W Reik

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Co-evolution of X-chromosome inactivation and imprinting in mammals
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Nat Rev Genet 6:403-10. 2005
  2. ncbi request reprint Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters
    W Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Cold Spring Harb Symp Quant Biol 69:29-37. 2004
  3. pmc Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis
    Miguel R Branco
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, United Kingdom
    Genes Dev 22:1567-71. 2008
  4. pmc Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes
    Cassandra R Farthing
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
    PLoS Genet 4:e1000116. 2008
  5. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
  6. ncbi request reprint Igf2 imprinting in development and disease
    W Reik
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 44:145-50. 2000
  7. ncbi request reprint Imprinting mechanisms in mammals
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Curr Opin Genet Dev 8:154-64. 1998
  8. ncbi request reprint Mammalian epigenomics: reprogramming the genome for development and therapy
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Theriogenology 59:21-32. 2003
  9. pmc Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Philos Trans R Soc Lond B Biol Sci 358:1403-9; discussion 1409. 2003
  10. ncbi request reprint Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Trends Genet 13:330-4. 1997

Detail Information

Publications84

  1. ncbi request reprint Co-evolution of X-chromosome inactivation and imprinting in mammals
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Nat Rev Genet 6:403-10. 2005
    ..This provides a unified hypothesis for the evolution of X-chromosome inactivation and imprinting...
  2. ncbi request reprint Chromosome loops, insulators, and histone methylation: new insights into regulation of imprinting in clusters
    W Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Cold Spring Harb Symp Quant Biol 69:29-37. 2004
  3. pmc Safeguarding parental identity: Dnmt1 maintains imprints during epigenetic reprogramming in early embryogenesis
    Miguel R Branco
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, United Kingdom
    Genes Dev 22:1567-71. 2008
    ..In this issue of Genes & Development, Hirasawa and colleagues (pp. 1607-1616) show that Dnmt1, and not Dnmt3a or Dnmt3b, maintains methylation at genomic imprints during preimplantation development...
  4. pmc Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes
    Cassandra R Farthing
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, United Kingdom
    PLoS Genet 4:e1000116. 2008
    ..Epigenetic reprogramming in the germline prior to fertilisation and the reprogramming of key pluripotency genes in the early embryo is thus crucial for transmission of pluripotency...
  5. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
    ....
  6. ncbi request reprint Igf2 imprinting in development and disease
    W Reik
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 44:145-50. 2000
    ..Here we review briefly the key features of Igf2 imprinting in normal development and in disease, and hope to show what a fascinating subject of study this gene and its biology provides...
  7. ncbi request reprint Imprinting mechanisms in mammals
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Curr Opin Genet Dev 8:154-64. 1998
    ..The interaction of these cis elements with transacting factors such as methylase and chromatin factors establishes a hierarchical control system with local and regional effects...
  8. ncbi request reprint Mammalian epigenomics: reprogramming the genome for development and therapy
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Theriogenology 59:21-32. 2003
    ..Epigenomics methods are being developed to catalogue genome modifications under normal and pathological conditions. Epigenetic engineering is likely to play an important role in medicine in the future...
  9. pmc Epigenetic asymmetry in the mammalian zygote and early embryo: relationship to lineage commitment?
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Philos Trans R Soc Lond B Biol Sci 358:1403-9; discussion 1409. 2003
    ..Maintaining epigenetic asymmetry appears important for development as asymmetry is lost in cloned embryos, most of which have developmental defects, and in particular an imbalance between extraembryonic and embryonic tissue development...
  10. ncbi request reprint Imprinting in clusters: lessons from Beckwith-Wiedemann syndrome
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Trends Genet 13:330-4. 1997
    ..In addition, the precise phenotypic spectrum of BWS might depend on which maternally expressed gene is mutated...
  11. ncbi request reprint Stability and flexibility of epigenetic gene regulation in mammalian development
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nature 447:425-32. 2007
    ..It is not known whether any of the epigenetic marks has a primary role in determining cell and lineage commitment during development...
  12. ncbi request reprint DNA methylation and mammalian epigenetics
    W Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Electrophoresis 22:2838-43. 2001
    ..Environmental factors can alter epigenetic modifications and may thus have long lasting effects on phenotype. Epigenetic engineering is likely to play an important role in medicine in the future...
  13. ncbi request reprint Genomic imprinting: parental influence on the genome
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, UK
    Nat Rev Genet 2:21-32. 2001
    ..Aberrant imprinting disturbs development and is the cause of various disease syndromes. The study of imprinting also provides new insights into epigenetic gene modification during development...
  14. ncbi request reprint Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes
    W Dean
    Laboratory of Developmental Genetics Programme, The Babraham Institute, Babraham Hall, Cambridge CB2 4AT, UK
    Development 125:2273-82. 1998
    ..Our study establishes a model for how early embryonic epigenetic alterations in imprinted genes persist to later developmental stages, and are associated with aberrant phenotypes...
  15. ncbi request reprint Culture of preimplantation mouse embryos affects fetal development and the expression of imprinted genes
    S Khosla
    Laboratory of Developmental Genetics and Imprinting and Laboratory of Computational Neuroscience, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    Biol Reprod 64:918-26. 2001
    ..No alterations were detected for the imprinted gene MEST: Preimplantation culture in the presence of serum can influence the regulation of multiple growth-related imprinted genes, thus leading to aberrant fetal growth and development...
  16. ncbi request reprint Epigenetic targeting in the mouse zygote marks DNA for later methylation: a mechanism for maternal effects in development
    B Pickard
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Mech Dev 103:35-47. 2001
    ..The most significant consequence is that the genotype of the mother can influence the epigenotype of the offspring by this marking process. A number of parental and imprinting effects may be explained by this epigenetic marking...
  17. ncbi request reprint Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
    M Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Babraham, Cambridge, UK
    Nat Genet 26:203-6. 2000
    ....
  18. pmc An intragenic methylated region in the imprinted Igf2 gene augments transcription
    A Murrell
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    EMBO Rep 2:1101-6. 2001
    ..These results reveal a novel mechanism of gene expression whereby intragenic methylation can increase levels of transcription...
  19. ncbi request reprint Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5
    M Paulsen
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 7:1149-59. 1998
    ..Our study opens the way for a systematic analysis of the cluster by genetic manipulation in the mouse which will lead to animal models of Beckwith-Wiedemann syndrome and childhood tumours...
  20. ncbi request reprint Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes
    R Feil
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Development 120:2933-43. 1994
    ..Our results suggest that allelic methylation patterns in Igf2 and H19 arise early in embryogenesis and change progressively during development. Some of these developmental changes are apparently under tissue-specific control...
  21. ncbi request reprint Chromatin structure and imprinting: developmental control of DNase-I sensitivity in the mouse insulin-like growth factor 2 gene
    R Feil
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, United Kingdom
    Dev Genet 17:240-52. 1995
    ..We propose that epigenetic features of tissue-specific control and of the control of allelic expression are intricately linked...
  22. pmc Loss of the maternal H19 gene induces changes in Igf2 methylation in both cis and trans
    T Forne
    Laboratory of Developmental Genetics and Imprinting, Department of Development and Genetics, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 94:10243-8. 1997
    ..Selection during development for the appropriate expression of Igf2, dosage-dependent factors that bind to the Igf2 gene, or methylation transfer between the parental alleles could be involved in this trans effect...
  23. ncbi request reprint Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Development 133:4203-10. 2006
    ..Our findings establish a model for how epigenetic gene silencing by non-coding RNA may depend on distance from the non-coding RNA and on lineage and differentiation specific factors...
  24. pmc Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2
    T Moore
    Department of Development and Genetics, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 94:12509-14. 1997
    ..Our results support the proposal that tandem repeats act to target methylation to imprinted genetic loci...
  25. ncbi request reprint Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome
    F L Sun
    Laboratory of Developmental Genetics and Imprinting, Department of Development and Genetics, The Babraham Institute, Cambridge, UK
    Nature 389:809-15. 1997
    ..These phenotypes establish Igf2 overexpression as a key determinant of Beckwith-Wiedemann syndrome...
  26. ncbi request reprint Epigenetic reprogramming in mammalian development
    W Reik
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Science 293:1089-93. 2001
    ..Here we look at what is known about reprogramming in mammals and discuss how it might relate to developmental potency and imprinting...
  27. ncbi request reprint Imprinted genes and the coordination of fetal and postnatal growth in mammals
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, UK
    Novartis Found Symp 237:19-31; discussion 31-42. 2001
    ..Imprinted genes may also be involved in postnatal growth up to weaning...
  28. ncbi request reprint Genomic imprinting and cancer; new paradigms in the genetics of neoplasia
    P N Schofield
    Laboratory of Stem Cell Biology, Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK
    Toxicol Lett 120:151-60. 2001
    ..This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer...
  29. ncbi request reprint Analysis of parent-specific gene expression in early mouse embryos and embryonic stem cells using high-resolution two-dimensional electrophoresis of proteins
    L Bowden
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 40:499-506. 1996
    ..These findings have important implications for estimates of the number of imprinted genes in the genome and for the interpretation of phenotypes of parthenogenetic and androgenetic embryos...
  30. pmc Conservation of methylation reprogramming in mammalian development: aberrant reprogramming in cloned embryos
    W Dean
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Program, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 98:13734-8. 2001
    ..Our study shows that epigenetic reprogramming occurs aberrantly in most cloned embryos; incomplete reprogramming may contribute to the low efficiency of cloning...
  31. ncbi request reprint A developmental window of opportunity for imprinted gene silencing mediated by DNA methylation and the Kcnq1ot1 noncoding RNA
    Kelly Green
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Mamm Genome 18:32-42. 2007
    ....
  32. pmc Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 24:5650-6. 2004
    ....
  33. ncbi request reprint Imprinted genes, placental development and fetal growth
    A L Fowden
    Department of Physiology, Cambridge, UK
    Horm Res 65:50-8. 2006
    ....
  34. ncbi request reprint How imprinting centres work
    A Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Cytogenet Genome Res 113:81-9. 2006
    ..The challenge now is to establish a chain of developmental events beginning with differential methylation of an IC in the germline and ending with imprinting of many genes, often in a lineage dependent manner...
  35. ncbi request reprint Culture of preimplantation embryos and its long-term effects on gene expression and phenotype
    S Khosla
    Programme in Developmental Genetics, The Babraham Institute, Cambridge, UK
    Hum Reprod Update 7:419-27. 2001
    ..Imprinted genes play key roles in the control of fetal growth, and altered imprinting can cause growth defects. Some recent in-vitro culture studies on mice and ruminant species now lend support to this hypothesis...
  36. ncbi request reprint Environmental effects on genomic imprinting in mammals
    S L Thompson
    Programme in Developmental Genetics, The Babraham Institute, CB2 4AT, Cambridge, UK
    Toxicol Lett 120:143-50. 2001
    ..These effects are associated with aberrant growth and morphology at fetal and perinatal stages of development...
  37. ncbi request reprint Dynamic reprogramming of DNA methylation in the early mouse embryo
    Fatima Santos
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, United Kingdom
    Dev Biol 241:172-82. 2002
    ..The three phases of methylation reprogramming may have roles in imprinting, the control of gene expression, and the establishment of nuclear totipotency...
  38. ncbi request reprint Cbx-rs2 (M31), a mouse homolog of the Drosophila Heterochromatin protein 1 gene, maps to distal chromosome 11 and is nonallelic to Om
    R Feil
    Developmental Genetics and Imprinting Laboratory, Babraham Institute, Cambridge, UK
    Mamm Genome 6:469-71. 1995
  39. ncbi request reprint Disruption of mesodermal enhancers for Igf2 in the minute mutant
    Karen Davies
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, UK
    Development 129:1657-68. 2002
    ..Our work shows that most known enhancers for Igf2 are located 3' of H19 and establishes an important genetic paradigm for the inheritance of complex regulatory mutations in imprinted gene clusters...
  40. ncbi request reprint Parental imprinting: potentially active chromatin of the repressed maternal allele of the mouse insulin-like growth factor II (Igf2) gene
    H Sasaki
    Department of Molecular Embryology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, UK
    Genes Dev 6:1843-56. 1992
    ..The differential activity of the parental Igf2 alleles could be achieved through epigenetic modifications situated outside the promoters or by subtle and yet unidentified modifications at the promoters...
  41. pmc Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
    Ray Kit Ng
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Nat Cell Biol 10:1280-90. 2008
    ..This epigenetic restriction of cell lineage fate provides a molecular mechanism for Waddington's concept of canalization of developmental pathways...
  42. ncbi request reprint Epigenetic reprogramming in mammals
    Hugh D Morgan
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Hum Mol Genet 14:R47-58. 2005
    ..A mechanistic understanding of reprogramming will be crucial for medical applications of stem cell technology...
  43. ncbi request reprint Epigenetic marking correlates with developmental potential in cloned bovine preimplantation embryos
    Fatima Santos
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Curr Biol 13:1116-21. 2003
    ..These results suggest a mechanistic link between DNA and histone methylation in the mammalian embryo and reveal an association between epigenetic marks and developmental potential of cloned embryos...
  44. ncbi request reprint Imprinting on distal chromosome 7 in the placenta involves repressive histone methylation independent of DNA methylation
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Genet 36:1291-5. 2004
    ....
  45. ncbi request reprint Regulation of placental efficiency for nutrient transport by imprinted genes
    E Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, UK
    Placenta 27:S98-102. 2006
    ..We propose that signalling mechanisms involving growth demand signals and nutrient transporters are likely to occur and are important for fine tuning normal fetal growth...
  46. ncbi request reprint Imprint switch mechanism indicated by mutations in Prader-Willi and Angelman syndromes
    G Kelsey
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Bioessays 19:361-5. 1997
    ....
  47. ncbi request reprint Resourceful imprinting
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 432:53-7. 2004
  48. pmc Regulation of supply and demand for maternal nutrients in mammals by imprinted genes
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    J Physiol 547:35-44. 2003
    ..These data and hypotheses are important, as deregulation of supply and demand affects fetal growth and has long term consequences for health in mammals both in the neonatal period and, as a result of fetal programming, in adulthood...
  49. ncbi request reprint Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
    ..We propose that the Igf2 gene, and perhaps other imprinted genes, control both the placental supply of, and the genetic demand for, maternal nutrients to the mammalian fetus...
  50. ncbi request reprint Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer
    Wendy Dean
    Developmental Genetics Programme, Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Semin Cell Dev Biol 14:93-100. 2003
    ..We propose the concept of 'epigenetic checkpoints' for normal progression of development and the loss of totipotency...
  51. doi request reprint Conservation of the H19 noncoding RNA and H19-IGF2 imprinting mechanism in therians
    Guillaume Smits
    The Babraham Institute, Laboratory of Developmental Genetics and Imprinting, Cambridge CB22 3AT, UK
    Nat Genet 40:971-6. 2008
    ..The conservation in all therians of the mechanism controlling imprinting of the IGF2-H19 locus suggests a sequential model of imprinting evolution...
  52. ncbi request reprint Back to the beginning
    Wolf Reik
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 420:127. 2002
  53. pmc Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005
    ..Thus, crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development...
  54. ncbi request reprint Dynamic chromatin modifications characterise the first cell cycle in mouse embryos
    Fatima Santos
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Dev Biol 280:225-36. 2005
    ..These differences begin to provide a chromatin based explanation for paternal-specific active DNA demethylation and maternal specific protection in the mouse...
  55. ncbi request reprint Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal
    Myriam Hemberger
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Nat Rev Mol Cell Biol 10:526-37. 2009
    ..The intersection of major epigenetic reprogramming and programming events in the early embryo creates plasticity followed by commitment to the principal cell lineages of the early conceptus...
  56. ncbi request reprint Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA
    Flavia Cerrato
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Hum Mol Genet 12:3123-32. 2003
    ..Replication asynchrony may thus be regulated differently from methylation imprints and have a separate function...
  57. pmc Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
    Christian Popp
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Nature 463:1101-5. 2010
    ..AID deficiency interferes with genome-wide erasure of DNA methylation patterns, indicating that AID has a critical function in epigenetic reprogramming and potentially in restricting the inheritance of epimutations in mammals...
  58. ncbi request reprint Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse
    Natasha Lane
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Genesis 35:88-93. 2003
    ..In turn, this can result in the transgenerational inheritance of epigenetic states of IAPs, which could lead to heritable epimutations of neighbouring genes through influencing their transcriptional states...
  59. ncbi request reprint An association between variants in the IGF2 gene and Beckwith-Wiedemann syndrome: interaction between genotype and epigenotype
    Adele Murrell
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Hum Mol Genet 13:247-55. 2004
    ..This indicates either a genetic predisposition to LOM or interactions between genotype and epigenotype that impinge on the disease phenotype...
  60. ncbi request reprint Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent-specific chromatin loops
    Adele Murrell
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nat Genet 36:889-93. 2004
    ..These interactions are epigenetically regulated and partition maternal and paternal chromatin into distinct loops. This generates a simple epigenetic switch for Igf2 through which it moves between an active and a silent chromatin domain...
  61. pmc Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus
    Raffaella Nativio
    Department of Oncology, University of Cambridge, Cancer Research UK Cambridge Research Institute, Cambridge, United Kingdom
    PLoS Genet 5:e1000739. 2009
    ....
  62. doi request reprint Evaluation of epigenetic marks in human embryos derived from IVF and ICSI
    Fatima Santos
    The Laboratory of Developmental Genetics and Imprinting, Babraham Research Campus, Cambridge CB22 3AT, UK
    Hum Reprod 25:2387-95. 2010
    ..However, the generality of the potential deregulation of DNA methylation in ART-derived human embryos has not been evaluated...
  63. pmc The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing
    Lisa Redrup
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, UK
    Development 136:525-30. 2009
    ..Long ncRNAs in imprinting clusters and the Xist RNA on the inactive X chromosome thus appear to regulate epigenetic gene silencing by similar mechanisms...
  64. ncbi request reprint Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming
    Hugh D Morgan
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 279:52353-60. 2004
    ....
  65. ncbi request reprint Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions
    Susana Lopes
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 12:295-305. 2003
    ..These observations are likely to be relevant to other gene clusters in which epigenetic regulation plays a role, and in pathological situations in which epigenetic regulation is disrupted...
  66. ncbi request reprint Active genes dynamically colocalize to shared sites of ongoing transcription
    Cameron S Osborne
    Laboratory of Chromatin and Gene Expression, The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    Nat Genet 36:1065-71. 2004
    ..Thus, rather than recruiting and assembling transcription complexes, active genes migrate to preassembled transcription sites...
  67. pmc Mice deficient in APOBEC2 and APOBEC3
    Marie C Mikl
    Medical Research Council Laboratory of Molecular Biology, Division of PNAC, Cambridge, UK
    Mol Cell Biol 25:7270-7. 2005
    ....
  68. ncbi request reprint The need for Eed
    Anne C Ferguson-Smith
    Nat Genet 33:433-4. 2003
  69. pmc Placental overgrowth in mice lacking the imprinted gene Ipl
    Dale Frank
    Institute for Cancer Genetics, Department of Pathology, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:7490-5. 2002
    ..The data further indicate that Ipl can act, at least in part, independently of insulin-like growth factor-2 signaling. Thus, genomic imprinting regulates multiple pathways to control placental size...
  70. pmc Non-coding transcripts in the H19 imprinting control region mediate gene silencing in transgenic Drosophila
    Stefan Schoenfelder
    Zentrum fuer Molekulare Biologie Heidelberg, Universitaet Heidelberg, INF 282, 69120 Heidelberg, Germany
    EMBO Rep 8:1068-73. 2007
    ....
  71. ncbi request reprint Gene expression: Silent clones speak up
    Wolf Reik
    Nature 423:390-1. 2003
  72. pmc Genomic imprinting controls matrix attachment regions in the Igf2 gene
    Michael Weber
    Institut de Genetique Moleculaire, UMR 5535 CNRS, Universite Montpellier II, IFR 122, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mol Cell Biol 23:8953-9. 2003
    ..Our work clearly demonstrates that genomic imprinting controls matrix attachment regions in the Igf2 gene...
  73. ncbi request reprint Asymmetric regulation of imprinting on the maternal and paternal chromosomes at the Dlk1-Gtl2 imprinted cluster on mouse chromosome 12
    Shau Ping Lin
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Nat Genet 35:97-102. 2003
    ..These results prove that the IG-DMR is a control element for all imprinted genes on the maternal chromosome only and indicate that the two parental chromosomes control allele-specific gene expression differently...
  74. ncbi request reprint The two-domain hypothesis in Beckwith-Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster
    Flavia Cerrato
    Dipartimento di Scienze Ambientali, Seconda Universita di Napoli, Via Vivaldi 43, 81100 Caserta, Italy
    Hum Mol Genet 14:503-11. 2005
    ....
  75. ncbi request reprint Molecular subtypes and phenotypic expression of Beckwith-Wiedemann syndrome
    Wendy N Cooper
    1Medical and Molecular Genetics Section, Institute of Biomedical Research, University of Birmingham, Birmingham, UK
    Eur J Hum Genet 13:1025-32. 2005
    ....
  76. ncbi request reprint Developmental biology: the X-inactivation yo-yo
    Wolf Reik
    Nature 438:297-8. 2005
  77. pmc Evidence that paternal expression of the epsilon-sarcoglycan gene accounts for reduced penetrance in myoclonus-dystonia
    Birgitt Müller
    Department of Neurology, University of Lubeck, Germany
    Am J Hum Genet 71:1303-11. 2002
    ..Loss of imprinting in the patient with M-D who had biallelic expression of the SGCE gene was associated with partial loss of methylation at several CpG dinucleotides...
  78. pmc CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2
    Sreenivasulu Kurukuti
    Department of Development and Genetics, Uppsala University, Norbyvagen 18A, S 752 36 Uppsala, Sweden
    Proc Natl Acad Sci U S A 103:10684-9. 2006
    ....
  79. ncbi request reprint Epigenetic reprogramming in mouse primordial germ cells
    Petra Hajkova
    Universitat des Saarlandes, FR 8 2 Genetik, Postfach 151150, 66041 Saarbrucken, Germany
    Mech Dev 117:15-23. 2002
    ..Aberrant epigenetic reprogramming in the germ line would cause the inheritance of epimutations that may have consequences for human diseases as suggested by studies on mouse models...
  80. ncbi request reprint Artificial sperm and epigenetic reprogramming
    Diana Lucifero
    Nat Biotechnol 24:1097-8. 2006
  81. ncbi request reprint Frequent RASSF1A tumour suppressor gene promoter methylation in Wilms' tumour and colorectal cancer
    Kate J Wagner
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Oncogene 21:7277-82. 2002
    ..We have demonstrated that RASSF1A inactivation is the most frequent genetic or epigenetic event yet reported in Wilms' tumourigenesis and that allelotyping studies may fail to identify regions containing important TSGs...
  82. ncbi request reprint Replication timing properties within the mouse distal chromosome 7 imprinting cluster
    Kazuhiro Kagotani
    Laboratory of Molecular and Cellular Biology, Faculty of Bioresources, Mie University, Tsu, Japan
    Biosci Biotechnol Biochem 66:1046-51. 2002
    ..Allele-specific asynchronous replication was observed even in ES cells. These results suggest that this imprinting cluster consists of a large replication domain which is already found at the early stage in development...
  83. ncbi request reprint Structural differences in centromeric heterochromatin are spatially reconciled on fertilisation in the mouse zygote
    Aline V Probst
    Laboratory of Nuclear Dynamics and Nuclear Plasticity, UMR218 CNRS Institut Curie, 75248, Paris Cedex 05, France
    Chromosoma 116:403-15. 2007
    ..Our findings highlight the importance of ensuring a proper centromere function while preserving the distinction of parental genome origin during the return to totipotency in the zygote...