Andrew D J Pearson

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial
    Andrew D J Pearson
    Children s Department, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK
    Lancet Oncol 9:247-56. 2008
  2. ncbi p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma
    Lindi Chen
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Cell Cycle 6:2685-96. 2007
  3. ncbi Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse
    Jane Carr
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, United Kingdom
    Cancer Res 66:2138-45. 2006
  4. ncbi Regions syntenic to human 17q are gained in mouse and rat neuroblastoma
    Maria Łastowska
    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Genes Chromosomes Cancer 40:158-63. 2004
  5. ncbi Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma
    S Murray Yule
    Department of Child Health, Yorkhill National Health Service Trust, Glasgow, United Kongdom
    Clin Cancer Res 10:455-60. 2004
  6. ncbi Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior
    Tamas Tornoczky
    Department of Pathology, Faculty of Medicine, Medical and Health Sciences Center, University of Pecs, Szigeti ut 12, H 7643 Pecs, Hungary
    Cancer 100:390-7. 2004
  7. ncbi Development of a real-time polymerase chain reaction assay for prediction of the uptake of meta-[(131)I]iodobenzylguanidine by neuroblastoma tumors
    Sean Carlin
    Departments of Radiation Oncology and Child Health, University of Glasgow, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, United Kingdom
    Clin Cancer Res 9:3338-44. 2003
  8. ncbi The p53 pathway and its inactivation in neuroblastoma
    Deborah A Tweddle
    Cancer Research Unit, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Cancer Lett 197:93-8. 2003
  9. ncbi Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression
    Quentin Campbell Hewson
    Department of Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Cell Biochem 87:284-91. 2002
  10. ncbi Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors
    Maria Łastowska
    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Genes Chromosomes Cancer 34:428-36. 2002

Collaborators

  • Rani E George
  • Hiroyuki Shimada
  • G J Veal
  • Deborah A Tweddle
  • John Lunec
  • Maria Łastowska
  • Lindi Chen
  • Jane Carr
  • Ursula R Kees
  • Sadick Variend
  • Catherine Cullinane
  • Tamas Tornoczky
  • S Murray Yule
  • Julian Board
  • Murray D Norris
  • Michelle Haber
  • Michael S Jackson
  • Sean Carlin
  • Birju Rana
  • Quentin Campbell Hewson
  • Christopher P F Redfern
  • Katrina M Wood
  • Michael Cole
  • Archie J Malcolm
  • Helen Beris
  • Emma Bell
  • Ngan Cheng Ching
  • Alex D McMahon
  • Yeun Jun Chung
  • Endre Kalman
  • Pál G Kajtár
  • Alan V Boddy
  • Tibor Nyari
  • Yeun-Jun Chung
  • Lisa Price
  • Caroline Ellershaw
  • Berthe L van Eck-Smit
  • Anthony G McCluskey
  • Huib N Caron
  • Claudia Flemming
  • Rob J Mairs
  • Godelieve A M Tytgat
  • Cees A Hoefnagel
  • Alan Sprigg
  • Christine Estlin
  • Marieke D van den Brug
  • Chengyuan Xue
  • Mirco Ponzoni
  • Paolo G Montaldo
  • Tom Strachan
  • Penny E Lovat
  • Simon Cotterill
  • Nick Bown

Detail Information

Publications12

  1. ncbi High-dose rapid and standard induction chemotherapy for patients aged over 1 year with stage 4 neuroblastoma: a randomised trial
    Andrew D J Pearson
    Children s Department, Institute of Cancer Research, Royal Marsden Hospital, Sutton, Surrey, UK
    Lancet Oncol 9:247-56. 2008
    ..We aimed to assess whether an intensive chemotherapy protocol that had a 10-day interval between treatments would improve event-free survival (EFS) in patients aged 1 year or over with high-risk neuroblastoma...
  2. ncbi p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma
    Lindi Chen
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Cell Cycle 6:2685-96. 2007
    ..In conclusion, p53 is predominantly nuclear and functional in neuroblastoma regardless of differentiation status...
  3. ncbi Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse
    Jane Carr
    Northern Institute for Cancer Research, University of Newcastle upon Tyne, United Kingdom
    Cancer Res 66:2138-45. 2006
    ..If these data are confirmed in neuroblastoma tumors, this suggests that p53-independent therapy and reactivation of inactive p53 approaches would be useful in the management of relapsed neuroblastoma...
  4. ncbi Regions syntenic to human 17q are gained in mouse and rat neuroblastoma
    Maria Łastowska
    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Genes Chromosomes Cancer 40:158-63. 2004
    ..2 Mb from the previously defined region of 17q gain in humans as a likely location of the candidate gene or genes, and strongly suggests that the molecular etiology of neuroblastoma is similar in all three species...
  5. ncbi Cyclophosphamide metabolism in children with non-Hodgkin's lymphoma
    S Murray Yule
    Department of Child Health, Yorkhill National Health Service Trust, Glasgow, United Kongdom
    Clin Cancer Res 10:455-60. 2004
    ..Modified chemotherapy strategies should be considered in patients who exhibit low rates of clearance of the parent drug and/or extensive production of inactive metabolites...
  6. ncbi Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior
    Tamas Tornoczky
    Department of Pathology, Faculty of Medicine, Medical and Health Sciences Center, University of Pecs, Szigeti ut 12, H 7643 Pecs, Hungary
    Cancer 100:390-7. 2004
    ....
  7. ncbi Development of a real-time polymerase chain reaction assay for prediction of the uptake of meta-[(131)I]iodobenzylguanidine by neuroblastoma tumors
    Sean Carlin
    Departments of Radiation Oncology and Child Health, University of Glasgow, Cancer Research UK Beatson Laboratories, Glasgow G61 1BD, United Kingdom
    Clin Cancer Res 9:3338-44. 2003
    ....
  8. ncbi The p53 pathway and its inactivation in neuroblastoma
    Deborah A Tweddle
    Cancer Research Unit, The Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Cancer Lett 197:93-8. 2003
    ..If p53 inactivation occurs frequently in relapsed tumours it may be appropriate to include p53 independent therapies in the initial management of high-risk neuroblastoma...
  9. ncbi Retinoid signalling and gene expression in neuroblastoma cells: RXR agonist and antagonist effects on CRABP-II and RARbeta expression
    Quentin Campbell Hewson
    Department of Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Cell Biochem 87:284-91. 2002
    ..The possibility that RXR-homodimers mediate, in part, the induction of CRABP-II by 9-cis RA and RXR-specific ligands is discussed...
  10. ncbi Breakpoint position on 17q identifies the most aggressive neuroblastoma tumors
    Maria Łastowska
    Institute of Human Genetics, International Centre for Life, University of Newcastle upon Tyne, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Genes Chromosomes Cancer 34:428-36. 2002
    ..1 and 17qter acting to promote tumor progression...
  11. ncbi Retinoid X receptors and retinoid response in neuroblastoma cells
    Birju Rana
    Department of Endocrinology, Medical Molecular Biology Group, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    J Cell Biochem 86:67-78. 2002
    ..The results of this study suggest that interactions between retinoid receptors and other nuclear proteins may be critical determinants of retinoid responses in neural cells...
  12. ncbi Influence of isomerisation on the growth inhibitory effects and cellular activity of 13-cis and all-trans retinoic acid in neuroblastoma cells
    Gareth J Veal
    Cancer Research Unit, Medical School, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, UK
    Biochem Pharmacol 63:207-15. 2002
    ..In summary, these results indicate either an intracellular conversion of 13-cis RA to ATRA or a selective uptake of ATRA and suggest that this may mediate the differential activity of 13-cis RA in neuroblastoma cell subtypes...