandez
    Molecular Pathology Team, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 227:42-52. 2012
    ....
  61. doi request reprint An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers
    Rachael Natrajan
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Breast Cancer Res Treat 121:575-89. 2010
    ..g. proliferation, HER2 and ER signalling) may be driven by specific patterns of copy number aberrations...
  62. pmc Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 7:R1028-35. 2005
    ..We investigated whether HER2 and EGFR overexpression was present and evaluated gene amplification in a series of metaplastic breast carcinomas...
  63. doi request reprint PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors
    Konstantin J Dedes
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, SW3 6JB London, UK
    Sci Transl Med 2:53ra75. 2010
    ..Given that up to 80% of endometrioid endometrial cancers lack PTEN expression, our results suggest that PARP inhibitors may be therapeutically useful for a subset of endometrioid endometrial cancers...
  64. doi request reprint Microglandular adenosis or microglandular adenoma? A molecular genetic analysis of a case associated with atypia and invasive carcinoma
    Felipe C Geyer
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Histopathology 55:732-43. 2009
    ..The aim of this study was to determine whether MGA is clonal and whether it harbours chromosomal aberrations similar to those found in matched invasive ductal carcinoma of no special type (IDC-NST)...
  65. ncbi request reprint Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
    Afshan McCarthy
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    J Pathol 219:306-16. 2009
    ..This mouse model of Lkb1 deficiency provides a potentially useful tool to investigate the role of Lkb1 in tumourigenesis and to guide the development of therapeutic approaches...
  66. doi request reprint β-catenin/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast
    Magali Lacroix-Triki
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 23:1438-48. 2010
    ..catenin nuclear expression should not be used as a single marker to differentiate fibromatosis from other spindle cell tumours of the breast...
  67. doi request reprint Genomic and immunohistochemical analysis of adenosquamous carcinoma of the breast
    Felipe C Geyer
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Mod Pathol 23:951-60. 2010
    ....
  68. ncbi request reprint The molecular genetics of breast cancer: the contribution of comparative genomic hybridization
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Pathol Res Pract 201:713-25. 2005
    ..CGH has been instrumental in dissecting distinct molecular pathways toward breast malignancy and in establishing a direct relationship between genotype and clinical pathological features...
  69. ncbi request reprint Identification of cellular and genetic drivers of breast cancer heterogeneity in genetically engineered mouse tumour models
    Lorenzo Melchor
    Division of Breast Cancer Research, Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 233:124-37. 2014
    ..This is a fundamental advance in our understanding of tumour aetiology...
  70. doi request reprint Genome-wide transcriptomic profiling of microdissected human breast tissue reveals differential expression of KIT (c-Kit, CD117) and oestrogen receptor-alpha (ERalpha) in response to therapeutic radiation
    Charlotte B Westbury
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 219:131-40. 2009
    ..The findings are relevant to both fibrosis and atrophy occurring after radiotherapy for early breast cancer...
  71. pmc Integrated functional, gene expression and genomic analysis for the identification of cancer targets
    Elizabeth Iorns
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    PLoS ONE 4:e5120. 2009
    ..In conclusion, this strategy represents a novel and effective strategy for the identification of functionally important therapeutic targets in cancer...
  72. pmc Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations
    Konstantin J Dedes
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Cell Cycle 10:1192-9. 2011
    ..Here we discuss the evidence that the clinical use of PARP inhibition may be broader than targeting of cancers in BRCA1/2 germ-line mutation carriers...
  73. pmc APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer
    Rachel Brough
    Cancer Research UK Gene Function and Regulation Group, London, UK
    EMBO J 31:1160-76. 2012
    ....
  74. doi request reprint Genomic profiling of mitochondrion-rich breast carcinoma: chromosomal changes may be relevant for mitochondria accumulation and tumour biology
    Felipe C Geyer
    The Breakthrough Breast Cancer Research Centre, ICR, 237 Fulham Road, London SW3 6JB, UK
    Breast Cancer Res Treat 132:15-28. 2012
    ....
  75. doi request reprint BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells
    Gemma Molyneux
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Cell Stem Cell 7:403-17. 2010
    ..They also demonstrate that when target cells for transformation have the potential for phenotypic plasticity, tumor phenotypes may not directly reflect histogenesis. This has important implications for cancer prevention strategies...
  76. doi request reprint Nuclear NF-κB/p65 expression and response to neoadjuvant chemotherapy in breast cancer
    Robin L Jones
    Academic Department of Biochemistry, Royal Marsden Hospital, London, UK
    J Clin Pathol 64:130-5. 2011
    ..To evaluate the clinicopathological associations and predictive value of the transcription factor NF-κB in a large series of breast cancer patients treated with neoadjuvant chemotherapy...
  77. pmc A mouse model of melanoma driven by oncogenic KRAS
    Carla Milagre
    Signal Transduction Team, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 70:5549-57. 2010
    ..These tumors invade and destroy the underlying muscles and cells derived from them can grow as subcutaneous tumors and colonize the lungs of nude mice. These data establish that oncogenic KRAS can be a founder event in melanomagenesis...
  78. pmc A novel, selective, and efficacious nanomolar pyridopyrazinone inhibitor of V600EBRAF
    Steven Whittaker
    Signal Transduction Team, Section of Cell and Molecular Biology, Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 70:8036-44. 2010
    ..As expected, the growth rate in vivo of a wild-type BRAF human tumor xenograft model is unaffected by inhibitor 1t. In contrast, 1t elicits significant therapeutic responses in mutant BRAF-driven human melanoma xenografts...
  79. ncbi request reprint Distribution and significance of caveolin 2 expression in normal breast and invasive breast cancer: an immunofluorescence and immunohistochemical analysis
    Kay Savage
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res Treat 110:245-56. 2008
    ..The aims of this study were to define the distribution of caveolin 2 (CAV2) in frozen and formalin fixed, paraffin embedded (FFPE) normal breast samples and the significance of CAV2 expression in breast cancer...
  80. pmc Establishment of the epithelial-specific transcriptome of normal and malignant human breast cells based on MPSS and array expression data
    Anita Grigoriadis
    Ludwig Institute for Cancer Research University College London Breast Cancer Laboratory, 91 Riding House Street, London, W1W 7BS, UK
    Breast Cancer Res 8:R56. 2006
    ....
  81. ncbi request reprint Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 64:3037-45. 2004
    ..These data provide a framework for the interpretation of breast cancer molecular profiling experiments, the identification of potential new diagnostic markers, and development of novel indicators of prognosis...
  82. doi request reprint Genomic characterisation of acral melanoma cell lines
    Simon J Furney
    Signal Transduction Team, Division of Cancer Biology, Institute of Cancer Research, London, UK
    Pigment Cell Melanoma Res 25:488-92. 2012
    ..Data are available at: http://rock.icr.ac.uk/collaborations/Furney_et_al_2012/...
  83. doi request reprint Molecular evidence in support of the neoplastic and precursor nature of microglandular adenosis
    Felipe C Geyer
    Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Histopathology 60:E115-30. 2012
    ..The aims of this study were to determine whether MGAs harbour genetic alterations and if any such genetic aberrations found in MGAs are similar to those found in matched invasive carcinomas...
  84. ncbi request reprint P63-driven nuclear accumulation of beta-catenin is not a frequent event in human neoplasms
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Pathol Res Pract 199:785-93. 2003
    ..Caution should be exercised when translating the results of studies performed on cell lines to human neoplasms...
  85. pmc A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer
    Monika Graeser
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Academic Department of Biochemistry, and Breast Unit, Royal Marsden Hospital, London, United Kingdom
    Clin Cancer Res 16:6159-68. 2010
    ....
  86. doi request reprint High-throughput detection of fusion genes in cancer using the Sequenom MassARRAY platform
    Maryou B K Lambros
    Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Lab Invest 91:1491-501. 2011
    ..In keeping with other highly sensitive assays, further refinement of this technique is necessary to reduce the number of false-positive results...
  87. pmc Absence of microsatellite instability in mucinous carcinomas of the breast
    Magali Lacroix-Triki
    Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, SW3 6JB, UK
    Int J Clin Exp Pathol 4:22-31. 2010
    ..Our results demonstrate that MSI-high phenotype is remarkably rare in invasive breast cancer, and that, in contrast to mucinous carcinomas of other anatomical sites, MSI is not a common event in mucinous carcinomas of the breast...
  88. doi request reprint Genomic analysis reveals the molecular heterogeneity of ovarian clear cell carcinomas
    David S P Tan
    Department of Gynaecologic Oncology, Royal Marsden Hospital NHS Foundation Trust, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Royal Marsden Hospital, London, United Kingdom
    Clin Cancer Res 17:1521-34. 2011
    ..Ovarian clear cell carcinomas (OCCC) are a drug-resistant and aggressive type of epithelial ovarian cancer. We analyzed the molecular genetic profiles of OCCCs to determine whether distinct genomic subgroups of OCCCs exist...
  89. ncbi request reprint Chromogenic and fluorescent in situ hybridization in breast cancer
    Maryou B K Lambros
    Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, SW3 6JB London, UK
    Hum Pathol 38:1105-22. 2007
    ....
  90. ncbi request reprint Getting it right: designing microarray (and not 'microawry') comparative genomic hybridization studies for cancer research
    David S P Tan
    Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lab Invest 87:737-54. 2007
    ....
  91. doi request reprint Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma
    Leisl M Packer
    Signal Transduction Team, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    Pigment Cell Melanoma Res 22:785-98. 2009
    ..This study provides a basis for understanding the molecular processes that are regulated by (V600E)BRAF/MEK signalling in melanoma cells...
  92. ncbi request reprint Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins
    Selma Esseghir
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK
    Clin Cancer Res 13:3164-73. 2007
    ..The purpose of this study was to assess the expression of these genes in human invasive breast tumors and to determine the significance of their expression for prognosis in breast cancer...
  93. doi request reprint Resistance to therapy caused by intragenic deletion in BRCA2
    Stacey L Edwards
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Nature 451:1111-5. 2008
    ..6174delT mutation carriers. These observations have implications for understanding drug resistance in BRCA mutation carriers as well as in defining functionally important domains within BRCA2...
  94. ncbi request reprint The collagen receptor Endo180 (CD280) Is expressed on basal-like breast tumor cells and promotes tumor growth in vivo
    Dirk Wienke
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 67:10230-40. 2007
    ..Together, these data argue that elevated expression of this receptor in tumor cells could have important consequences in subsets of basal-like carcinomas for which there is a current lack of effective treatment...
  95. ncbi request reprint A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer
    Selma Esseghir
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 67:11732-41. 2007
    ....
  96. ncbi request reprint Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Clin Cancer Res 10:5988-97. 2004
    ..Robust characterization of this basal group is necessary if it is to have a major impact on management of patients with breast cancer...
  97. ncbi request reprint Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 202:274-85. 2004
    ..This analysis demonstrates the utility of 14-3-3sigma as a new adjunct antibody for characterization of myoepithelial cells and myoepithelial lesions and it may be a novel prognostic factor for breast cancer patients...
  98. doi request reprint The role of molecular analysis in breast cancer
    Felipe C Geyer
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Pathology 41:77-88. 2009
    ..This review will address the contribution of molecular methods to our understanding of breast cancer and its precursors, their use in breast cancer translational research and their impact on diagnostic breast cancer histopathology...
  99. doi request reprint Does chromosome 17 centromere copy number predict polysomy in breast cancer? A fluorescence in situ hybridization and microarray-based CGH analysis
    Caterina Marchio
    The Breakthrough Breast Cancer Research Centre Institute of Cancer Research, London, UK
    J Pathol 219:16-24. 2009
    ..0 in FISH analysis is frequently related to gain or amplification of the centromeric region. Larger studies investigating the genetic profiles of CEP17 polysomic cases are warranted...
  100. ncbi request reprint Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha
    Paraskevi Briassouli
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, 237 Fulham Road, London, United Kingdom
    Cancer Res 67:1689-95. 2007
    ....