Affiliation: Institute of Cancer Research
- Molecular cytogenetics in haematological malignancy: current technology and future prospectsLyndal Kearney
Section of Haemato oncology, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
Chromosoma 114:286-94. 2005..In the lymphomas, high-resolution array CGH has successfully identified new regions of deletion and amplification, providing the prospect of disease-specific arrays...
- Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia researchLyndal Kearney
Section of Haemato oncology, Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
Methods Mol Biol 538:57-70. 2009....
- Specific JAK2 mutation (JAK2R683) and multiple gene deletions in Down syndrome acute lymphoblastic leukemiaLyndal Kearney
Section of Haemato oncology, The Institute of Cancer Research, Sutton, United Kingdom
Blood 113:646-8. 2009..These results infer a complex molecular pathogenesis for DS-ALL leukemogenesis, with trisomy 21 as an initiating or first hit and with chromosome aneuploidy, gene deletions, and activating JAK2 mutations as complementary genetic events...
- Multiplex-FISH (M-FISH): technique, developments and applicationsL Kearney
Section of Haemato oncology, Institute of Cancer Research, London, UK
Cytogenet Genome Res 114:189-98. 2006..Finally, M-FISH has emerged as the perfect partner for the developing genomic microarray (array CGH) technologies, providing a powerful approach to gene discovery...
- Genetic lesions in a preleukemic aplasia phase in a child with acute lymphoblastic leukemiaSharon W Horsley
Section of Haemato oncology, The Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey, UK
Genes Chromosomes Cancer 47:333-40. 2008..These data have implications for the biology of ALL and for management of similar patients...
- Genetic variegation of clonal architecture and propagating cells in leukaemiaKristina Anderson
Section of Haemato oncology, The Institute of Cancer Research, Sutton SM2 5NG, UK
Nature 469:356-61. 2011..These data have implications for cancer genomics and for the targeted therapy of cancer...
- Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukemiaCaroline M Bateman
Section of Haemato oncology, The Institute of Cancer Research, Surrey, UK
Blood 115:3553-8. 2010..These data place all "driver" CNAs secondary to the prenatal gene fusion event and most probably postnatal in the sequential, molecular pathogenesis of ALL...
- Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and lossSharon W Horsley
Section of Haemato oncology, Institute of Cancer Research, London, United Kingdom
Genes Chromosomes Cancer 45:554-64. 2006..Finally, small regions of deletion and amplification, often including genes known to be involved in leukemia progression (for example MYC, TP53, CDKN2A, and KIT), were identified...
- Single-cell mutational profiling and clonal phylogeny in cancerNicola E Potter
The Institute of Cancer Research, London, SM2 5NG, United Kingdom
Genome Res 23:2115-25. 2013..We show, in this proof-of-principle study, that the method has a low error rate and can provide detailed subclonal genetic architectures and phylogenies. ..
- Clonal origins of relapse in ETV6-RUNX1 acute lymphoblastic leukemiaFrederik W van Delft
Section of Haemato oncology, Institute of Cancer Research, Sutton, UK
Blood 117:6247-54. 2011....
- MLL chimeric protein activation renders cells vulnerable to chromosomal damage: an explanation for the very short latency of infant leukemiaMariko Eguchi
Section of Haemato oncology, The Institute of Cancer Research, London, UK
Genes Chromosomes Cancer 45:754-60. 2006..This phenotype is associated with an altered pattern of cell cycle arrest and/or apoptosis...
- Comparative expressed sequence hybridization studies of high-hyperdiploid childhood acute lymphoblastic leukemiaAlicja M Gruszka-Westwood
Section of Haematological Oncology, Institute of Cancer Research, London, United Kingdom
Genes Chromosomes Cancer 41:191-202. 2004..In conclusion, we have shown that tri-/tetrasomies in hyperdiploid ALL lead to an increase in the expression of associated sequences. The choice of a biologically relevant reference is crucial for data interpretation...
- Characterization of a t(10;11)(p13-14;q14-21) in the monoblastic cell line U937J Shipley
Institute of Cancer Research, Sutton, Surrey, United Kingdom
Genes Chromosomes Cancer 13:138-42. 1995..Further characterization of the genetic rearrangements in U937 may lead to the isolation of genes important in leukemogenesis and provide an in vitro system for their study...
- The mouse homologue of the polycystic kidney disease gene (Pkd1) is a single-copy geneP G Olsson
Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, United Kingdom
Genomics 34:233-5. 1996..Like their human counterparts, the mouse Tsc2 and Pkd1 genes are arranged in a tail-to-tail orientation with a distance of only 63 bp between the polyadenylation signals of the two genes...
- Cytogenetic and molecular evidence of marrow involvement in extramedullary acute myeloid leukaemiaD M Lillington
Department of Medical Oncology, The Imperial Cancer Research Fund, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, UK
Br J Haematol 110:547-51. 2000....
- Prenatal chromosomal diversification of leukemia in monozygotic twinsHelena Kempski
Molecular Haematology Unit, Institute of Child Health, London, United Kingdom
Genes Chromosomes Cancer 37:406-11. 2003..This case of leukemia illustrates in utero initiation with early imposition of chromosomal instability, the progressively divergent evolution of which can be mapped in the twins into pre- and postnatal periods...
- A mitotically stable marker chromosome negative for whole chromosome libraries, centromere probes and chromosome specific telomere regions: a novel class of supernumerary marker chromosome?C Mackie Ogilvie
Division of Medical and Molecular Genetics, King s, Guy s and St Thomas Medical School, London, UK
Cytogenet Cell Genet 92:69-73. 2001..Prognostic implications for the proband were difficult to assess due to the absence of reports of similar marker chromosomes in the literature...
- A cryptic t(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assayJill Brown
Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Blood 99:2526-31. 2002..This is the first report of the t(5;11)(q35;p15.5) in association with an apparently normal karyotype, and highlights this as a new, potentially clinically significant chromosome rearrangement in childhood AML...
- Detection of chromosome abnormalities in leukemia using fluorescence in situ hybridizationLyndal Kearney
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
Methods Mol Med 68:7-27. 2002
- Study of 30 patients with unexplained developmental delay and dysmorphic features or congenital abnormalities using conventional cytogenetics and multiplex FISH telomere (M-TEL) integrity assaySusanne Popp
Deutsches Krebsforschungszentrum, Division of Genetics of Skin Carcinogenesis, Heidelberg, Germany
Hum Genet 111:31-9. 2002..The detection of familial balanced translocation carriers in 50% of the cases emphasizes the significance of such an integrated approach for genetic counselling and prenatal diagnosis...
- Heterogeneity of the 7q36 breakpoints in the t(7;12) involving ETV6 in infant leukemiaSabrina Tosi
MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
Genes Chromosomes Cancer 38:191-200. 2003..These data show some heterogeneity in the distribution of breakpoints in 7q36, indicating that the generation of a fusion gene might not be the mechanism responsible for leukemogenesis in the t(7;12), at least in some cases...
- Molecular cytogenetics in childhood leukemiaChristine J Harrison
Leukaemia Research Fund Cytogenetics Group, University of Southampton, UK
Methods Mol Med 91:123-37. 2004