D A MacKenzie

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. doi request reprint Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of Lactobacillus reuteri
    Donald A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Microbiology 156:3368-78. 2010
  2. pmc Isolation and use of a homologous histone H4 promoter and a ribosomal DNA region in a transformation vector for the oil-producing fungus Mortierella alpina
    D A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk, NR4 7UA, United Kingdom
    Appl Environ Microbiol 66:4655-61. 2000
  3. ncbi request reprint A third fatty acid delta9-desaturase from Mortierella alpina with a different substrate specificity to ole1p and ole2p
    Donald A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Microbiology 148:1725-35. 2002
  4. doi request reprint Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics
    Donald A MacKenzie
    National Collection of Yeast Cultures, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Yeast 25:501-12. 2008
  5. ncbi request reprint UPR-independent dithiothreitol stress-induced genes in Aspergillus niger
    D A MacKenzie
    Department of Food Safety Science, Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Mol Genet Genomics 274:410-8. 2005
  6. ncbi request reprint Metabolic footprinting as a tool for discriminating between brewing yeasts
    Georgina A Pope
    National Collection of Yeast Cultures, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Yeast 24:667-79. 2007
  7. doi request reprint Species-specific variation in efficacy of yeast genomic DNA isolation techniques assessed using amplified fragment length polymorphism
    Linda J Fuller
    National Collection of Yeast Cultures, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Anal Biochem 381:154-6. 2008
  8. ncbi request reprint Isolation and characterisation of the acetyl-CoA carboxylase gene from Aspergillus nidulans
    J Morrice
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, Norfolk, NR4 7UA, UK
    Curr Genet 34:379-85. 1998
  9. pmc Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity
    Donald A MacKenzie
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, United Kingdom
    J Biol Chem 284:32444-53. 2009
  10. ncbi request reprint Endoplasmic reticulum stress leads to the selective transcriptional downregulation of the glucoamylase gene in Aspergillus niger
    Hashem Al-Sheikh
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Mol Microbiol 53:1731-42. 2004

Collaborators

Detail Information

Publications13

  1. doi request reprint Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of Lactobacillus reuteri
    Donald A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Microbiology 156:3368-78. 2010
    ..reuteri, and further demonstrated that MUB and MUB-like proteins, although present in many L. reuteri isolates, show a high genetic heterogeneity among strains...
  2. pmc Isolation and use of a homologous histone H4 promoter and a ribosomal DNA region in a transformation vector for the oil-producing fungus Mortierella alpina
    D A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk, NR4 7UA, United Kingdom
    Appl Environ Microbiol 66:4655-61. 2000
    ..The generation of stable, hygromycin B-resistant transformants required the incorporation of a homologous ribosomal DNA region into the transformation vector to promote chromosomal integration...
  3. ncbi request reprint A third fatty acid delta9-desaturase from Mortierella alpina with a different substrate specificity to ole1p and ole2p
    Donald A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Microbiology 148:1725-35. 2002
    ..Conversely, high levels of desaturase in the endoplasmic reticulum membrane of these yeast transformants may increase the availability of suitable monounsaturated substrates for fatty acid elongation...
  4. doi request reprint Relatedness of medically important strains of Saccharomyces cerevisiae as revealed by phylogenetics and metabolomics
    Donald A MacKenzie
    National Collection of Yeast Cultures, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Yeast 25:501-12. 2008
    ..This study confirmed the link between a subset of clinical isolates and baking or probiotic strains but also highlighted that in general the clinical strains were more diverse at both the genomic and metabolic levels...
  5. ncbi request reprint UPR-independent dithiothreitol stress-induced genes in Aspergillus niger
    D A MacKenzie
    Department of Food Safety Science, Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Mol Genet Genomics 274:410-8. 2005
    ..We conclude that DTT alone does not provide for specific induction of UPR genes and that other stress conditions must also be examined...
  6. ncbi request reprint Metabolic footprinting as a tool for discriminating between brewing yeasts
    Georgina A Pope
    National Collection of Yeast Cultures, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Yeast 24:667-79. 2007
    ..For some strains discrimination not achieved genomically was observed metabolomically...
  7. doi request reprint Species-specific variation in efficacy of yeast genomic DNA isolation techniques assessed using amplified fragment length polymorphism
    Linda J Fuller
    National Collection of Yeast Cultures, Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Anal Biochem 381:154-6. 2008
    ..Two alternative yeast DNA purification kits, MasterPure and Y-DER, were effective with 6 of these and 2 additional species, leaving only 9 species that remained recalcitrant to yielding sufficient amounts of DNA with the required purity...
  8. ncbi request reprint Isolation and characterisation of the acetyl-CoA carboxylase gene from Aspergillus nidulans
    J Morrice
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, Norfolk, NR4 7UA, UK
    Curr Genet 34:379-85. 1998
    ..Deletion of accA in A. nidulans was unsuccessful. The failure of A. nidulans to grow in the presence of the ACC-specific inhibitor, soraphen A, supplemented with C16-18 fatty acids suggested that ACC is an essential enzyme...
  9. pmc Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity
    Donald A MacKenzie
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, United Kingdom
    J Biol Chem 284:32444-53. 2009
    ..This hitherto undetected activity is consistent with the current model that antibody responses against commensal flora are of broad specificity and low affinity...
  10. ncbi request reprint Endoplasmic reticulum stress leads to the selective transcriptional downregulation of the glucoamylase gene in Aspergillus niger
    Hashem Al-Sheikh
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, UK
    Mol Microbiol 53:1731-42. 2004
    ..niger. Although the transcription of glaA was attenuated in that strain of A. niger, UPR was not evident, suggesting that the transcriptional downregulation mechanism is controlled differently from the UPR...
  11. pmc HacA-independent induction of chaperone-encoding gene bipA in Aspergillus niger strains overproducing membrane proteins
    Anoushka Davé
    School of Biology, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom
    Appl Environ Microbiol 72:953-5. 2006
    ..Despite elevated bipA mRNA levels, no 5'-truncated hacA transcript was detected, raising the possibility of a hacA-independent induction of bipA mRNA under the stress of membrane protein overproduction in A. niger...
  12. doi request reprint Filamentous fungi for production of food additives and processing aids
    David B Archer
    School of Biology, University of Nottingham, University Park, NG7 2RD, Nottingham, UK
    Adv Biochem Eng Biotechnol 111:99-147. 2008
    ..In this review chapter we focus on the use of fungi in the production of food additives but take a largely pre-genomic, albeit a mainly molecular, view of the topic...
  13. ncbi request reprint The effect of variation within inhibitory domains on the activity of pea protease inhibitors from the Bowman-Birk class
    Alfonso Clemente
    Department of Metabolic Biology, John Innes Centre, Norwich Research Park, NR4 7UH, UK
    Protein Expr Purif 36:106-14. 2004
    ..Differences in trypsin and chymotrypsin specific inhibitory activities, and in inhibition constants, were observed in studies of the two recombinant variants and BBI...