Gavin Kelsey

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition
    Elena Ivanova
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Epigenetics 7:1200-10. 2012
  2. pmc Dynamic CpG island methylation landscape in oocytes and preimplantation embryos
    Sebastien A Smallwood
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Nat Genet 43:811-4. 2011
  3. pmc Transcriptional profiles underlying parent-of-origin effects in seeds of Arabidopsis thaliana
    Sushma Tiwari
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    BMC Plant Biol 10:72. 2010
  4. ncbi request reprint Imprint switch mechanism indicated by mutations in Prader-Willi and Angelman syndromes
    G Kelsey
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Bioessays 19:361-5. 1997
  5. ncbi request reprint Genomic imprinting--roles and regulation in development
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Endocr Dev 12:99-112. 2007
  6. doi request reprint Epigenetics and imprinted genes: insights from the imprinted Gnas locus
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Horm Res 71:22-9. 2009
  7. doi request reprint Imprinting on chromosome 20: tissue-specific imprinting and imprinting mutations in the GNAS locus
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Am J Med Genet C Semin Med Genet 154:377-86. 2010
  8. doi request reprint Epigenetics and the brain: transcriptome sequencing reveals new depths to genomic imprinting
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Bioessays 33:362-7. 2011
  9. ncbi request reprint Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2
    G Kelsey
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Genomics 62:129-38. 1999
  10. pmc Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005

Collaborators

Detail Information

Publications47

  1. pmc DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition
    Elena Ivanova
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Epigenetics 7:1200-10. 2012
    ..We conclude that deregulation of imprinting through a general effect on DMR methylation is unlikely to be a common factor in developmental programming...
  2. pmc Dynamic CpG island methylation landscape in oocytes and preimplantation embryos
    Sebastien A Smallwood
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Nat Genet 43:811-4. 2011
    ....
  3. pmc Transcriptional profiles underlying parent-of-origin effects in seeds of Arabidopsis thaliana
    Sushma Tiwari
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    BMC Plant Biol 10:72. 2010
    ..Here we investigated gene expression underlying parent-of-origin effects in Arabidopsis through transcriptional profiling of siliques generated by interploidy crosses and FIS-class mutants...
  4. ncbi request reprint Imprint switch mechanism indicated by mutations in Prader-Willi and Angelman syndromes
    G Kelsey
    Laboratory of Developmental Genetics and Imprinting, Babraham Institute, Cambridge, UK
    Bioessays 19:361-5. 1997
    ....
  5. ncbi request reprint Genomic imprinting--roles and regulation in development
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Endocr Dev 12:99-112. 2007
    ..The intention of this chapter is therefore to equip the readers with the general principles governing imprinting, so that they are able to comprehend this intriguing and important form of gene regulation when they encounter it next...
  6. doi request reprint Epigenetics and imprinted genes: insights from the imprinted Gnas locus
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Horm Res 71:22-9. 2009
    ..Finally, given the pervasive effects of imprinted genes, I shall discuss the likelihood that epigenetic deregulation, for example of imprinted genes, could contribute to the developmental programming of chronic adult diseases...
  7. doi request reprint Imprinting on chromosome 20: tissue-specific imprinting and imprinting mutations in the GNAS locus
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Am J Med Genet C Semin Med Genet 154:377-86. 2010
    ....
  8. doi request reprint Epigenetics and the brain: transcriptome sequencing reveals new depths to genomic imprinting
    Gavin Kelsey
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Bioessays 33:362-7. 2011
    ..Editor's suggested further reading in BioEssays RNA as the substrate for epigenome-environment interactions Abstract...
  9. ncbi request reprint Identification of imprinted loci by methylation-sensitive representational difference analysis: application to mouse distal chromosome 2
    G Kelsey
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Genomics 62:129-38. 1999
    ..RDA was highly effective at identifying imprinted methylation, and its potential applications to imprinting studies are discussed...
  10. pmc Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005
    ..Thus, crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development...
  11. pmc Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus
    Candice Coombes
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 23:5475-88. 2003
    ..This is the second gametic mark identified at Gnas and suggests that the Nesp and Gnasxl promoters are under separate control from the Gnas promoter. We propose models to account for the regulation of imprinting at the locus...
  12. pmc Transcription is required for establishment of germline methylation marks at imprinted genes
    Mita Chotalia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, United Kingdom
    Genes Dev 23:105-17. 2009
    ....
  13. pmc Identification of novel imprinted genes in a genome-wide screen for maternal methylation
    Rachel J Smith
    Developmental Genetics Program, The Babraham Institute, Cambridge CB2 4AT, UK
    Genome Res 13:558-69. 2003
    ..Interestingly, two of the three novel genes identified in this screen are located within the introns of other genes; their identification indicates that such "microimprinted" domains may be more common than previously thought...
  14. ncbi request reprint Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain
    William Davies
    Developmental Genetics and Neurobiology Programmes, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Gene Expr Patterns 4:741-7. 2004
    ..Nap1l5 expression was localised mainly to the adrenal medulla, whilst Peg13 expression was observed more generally throughout the adrenal medulla and the outer cortical layers...
  15. ncbi request reprint Resourceful imprinting
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 432:53-7. 2004
  16. ncbi request reprint Imprinting weaves its web
    Guillaume Smits
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB22 3AT, United Kingdom
    Dev Cell 11:598-9. 2006
    ..It has long been recognized that imprinted genes often act in common developmental or physiological pathways. A new knockout of the gene Zac1 reveals just how extensive the transcriptional network of imprinted genes may be...
  17. pmc Imprinted Nesp55 influences behavioral reactivity to novel environments
    Antonius Plagge
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 25:3019-26. 2005
    ..These results indicate a role of maternally expressed Nesp55 in controlling exploratory behavior and are the first demonstration that imprinted genes affect such a fundamental behavior...
  18. pmc Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
    Dan Ma
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    J Clin Invest 114:339-48. 2004
    ..Expression of human ZAC and HYMAI in these transgenic mice thus recapitulates key features of TNDM and implicates impaired development of the endocrine pancreas and beta cell function in disease pathogenesis...
  19. ncbi request reprint The imprinted signaling protein XL alpha s is required for postnatal adaptation to feeding
    Antonius Plagge
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, CB2 4AT, UK
    Nat Genet 36:818-26. 2004
    ..The opposing effects of maternally and paternally expressed products of the Gnas locus provide tangible molecular support for the parental-conflict hypothesis of imprinting...
  20. ncbi request reprint Conserved methylation imprints in the human and mouse GRB10 genes with divergent allelic expression suggests differential reading of the same mark
    Philippe Arnaud
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 12:1005-19. 2003
    ..In the mouse this DMR is a gametic methylation mark. Our results suggest that the difference in imprinted expression in mouse and human is not due to acquisition of an imprint mark but in differences in the reading of this mark...
  21. pmc New insights into establishment and maintenance of DNA methylation imprints in mammals
    Gavin Kelsey
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 368:20110336. 2013
    ..Addressing these mechanisms will be essential to understanding the specificity and evolution of genomic imprinting...
  22. doi request reprint DNA methylation establishment during oocyte growth: mechanisms and significance
    Shin Ichi Tomizawa
    Epigenetics Programme, The Babraham Institute, Cambridge, U K
    Int J Dev Biol 56:867-75. 2012
    ....
  23. ncbi request reprint Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19
    M Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Babraham, Cambridge, UK
    Nat Genet 26:203-6. 2000
    ....
  24. pmc An intragenic methylated region in the imprinted Igf2 gene augments transcription
    A Murrell
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    EMBO Rep 2:1101-6. 2001
    ..These results reveal a novel mechanism of gene expression whereby intragenic methylation can increase levels of transcription...
  25. doi request reprint De novo DNA methylation: a germ cell perspective
    Sebastien A Smallwood
    Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
    Trends Genet 28:33-42. 2012
    ....
  26. ncbi request reprint Imprinted genes, postnatal adaptations and enduring effects on energy homeostasis
    Margalida Frontera
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge, UK
    Adv Exp Med Biol 626:41-61. 2008
    ..Finally, we shall discuss whether these observations fit expectations of the prevailing theory for the existence of imprinting in mammals and go on to consider imprinted genes as targets for developmental programming...
  27. ncbi request reprint Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19
    Shuji Takada
    Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK
    Hum Mol Genet 11:77-86. 2002
    ..An intronic DMR contains a conserved putative CTCF-binding domain. All three DMRs have both unique and common features compared to those identified in the Igf2-H19 domain...
  28. ncbi request reprint Imprinting the Gnas locus
    A Plagge
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    Cytogenet Genome Res 113:178-87. 2006
    ....
  29. ncbi request reprint Igf2 imprinting in development and disease
    W Reik
    Developmental Genetics Programme, The Babraham Institute, Cambridge, United Kingdom
    Int J Dev Biol 44:145-50. 2000
    ..Here we review briefly the key features of Igf2 imprinting in normal development and in disease, and hope to show what a fascinating subject of study this gene and its biology provides...
  30. ncbi request reprint Parental chromosome-specific chromatin conformation in the imprinted U2af1-rs1 gene in the mouse
    R Feil
    Department of Development and Genetics, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 272:20893-900. 1997
    ..This demonstrates that these parental chromosome-specific epigenotypes are independently established and maintained and provides no evidence for interallelic trans-sensing and counting mechanisms in U2af1-rs1...
  31. doi request reprint Genome-wide analysis of DNA methylation in low cell numbers by reduced representation bisulfite sequencing
    Sebastien A Smallwood
    Epigenetics Programme, The Babraham Institute, Cambridge, UK
    Methods Mol Biol 925:187-97. 2012
    ..Typically one sequencing experiment using the Illumina Genome Analyser IIx platform provides information on the DNA methylation status of more than half of the CpG islands of the mouse genome...
  32. ncbi request reprint Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
    ..We propose that the Igf2 gene, and perhaps other imprinted genes, control both the placental supply of, and the genetic demand for, maternal nutrients to the mammalian fetus...
  33. ncbi request reprint Transactivation of Igf2 in a mouse model of Beckwith-Wiedemann syndrome
    F L Sun
    Laboratory of Developmental Genetics and Imprinting, Department of Development and Genetics, The Babraham Institute, Cambridge, UK
    Nature 389:809-15. 1997
    ..These phenotypes establish Igf2 overexpression as a key determinant of Beckwith-Wiedemann syndrome...
  34. ncbi request reprint Identification and properties of imprinted genes and their control elements
    R J Smith
    Developmental Genetics Programme, The Babraham Institute, Cambridge, UK
    Cytogenet Genome Res 105:335-45. 2004
    ....
  35. doi request reprint Imprinted genes and hypothalamic function
    Elena Ivanova
    Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
    J Mol Endocrinol 47:R67-74. 2011
    ....
  36. ncbi request reprint The mouse Zac1 locus: basis for imprinting and comparison with human ZAC
    Rachel J Smith
    Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Gene 292:101-12. 2002
    ..10 exhibit appropriate parent-of-origin dependent expression of Zac1, indicating that the absence of phenotypes comparable to aspects of human TNDM is not because imprinting of Zac1 is relaxed in these UPD mice...
  37. doi request reprint A web of imprinting in stem cells
    Gavin Kelsey
    Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK
    Cell Stem Cell 9:177-8. 2011
    ..2011) suggest in this issue of Cell Stem Cell that epigenetic silencing of imprinted genes is a common requirement for maintaining self-renewal in adult stem cell populations...
  38. ncbi request reprint Imprinted genes and the coordination of fetal and postnatal growth in mammals
    W Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, Babraham Institute, Cambridge CB2 4AT, UK
    Novartis Found Symp 237:19-31; discussion 31-42. 2001
    ..Imprinted genes may also be involved in postnatal growth up to weaning...
  39. ncbi request reprint Epigenetics and imprinting of the trophoblast -- a workshop report
    A C Ferguson-Smith
    Department of Anatomy, University of Cambridge, Downing St, Cambridge CB2 3DY, UK
    Placenta 27:S122-6. 2006
    ..In addition, epigenetic control of trophoblast development and function were considered. This report summarises the contributions to the workshop...
  40. ncbi request reprint Imprinted methylation profiles for proximal mouse chromosomes 11 and 7 as revealed by methylation-sensitive representational difference analysis
    David Monk
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mamm Genome 14:805-16. 2003
    ..No such mutations were found...
  41. ncbi request reprint Stochastic imprinting in the progeny of Dnmt3L-/- females
    Philippe Arnaud
    Institute of Molecular Genetics, CNRS UMR 5535 and University of Montpellier II, 1919 Route de Mende, 34090 Montpellier, France
    Hum Mol Genet 15:589-98. 2006
    ..This observation can provide a basis to understand mechanisms involved in some sporadic cases of imprinting-related diseases and polymorphic imprinting in human...
  42. ncbi request reprint Identification of an imprinting control region affecting the expression of all transcripts in the Gnas cluster
    Christine M Williamson
    MRC Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK
    Nat Genet 38:350-5. 2006
    ..Uniquely, the Nespas DMR acts on the downstream ICR at exon 1A to regulate tissue-specific imprinting of the Gnas gene...
  43. ncbi request reprint Sequence-based bioinformatic prediction and QUASEP identify genomic imprinting of the KCNK9 potassium channel gene in mouse and human
    Nico Ruf
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Hum Mol Genet 16:2591-9. 2007
    ..Our data have major implications for the proposed role of Kcnk9 in neurodevelopment, apoptosis and tumourigenesis, as well as for the efficiency of sequence-based bioinformatic predictions of novel imprinted genes...
  44. pmc The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice
    Tao Xie
    Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:18989-99. 2006
    ..XLalphas (or XLN1) is a negative regulator of sympathetic nervous system activity in mice...
  45. ncbi request reprint Alternative non-coding splice variants of Nespas, an imprinted gene antisense to Nesp in the Gnas imprinting cluster
    Christine M Williamson
    MRC Mammalian Genetics Unit, Harwell, Didcot, Oxfordshire, OX11 0RD, UK
    Mamm Genome 13:74-9. 2002
    ..The identification of a set of small spliced imprinted transcripts in the human and now in the mouse suggests that these antisense transcripts are functionally important...
  46. ncbi request reprint DDC and COBL, flanking the imprinted GRB10 gene on 7p12, are biallelically expressed
    Megan P Hitchins
    Department of Fetal and Maternal Medicine, Institute of Reproductive and Developmental Biology, Imperial College, Faculty of Medicine, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Mamm Genome 13:686-91. 2002
    ..This may be a further example of over-expression of maternally derived transcripts in inter-specific mouse crosses. GRB10 remains the only imprinted gene identified within 7p11.2-p13...
  47. doi request reprint Physiological functions of the imprinted Gnas locus and its protein variants Galpha(s) and XLalpha(s) in human and mouse
    Antonius Plagge
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Endocrinol 196:193-214. 2008
    ....