Lyndal Kearney

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint Molecular cytogenetics in haematological malignancy: current technology and future prospects
    Lyndal Kearney
    Section of Haemato oncology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Chromosoma 114:286-94. 2005
  2. doi request reprint Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research
    Lyndal Kearney
    Section of Haemato oncology, Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Methods Mol Biol 538:57-70. 2009
  3. doi request reprint Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
    Lyndal Kearney
    Section of Haemato oncology, The Institute of Cancer Research, Sutton, United Kingdom
    Blood 113:646-8. 2009
  4. ncbi request reprint Multiplex-FISH (M-FISH): technique, developments and applications
    L Kearney
    Section of Haemato oncology, Institute of Cancer Research, London, UK
    Cytogenet Genome Res 114:189-98. 2006
  5. doi request reprint Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia
    Sharon W Horsley
    Section of Haemato oncology, The Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey, UK
    Genes Chromosomes Cancer 47:333-40. 2008
  6. doi request reprint Genetic variegation of clonal architecture and propagating cells in leukaemia
    Kristina Anderson
    Section of Haemato oncology, The Institute of Cancer Research, Sutton SM2 5NG, UK
    Nature 469:356-61. 2011
  7. doi request reprint Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
    Caroline M Bateman
    Section of Haemato oncology, The Institute of Cancer Research, Surrey, UK
    Blood 115:3553-8. 2010
  8. ncbi request reprint Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss
    Sharon W Horsley
    Section of Haemato oncology, Institute of Cancer Research, London, United Kingdom
    Genes Chromosomes Cancer 45:554-64. 2006
  9. pmc Single-cell mutational profiling and clonal phylogeny in cancer
    Nicola E Potter
    The Institute of Cancer Research, London, SM2 5NG, United Kingdom
    Genome Res 23:2115-25. 2013
  10. doi request reprint Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia
    Frederik W van Delft
    Section of Haemato oncology, Institute of Cancer Research, Sutton, UK
    Blood 117:6247-54. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Molecular cytogenetics in haematological malignancy: current technology and future prospects
    Lyndal Kearney
    Section of Haemato oncology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Chromosoma 114:286-94. 2005
    ..In the lymphomas, high-resolution array CGH has successfully identified new regions of deletion and amplification, providing the prospect of disease-specific arrays...
  2. doi request reprint Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research
    Lyndal Kearney
    Section of Haemato oncology, Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Methods Mol Biol 538:57-70. 2009
    ....
  3. doi request reprint Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemia
    Lyndal Kearney
    Section of Haemato oncology, The Institute of Cancer Research, Sutton, United Kingdom
    Blood 113:646-8. 2009
    ..These results infer a complex molecular pathogenesis for DS-ALL leukemogenesis, with trisomy 21 as an initiating or first hit and with chromosome aneuploidy, gene deletions, and activating JAK2 mutations as complementary genetic events...
  4. ncbi request reprint Multiplex-FISH (M-FISH): technique, developments and applications
    L Kearney
    Section of Haemato oncology, Institute of Cancer Research, London, UK
    Cytogenet Genome Res 114:189-98. 2006
    ..Finally, M-FISH has emerged as the perfect partner for the developing genomic microarray (array CGH) technologies, providing a powerful approach to gene discovery...
  5. doi request reprint Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemia
    Sharon W Horsley
    Section of Haemato oncology, The Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey, UK
    Genes Chromosomes Cancer 47:333-40. 2008
    ..These data have implications for the biology of ALL and for management of similar patients...
  6. doi request reprint Genetic variegation of clonal architecture and propagating cells in leukaemia
    Kristina Anderson
    Section of Haemato oncology, The Institute of Cancer Research, Sutton SM2 5NG, UK
    Nature 469:356-61. 2011
    ..These data have implications for cancer genomics and for the targeted therapy of cancer...
  7. doi request reprint Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemia
    Caroline M Bateman
    Section of Haemato oncology, The Institute of Cancer Research, Surrey, UK
    Blood 115:3553-8. 2010
    ..These data place all "driver" CNAs secondary to the prenatal gene fusion event and most probably postnatal in the sequential, molecular pathogenesis of ALL...
  8. ncbi request reprint Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss
    Sharon W Horsley
    Section of Haemato oncology, Institute of Cancer Research, London, United Kingdom
    Genes Chromosomes Cancer 45:554-64. 2006
    ..Finally, small regions of deletion and amplification, often including genes known to be involved in leukemia progression (for example MYC, TP53, CDKN2A, and KIT), were identified...
  9. pmc Single-cell mutational profiling and clonal phylogeny in cancer
    Nicola E Potter
    The Institute of Cancer Research, London, SM2 5NG, United Kingdom
    Genome Res 23:2115-25. 2013
    ..We show, in this proof-of-principle study, that the method has a low error rate and can provide detailed subclonal genetic architectures and phylogenies. ..
  10. doi request reprint Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemia
    Frederik W van Delft
    Section of Haemato oncology, Institute of Cancer Research, Sutton, UK
    Blood 117:6247-54. 2011
    ....
  11. ncbi request reprint MLL chimeric protein activation renders cells vulnerable to chromosomal damage: an explanation for the very short latency of infant leukemia
    Mariko Eguchi
    Section of Haemato oncology, The Institute of Cancer Research, London, UK
    Genes Chromosomes Cancer 45:754-60. 2006
    ..This phenotype is associated with an altered pattern of cell cycle arrest and/or apoptosis...
  12. ncbi request reprint Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemia
    Alicja M Gruszka-Westwood
    Section of Haematological Oncology, Institute of Cancer Research, London, United Kingdom
    Genes Chromosomes Cancer 41:191-202. 2004
    ..In conclusion, we have shown that tri-/tetrasomies in hyperdiploid ALL lead to an increase in the expression of associated sequences. The choice of a biologically relevant reference is crucial for data interpretation...
  13. ncbi request reprint Characterization of a t(10;11)(p13-14;q14-21) in the monoblastic cell line U937
    J Shipley
    Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Genes Chromosomes Cancer 13:138-42. 1995
    ..Further characterization of the genetic rearrangements in U937 may lead to the isolation of genes important in leukemogenesis and provide an in vitro system for their study...
  14. ncbi request reprint The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy gene
    P G Olsson
    Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
    Genomics 34:233-5. 1996
    ..Like their human counterparts, the mouse Tsc2 and Pkd1 genes are arranged in a tail-to-tail orientation with a distance of only 63 bp between the polyadenylation signals of the two genes...
  15. ncbi request reprint Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemia
    D M Lillington
    Department of Medical Oncology, The Imperial Cancer Research Fund, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
    Br J Haematol 110:547-51. 2000
    ....
  16. ncbi request reprint Prenatal chromosomal diversification of leukemia in monozygotic twins
    Helena Kempski
    Molecular Haematology Unit, Institute of Child Health, London, United Kingdom
    Genes Chromosomes Cancer 37:406-11. 2003
    ..This case of leukemia illustrates in utero initiation with early imposition of chromosomal instability, the progressively divergent evolution of which can be mapped in the twins into pre- and postnatal periods...
  17. ncbi request reprint A mitotically stable marker chromosome negative for whole chromosome libraries, centromere probes and chromosome specific telomere regions: a novel class of supernumerary marker chromosome?
    C Mackie Ogilvie
    Division of Medical and Molecular Genetics, King s, Guy s and St Thomas Medical School, London, UK
    Cytogenet Cell Genet 92:69-73. 2001
    ..Prognostic implications for the proband were difficult to assess due to the absence of reports of similar marker chromosomes in the literature...
  18. ncbi request reprint A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay
    Jill Brown
    Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Blood 99:2526-31. 2002
    ..This is the first report of the t(5;11)(q35;p15.5) in association with an apparently normal karyotype, and highlights this as a new, potentially clinically significant chromosome rearrangement in childhood AML...
  19. ncbi request reprint Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridization
    Lyndal Kearney
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
    Methods Mol Med 68:7-27. 2002
  20. ncbi request reprint Study of 30 patients with unexplained developmental delay and dysmorphic features or congenital abnormalities using conventional cytogenetics and multiplex FISH telomere (M-TEL) integrity assay
    Susanne Popp
    Deutsches Krebsforschungszentrum, Division of Genetics of Skin Carcinogenesis, Heidelberg, Germany
    Hum Genet 111:31-9. 2002
    ..The detection of familial balanced translocation carriers in 50% of the cases emphasizes the significance of such an integrated approach for genetic counselling and prenatal diagnosis...
  21. ncbi request reprint Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemia
    Sabrina Tosi
    MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
    Genes Chromosomes Cancer 38:191-200. 2003
    ..These data show some heterogeneity in the distribution of breakpoints in 7q36, indicating that the generation of a fusion gene might not be the mechanism responsible for leukemogenesis in the t(7;12), at least in some cases...
  22. ncbi request reprint Molecular cytogenetics in childhood leukemia
    Christine J Harrison
    Leukaemia Research Fund Cytogenetics Group, University of Southampton, UK
    Methods Mol Med 91:123-37. 2004