J A Napier

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Trafficking of wheat gluten proteins in transgenic tobacco plants: gamma-gliadin does not contain an endoplasmic reticulum-retention signal
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Planta 203:488-94. 1997
  2. ncbi request reprint Plant desaturases: harvesting the fat of the land
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol, BS41 9AF, UK
    Curr Opin Plant Biol 2:123-7. 1999
  3. ncbi request reprint Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, United Kingdom
    Lipids 36:761-6. 2001
  4. ncbi request reprint The role of cytochrome b5 fusion desaturases in the synthesis of polyunsaturated fatty acids
    Johnathan A Napier
    IACR Long Ashton Research Station, Long Ashton, Bristol BS41 9AF, UK
    Prostaglandins Leukot Essent Fatty Acids 68:135-43. 2003
  5. ncbi request reprint A new class of lipid desaturase central to sphingolipid biosynthesis and signalling
    Johnathan A Napier
    IACR Long Ashton Research Station, Long Ashton, Bristol, UK BS41 9AF
    Trends Plant Sci 7:475-8. 2002
  6. pmc Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco
    O Sayanova
    Institute of Arable Crops Research Long Ashton Research Station, University of Bristol, United Kingdom
    Proc Natl Acad Sci U S A 94:4211-6. 1997
  7. ncbi request reprint Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpina
    L V Michaelson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    J Biol Chem 273:19055-9. 1998
  8. ncbi request reprint Functional identification of a fatty acid delta5 desaturase gene from Caenorhabditis elegans
    L V Michaelson
    School of Biological Sciences, University of Bristol, UK
    FEBS Lett 439:215-8. 1998
  9. ncbi request reprint Mutagenesis and heterologous expression in yeast of a plant Delta6-fatty acid desaturase
    O Sayanova
    IACR-Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    J Exp Bot 52:1581-5. 2001
  10. ncbi request reprint Tobacco cytochrome b5: cDNA isolation, expression analysis and in vitro protein targeting
    M A Smith
    Department of Botany, University of Bristol, UK
    Plant Mol Biol 25:527-37. 1994

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Trafficking of wheat gluten proteins in transgenic tobacco plants: gamma-gliadin does not contain an endoplasmic reticulum-retention signal
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Planta 203:488-94. 1997
    ..Taken together, these results indicate that gamma-gliadin is targeted to the vacuole in transgenic tobacco plants and does not contain any structural determinants which confer retention in the endoplasmic reticulum...
  2. ncbi request reprint Plant desaturases: harvesting the fat of the land
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol, BS41 9AF, UK
    Curr Opin Plant Biol 2:123-7. 1999
    ..It is to be hoped that, in the near future, the goal of producing unusual and valuable fatty acids in transgenic oilseeds will be achieved on a commercial scale...
  3. ncbi request reprint Genomic and functional characterization of polyunsaturated fatty acid biosynthesis in Caenorhabditis elegans
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, United Kingdom
    Lipids 36:761-6. 2001
    ..A pathway for the biosynthesis of polyunsaturated fatty acids in C. elegans was proposed based on these genes. The role of gene duplication in enzyme evolution and proliferation is discussed...
  4. ncbi request reprint The role of cytochrome b5 fusion desaturases in the synthesis of polyunsaturated fatty acids
    Johnathan A Napier
    IACR Long Ashton Research Station, Long Ashton, Bristol BS41 9AF, UK
    Prostaglandins Leukot Essent Fatty Acids 68:135-43. 2003
    ..More importantly, this knowledge helps underpin our understanding of polyunsaturated fatty acid biosynthesis...
  5. ncbi request reprint A new class of lipid desaturase central to sphingolipid biosynthesis and signalling
    Johnathan A Napier
    IACR Long Ashton Research Station, Long Ashton, Bristol, UK BS41 9AF
    Trends Plant Sci 7:475-8. 2002
    ..Orthologues are present in animals, plants and fungi, raising the possibility of using reverse genetics to determine the contribution of sphingosine-1-phosphate to signalling networks...
  6. pmc Expression of a borage desaturase cDNA containing an N-terminal cytochrome b5 domain results in the accumulation of high levels of delta6-desaturated fatty acids in transgenic tobacco
    O Sayanova
    Institute of Arable Crops Research Long Ashton Research Station, University of Bristol, United Kingdom
    Proc Natl Acad Sci U S A 94:4211-6. 1997
    ..6% of the total fatty acids, respectively. The borage delta6-fatty acid desaturase differs from other desaturase enzymes, characterized from higher plants previously, by the presence of an N-terminal domain related to cytochrome b5...
  7. ncbi request reprint Isolation of a Delta5-fatty acid desaturase gene from Mortierella alpina
    L V Michaelson
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, United Kingdom
    J Biol Chem 273:19055-9. 1998
    ..The M. alpina Delta5-desaturase is the first example of a cloned Delta5-desaturase, and differs from other fungal desaturases previously characterized by the presence of an N-terminal domain related to cytochrome b5...
  8. ncbi request reprint Functional identification of a fatty acid delta5 desaturase gene from Caenorhabditis elegans
    L V Michaelson
    School of Biological Sciences, University of Bristol, UK
    FEBS Lett 439:215-8. 1998
    ..With an amino acid identity of 45% it is possible that one of these genes arose from the other by gene duplication. This is the first example of a delta5 desaturase gene isolated from an animal...
  9. ncbi request reprint Mutagenesis and heterologous expression in yeast of a plant Delta6-fatty acid desaturase
    O Sayanova
    IACR-Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    J Exp Bot 52:1581-5. 2001
    ..This showed that the variant glutamine in the third histidine box is essential for enzyme activity and that histidine is not able to substitute for this residue...
  10. ncbi request reprint Tobacco cytochrome b5: cDNA isolation, expression analysis and in vitro protein targeting
    M A Smith
    Department of Botany, University of Bristol, UK
    Plant Mol Biol 25:527-37. 1994
    ..In vitro transcription and translation studies of the cDNA indicated that the protein inserts into the ER membrane by a non-SRP-mediated pathway and that the C-terminus of the protein is required for targeting and insertion...
  11. ncbi request reprint Isolation and characterization of a cDNA encoding a Delta8 sphingolipid desaturase from Aquilegia vulgaris
    L V Michaelson
    Institute of Arable Crops Research, Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Biochem Soc Trans 30:1073-5. 2002
    ..The Delta(8) long-chain base desaturase was also able to desaturate dihydrosphingosine substrates. This is the first report of the functional characterization of an A. vulgaris gene product...
  12. pmc Identification of a Caenorhabditis elegans Delta6-fatty-acid-desaturase by heterologous expression in Saccharomyces cerevisiae
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS18 9AF, U K
    Biochem J 330:611-4. 1998
    ..elegans Delta6-desaturase mapped to cosmid W08D2, a region of chromosome III. This is the first example of a Delta6-desaturase isolated from an animal and also the first example of an animal desaturase containing a cytochrome b5 domain...
  13. ncbi request reprint Plant stress signalling: understanding and exploiting plant-plant interactions
    J A Pickett
    Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Biochem Soc Trans 31:123-7. 2003
    ....
  14. ncbi request reprint Isolation of a cDNA encoding a cytochrome b5 specifically expressed in developing tobacco seeds
    J A Napier
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Planta 197:200-2. 1995
    ..Therefore, it seems likely that this message is the product of a tobacco cytochrome b5 gene specifically expressed in seeds...
  15. ncbi request reprint Isolation of two putative acyl-acyl carrier protein desaturase enzymes from Kochia scoparia
    H Whitney
    IACR Long Ashton Research Station, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    Biochem Soc Trans 28:623-4. 2000
    ..This unusual fatty acid is produced in the seed of Kochia scoparia. We have isolated two acyl-acyl carrier protein desaturases from this species and expressed them in Escherichia coli to facilitate functional characterisation...
  16. ncbi request reprint Fatty acid desaturases from the microalga Thalassiosira pseudonana
    Thierry Tonon
    CNAP, Department of Biology, University of York, Heslington, York, UK
    FEBS J 272:3401-12. 2005
    ..Furthermore, we show that one of the remaining genes, TpdesB, encodes a Delta8-sphingolipid desaturase with strong preference for dihydroxylated substrates...
  17. ncbi request reprint The production of very-long-chain PUFA biosynthesis in transgenic plants: towards a sustainable source of fish oils
    Johnathan A Napier
    Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Proc Nutr Soc 64:387-93. 2005
    ..The approaches taken to realise this outcome will be discussed, as will their prospects for providing a sustainable resource for the future...
  18. ncbi request reprint Members of the Arabidopsis FAE1-like 3-ketoacyl-CoA synthase gene family substitute for the Elop proteins of Saccharomyces cerevisiae
    Shilpi Paul
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184, USA
    J Biol Chem 281:9018-29. 2006
    ....
  19. ncbi request reprint Progress toward the production of long-chain polyunsaturated fatty acids in transgenic plants
    Johnathan A Napier
    Rothamsted Research, Harpenden, Herts AL5 2JQ, United Kingdom
    Lipids 39:1067-75. 2004
    ..This review will describe recent advances in the production of transgenic plant oils nutritionally enhanced to produce long-chain PUFA...
  20. pmc The very-long-chain hydroxy fatty acyl-CoA dehydratase PASTICCINO2 is essential and limiting for plant development
    Lien Bach
    Laboratoire Biologie Cellulaire, Institut National de la Recherche Agronomique, 78000 Versailles Cedex, France
    Proc Natl Acad Sci U S A 105:14727-31. 2008
    ....
  21. ncbi request reprint The production of long chain polyunsaturated fatty acids in transgenic plants by reverse-engineering
    Johnathan A Napier
    Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Biochimie 86:785-92. 2004
    ..Recent progress in validating this approach has now emerged, demonstrating the feasibility of using transgenic plants to synthesise these important human nutrients...
  22. ncbi request reprint The alternative pathway C20 Delta8-desaturase from the non-photosynthetic organism Acanthamoeba castellanii is an atypical cytochrome b5-fusion desaturase
    Olga Sayanova
    Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    FEBS Lett 580:1946-52. 2006
    ..This is the first report of an alternative pathway C20 Delta8-desaturase from a non-photosynthetic organism, and also the first report of a front-end desaturase lacking the canonical cytochrome b5 domain...
  23. ncbi request reprint Identification of Primula "front-end" desaturases with distinct n-6 or n-3 substrate preferences
    Olga Sayanova
    Rothamsted Research, Harpenden, Herts, AL5 2JQ, UK
    Planta 224:1269-77. 2006
    ....
  24. ncbi request reprint A bifunctional Delta12,Delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n-1 series unsaturated fatty acids
    Olga Sayanova
    Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom
    J Biol Chem 281:36533-41. 2006
    ..The presence of a bifunctional Delta12,Delta15-desaturase in A. castellanii is also considered with reference to the evolution of desaturases and the lineage of this protist...
  25. ncbi request reprint Properties and exploitation of oleosins
    Floriana Capuano
    Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Biotechnol Adv 25:203-6. 2007
    ..The oleosin proteins may be exploited to stabilize emulsions while the ease of oil body preparation has led to the expression of bioactive proteins as oleosin fusions in molecular farming...
  26. ncbi request reprint Rational metabolic engineering of transgenic plants for biosynthesis of omega-3 polyunsaturates
    Ian A Graham
    CNAP, Department of Biology Area 7, University of York, PO Box 373, York YO10 5YW, UK
    Curr Opin Biotechnol 18:142-7. 2007
    ..In addition, efficient substrate channelling and lipid synthesis could depend on specific endoplasmic reticulum subdomain localisation for key endogenous enzymes, and this organization could be compromised in heterologous systems...
  27. ncbi request reprint Cloning and molecular characterisation of a Delta8-sphingolipid-desaturase from Nicotiana tabacum closely related to Delta6-acyl-desaturases
    Federico García-Maroto
    Area de Bioquímica, Facultad de Ciencias Experimentales, Universidad de Almeria, 04120, Almeria, Spain
    Plant Mol Biol 64:241-50. 2007
    ..These data indicate that NTDXDES represent a novel desaturase gene placed in a different evolutionary lineage to that of previously characterised Delta(8)-desaturases...
  28. pmc Cloning and characterization of unusual fatty acid desaturases from Anemone leveillei: identification of an acyl-coenzyme A C20 Delta5-desaturase responsible for the synthesis of sciadonic acid
    Olga Sayanova
    Rothamsted Research, Harpenden, Herts, United Kingdom
    Plant Physiol 144:455-67. 2007
    ..Our data provide biochemical evidence for the A. leveillei Delta(5)-desaturases using acyl-CoA substrates...
  29. ncbi request reprint The production of unusual fatty acids in transgenic plants
    Johnathan A Napier
    Rothamsted Research, Harpenden, Hertfordshire, United Kingdom
    Annu Rev Plant Biol 58:295-319. 2007
    ..In this review, we consider the probable factors responsible for these different outcomes, as well as the potential for further optimization of the transgenic production of unusual fatty acids in transgenic plants...
  30. ncbi request reprint Developments in aspects of ecological phytochemistry: the role of cis-jasmone in inducible defence systems in plants
    John A Pickett
    Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Phytochemistry 68:2937-45. 2007
    ....
  31. pmc cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids
    Toby J A Bruce
    Rothamsted Research, Harpenden AL5 2JQ, United Kingdom
    Proc Natl Acad Sci U S A 105:4553-8. 2008
    ....
  32. ncbi request reprint A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase
    Frederic Beaudoin
    Institute of Arable Crops Research Long Ashton Research Station, Long Ashton, Bristol BS41 9AF, United Kingdom
    J Biol Chem 277:11481-8. 2002
    ..Biochemical characterization of microsomal preparations from ybr159Delta cells revealed a primary perturbation in beta-ketoacyl reduction, confirming the assignment of YBR159w as encoding a component of the microsomal elongase...
  33. pmc Biosynthesis of very-long-chain polyunsaturated fatty acids in transgenic oilseeds: constraints on their accumulation
    Amine Abbadi
    Institut fur Allgemeine Botanik, Universitat Hamburg, 22609 Hamburg, Germany
    Plant Cell 16:2734-48. 2004
    ..As well as the successful production of VLCPUFA in transgenic oilseeds and the identification of constraints on their accumulation, our results indicate alternative strategies to circumvent this bottleneck...
  34. ncbi request reprint Production of very long chain polyunsaturated omega-3 and omega-6 fatty acids in plants
    Baoxiu Qi
    School of Biological Sciences, University of Bristol, BS8 1UG, England, UK
    Nat Biotechnol 22:739-45. 2004
    ..The accumulation of EPA and AA in transgenic plants is a breakthrough in the search for alternative sustainable sources of fish oils...
  35. pmc A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thaliana
    Teresa M Dunn
    Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Ann Bot 93:483-97. 2004
    ..To highlight the importance of sphingolipids and their metabolites in plant biology...
  36. ncbi request reprint Identification of a cDNA encoding a novel C18-Delta(9) polyunsaturated fatty acid-specific elongating activity from the docosahexaenoic acid (DHA)-producing microalga, Isochrysis galbana
    Baoxiu Qi
    School of Biological Sciences, University of Bristol, UK
    FEBS Lett 510:159-65. 2002
    ..The results also suggest that a major route for eicosapentaenoic acid (C20:5n-3, Delta(5,8,11,14,17)) and docosahexaenoic acid syntheses in I. galbana may involve a Delta(8) desaturation pathway...
  37. ncbi request reprint Eicosapentaenoic acid: biosynthetic routes and the potential for synthesis in transgenic plants
    Olga V Sayanova
    Rothamsted Research, Harpenden, AL5 2JQ, Herts, UK
    Phytochemistry 65:147-58. 2004
    ..In particular, the prospect of producing this important polyunsaturated fatty acid in transgenic oilseeds is highlighted, as is the urgent need for a sustainable replacement for diminishing fish stocks...
  38. ncbi request reprint Functional characterization of the Arabidopsis thaliana orthologue of Tsc13p, the enoyl reductase of the yeast microsomal fatty acid elongating system
    Kenneth Gable
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 21084, USA
    J Exp Bot 55:543-5. 2004
    ..At3g55360 apparently encodes the sole enoyl reductase activity associated with microsomal fatty acid elongation in Arabidopsis. Consistent with this conclusion, AtTSC13 is ubiquitously expressed in Arabidopsis...
  39. ncbi request reprint Functional characterisation of two cytochrome b5-fusion desaturases from Anemone leveillei: the unexpected identification of a fatty acid Delta6-desaturase
    Heather M Whitney
    Long Ashton Research Station, Long Ashton, Bristol, BS41 9AF, UK
    Planta 217:983-92. 2003
    ..leveillei has implications for the use of fatty acids in chemotaxonomic studies. This is also the first report of a higher-plant Delta6-desaturase from a family other than the Boraginaceae...
  40. ncbi request reprint Plumbing the depths of PUFA biosynthesis: a novel polyketide synthase-like pathway from marine organisms
    Johnathan A Napier
    Trends Plant Sci 7:51-4. 2002
    ..These novel PKS genes could be used to direct the synthesis of PUFAs in heterologous hosts, as well as exploiting the combinatorial chemistry of PKSs to make unusual fatty acids...
  41. ncbi request reprint Characterization and modelling of the hydrophobic domain of a sunflower oleosin
    Lucille G Alexander
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Planta 214:546-51. 2002
    ..We consider that this model is consistent with our current knowledge of oleosin structure and properties...
  42. ncbi request reprint Identification of primula fatty acid delta 6-desaturases with n-3 substrate preferences
    Olga V Sayanova
    Long Ashton Research Station, Long Ashton, Bristol BS41 9AF, UK
    FEBS Lett 542:100-4. 2003
    ..These results indicate that the accumulation of octadecatetraenoic acid (18:4 Delta(6,9,12,15)) in planta is due to the activity of a novel n-3-specific fatty acid Delta(6)-desaturase...
  43. ncbi request reprint The dihydroceramide desaturase is not essential for cell viability in Schizosaccharomyces pombe
    Sarah Garton
    Long Ashton Research Station, Long Ashton, Bristol BS41 9AF, UK
    FEBS Lett 538:192-6. 2003
    ..pombe functions. This observation has implications for our understanding of the role of sphingosine and its phosphorylated metabolite sphingosine-1-phosphate in lower eukaryotes...
  44. ncbi request reprint Targeting and membrane-insertion of a sunflower oleosin in vitro and in Saccharomyces cerevisiae: the central hydrophobic domain contains more than one signal sequence, and directs oleosin insertion into the endoplasmic reticulum membrane using a signal a
    Frederic Beaudoin
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    Planta 215:293-303. 2002
    ..Taken together, these results indicate that oleosin contains more than one domain that is capable of interacting with the signal recognition particle to direct the protein to the ER membrane...
  45. ncbi request reprint A metabolomic study of substantial equivalence of field-grown genetically modified wheat
    John M Baker
    National Centre for Plant and Microbial Metabolomics, Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Plant Biotechnol J 4:381-92. 2006
    ....
  46. pmc Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system
    Benoit Lefebvre
    Laboratoire des Interactions Plantes Micro organismes, Unite Mixte de Recherche, Centre National de la Recherche Scientifique Institut National de la Recherche Agronomique 2594 441, 31326 Castanet Tolosan Cedex, France
    Plant Physiol 144:402-18. 2007
    ..Evidence is also given for the presence of a complete PM redox system in the lipid rafts...
  47. ncbi request reprint The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase
    Gongshe Han
    Department of Biochemistry and Molecular Biology, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20184, USA
    J Biol Chem 277:35440-9. 2002
    ..By disrupting the orthologs of Ybr159w in the ybr159Delta mutant we found that the ybr159Deltaayr1Delta double mutant was inviable, suggesting that Ayr1p is responsible for the residual 3-ketoreductase activity...
  48. ncbi request reprint The production of long chain polyunsaturated fatty acids in transgenic plants
    Johnathan A Napier
    Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Genet Eng (N Y) 26:143-57. 2004
  49. ncbi request reprint Co-transcribed genes for long chain polyunsaturated fatty acid biosynthesis in the protozoon Perkinsus marinus include a plant-like FAE1 3-ketoacyl coenzyme A synthase
    Mónica Venegas-Calerón
    Crop Performance and Improvement Division, Rothamsted Research, Harpenden, Herts AL5 2JQ, United Kingdom
    J Biol Chem 282:2996-3003. 2007
    ..The P. marinus FAE1-like elongating activity is also indicative of the independent evolution of the alternative Delta8 pathway, distinct from ELO/SUR4-dependent examples...
  50. ncbi request reprint Isolation and expression pattern of two putative acyl-ACP desaturase cDNAs from Bassia scoparia
    Heather M Whitney
    Long Ashton Research Station, Long Ashton, Bristol BS41 9AF, UK
    J Exp Bot 55:787-9. 2004
    ..The isolation and initial characterization of two putative acyl-ACP desaturases from B. scoparia, one of which is seed-specific, suggests that such a variant enzyme occurs in this species...
  51. pmc Analysis of detergent-resistant membranes in Arabidopsis. Evidence for plasma membrane lipid rafts
    Georg H H Borner
    Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK
    Plant Physiol 137:104-16. 2005
    ..The proteins associated with these domains provide important new experimental avenues into understanding plant cell polarity and cell surface processes...