Sunil R Lakhani

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint Pathology of ovarian cancers in BRCA1 and BRCA2 carriers
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 10:2473-81. 2004
  2. pmc The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:313-9. 2003
  3. ncbi request reprint FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
    Jorge Sergio Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 12:6652-62. 2006
  4. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
  5. ncbi request reprint Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    J Pathol 207:1-13. 2005
  6. ncbi request reprint Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis
    Peter T Simpson
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Am J Surg Pathol 29:734-46. 2005
  7. ncbi request reprint Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Clin Cancer Res 10:5988-97. 2004
  8. ncbi request reprint The molecular genetics of breast cancer: the contribution of comparative genomic hybridization
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Pathol Res Pract 201:713-25. 2005
  9. ncbi request reprint Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 64:3037-45. 2004
  10. ncbi request reprint Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 202:274-85. 2004

Detail Information

Publications42

  1. ncbi request reprint Pathology of ovarian cancers in BRCA1 and BRCA2 carriers
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 10:2473-81. 2004
    ..Our aim was to evaluate the morphologies and immunophenotypes in a large cohort of patients with familial ovarian cancer...
  2. pmc The diagnosis and management of pre-invasive breast disease: genetic alterations in pre-invasive lesions
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:313-9. 2003
    ..We review current knowledge and the contribution of molecular genetics in the understanding of breast cancer precursors and pre-invasive lesions...
  3. ncbi request reprint FGFR1 emerges as a potential therapeutic target for lobular breast carcinomas
    Jorge Sergio Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 12:6652-62. 2006
    ..However, little is known about the putative therapeutic targets for these tumors. The aim of this study was to characterize CLCs at the molecular genetic level and identify putative therapeutic targets...
  4. ncbi request reprint Prediction of BRCA1 status in patients with breast cancer using estrogen receptor and basal phenotype
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Clin Cancer Res 11:5175-80. 2005
    ..To investigate the proportion of breast cancers arising in patients with germ line BRCA1 and BRCA2 mutations expressing basal markers and developing predictive tests for identification of high-risk patients...
  5. ncbi request reprint Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London SW3 6JB, UK
    J Pathol 207:1-13. 2005
    ..Taken together, these data suggest that at least some PLCs may evolve from the same precursor or through the same genetic pathway as classic lobular carcinomas...
  6. ncbi request reprint Columnar cell lesions of the breast: the missing link in breast cancer progression? A morphological and molecular analysis
    Peter T Simpson
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Am J Surg Pathol 29:734-46. 2005
    ..These data further support the hypothesis that CCLs are a nonobligate, intermediary step in the development of some forms of low grade in situ and invasive carcinoma...
  7. ncbi request reprint Molecular cytogenetic identification of subgroups of grade III invasive ductal breast carcinomas with different clinical outcomes
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Clin Cancer Res 10:5988-97. 2004
    ..Robust characterization of this basal group is necessary if it is to have a major impact on management of patients with breast cancer...
  8. ncbi request reprint The molecular genetics of breast cancer: the contribution of comparative genomic hybridization
    Jorge S Reis-Filho
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Pathol Res Pract 201:713-25. 2005
    ..CGH has been instrumental in dissecting distinct molecular pathways toward breast malignancy and in establishing a direct relationship between genotype and clinical pathological features...
  9. ncbi request reprint Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Cancer Res 64:3037-45. 2004
    ..These data provide a framework for the interpretation of breast cancer molecular profiling experiments, the identification of potential new diagnostic markers, and development of novel indicators of prognosis...
  10. ncbi request reprint Distribution and significance of 14-3-3sigma, a novel myoepithelial marker, in normal, benign, and malignant breast tissue
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 202:274-85. 2004
    ..This analysis demonstrates the utility of 14-3-3sigma as a new adjunct antibody for characterization of myoepithelial cells and myoepithelial lesions and it may be a novel prognostic factor for breast cancer patients...
  11. ncbi request reprint The pathology of familial breast cancer: predictive value of immunohistochemical markers estrogen receptor, progesterone receptor, HER-2, and p53 in patients with mutations in BRCA1 and BRCA2
    Sunil R Lakhani
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research and the Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 20:2310-8. 2002
    ..This study evaluates the immunohistochemical profiles of tumors arising in patients with mutations in these genes...
  12. pmc Basal-like grade III invasive ductal carcinoma of the breast: patterns of metastasis and long-term survival
    Laura G Fulford
    Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Breast Cancer Res 9:R4. 2007
    ..Previous studies have suggested that expression of such 'basal' markers predicts different biological behaviour, with more frequent lung and brain metastases and poorer prognosis than other carcinomas...
  13. pmc The diagnosis and management of pre-invasive breast disease: pathology of atypical lobular hyperplasia and lobular carcinoma in situ
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 5:258-62. 2003
    ..LCIS is now considered a risk factor and a non-obligate precursor for the subsequent development of invasive cancer...
  14. pmc Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
    Jorge S Reis-Filho
    The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    Breast Cancer Res 7:R1028-35. 2005
    ..We investigated whether HER2 and EGFR overexpression was present and evaluated gene amplification in a series of metaplastic breast carcinomas...
  15. ncbi request reprint Molecular evolution of breast cancer
    Peter T Simpson
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 205:248-54. 2005
    ..However, only through the combination of comprehensive morphological analysis and cutting-edge molecular tools can this knowledge be translated into clinical practice and patient management...
  16. ncbi request reprint Expression profiling using cDNA microarrays
    Chris Jones
    The Breakthrough Toby Robins Breast Research Centre at the Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Methods Mol Med 120:403-14. 2006
    ....
  17. ncbi request reprint Cytokeratin 5/6 in normal human breast: lack of evidence for a stem cell phenotype
    Catherine L Clarke
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 204:147-52. 2004
    ..This study brings into question the previously described profile of breast 'stem cells' based on CK5/6 staining and hence the breast cancer progression model and classification based on this phenotype...
  18. ncbi request reprint Gene expression analysis using filter cDNA microarrays
    Peter Simpson
    The Breakthrough Toby Robins Breast Research Centre at the Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Methods Mol Med 120:415-24. 2006
    ..This chapter provides an overview of the methods necessary to carry out the production of membrane-based cDNA arrays and the subsequent synthesis and hybridization of radiolabeled cDNA probes...
  19. ncbi request reprint Pathologic quiz case: a 62-year-old woman with a 4.5-cm nodule in the right breast. Lipid-rich breast carcinoma
    Jorge S Reis-Filho
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, United Kingdom
    Arch Pathol Lab Med 127:e396-8. 2003
  20. ncbi request reprint Pathologic quiz case: a 93-year-old woman with an enlarged and tender left breast. Histiocytoid variant of lobular breast carcinoma
    Jorge S Reis-Filho
    Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, England
    Arch Pathol Lab Med 127:1626-8. 2003
  21. ncbi request reprint Comparative genomic hybridization analysis of bilateral hyperplasia of usual type of the breast
    Chris Jones
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK
    J Pathol 199:152-6. 2003
    ..The limited data from these experiments do not reveal a specific predisposition locus...
  22. ncbi request reprint The expression patterns of integrin subunits on human breast tissues obtained during pregnancy
    Rami N Suzuki
    Ludwig Institute for Cancer Research LICR Breast Cancer Laboratory Royal Free and University College Medical School, Department of Surgery, 67 73 Riding House Street, London, W1W 7EJ, UK
    Cell Biol Int 26:593-8. 2002
    ..Therefore, the expression patterns of most integrins existing prior to pregnancy seem sufficient in this cell type to support the morphological and functional development during early pregnancy...
  23. ncbi request reprint cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells
    Alan Mackay
    LICR UCL Breast Cancer Laboratory, University College London, London, UK
    Oncogene 22:2680-8. 2003
    ..These data represent profiles of the transcriptional changes associated with ERBB2-related pathways in the breast, and identify novel and potentially useful targets for prognosis and therapy...
  24. ncbi request reprint In-situ lobular neoplasia: time for an awakening
    Sunil R Lakhani
    The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, and Royal Marsden Hospital, SW3 6JB, London, UK
    Lancet 361:96. 2003
  25. ncbi request reprint Myoepithelial cells: pathology, cell separation and markers of myoepithelial differentiation
    Catherine Clarke
    Molecular and Cellular Pathology, Mayne Medical School, Queensland Institute of Medical Research and The Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, QLD, Australia
    J Mammary Gland Biol Neoplasia 10:273-80. 2005
    ..These immunohistochemical data, combined with genomic studies, may lead to better identification and management of patients with 'basal' tumors...
  26. pmc Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?
    Paul K Lovelock
    Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Herston Road, Queensland 4029, Australia
    Breast Cancer Res 9:R82. 2007
    ....
  27. doi request reprint Aberrant expression of E-cadherin in lobular carcinomas of the breast
    Leonard Da Silva
    Molecular and Cellular Pathology, Mayne Medical School, University of Queensland, Brisbane, Australia
    Am J Surg Pathol 32:773-83. 2008
    ..Misclassification of tumors may lead to mismanagement of patients in clinical practice, particularly in the context of in situ disease at margins...
  28. ncbi request reprint The management of lobular carcinoma in situ (LCIS). Is LCIS the same as ductal carcinoma in situ (DCIS)?
    Sunil R Lakhani
    Molecular and Cellular Pathology, School of Medicine, The University of Queensland, Mayne Medical School, Brisbane, QLD 4006, Australia
    Eur J Cancer 42:2205-11. 2006
    ..In this review, the working group on behalf of EUSOMA has attempted to summarise the current thinking and management of this interesting lesion...
  29. doi request reprint Clinical classification of BRCA1 and BRCA2 DNA sequence variants: the value of cytokeratin profiles and evolutionary analysis--a report from the kConFab Investigators
    Amanda B Spurdle
    Queensland Institute of Medical Research, c o Royal Brisbane Hospital Post Office, Herston, Queensland 4029, Australia
    J Clin Oncol 26:1657-63. 2008
    ..We assessed the value of tumor immunohistochemical markers in conjunction with genetic and evolutionary approaches for investigating the clinical significance of unclassified variants...
  30. ncbi request reprint Mutation analysis of five candidate genes in familial breast cancer
    Anna Marsh
    Cancer and Cell Biology, Queensland Institute of Medical Research, c o RBH Post Office, Herston, Brisbane, QLD, 4029, Australia
    Breast Cancer Res Treat 105:377-89. 2007
    ..Although we identified many novel variants, we found no evidence that highly penetrant germline mutations in these five genes contribute to familial breast cancer susceptibility...
  31. ncbi request reprint Typical medullary breast carcinomas have a basal/myoepithelial phenotype
    Jocelyne Jacquemier
    Marseille Cancer Institute, Molecular Oncology Department, UMR599 INSERM and Paoli Calmettes Institute, Marseille, France
    J Pathol 207:260-8. 2005
    ..In multivariate analysis with logistic regression, TMBC was defined by the association of P-cadherin (R=2.29), MIB1 > 50 (R=3.80), ERBB2 negativity (R=2.24) and p53 positivity (RR=1.45)...
  32. ncbi request reprint The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours
    Elinor J Sawyer
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Pathol 196:437-44. 2002
    ..In the progression to malignancy, the stromal proliferation appears to become independent of the Wnt pathway and, presumably, of the epithelial component of these tumours...
  33. ncbi request reprint Evaluation of a prospective scoring system designed for a multicenter breast MR imaging screening study
    Ruth M L Warren
    Department of Radiology, Addenbrooke s Hospital, Cambridge, England, and Department of Radiology, University of Aberdeen, Aberdeen, Scotland
    Radiology 239:677-85. 2006
    ..To evaluate prospectively the accuracy of a lesion classification system designed for use in a magnetic resonance (MR) imaging high-breast-cancer-risk screening study...
  34. ncbi request reprint Progesterone receptor-positive eruptive syringoma associated with diabetes
    Penelope C Timpanidis
    Department of Dermatology, University College London Hospitals Trust, United Kingdom
    J Am Acad Dermatol 48:S103-4. 2003
    ..We report a case in which eruptive syringoma with clear cell morphology was found to express progesterone receptors, suggesting the possibility of hormonal control of the tumor...
  35. pmc Can the stroma provide the clue to the cellular basis for mammographic density?
    Ruth Warren
    Department of Radiology, Addenbrooke s Hospital, Cambridge, UK
    Breast Cancer Res 5:225-7. 2003
    ..In a paper in this issue of Breast Cancer Research, Alowami has shown a relationship between density and stromal proteins, which might provide useful insight into mammographic density...
  36. pmc The diagnosis and management of pre-invasive breast disease--current challenges, future hopes
    Sunil R Lakhani
    Breast Cancer Res 5:248-9. 2003
  37. ncbi request reprint In situ carcinoma - can we predict which patient will come back with a recurrence?
    Peter T Simpson
    Molecular and Cellular Pathology, School of Medicine, University of Queensland, Herston QLD 4006, Australia
    Cancer Cell 12:409-11. 2007
    ..In this issue of Cancer Cell, Gauthier and colleagues suggest that abrogated response to cell stress measured by analysis of p16 and the proliferation marker Ki67 accurately predicts recurrence in ductal carcinoma in situ...
  38. ncbi request reprint Malignant adenomyoepithelioma of the breast metastasizing to the liver
    Chris Jones
    Virchows Arch 442:504-6. 2003
  39. ncbi request reprint Reading protocol for dynamic contrast-enhanced MR images of the breast: sensitivity and specificity analysis
    Ruth M L Warren
    Department of Radiology, Addenbrooke s Hospital, Cambridge, England
    Radiology 236:779-88. 2005
    ....
  40. ncbi request reprint A test of performance of breast MRI interpretation in a multicentre screening study
    Ruth Warren
    Department of Radiology, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Magn Reson Imaging 24:917-29. 2006
    ..The aim of this study was to assess the consistency and performance of radiologists interpreting breast magnetic resonance imaging (MRI) examinations...
  41. ncbi request reprint Somatic mutations of the protein kinase gene family in human lung cancer
    Helen Davies
    The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, United Kingdom
    Cancer Res 65:7591-5. 2005
    ..The results suggest that several mutated protein kinases may be contributing to lung cancer development, but that mutations in each one are infrequent...
  42. doi request reprint What's in a cancer syndrome? Genes, phenotype and pathology
    Nicola Wayte
    The Queensland Institute of Medical Research, Brisbane, Australia
    Pathology 40:247-59. 2008
    ....