Julian Peto

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint High constant incidence in twins and other relatives of women with breast cancer
    J Peto
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 26:411-4. 2000
  2. ncbi request reprint Genetics and the common cancers
    J Peto
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Eur J Cancer 37:S88-96. 2001
  3. ncbi request reprint Breast cancer susceptibility-A new look at an old model
    Julian Peto
    Institute of Cancer Research, Sutton, Surrey SM2 5NG, London, UK
    Cancer Cell 1:411-2. 2002
  4. ncbi request reprint CYP3A variation, premenopausal estrone levels, and breast cancer risk
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 104:657-69. 2012
  5. doi request reprint Association of genetic variants at 8q24 with breast cancer risk
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:702-5. 2008
  6. pmc Genome-wide association studies identify four ER negative-specific breast cancer risk loci
    Montserrat Garcia-Closas
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK 2 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK 3
    Nat Genet 45:392-8, 398e1-2. 2013
  7. doi request reprint Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer
    Alan M Pittman
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Hum Mol Genet 17:3720-7. 2008
  8. pmc Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
    Tom Treasure
    Department of Mathematics, Clinical Operational Research Unit, University College London, London, UK
    Lancet Oncol 12:763-72. 2011
  9. pmc Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    James M Flanagan
    CR UK Viral Oncology Group, UCL Cancer Institute, London, UK
    Hum Mol Genet 18:1332-42. 2009
  10. doi request reprint Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011

Detail Information

Publications44

  1. ncbi request reprint High constant incidence in twins and other relatives of women with breast cancer
    J Peto
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 26:411-4. 2000
    ..The very high incidence in monozygotic twins of patients indicates that a high proportion, and perhaps the majority, of breast cancers arise in a susceptible minority of women...
  2. ncbi request reprint Genetics and the common cancers
    J Peto
    Section of Epidemiology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Eur J Cancer 37:S88-96. 2001
    ..The evidence for the existence of such genes and the prospects for identifying them are reviewed...
  3. ncbi request reprint Breast cancer susceptibility-A new look at an old model
    Julian Peto
    Institute of Cancer Research, Sutton, Surrey SM2 5NG, London, UK
    Cancer Cell 1:411-2. 2002
    ....
  4. ncbi request reprint CYP3A variation, premenopausal estrone levels, and breast cancer risk
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Division of Breast Cancer Research, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 104:657-69. 2012
    ..Our aim was to identify common variants in genes involved in sex steroid synthesis or metabolism that are associated with hormone levels and the risk of breast cancer in premenopausal women...
  5. doi request reprint Association of genetic variants at 8q24 with breast cancer risk
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 17:702-5. 2008
    ..25-fold increased risk of prostate cancer, with no effect for the two other variants, indicates that the effects of the risk alleles clustered at 8q24 are cancer site specific...
  6. pmc Genome-wide association studies identify four ER negative-specific breast cancer risk loci
    Montserrat Garcia-Closas
    1 Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK 2 Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK 3
    Nat Genet 45:392-8, 398e1-2. 2013
    ..0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers...
  7. doi request reprint Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer
    Alan M Pittman
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Hum Mol Genet 17:3720-7. 2008
    ..The absence of exonic mutations in any of the transcripts (FLJ45803, LOC120376, C11orf53 and POU2AF1) mapping to this region makes the association likely to be a consequence of non-coding effects on gene expression...
  8. pmc Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study
    Tom Treasure
    Department of Mathematics, Clinical Operational Research Unit, University College London, London, UK
    Lancet Oncol 12:763-72. 2011
    ..We aimed to assess the clinical outcomes of patients who were randomly assigned to EPP or no EPP in the context of trimodal therapy in the Mesothelioma and Radical Surgery (MARS) feasibility study...
  9. pmc Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    James M Flanagan
    CR UK Viral Oncology Group, UCL Cancer Institute, London, UK
    Hum Mol Genet 18:1332-42. 2009
    ..ACCESSION NUMBERS: The microarray data and associated .BED and .WIG files can be accessed through Gene Expression Omnibus accession number: GSE14603...
  10. doi request reprint Novel breast cancer susceptibility locus at 9q31.2: results of a genome-wide association study
    Olivia Fletcher
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:425-35. 2011
    ..Genome-wide association studies have identified several common genetic variants associated with breast cancer risk. It is likely, however, that a substantial proportion of such loci have not yet been discovered...
  11. ncbi request reprint Counting potentially functional variants in BRCA1, BRCA2 and ATM predicts breast cancer susceptibility
    Nichola Johnson
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK
    Hum Mol Genet 16:1051-7. 2007
    ..A risk score incorporating a suitably weighted sum of all potentially functional variants in these and a few other candidate genes may provide clinically useful identification of women at high genetic risk...
  12. ncbi request reprint Inconsistent association between the STK15 F31I genetic polymorphism and breast cancer risk
    Olivia Fletcher
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    J Natl Cancer Inst 98:1014-8. 2006
    ..001). This heterogeneity could reflect either population-specific linkage disequilibrium with a functional variant or artifacts such as population stratification or publication bias...
  13. ncbi request reprint A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
    Peter Broderick
    Section of Cancer Genetics, Institute of Cancer Research, Sutton SM2 5NG, UK
    Nat Genet 39:1315-7. 2007
    ..Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12))...
  14. ncbi request reprint Search for low penetrance alleles for colorectal cancer through a scan of 1467 non-synonymous SNPs in 2575 cases and 2707 controls with validation by kin-cohort analysis of 14 704 first-degree relatives
    Emily L Webb
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, UK
    Hum Mol Genet 15:3263-71. 2006
    ..shtml in order to facilitate the identification of low penetrance CRC susceptibility alleles through pooled analyses...
  15. pmc Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
    Elise Ruark
    Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, UK
    Nat Genet 45:686-9. 2013
    ..3, is required for the regulation of germ cell development. Furthermore, PITX1, at 5q31.1, regulates TERT expression and is the third TGCT-associated locus implicated in telomerase regulation...
  16. doi request reprint Identification of genetic variants that influence circulating IGF1 levels: a targeted search strategy
    Claire Palles
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Hum Mol Genet 17:1457-64. 2008
    ..Targeting ECRs appears to be a useful strategy for identifying a subset of potentially functional non-coding regulatory SNPs...
  17. pmc Missense variants in ATM in 26,101 breast cancer cases and 29,842 controls
    Olivia Fletcher
    British Breast Cancer Study, The Breakthrough Breast Cancer Research Centre, London, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2143-51. 2010
    ..Truncating mutations in ATM have been shown to increase the risk of breast cancer but the effect of missense variants remains contentious...
  18. doi request reprint Premenopausal mammographic density in relation to cyclic variations in endogenous sex hormone levels, prolactin, and insulin-like growth factors
    Kate Walker
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, and The Academic Department of Biochemistry, The Royal Marsden Hospital, London, UK
    Cancer Res 69:6490-9. 2009
    ..Most of these hormone-density associations were attenuated with further adjustment for BMI...
  19. ncbi request reprint Interaction between CHEK2*1100delC and other low-penetrance breast-cancer susceptibility genes: a familial study
    Nichola Johnson
    Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Lancet 366:1554-7. 2005
    ..Our aim was to measure the risk of breast cancer in relatives of women with bilateral breast cancer who were carriers of this allele...
  20. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
    ..To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients...
  21. pmc A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11
    Afshan Siddiq
    Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    Hum Mol Genet 21:5373-84. 2012
    ..Our results highlight the value of large-scale collaborative studies to identify novel breast cancer risk loci...
  22. doi request reprint The Mesothelioma and Radical surgery randomized controlled trial: the Mars feasibility study
    Tom Treasure
    Guy s and St Thomas Hospital, London, UK
    J Thorac Oncol 4:1254-8. 2009
    ..The question was whether randomization to surgery versus no surgery would be possible...
  23. pmc Certified causes of death in patients with mesothelioma in South East England
    Catherine Okello
    King s College London, Thames Cancer Registry, London, UK
    BMC Cancer 9:28. 2009
    ..We examine certified causes of death of patients who have been diagnosed with mesothelioma, and assess the validity of death certification data as a proxy for mesothelioma incidence...
  24. doi request reprint Sexual behavior and HPV infection in British women, by postal questionnaires and telephone interviews
    Maribel Almonte
    Cancer Research UK Centre for Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK
    J Med Virol 83:1238-46. 2011
    ..4, 95% CI: 1.7-11.2) was stronger than that of earlier (> 5 years ago) partners (OR for 2+ earlier partners: 2.2, 95% CI: 0.7-6.7) suggesting that most incident HPV infections are newly acquired rather than recurrent...
  25. ncbi request reprint The search for low-penetrance cancer susceptibility alleles
    Richard S Houlston
    Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
    Oncogene 23:6471-6. 2004
    ..Cancer patients with affected relatives are considerably more informative than unselected cases for such studies...
  26. ncbi request reprint Comprehensive analysis of the contribution of germline MYH variation to early-onset colorectal cancer
    Christina Fleischmann
    Section of Cancer Genetics, Institute of Cancer Research, Surrey, United Kingdom
    Int J Cancer 109:554-8. 2004
    ..No biallelic mutations were detected among 354 controls. These results confirm that biallelic MYH mutations confer susceptibility to colorectal cancer but are unlikely to account for more than 3% of early-onset colorectal cancer...
  27. ncbi request reprint Lifetime risks of common cancers among retinoblastoma survivors
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Natl Cancer Inst 96:357-63. 2004
    ..However, their risks for the epithelial cancers that commonly occur after age 50 years are not known...
  28. ncbi request reprint Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations
    Hanne Meijers-Heijboer
    Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 31:55-9. 2002
    ....
  29. ncbi request reprint The future of association studies of common cancers
    Richard S Houlston
    Hum Genet 112:434-5. 2003
  30. ncbi request reprint Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review
    Olivia Fletcher
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2-19. 2005
    ..Further large studies, or combined analysis of data from existing studies, are needed to quantify these effects more precisely...
  31. ncbi request reprint The insulin-like growth factor system and mammographic features in premenopausal and postmenopausal women
    Isabel dos Santos Silva
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom
    Cancer Epidemiol Biomarkers Prev 15:449-55. 2006
    ....
  32. ncbi request reprint Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study
    Paul Brennan
    International Agency for Research on Cancer IARC, Lyon, France
    Hum Mol Genet 16:1794-801. 2007
    ..g. by forcing nearby stem cells to divide before they have repaired their own DNA damage from tobacco smoke). If so, reducing the rate of apoptosis by reducing CHEK2 activity could be protective-although not smoking would be far more so...
  33. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  34. ncbi request reprint A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21
    Ian Tomlinson
    Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK
    Nat Genet 39:984-8. 2007
    ..21, 95% c.i.: 1.10-1.34; P = 6.89 x 10(-5)). These data show that common, low-penetrance susceptibility alleles predispose to colorectal neoplasia...
  35. doi request reprint Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis
    Bernd Frank
    Helmholtz University Group Molecular Epidemiology, Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Natl Cancer Inst 100:437-42. 2008
    ..10 (95% CI = 1.04 to 1.17, P = .001). Among the combined subset of 2795 familial breast cancer patients, the respective ORs were 1.27 (95% CI = 1.12 to 1.45, P = .0003) and 1.16 (95% CI = 1.06 to 1.27, P = .001)...
  36. ncbi request reprint Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortium
    Marjanka K Schmidt
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 67:9584-90. 2007
    ..This suggests that any effect of these two variants would be very small and possibly confined to subgroups that were not assessed in our present study...
  37. doi request reprint A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
    Ian P M Tomlinson
    Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    Nat Genet 40:623-30. 2008
    ..3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition...
  38. ncbi request reprint ESR1 gene amplification in breast cancer: a common phenomenon?
    Jorge S Reis-Filho
    Nat Genet 40:809-10; author reply 810-2. 2008
  39. doi request reprint Breast cancer onset in twins and women with bilateral disease
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 26:4086-91. 2008
    ..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration...
  40. ncbi request reprint Cancer survival is dependent on season of diagnosis and sunlight exposure
    Hyun Sook Lim
    King s College London, Thames Cancer Registry, London, United Kingdom
    Int J Cancer 119:1530-6. 2006
    ..We found seasonality in cancer survival to be stronger in women than in men. Our results add to a growing body of evidence that vitamin D metabolites play an important role in cancer survival...
  41. doi request reprint Current CD4 cell count and the short-term risk of AIDS and death before the availability of effective antiretroviral therapy in HIV-infected children and adults
    David Dunn
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    J Infect Dis 197:398-404. 2008
    ..Currently, there are no comparable estimates of the short-term risk of disease progression in the absence of effective antiretroviral therapy for human immunodeficiency virus (HIV)-infected adults and children...
  42. ncbi request reprint Cervical cancer and use of hormonal contraceptives: a systematic review
    Jennifer S Smith
    International Agency for Research on Cancer, Lyon, France
    Lancet 361:1159-67. 2003
    ..Human papillomavirus (HPV) is believed to be the most important cause of cervical cancer. Recent studies suggest that long duration use of oral contraceptives increases the risk of cervical cancer in HPV positive women...
  43. ncbi request reprint Oral contraceptives and cervical cancer
    Amy Berrington
    Lancet 360:410. 2002
  44. ncbi request reprint Common genetic variants at the CRAC1 (HMPS) locus on chromosome 15q13.3 influence colorectal cancer risk
    Emma Jaeger
    Molecular and Population Genetics Laboratory, Cancer Research UK, London WC2A 3PX, UK
    Nat Genet 40:26-8. 2008
    ..In a large series of colorectal cancer cases and controls, SNPs near GREM1 and SCG5 were strongly associated with increased CRC risk (for rs4779584, P = 4.44 x 10(-14))...