N Osuji

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi Granulomatous slack skin disease--disease features and response to pentostatin
    Nnenna Osuji
    Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, UK
    Br J Haematol 123:297-304. 2003
  2. ncbi Characteristic appearances of the bone marrow in T-cell large granular lymphocyte leukaemia
    N Osuji
    Section of Haemato oncology, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, Sutton, Surrey, UK
    Histopathology 50:547-54. 2007
  3. ncbi T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature
    Nnenna Osuji
    Section of Haemato oncology, Institute of Cancer Research, London, United Kingdom
    Cancer 107:570-8. 2006
  4. ncbi Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review
    Nnenna Osuji
    Section of Haemato oncology, Royal Marsden Hospital Foundation Trust Institute of Cancer Research, London UK
    Am J Surg Pathol 29:935-41. 2005
  5. ncbi Prolonged treatment response in aggressive natural killer cell leukemia
    N Osuji
    Section of Haemato-Oncology, Royal Marsden NHS Trust/Institute of Cancer Research, London, UK
    Leuk Lymphoma 46:757-63. 2005
  6. ncbi IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)
    I Del Giudice
    Section of Haemato Oncology Institute of Cancer Research, Sutton, UK
    Leukemia 20:1231-7. 2006
  7. ncbi Transformation of T-cell large granular lymphocyte leukaemia into a high-grade large T-cell lymphoma
    E Matutes
    Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, NHS Trust, Fulham Road, London SW3 6JJ, UK
    Br J Haematol 115:801-6. 2001
  8. ncbi High-grade transformation in splenic marginal zone lymphoma with circulating villous lymphocytes: the site of transformation influences response to therapy and prognosis
    M Dungarwalla
    Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, UK
    Br J Haematol 143:71-4. 2008
  9. ncbi CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab
    N Osuji
    Section of Haemato-Oncology, Royal Marsden NHS Trust and Institute of Cancer Research, London, UK
    Leuk Lymphoma 46:723-7. 2005
  10. ncbi Isolated central nervous system involvement in adult T-cell lymphoma/leukaemia
    M Dungerwalla
    Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK
    Br J Haematol 130:511-5. 2005

Collaborators

  • E Matutes
  • Daniel Catovsky
  • S Kulkarni
  • D Oscier
  • Claire Dearden
  • F Forconi
  • Ilaria del Giudice
  • Monica Else
  • John Swansbury
  • M Dungarwalla
  • A Wotherspoon
  • Andrew Wotherspoon
  • I Del Giudice
  • M Dungerwalla
  • R Saso
  • J Swansbury
  • S Appiah-Cubi
  • D C Cunningham
  • Francesco Lauria
  • V Brito-Babapulle
  • N Parry-Jones
  • Z Davis
  • A Morilla
  • Sonia Maravelaki
  • A D Waldman
  • Rosa Ruchlemer
  • Alison Morilla
  • Nilima Parry-Jones
  • F Al Jehani
  • G Cogill
  • Ricardo Morilla
  • Anthony Woodman
  • R Taylor
  • Kwasi Owusu-Ankomah
  • Anna Burford
  • A Mehta
  • Vasantha Brito-Babapulle
  • R Tailor

Detail Information

Publications17

  1. ncbi Granulomatous slack skin disease--disease features and response to pentostatin
    Nnenna Osuji
    Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, UK
    Br J Haematol 123:297-304. 2003
    ..The patient has twice achieved a good response to pentostatin after failure of combination chemotherapy. This is the first report of the successful use of the purine analogue pentostatin in the management of GSSD...
  2. ncbi Characteristic appearances of the bone marrow in T-cell large granular lymphocyte leukaemia
    N Osuji
    Section of Haemato oncology, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, Sutton, Surrey, UK
    Histopathology 50:547-54. 2007
    ..To augment the limited literature on bone marrow (BM) appearances in T-cell large granular lymphocyte (LGL) leukaemia and to identify a histological signature to aid in diagnosis of this condition...
  3. ncbi T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature
    Nnenna Osuji
    Section of Haemato oncology, Institute of Cancer Research, London, United Kingdom
    Cancer 107:570-8. 2006
    ..To the authors' knowledge, there is no standard treatment for patients with T-cell large granular lymphocyte (LGL) leukemia. Available data are limited by patient numbers and coexisting pathologies...
  4. ncbi Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative review
    Nnenna Osuji
    Section of Haemato oncology, Royal Marsden Hospital Foundation Trust Institute of Cancer Research, London UK
    Am J Surg Pathol 29:935-41. 2005
    ....
  5. ncbi Prolonged treatment response in aggressive natural killer cell leukemia
    N Osuji
    Section of Haemato-Oncology, Royal Marsden NHS Trust/Institute of Cancer Research, London, UK
    Leuk Lymphoma 46:757-63. 2005
    ....
  6. ncbi IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)
    I Del Giudice
    Section of Haemato Oncology Institute of Cancer Research, Sutton, UK
    Leukemia 20:1231-7. 2006
    ..B-PLL appears biologically heterogeneous regarding IgVH mutations, ZAP-70 and CD38 expression, showing a pattern distinct from that of other lymphoproliferative disorders...
  7. ncbi Transformation of T-cell large granular lymphocyte leukaemia into a high-grade large T-cell lymphoma
    E Matutes
    Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, NHS Trust, Fulham Road, London SW3 6JJ, UK
    Br J Haematol 115:801-6. 2001
    ..This is the first case documented by molecular methods of the transformation of the pre-existing clone...
  8. ncbi High-grade transformation in splenic marginal zone lymphoma with circulating villous lymphocytes: the site of transformation influences response to therapy and prognosis
    M Dungarwalla
    Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, UK
    Br J Haematol 143:71-4. 2008
    ..03). While transformation in the bone marrow is frequently refractory to therapy and associated with poor outcome in SMZL, lymph node transformation responds well to chemotherapy with durable progression-free and overall survival...
  9. ncbi CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumab
    N Osuji
    Section of Haemato-Oncology, Royal Marsden NHS Trust and Institute of Cancer Research, London, UK
    Leuk Lymphoma 46:723-7. 2005
    ..The strong and consistent expression of CD52 shown here highlights the potential role of alemtuzumab in the treatment of refractory T-cell LGL leukemia and possibly aggressive NK cell leukemia...
  10. ncbi Isolated central nervous system involvement in adult T-cell lymphoma/leukaemia
    M Dungerwalla
    Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK
    Br J Haematol 130:511-5. 2005
    ..We also describe objective response to antiviral therapy. To our knowledge, this is the first report of such presentation and response...
  11. ncbi Lessons from a case of T-cell large granular lymphocytic leukaemia suggesting that immunomodulatory therapy is more effective than intensive treatment
    Nnenna Osuji
    Section of Haemato-Oncology, Department of Histopathology, Institute of Cancer Research, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom
    Leuk Res 29:225-8. 2005
    ..We highlight the resistant nature of the LGL clone and discuss the relative merits of immunomodulatory type therapy in this disease...
  12. ncbi The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemia
    Monica Else
    Section of Haemato oncology, Royal Marsden Hospital Institute of Cancer Research, Sutton, United Kingdom
    Cancer 110:2240-7. 2007
    ..They continue to be effective at second- and even third-line therapy; however, alternative treatments are needed for patients who are or have become refractory to these agents or whose remissions are shorter with each course of therapy...
  13. ncbi The WHO classification of mature T-cell leukemias
    Daniel Catovsky
    Blood 104:2989-90; author reply 2990. 2004
  14. ncbi Long remissions in hairy cell leukemia with purine analogs: a report of 219 patients with a median follow-up of 12.5 years
    Monica Else
    Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust/Institute of Cancer Research (ICR, Sutton, United Kingdom
    Cancer 104:2442-8. 2005
    ..True cure in HCL remains elusive, but the addition of monoclonal antibodies may be beneficial. Our results suggest that achieving CR should remain the main goal of treatment...
  15. ncbi Zeta-chain associated protein 70 and CD38 combined predict the time to first treatment in patients with chronic lymphocytic leukemia
    Ilaria del Giudice
    Section of Hemato-Oncology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer 104:2124-32. 2005
    ..00001). CONCLUSIONS: The current findings suggested that both ZAP-70 and CD38 should be tested prospectively in all patients with early-stage CLL...
  16. ncbi Delayed response to fludarabine in lymphoplasmacytic lymphoma/Waldenström's macroglobulinemia
    Ilaria del Giudice
    Haematologica 90:268-70. 2005
    ..During follow-up post-treatment, seven delayed responses (54%) were observed, improving the initial overall response rate of 61% to a final response rate of 77%...
  17. ncbi Pregnancy improves neutropenia in T-cell large granular lymphocyte leukaemia
    Nnenna Osuji
    Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Surrey SM2 5PT, UK
    Br J Haematol 128:645-8. 2005
    ..Pregnancy thus appears to have a beneficial effect on neutrophil count in T-cell LGL leukaemia...