Venugopal Nair

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Retrovirus-induced oncogenesis and safety of retroviral vectors
    Venugopal Nair
    Institute for Animal Health, Division of Microbiology, Oncogenic Virus Group, Compton, Berkshire, UK
    Curr Opin Mol Ther 10:431-8. 2008
  2. pmc MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines
    Hongtao Xu
    Avian Oncogenic Virus Group, Avian Infectious Diseases Programme, Institute for Animal Health, Compton, Berkshire, UK RG20 7NN
    Cancer Cell Int 10:15. 2010
  3. ncbi request reprint Successful control of Marek's disease by vaccination
    V Nair
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, United Kingdom
    Dev Biol (Basel) 119:147-54. 2004
  4. ncbi request reprint Evolution of Marek's disease -- a paradigm for incessant race between the pathogen and the host
    Venugopal Nair
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Vet J 170:175-83. 2005
  5. ncbi request reprint Virus-encoded microRNAs: novel regulators of gene expression
    Venugopal Nair
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire, UK, RG20 7NN
    Trends Microbiol 14:169-75. 2006
  6. doi request reprint Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine
    Luke S Lambeth
    Division of Microbiology, Institute for Animal Health, High Street, Compton, Berkshire RG20 7NN, United Kingdom
    Vaccine 27:298-306. 2009
  7. ncbi request reprint Identification of a neurovirulence factor from Marek's disease virus
    Abdessamad Tahiri-Alaoui
    The Pirbright Institute, Compton Laboratory, Compton, Berkshire RG20 7NN, U K
    Avian Dis 57:387-94. 2013
  8. doi request reprint Cloning of Gallid herpesvirus 3 (Marek's disease virus serotype-2) genome as infectious bacterial artificial chromosomes for analysis of viral gene functions
    Lawrence Petherbridge
    Microbiology Division, Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Virol Methods 158:11-7. 2009
  9. pmc MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs
    Yongxiu Yao
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Virol 82:4007-15. 2008
  10. doi request reprint Analysis of the expression profiles of Marek's disease virus-encoded microRNAs by real-time quantitative PCR
    Hongtao Xu
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol Methods 149:201-8. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Retrovirus-induced oncogenesis and safety of retroviral vectors
    Venugopal Nair
    Institute for Animal Health, Division of Microbiology, Oncogenic Virus Group, Compton, Berkshire, UK
    Curr Opin Mol Ther 10:431-8. 2008
    ..Furthermore, insertional activation of non-coding sequences, such as microRNAs, in addition to insertional effects on protein-coding genes, should be examined when considering the risks of retroviral therapy...
  2. pmc MicroRNA-26a-mediated regulation of interleukin-2 expression in transformed avian lymphocyte lines
    Hongtao Xu
    Avian Oncogenic Virus Group, Avian Infectious Diseases Programme, Institute for Animal Health, Compton, Berkshire, UK RG20 7NN
    Cancer Cell Int 10:15. 2010
    ..Chicken IL-2 can modulate T-cell proliferation and cytotoxicity in vitro and in vivo and dysregulation of IL-2 expression is observed in diseases such as leukaemia...
  3. ncbi request reprint Successful control of Marek's disease by vaccination
    V Nair
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, United Kingdom
    Dev Biol (Basel) 119:147-54. 2004
    ..In addition, the availability of the whole chicken genome sequence allows the opportunity of exploiting genetic resistance against MD as another sustainable strategy...
  4. ncbi request reprint Evolution of Marek's disease -- a paradigm for incessant race between the pathogen and the host
    Venugopal Nair
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Vet J 170:175-83. 2005
    ..However, the virus has countered each new vaccine with ever more virulent strains. This continuous race between the virus and the host is making the control of this poultry health problem a major challenge for the future...
  5. ncbi request reprint Virus-encoded microRNAs: novel regulators of gene expression
    Venugopal Nair
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire, UK, RG20 7NN
    Trends Microbiol 14:169-75. 2006
    ..Virus-encoded miRNAs seem to evolve rapidly and regulate both the viral life cycle and the interaction between viruses and their hosts...
  6. doi request reprint Targeting Marek's disease virus by RNA interference delivered from a herpesvirus vaccine
    Luke S Lambeth
    Division of Microbiology, Institute for Animal Health, High Street, Compton, Berkshire RG20 7NN, United Kingdom
    Vaccine 27:298-306. 2009
    ..Delivery of RNAi-based gene silencing through live attenuated vaccines for reducing replication of pathogenic viruses is a novel approach for the control of infectious diseases...
  7. ncbi request reprint Identification of a neurovirulence factor from Marek's disease virus
    Abdessamad Tahiri-Alaoui
    The Pirbright Institute, Compton Laboratory, Compton, Berkshire RG20 7NN, U K
    Avian Dis 57:387-94. 2013
    ..Our data identify for the first time pp14 as a neurovirulence factor from MDV1 and open the possibility to investigate the molecular mechanisms by which pp14 mediates the damage to the avian nervous system...
  8. doi request reprint Cloning of Gallid herpesvirus 3 (Marek's disease virus serotype-2) genome as infectious bacterial artificial chromosomes for analysis of viral gene functions
    Lawrence Petherbridge
    Microbiology Division, Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Virol Methods 158:11-7. 2009
    ....
  9. pmc MicroRNA profile of Marek's disease virus-transformed T-cell line MSB-1: predominance of virus-encoded microRNAs
    Yongxiu Yao
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Virol 82:4007-15. 2008
    ..High levels of expression of MDV-1-encoded miRNAs and potentially oncogenic host miRNAs suggest that miRNAs may have major roles in MDV pathogenesis and neoplastic transformation...
  10. doi request reprint Analysis of the expression profiles of Marek's disease virus-encoded microRNAs by real-time quantitative PCR
    Hongtao Xu
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol Methods 149:201-8. 2008
    ....
  11. doi request reprint MicroRNAs 221 and 222 target p27Kip1 in Marek's disease virus-transformed tumour cell line MSB-1
    Luke S Lambeth
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 90:1164-71. 2009
    ..These data show that an oncogenic herpesvirus, as in the case of many cancers, can exploit the miRNA machinery for suppressing cell cycle regulatory molecules such as p27(Kip1) in the induction and progression of T-cell lymphomas...
  12. doi request reprint Interaction of Marek's disease virus oncoprotein Meq with heat-shock protein 70 in lymphoid tumour cells
    Yuguang Zhao
    Viral Oncogenesis Group, Institute for Animal Health, Compton RG20 7NN, UK
    J Gen Virol 90:2201-8. 2009
    ..Given the well-documented evidence of the tumorigenic properties of Hsp70 and its interaction with a number of other known viral oncoproteins, demonstration of the interaction of Meq and Hsp70 is significant in MDV oncogenesis...
  13. pmc Novel microRNAs (miRNAs) encoded by herpesvirus of Turkeys: evidence of miRNA evolution by duplication
    Yongxiu Yao
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 83:6969-73. 2009
    ..Close sequence and phylogenetic relationships of some miRNAs in this cluster indicate evolution by duplication. HVT miRNAs represent the first example of virus-encoded miRNAs that show evolution by duplication...
  14. pmc Pathogenicity of a very virulent strain of Marek's disease herpesvirus cloned as infectious bacterial artificial chromosomes
    Lorraine P Smith
    Avian Infectious Disease Programme, Institute for Animal Health, Compton, Newbury, Berkshire, UK
    J Biomed Biotechnol 2011:412829. 2011
    ....
  15. doi request reprint Differential expression of microRNAs in Marek's disease virus-transformed T-lymphoma cell lines
    Yongxiu Yao
    Division of Microbiology, Institute for Animal Health, Compton RG20 7NN, UK
    J Gen Virol 90:1551-9. 2009
    ..Analysis of the functional targets of these miRNAs would contribute to the understanding of the molecular pathways of MD oncogenicity...
  16. pmc Identification of an intercistronic internal ribosome entry site in a Marek's disease virus immediate-early gene
    Abdessamad Tahiri-Alaoui
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire, United Kingdom
    J Virol 83:5846-53. 2009
    ..Reverse genetic experiments with the oncogenic strain of MDV type 1 indicated that deletion of IRES-controlled RLORF9 does not significantly affect viral replication or MDV-induced mortality...
  17. pmc Self-excision of the BAC sequences from the recombinant Marek's disease virus genome increases replication and pathogenicity
    Yuguang Zhao
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    Virol J 5:19. 2008
    ....
  18. doi request reprint Recombinant herpesvirus of turkeys as a vector-based vaccine against highly pathogenic H7N1 avian influenza and Marek's disease
    Yongqing Li
    Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire RG20 7NN, UK
    Vaccine 29:8257-66. 2011
    ..The rHVT-H7HA not only provided protection against a lethal challenge with highly pathogenic H7N1 virus but also against highly virulent Marek's disease virus and can be used as a DIVA vaccine...
  19. pmc The 5' leader of the mRNA encoding the marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties
    Abdessamad Tahiri-Alaoui
    Institute for Animal Health, Division of Microbiology, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 83:12769-78. 2009
    ..In analogy with allosteric models in proteins, we propose IRES allostery to describe such a novel phenomenon. The functional implications of our findings are discussed in relation to host-virus interactions and translational control...
  20. ncbi request reprint Use of Marek's disease vaccines: could they be driving the virus to increasing virulence?
    Fred Davison
    Head and Avian Immunology Group, Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, UK
    Expert Rev Vaccines 4:77-88. 2005
    ..The future aim must be to develop a sustainable vaccine strategy that does not drive MDV to increased virulence...
  21. pmc Marek's disease virus type 2 (MDV-2)-encoded microRNAs show no sequence conservation with those encoded by MDV-1
    Yongxiu Yao
    Avian Oncogenic Virus Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 81:7164-70. 2007
    ..The identification of these novel miRNAs adds to the growing list of virus-encoded miRNAs...
  22. pmc A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus
    Yuguang Zhao
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol 83:489-92. 2009
    ....
  23. doi request reprint Novel microRNAs encoded by duck enteritis virus
    Yongxiu Yao
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 93:1530-6. 2012
    ..Identification of these novel miRNAs will add to the growing list of virus-encoded miRNAs enabling the exploration of their roles in pathogenesis...
  24. pmc A direct comparison of strategies for combinatorial RNA interference
    Luke S Lambeth
    Institute for Animal Health, Compton, Berkshire, UK
    BMC Mol Biol 11:77. 2010
    ..The current study directly compares the ability of each co-RNAi method to deliver pre-validated siRNA molecules to the same gene targets...
  25. doi request reprint Mutagenesis of the repeat regions of herpesviruses cloned as bacterial artificial chromosomes
    Yuguang Zhao
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire, UK
    Methods Mol Biol 634:53-74. 2010
    ..Here, we describe the various technologies of manipulating the infectious BAC clones of a group E herpesvirus as an example through a combination of different approaches...
  26. pmc Clonal structure of rapid-onset MDV-driven CD4+ lymphomas and responding CD8+ T cells
    William N Mwangi
    Avian Infectious Disease Programme, Institute for Animal Health, Compton, Berkshire, United Kingdom
    PLoS Pathog 7:e1001337. 2011
    ..These studies improve our understanding of the biology of MDV, an important poultry pathogen and a natural infection model of virus-induced tumor formation...
  27. ncbi request reprint Latency and tumorigenesis in Marek's disease
    Venugopal Nair
    Avian Viral Diseases Programme, The Pirbright Institute, Compton Laboratory, Compton, Berkshire RG20 7NN, United Kingdom
    Avian Dis 57:360-5. 2013
    ..In addition, the noncoding sequences in the viral genome, such as the viral telomerase RNA and the virus-encoded microRNAs, also have significant influence on MDV-encoded oncogenesis...
  28. doi request reprint Induction of lymphomas by inoculation of Marek's disease virus-derived lymphoblastoid cell lines: prevention by CVI988 vaccination
    William N Mwangi
    Avian Viral Disease Programme, Institute for Animal Health, Compton, Newbury, RG20 7NN, UK
    Avian Pathol 41:589-98. 2012
    ..The data also demonstrated the application of spectratyping as a tool to track tumour identity in lymphoma transplantation studies...
  29. pmc Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus
    Andrew C Brown
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Proc Natl Acad Sci U S A 103:1687-92. 2006
    ..Engineering MDV with precisely defined attenuating mutations, therefore, represents an effective strategy for generating new vaccines against this major poultry disease...
  30. ncbi request reprint E (XSR) element contributes to the oncogenicity of Avian leukosis virus (subgroup J)
    Peter M Chesters
    Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, UK
    J Gen Virol 87:2685-92. 2006
    ..These results indicate that, although the E element per se is not absolutely essential for tumour induction by this subgroup of viruses, it does contribute to oncogenicity in certain genetic lines of chicken...
  31. ncbi request reprint Real-time quantitative PCR for Marek's disease vaccine virus in feather samples: applications and opportunities
    S Baigent
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, UK
    Dev Biol (Basel) 126:271-81; discussion 327. 2006
    ..Furthermore, the q-PCR test can be applied to researching optimal timing and vaccine delivery routes, and optimal vaccination regimes for different breeds of chick...
  32. ncbi request reprint Rapid identification of non-essential genes for in vitro replication of Marek's disease virus by random transposon mutagenesis
    Jason P Chattoo
    Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom
    J Virol Methods 135:288-91. 2006
    ..The application of the screening method to identify some of the non-essential genes for MDV replication in vitro is described...
  33. pmc Replication-competent bacterial artificial chromosomes of Marek's disease virus: novel tools for generation of molecularly defined herpesvirus vaccines
    Lawrence Petherbridge
    Viral Oncogenesis Group, Institute for Animal Health, Compton, Berkshire, RG20 7NN, United Kingdom
    J Virol 77:8712-8. 2003
    ....
  34. ncbi request reprint Analysis of part of the chicken Rfp-Y region reveals two novel lectin genes, the first complete genomic sequence of a class I alpha-chain gene, a truncated class II beta-chain gene, and a large CR1 repeat
    Sally Rogers
    Institute for Animal Health, Compton, Berkshire, RG20 7NN, UK
    Immunogenetics 55:100-8. 2003
    ..The promoter contains an altered enhancer A element. This portion of the Rfp-Y region also contains a truncated class II B-chain ( Y-LB) gene, as well as a large chicken repeat 1 (CR1) element...
  35. ncbi request reprint Comparative sequence analysis of a highly oncogenic but horizontal spread-defective clone of Marek's disease virus
    Stephen J Spatz
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 934 College Station Rd, Athens, GA 30605, USA
    Virus Genes 35:753-66. 2007
    ..Although further studies are needed to evaluate the role of these genes in the horizontal-spreading defective phenotype, our data clearly indicate that mutations in these genes do not affect the oncogenicity of MDV...
  36. ncbi request reprint Comparative full-length sequence analysis of oncogenic and vaccine (Rispens) strains of Marek's disease virus
    Stephen J Spatz
    Southeast Poultry Research Laboratory, Agricultural Research Service, United States Department of Agriculture, Athens, GA 30605, USA
    J Gen Virol 88:1080-96. 2007
    ..No CVI988 ORF was found to be under positive evolutionary selection (omega>>1)...