Clare Mills

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Improved quality of life to food allergic consumers
    Clare Mills
    Institute of Food Research, Norwich, UK
    Mol Nutr Food Res 51:148-9. 2007
  2. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  3. pmc Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin
    Apostolos Bossios
    Athens University, P, and A, Kyriakou Children s Hospital, Athens, Greece
    Clin Transl Allergy 1:6. 2011
  4. pmc Transcriptome analysis of grain development in hexaploid wheat
    Yongfang Wan
    Rothamsted Research, Harpenden, Hertfordshire, UK
    BMC Genomics 9:121. 2008
  5. ncbi request reprint Formation of thermally induced aggregates of the soya globulin beta-conglycinin
    E N Mills
    Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK
    Biochim Biophys Acta 1547:339-50. 2001
  6. ncbi request reprint Food allergy and its relevance to industrial food proteins
    E N C Mills
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Biotechnol Adv 23:409-14. 2005
  7. doi request reprint The impact of processing on allergenicity of food
    E N Clare Mills
    Institute of Food Research, Norwich, UK
    Curr Opin Allergy Clin Immunol 8:249-53. 2008
  8. doi request reprint Impact of food processing on the structural and allergenic properties of food allergens
    E N Clare Mills
    Institute of Food Research, Norwich Research Park, Colney Norwich, NR4 7UA UK
    Mol Nutr Food Res 53:963-9. 2009
  9. ncbi request reprint Allergens of the cupin superfamily
    E N Mills
    Institute of Food Research, Norwich Research Park, Colney, UK
    Biochem Soc Trans 30:925-9. 2002
  10. ncbi request reprint Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract
    E N Clare Mills
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Crit Rev Food Sci Nutr 44:379-407. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Improved quality of life to food allergic consumers
    Clare Mills
    Institute of Food Research, Norwich, UK
    Mol Nutr Food Res 51:148-9. 2007
  2. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  3. pmc Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin
    Apostolos Bossios
    Athens University, P, and A, Kyriakou Children s Hospital, Athens, Greece
    Clin Transl Allergy 1:6. 2011
    ..abstract:..
  4. pmc Transcriptome analysis of grain development in hexaploid wheat
    Yongfang Wan
    Rothamsted Research, Harpenden, Hertfordshire, UK
    BMC Genomics 9:121. 2008
    ..Molecular understanding of the biology of the developing grain will assist the improvement of yield and quality traits for different environments. High quality transcriptomics is a powerful method to increase this understanding...
  5. ncbi request reprint Formation of thermally induced aggregates of the soya globulin beta-conglycinin
    E N Mills
    Institute of Food Research, Norwich Research Park, Colney, NR4 7UA, Norwich, UK
    Biochim Biophys Acta 1547:339-50. 2001
    ..The ability of beta-conglycinin to form such distinctive aggregates is discussed in relation to the presence of acidic inserts in certain of the beta-conglycinin subunits, which may play an important role in limiting aggregate length...
  6. ncbi request reprint Food allergy and its relevance to industrial food proteins
    E N C Mills
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Biotechnol Adv 23:409-14. 2005
    ....
  7. doi request reprint The impact of processing on allergenicity of food
    E N Clare Mills
    Institute of Food Research, Norwich, UK
    Curr Opin Allergy Clin Immunol 8:249-53. 2008
    ..However, our lack of knowledge on this topic makes it difficult to both predict and minimize the impact of processing on allergenicity of foods and provide allergic patients with appropriate advice over what is safe to eat...
  8. doi request reprint Impact of food processing on the structural and allergenic properties of food allergens
    E N Clare Mills
    Institute of Food Research, Norwich Research Park, Colney Norwich, NR4 7UA UK
    Mol Nutr Food Res 53:963-9. 2009
    ..This article reviews recent studies that address one of the major unanswered questions in food allergy research: what attributes of food or food proteins contribute to or enhance food allergenicity?..
  9. ncbi request reprint Allergens of the cupin superfamily
    E N Mills
    Institute of Food Research, Norwich Research Park, Colney, UK
    Biochem Soc Trans 30:925-9. 2002
    ....
  10. ncbi request reprint Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract
    E N Clare Mills
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Crit Rev Food Sci Nutr 44:379-407. 2004
    ....
  11. ncbi request reprint Thermally induced structural changes in glycinin, the 11S globulin of soya bean (Glycine max)--an in situ spectroscopic study
    E N Clare Mills
    Institute of Food Research, Norwich Research Park, Colney, UK
    Biochim Biophys Acta 1648:105-14. 2003
    ..Such information contributes to our understanding the aggregative behaviour of proteins, and hence develops knowledge-based strategies for controlling and manipulating it...
  12. doi request reprint The purification and characterisation of allergenic hazelnut seed proteins
    Neil M Rigby
    Institute of Food Research, Norwich, UK
    Mol Nutr Food Res 52:S251-61. 2008
    ..These preparations form a basis for development of improved methods of diagnosis of food allergy based on the concept of component-resolved diagnosis...
  13. ncbi request reprint Effect of postharvest storage on the expression of the apple allergen Mal d 1
    Ana I Sancho
    Institute of Food Research, Norwich Research Park, Colney, UK
    J Agric Food Chem 54:5917-23. 2006
    ..In conclusion, Mal d 1 gene expression was significantly increased during modified atmosphere storage. Individuals suffering from birch pollen-apple allergy syndrome might experience fewer problems consuming freshly picked apples...
  14. ncbi request reprint Characterization of the emulsification properties of 2S albumins from sunflower seed
    Gary R Burnett
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, NR4 7UA, United Kingdom
    J Colloid Interface Sci 247:177-85. 2002
    ....
  15. ncbi request reprint Evolutionary distance from human homologs reflects allergenicity of animal food proteins
    John A Jenkins
    Institute of Food Research, Norwich, United Kingdom
    J Allergy Clin Immunol 120:1399-405. 2007
    ..Such systematic analysis reveals that most plant food allergens belong to a restricted number of protein superfamilies, with pollen allergens behaving similarly...
  16. ncbi request reprint Plasticization of a protein-based film by glycerol: a spectroscopic, mechanical, and thermal study
    Chunli Gao
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, United Kingdom
    J Agric Food Chem 54:4611-6. 2006
    ..This result indicates that at this level of plasticizer there are sufficient glycerol/glycerol interactions occurring to allow a separate glass formation process for glycerol...
  17. doi request reprint Surface properties are highly sensitive to small ph induced changes in the 3-D structure of alpha-lactalbumin
    Chunli Gao
    Structuring Food for Health Programme, Institute of Food Research, Norwich Research Park, Colney NR4 7UA, UK
    Biochemistry 47:1659-66. 2008
    ..Interestingly the interfacial dilatational rheology was highest at the isoelectric point, indicating the dominant role of the charge interaction in controlling this parameter...
  18. ncbi request reprint Thermostability and in vitro digestibility of a purified major allergen 2S albumin (Ses i 1) from white sesame seeds (Sesamum indicum L.)
    F Javier Moreno
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, United Kingdom
    Biochim Biophys Acta 1752:142-53. 2005
    ....
  19. doi request reprint Physiological phosphatidylcholine protects bovine beta-lactoglobulin from simulated gastrointestinal proteolysis
    Giuseppina Mandalari
    Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    Mol Nutr Food Res 53:S131-9. 2009
    ..These data indicate how biomolecular interactions between proteins and lipids may alter patterns of proteolysis and need to be taken into consideration in any in vitro model of digestion...
  20. doi request reprint High pressure, thermal and pulsed electric-field-induced structural changes in selected food allergens
    Phil E Johnson
    Structuring Food for Health Programme, Institute of Food Research, Norwich Research Park, Colney, UK
    Mol Nutr Food Res 54:1701-10. 2010
    ..The effects of high-pressure/temperature treatment and pulsed electric field treatment on native peanut Ara h 2, 6 and apple Mal d 3 and Mal d 1b prepared by heterologous expression were examined...
  21. ncbi request reprint Structural relatedness of plant food allergens with specific reference to cross-reactive allergens: an in silico analysis
    John A Jenkins
    Institute of Food Research, Norwich, Cambridge, United Kingdom
    J Allergy Clin Immunol 115:163-70. 2005
    ..The body of sequence and structural information on allergens and the sequence analysis of whole plant genomes are facilitating the application of bioinformatic approaches to identifying and defining plant allergens...
  22. doi request reprint Effect of environmental stress during grain filling on the soluble proteome of wheat (Triticum aestivum) dough liquor
    Ana I Sancho
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR47UA, United Kingdom
    J Agric Food Chem 56:5386-93. 2008
    ..Hereward, including two 19 kDa alpha-globulins, precursors of endochitinases A and C, and several polypeptides belonging to the 7S globulin (vicilin-like) family...
  23. doi request reprint Quantification and partial characterization of the residual protein in fully and partially refined commercial soybean oils
    Neil M Rigby
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom
    J Agric Food Chem 59:1752-9. 2011
    ..These analyses and published data on cumulative threshold doses for soybean suggest that even the most sensitive individuals would need to consume at least 50 g of highly refined oil to experience subjective symptoms...
  24. ncbi request reprint Measurement of lipid transfer protein in 88 apple cultivars
    Ana I Sancho
    Institute of Food Research, Norwich, UK
    Int Arch Allergy Immunol 146:19-26. 2008
    ..Fruits are a major cause of food allergy in adults. Lipid transfer proteins (LTP) are implicated in severe allergic reactions to fruits, but little is known about LTP content in different cultivars...
  25. ncbi request reprint Phospholipid interactions protect the milk allergen alpha-lactalbumin from proteolysis during in vitro digestion
    F Javier Moreno
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, United Kingdom
    J Agric Food Chem 53:9810-6. 2005
    ....
  26. ncbi request reprint Temperature-dependent binding of monoclonal antibodies to C hordein
    Gary M Brett
    of Food Research, Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Biochim Biophys Acta 1594:17-26. 2002
    ....
  27. ncbi request reprint Changes in protein secondary structure during gluten deformation studied by dynamic fourier transform infrared spectroscopy
    Nikolaus Wellner
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom
    Biomacromolecules 6:255-61. 2005
    ....
  28. ncbi request reprint Maturity and storage influence on the apple (Malus domestica) allergen Mal d 3, a nonspecific lipid transfer protein
    Ana I Sancho
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR47UA, United Kingdom
    J Agric Food Chem 54:5098-104. 2006
    ..Thus pre- and postharvest treatments (i.e., storage) can modify the allergen load in apple peel, the highest levels being found in overly mature and freshly harvested fruits...
  29. doi request reprint Spectroscopic analysis of diversity of Arabinoxylan structures in endosperm cell walls of wheat cultivars (Triticum aestivum) in the HEALTHGRAIN diversity collection
    Geraldine A Toole
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    J Agric Food Chem 59:7075-82. 2011
    ....
  30. ncbi request reprint Effect of preparation conditions on protein secondary structure and biofilm formation of kafirin
    Chunli Gao
    Institute of Food Research, Norwich, NR4 7UA, United Kingdom
    J Agric Food Chem 53:306-12. 2005
    ..Heat drying resulted in a greater proportion of intermolecular beta-sheets. Any industrial-scale extraction must therefore minimize protein aggregation and maximize native alpha-helical structures to achieve optimal film quality...
  31. ncbi request reprint Identification of the wheat seed protein CM3 as a highly active emulsifier using a novel functional screen
    Simon M Gilbert
    Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, UK
    J Agric Food Chem 51:2019-25. 2003
    ..It is concluded that functional screening is a valid approach to identify novel protein emulsifiers in complex mixtures...
  32. doi request reprint In vitro digestion methods for assessing the effect of food structure on allergen breakdown
    Martin Wickham
    Institute of Food Research, Colney, Norwich NR4 7UA, UK
    Mol Nutr Food Res 53:952-8. 2009
    ....
  33. ncbi request reprint The identification of foam-forming soluble proteins from wheat (Triticum aestivum) dough
    Louise J Salt
    Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    Proteomics 5:1612-23. 2005
    ..Such proteins may play a role determining the ability of the aqueous phase of doughs, as represented by dough liquor, to form an elastic interface lining the bubbles, and hence maintain their integrity during dough proving...
  34. ncbi request reprint Stability of the major allergen Brazil nut 2S albumin (Ber e 1) to physiologically relevant in vitro gastrointestinal digestion
    F Javier Moreno
    Institute of Food Research, Norwich Research Park, Norwich, UK
    FEBS J 272:341-52. 2005
    ....
  35. doi request reprint Rapid fingerprinting of milk thermal processing history by intact protein mass spectrometry with nondenaturing chromatography
    Phil Johnson
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, United Kingdom
    J Agric Food Chem 59:12420-7. 2011
    ..The method described here can profile milk protein oligomeric state, aggregation, and Maillard modification in a single shot, rapid analysis...
  36. ncbi request reprint Current perspectives and recommendations for the development of mass spectrometry methods for the determination of allergens in foods
    Phil E Johnson
    Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    J AOAC Int 94:1026-33. 2011
    ....
  37. ncbi request reprint Protein extraction from plant tissues
    Roger J Fido
    Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, UK
    Methods Mol Biol 244:21-7. 2004
  38. ncbi request reprint Severe immediate allergic reactions to grapes: part of a lipid transfer protein-associated clinical syndrome
    Emilia Vassilopoulou
    Allergy Research Centre, Second Pediatric Clinic, University of Athens, Athens, Greece
    Int Arch Allergy Immunol 143:92-102. 2007
    ..A considerable number of patients have referred to our department for severe reactions to grapes, and several IgE binding proteins were detected...
  39. ncbi request reprint Molecular properties of food allergens
    Heimo Breiteneder
    Department of Pathophysiology, Medical University of Vienna, Austria
    J Allergy Clin Immunol 115:14-23; quiz 24. 2005
    ....
  40. ncbi request reprint IgE-mediated food allergy diagnosis: Current status and new perspectives
    Riccardo Asero
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy
    Mol Nutr Food Res 51:135-47. 2007
    ....
  41. ncbi request reprint Post-translational modification of barley LTP1b: the lipid adduct lies in the hydrophobic cavity and alters the protein dynamics
    Ramani Wijesinha-Bettoni
    Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, South Parks Road, Oxford OX1 3QR, UK
    FEBS Lett 581:4557-61. 2007
    ..This may result from a loosening of the protein structure and may explain the enhanced surface properties observed for LTP1b...
  42. ncbi request reprint Heat treatment of bovine alpha-lactalbumin results in partially folded, disulfide bond shuffled states with enhanced surface activity
    Ramani Wijesinha-Bettoni
    Department of Chemistry, University of Oxford, Inorganic Chemistry Laboratory, UK
    Biochemistry 46:9774-84. 2007
    ..These partially folded, disulfide shuffled species are largely responsible for the pronounced improvement in surface activity of the protein on heating...