P A Kroon

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
  2. ncbi request reprint A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module
    P A Kroon
    Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    Eur J Biochem 267:6740-52. 2000
  3. ncbi request reprint A cinnamoyl esterase from Aspergillus niger can break plant cell wall cross-links without release of free diferulic acids
    M T Garcia-Conesa
    Institute of Food Research, Norwich Research Park, Colney, UK
    Eur J Biochem 266:644-52. 1999
  4. ncbi request reprint Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
    A J Day
    Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    FEBS Lett 468:166-70. 2000
  5. ncbi request reprint Influence of ferulic acid on the production of feruloyl esterases by Aspergillus niger
    C B Faulds
    Department of Biochemistry, Institute of Food Research, Colney, Norwich, UK
    FEMS Microbiol Lett 157:239-44. 1997
  6. doi request reprint Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability
    S Saha
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Pharmacol Res 65:592-602. 2012
  7. ncbi request reprint Activity of an Aspergillus terreus alpha-arabinofuranosidase on phenolic-substituted oligosaccharides
    E Luonteri
    Biochemistry Department, Norwich Research Park, UK
    J Biotechnol 67:41-8. 1999
  8. ncbi request reprint Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals
    M F Andreasen
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom
    J Agric Food Chem 49:5679-84. 2001
  9. pmc An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls
    B Bartolome
    Department of Biochemistry, Institute of Food Research, Colney, Norwich, United Kingdom
    Appl Environ Microbiol 63:208-12. 1997
  10. ncbi request reprint Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans
    M S DuPont
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, UK
    Eur J Clin Nutr 58:947-54. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
    ..1-10 micromol/L. For correct interpretation of results, future efforts to define biological activities of polyphenols must make use of the available data concerning bioavailability and metabolism in humans...
  2. ncbi request reprint A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module
    P A Kroon
    Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    Eur J Biochem 267:6740-52. 2000
    ..and plants. The C-terminal domain comprised 39 amino acids and closely resembled the family 1 cellulose binding carbohydrate-binding modules (CBM) of fungal glycosyl hydrolases. This is the first report of a fungal CE with a CBM...
  3. ncbi request reprint A cinnamoyl esterase from Aspergillus niger can break plant cell wall cross-links without release of free diferulic acids
    M T Garcia-Conesa
    Institute of Food Research, Norwich Research Park, Colney, UK
    Eur J Biochem 266:644-52. 1999
    ....
  4. ncbi request reprint Dietary flavonoid and isoflavone glycosides are hydrolysed by the lactase site of lactase phlorizin hydrolase
    A J Day
    Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
    FEBS Lett 468:166-70. 2000
    ..The ability of LPH to deglycosylate dietary (iso)flavonoid glycosides suggests a possible role for this enzyme in the metabolism of these biologically active compounds...
  5. ncbi request reprint Influence of ferulic acid on the production of feruloyl esterases by Aspergillus niger
    C B Faulds
    Department of Biochemistry, Institute of Food Research, Colney, Norwich, UK
    FEMS Microbiol Lett 157:239-44. 1997
    ..However, production is stimulated by the presence of free ferulic acid through increased expression, and is reduced by the removal of esterified ferulic acid from the growth substrate...
  6. doi request reprint Human O-sulfated metabolites of (-)-epicatechin and methyl-(-)-epicatechin are poor substrates for commercial aryl-sulfatases: implications for studies concerned with quantifying epicatechin bioavailability
    S Saha
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Pharmacol Res 65:592-602. 2012
    ..Methods for quantifying epicatechin concentrations in blood and urine need to take account of the lack of hydrolysis of (methyl)epicatechin-sulfates, for example by quantifying these directly using LC-MS/MS...
  7. ncbi request reprint Activity of an Aspergillus terreus alpha-arabinofuranosidase on phenolic-substituted oligosaccharides
    E Luonteri
    Biochemistry Department, Norwich Research Park, UK
    J Biotechnol 67:41-8. 1999
    ..Somewhat surprisingly, the LCC-model compound, in which the arabinose residue is substituted with a bulky dilignol group, was degraded by the enzyme. This indicated that the enzyme is able to approach this linkage from the xylose side...
  8. ncbi request reprint Esterase activity able to hydrolyze dietary antioxidant hydroxycinnamates is distributed along the intestine of mammals
    M F Andreasen
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, United Kingdom
    J Agric Food Chem 49:5679-84. 2001
    ..Hydrolysis by intestinal esterase(s) is very likely the major route for release of antioxidant hydroxycinnamic acids in vivo...
  9. pmc An Aspergillus niger esterase (ferulic acid esterase III) and a recombinant Pseudomonas fluorescens subsp. cellulosa esterase (Xy1D) release a 5-5' ferulic dehydrodimer (diferulic acid) from barley and wheat cell walls
    B Bartolome
    Department of Biochemistry, Institute of Food Research, Colney, Norwich, United Kingdom
    Appl Environ Microbiol 63:208-12. 1997
    ..It is also concluded that the esterified dimer content of the xylanase-solubilized fraction depends on the source of the xylanase...
  10. ncbi request reprint Absorption of kaempferol from endive, a source of kaempferol-3-glucuronide, in humans
    M S DuPont
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich, UK
    Eur J Clin Nutr 58:947-54. 2004
    ..To determine the absorption, excretion and metabolism of kaempferol in humans...
  11. doi request reprint Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol
    G Pereira-Caro
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
    Food Chem 138:1172-82. 2013
    ..In conclusion, these results highlight that HTy and its derivative HTy-Et modulate molecular mechanisms involved in colon cancer, with HTy-Et being more effective than HTy...
  12. doi request reprint The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21(Cip1/WAF1)
    R Pierini
    Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
    Cancer Lett 270:234-41. 2008
    ..However, blocking the PA-induced up-regulation of p21 expression with siRNA did not alter PA-mediated changes in apoptosis and cell cycle, demonstrating that p21 is not responsible for the PA-induced effects...
  13. ncbi request reprint Intestinal release and uptake of phenolic antioxidant diferulic acids
    M F Andreasen
    Department of Horticulture, Danish Institute of Agricultural Sciences, Aarslev, Denmark
    Free Radic Biol Med 31:304-14. 2001
    ..Our results suggest that the phenolic antioxidant diferulic acids are bioavailable...