Affiliation: Institute of Cancer Research
- Granulomatous slack skin disease--disease features and response to pentostatinNnenna Osuji
Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, London, UK
Br J Haematol 123:297-304. 2003..The patient has twice achieved a good response to pentostatin after failure of combination chemotherapy. This is the first report of the successful use of the purine analogue pentostatin in the management of GSSD...
- Characteristic appearances of the bone marrow in T-cell large granular lymphocyte leukaemiaN Osuji
Section of Haemato oncology, Royal Marsden NHS Foundation Trust, Institute of Cancer Research, Sutton, Surrey, UK
Histopathology 50:547-54. 2007..To augment the limited literature on bone marrow (BM) appearances in T-cell large granular lymphocyte (LGL) leukaemia and to identify a histological signature to aid in diagnosis of this condition...
- T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literatureNnenna Osuji
Section of Haemato oncology, Institute of Cancer Research, London, United Kingdom
Cancer 107:570-8. 2006..To the authors' knowledge, there is no standard treatment for patients with T-cell large granular lymphocyte (LGL) leukemia. Available data are limited by patient numbers and coexisting pathologies...
- Histopathology of the spleen in T-cell large granular lymphocyte leukemia and T-cell prolymphocytic leukemia: a comparative reviewNnenna Osuji
Section of Haemato oncology, Royal Marsden Hospital Foundation Trust Institute of Cancer Research, London UK
Am J Surg Pathol 29:935-41. 2005....
- Prolonged treatment response in aggressive natural killer cell leukemiaN Osuji
Section of Haemato-Oncology, Royal Marsden NHS Trust/Institute of Cancer Research, London, UK
Leuk Lymphoma 46:757-63. 2005....
- IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)I Del Giudice
Section of Haemato Oncology Institute of Cancer Research, Sutton, UK
Leukemia 20:1231-7. 2006..B-PLL appears biologically heterogeneous regarding IgVH mutations, ZAP-70 and CD38 expression, showing a pattern distinct from that of other lymphoproliferative disorders...
- Transformation of T-cell large granular lymphocyte leukaemia into a high-grade large T-cell lymphomaE Matutes
Academic Department of Haematology and Cytogenetics, Royal Marsden Hospital, NHS Trust, Fulham Road, London SW3 6JJ, UK
Br J Haematol 115:801-6. 2001..This is the first case documented by molecular methods of the transformation of the pre-existing clone...
- High-grade transformation in splenic marginal zone lymphoma with circulating villous lymphocytes: the site of transformation influences response to therapy and prognosisM Dungarwalla
Department of Haematology, The Royal Marsden Hospital NHS Foundation Trust, London, UK
Br J Haematol 143:71-4. 2008..03). While transformation in the bone marrow is frequently refractory to therapy and associated with poor outcome in SMZL, lymph node transformation responds well to chemotherapy with durable progression-free and overall survival...
- CD52 expression in T-cell large granular lymphocyte leukemia--implications for treatment with alemtuzumabN Osuji
Section of Haemato-Oncology, Royal Marsden NHS Trust and Institute of Cancer Research, London, UK
Leuk Lymphoma 46:723-7. 2005..The strong and consistent expression of CD52 shown here highlights the potential role of alemtuzumab in the treatment of refractory T-cell LGL leukemia and possibly aggressive NK cell leukemia...
- Isolated central nervous system involvement in adult T-cell lymphoma/leukaemiaM Dungerwalla
Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, London, UK
Br J Haematol 130:511-5. 2005..We also describe objective response to antiviral therapy. To our knowledge, this is the first report of such presentation and response...
- Lessons from a case of T-cell large granular lymphocytic leukaemia suggesting that immunomodulatory therapy is more effective than intensive treatmentNnenna Osuji
Section of Haemato-Oncology, Department of Histopathology, Institute of Cancer Research, Royal Marsden Hospital, Fulham Road, London, SW3 6JJ, United Kingdom
Leuk Res 29:225-8. 2005..We highlight the resistant nature of the LGL clone and discuss the relative merits of immunomodulatory type therapy in this disease...
- The role of rituximab in combination with pentostatin or cladribine for the treatment of recurrent/refractory hairy cell leukemiaMonica Else
Section of Haemato oncology, Royal Marsden Hospital Institute of Cancer Research, Sutton, United Kingdom
Cancer 110:2240-7. 2007..They continue to be effective at second- and even third-line therapy; however, alternative treatments are needed for patients who are or have become refractory to these agents or whose remissions are shorter with each course of therapy...
- The WHO classification of mature T-cell leukemiasDaniel Catovsky
Blood 104:2989-90; author reply 2990. 2004
- Long remissions in hairy cell leukemia with purine analogs: a report of 219 patients with a median follow-up of 12.5 yearsMonica Else
Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust/Institute of Cancer Research (ICR, Sutton, United Kingdom
Cancer 104:2442-8. 2005..True cure in HCL remains elusive, but the addition of monoclonal antibodies may be beneficial. Our results suggest that achieving CR should remain the main goal of treatment...
- Zeta-chain associated protein 70 and CD38 combined predict the time to first treatment in patients with chronic lymphocytic leukemiaIlaria del Giudice
Section of Hemato-Oncology, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Cancer 104:2124-32. 2005..00001). CONCLUSIONS: The current findings suggested that both ZAP-70 and CD38 should be tested prospectively in all patients with early-stage CLL...
- Delayed response to fludarabine in lymphoplasmacytic lymphoma/WaldenstrÃ¶m's macroglobulinemiaIlaria del Giudice
Haematologica 90:268-70. 2005..During follow-up post-treatment, seven delayed responses (54%) were observed, improving the initial overall response rate of 61% to a final response rate of 77%...
- Pregnancy improves neutropenia in T-cell large granular lymphocyte leukaemiaNnenna Osuji
Section of Haemato-Oncology, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Surrey SM2 5PT, UK
Br J Haematol 128:645-8. 2005..Pregnancy thus appears to have a beneficial effect on neutrophil count in T-cell LGL leukaemia...