M Katan

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint Structural and mechanistic aspects of phospholipase Cgamma regulation
    Matilda Katan
    Chester Beatty Laboratories, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Adv Enzyme Regul 43:77-85. 2003
  2. pmc Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
    M Matsuda
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, United Kingdom
    J Cell Biol 153:599-612. 2001
  3. pmc New insights into the families of PLC enzymes: looking back and going forward
    Matilda Katan
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Biochem J 391:e7-9. 2005
  4. ncbi request reprint Families of phosphoinositide-specific phospholipase C: structure and function
    M Katan
    CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Biochim Biophys Acta 1436:5-17. 1998
  5. ncbi request reprint Modular PH and C2 domains in membrane attachment and other functions
    M Katan
    CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK
    FEBS Lett 452:36-40. 1999
  6. ncbi request reprint Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling
    R Rodriguez
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Rd, London SW3 6JB, United Kingdom
    J Biol Chem 276:47982-92. 2001
  7. ncbi request reprint Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis
    F Rodrigues-Lima
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom
    J Biol Chem 275:28316-25. 2000
  8. pmc Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs
    K T Jones
    Department of Anatomy, University College, Gower Street, London, WC1E 6BT, UK
    Biochem J 346:743-9. 2000
  9. ncbi request reprint Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1
    M V Ellis
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, United Kingdom
    J Biol Chem 273:11650-9. 1998
  10. ncbi request reprint A novel inositol-phospholipid-specific phospholipase C. Rapid purification and characterization
    E Meldrum
    Ludwig Institute for Cancer Research, London, UK
    Eur J Biochem 182:673-7. 1989

Collaborators

  • M Matsuda
  • K Swann
  • R L Williams
  • J Parrington
  • K T Jones
  • S R James
  • Fernando Rodrigues-Lima
  • Nicola E Wilsher
  • L Cocco
  • GRANT KELLEY
  • Florence I Raynaud
  • K Fukami
  • Laurence H Pearl
  • Tom D Bunney
  • Neil P Jones
  • Richard Harris
  • Michelle Josephs
  • Pann Ghill Suh
  • Mandy Miertzschke
  • Bernward Hinkes
  • Paul C Driscoll
  • Hugh F Paterson
  • Sonia Caroline Sorli
  • Philipp Yu
  • Richard D Byrne
  • Rosie Rodriguez
  • R Rodriguez
  • O Perisic
  • Tohru Kataoka
  • Lucia Manzoli
  • Jae Il Park
  • Sung Ho Ryu
  • Sanguk Yun
  • Joanna C Peak
  • Paula Stanley
  • Nancy Hogg
  • Hans Christian Hennies
  • Alan V Smrcka
  • S Mark Roe
  • Chris P Ponting
  • Michelle B Josephs
  • Friedhelm Hildebrandt
  • Diego Esposito
  • Dominik Seelow
  • Sudha Mudumana
  • Thomas Gudermann
  • Alexander Dietrich
  • Peter Gierschik
  • Dontscho Kerjaschki
  • Bethan E Hoskins
  • Roger C Wiggins
  • Katrin Hasselbacher
  • Lina Basel-Vanagaite
  • Martin Griebel
  • Andreas Kispert
  • Rakesh Verma
  • Alexey N Tsygin
  • Rudiger Waldherr
  • Jinhong Liu
  • Gudrun Nurnberg
  • JOHN F O'TOOLE
  • Massimo Attanasio
  • Puneet Garg
  • Fatih Ozaltin
  • Meera Goyal
  • Peter Nurnberg
  • Aysin Bakkaloglu
  • Bettina Mucha
  • Asher D Schachter
  • Hassan Chaib
  • Edgar A Otto
  • Rannar Airik
  • S Caroline Sorli
  • Alper Soylu
  • Christopher N Vlangos
  • Lawrence B Holzman
  • Christian Becker
  • Shazia Ashraf
  • Bryan L Wharram
  • Natalia Lamuño Gandarillas
  • Rasheed Gbadegesin
  • Iain Drummond
  • Dominik Muller
  • Caroline S Sorli
  • Roxana Cleper
  • M V Ellis
  • Martin Pohl
  • Banafshe Larijani
  • Jürgen Laufs
  • Suzanne A Eccles

Detail Information

Publications24

  1. ncbi request reprint Structural and mechanistic aspects of phospholipase Cgamma regulation
    Matilda Katan
    Chester Beatty Laboratories, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Adv Enzyme Regul 43:77-85. 2003
  2. pmc Real time fluorescence imaging of PLC gamma translocation and its interaction with the epidermal growth factor receptor
    M Matsuda
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, United Kingdom
    J Cell Biol 153:599-612. 2001
    ..The presence of PLC gamma in membrane structures and its access to the substrate appear to be transient and are followed by a rapid incorporation into intracellular vesicles, leading to downregulation of the PLC activity...
  3. pmc New insights into the families of PLC enzymes: looking back and going forward
    Matilda Katan
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Biochem J 391:e7-9. 2005
    ....
  4. ncbi request reprint Families of phosphoinositide-specific phospholipase C: structure and function
    M Katan
    CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, UK
    Biochim Biophys Acta 1436:5-17. 1998
    ....
  5. ncbi request reprint Modular PH and C2 domains in membrane attachment and other functions
    M Katan
    CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK
    FEBS Lett 452:36-40. 1999
    ..A number of recent examples illustrate the function of some of these domains in regulated membrane attachment, with an important role in many cellular signalling pathways...
  6. ncbi request reprint Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling
    R Rodriguez
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Rd, London SW3 6JB, United Kingdom
    J Biol Chem 276:47982-92. 2001
    ....
  7. ncbi request reprint Structural requirements for catalysis and membrane targeting of mammalian enzymes with neutral sphingomyelinase and lysophospholipid phospholipase C activities. Analysis by chemical modification and site-directed mutagenesis
    F Rodrigues-Lima
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom
    J Biol Chem 275:28316-25. 2000
    ..Cellular localization studies of a series of deletion mutants, expressed as green fluorescent protein fusion proteins, demonstrated that the transmembrane region contains determinants for the endoplasmic reticulum localization...
  8. pmc Different Ca2+-releasing abilities of sperm extracts compared with tissue extracts and phospholipase C isoforms in sea urchin egg homogenate and mouse eggs
    K T Jones
    Department of Anatomy, University College, Gower Street, London, WC1E 6BT, UK
    Biochem J 346:743-9. 2000
    ..In addition these PLCs were not able to cause Ca(2+) oscillations following microinjection into mouse eggs. These results imply that the sperm PLC possesses distinct properties that allow it to hydrolyse PtdIns(4,5)P(2) in eggs...
  9. ncbi request reprint Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1
    M V Ellis
    Cancer Research Campaign Centre for Cell and Molecular Biology, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, United Kingdom
    J Biol Chem 273:11650-9. 1998
    ....
  10. ncbi request reprint A novel inositol-phospholipid-specific phospholipase C. Rapid purification and characterization
    E Meldrum
    Ludwig Institute for Cancer Research, London, UK
    Eur J Biochem 182:673-7. 1989
    ..min-1.mg-1. The enzyme is dependent on Ca2+ and shows a marked preference for inositol phospholipid substrates. The unique nature of this polypeptide was confirmed through partial protein sequence analysis...
  11. ncbi request reprint The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium
    Nicola E Wilsher
    Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Belmont, Surrey, UK
    Drug Metab Dispos 35:1017-22. 2007
    ..In complex cellular assays, the availability of U73122 to inhibit PLC may be limited by its chemical reactivity and lead to the misinterpretation of results in pharmacological assays...
  12. ncbi request reprint Phospholipase C epsilon: linking second messengers and small GTPases
    Tom D Bunney
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Trends Cell Biol 16:640-8. 2006
    ....
  13. pmc Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1
    Neil P Jones
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London SW3 6JB, United Kingdom
    Mol Cell Biol 27:5790-805. 2007
    ..As a component of this complex, PLCgamma1 is also involved in the activation of Cdc42 and Rac1...
  14. ncbi request reprint Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible
    Bernward Hinkes
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 38:1397-405. 2006
    ..These findings, together with the zebrafish model of human nephrotic syndrome generated by plce1 knockdown, open new inroads into pathophysiology and treatment mechanisms of nephrotic syndrome...
  15. ncbi request reprint Structural and mechanistic insights into ras association domains of phospholipase C epsilon
    Tom D Bunney
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom
    Mol Cell 21:495-507. 2006
    ..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity...
  16. ncbi request reprint Characterization of interactions of adapter protein RAPL/Nore1B with RAP GTPases and their role in T cell migration
    Mandy Miertzschke
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom
    J Biol Chem 282:30629-42. 2007
    ....
  17. ncbi request reprint Backbone 1H, 13C, and 15N resonance assignments for the two 13 kD Ras associating domains (RA1 and RA2) from phospholipase C epsilon
    Richard Harris
    J Biomol NMR 33:138. 2005
  18. ncbi request reprint PLCgamma1 is essential for early events in integrin signalling required for cell motility
    Neil P Jones
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, London, UK
    J Cell Sci 118:2695-706. 2005
    ..This suggests a more general role for PLCgamma1 in cell motility, functioning as a mediator of both growth factor and integrin-initiated signals...
  19. ncbi request reprint Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry
    Philipp Yu
    Ingenium Pharmaceuticals AG, Fraunhoferstrasse 13, 82152 Martinsried, Munich, Germany
    Immunity 22:451-65. 2005
    ....
  20. ncbi request reprint Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants
    Sonia Caroline Sorli
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Oncogene 24:90-100. 2005
    ..Taken together, our findings suggest that regulatory mechanisms controlling expression of PLCepsilon, broadened by diversity introduced by splice variants, could play important role in PLCepsilon regulation in normal and tumor cells...
  21. pmc Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes
    Richard D Byrne
    Cell Biophysics Laboratory, London Research Institute LRI, Cancer Research UK CR UK, 44, Lincoln s Inn Fields, London, WC2A 3PX, UK
    Biochem J 387:393-400. 2005
    ..We have exploited this and the intervention studies to illustrate a pivotal role for PI-PLC and its product DAG in the formation of NEs...
  22. pmc Requirements for distinct steps of phospholipase Cgamma2 regulation, membrane-raft-dependent targeting and subsequent enzyme activation in B-cell signalling
    Rosie Rodriguez
    Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    Biochem J 374:269-80. 2003
    ....
  23. ncbi request reprint Irreversible inactivation of magnesium-dependent neutral sphingomyelinase 1 (NSM1) by peroxynitrite, a nitric oxide-derived oxidant
    Michelle Josephs
    Protein Biochemistry Group, Cancer Research UK Centre for Cell and Molecular Biology, The Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    FEBS Lett 531:329-34. 2002
    ..These results suggest that depending on the nature of the oxidative stress, the enzymatic activity of NSM1 could be reversibly or irreversibly inactivated...
  24. ncbi request reprint Multiple roles of phosphoinositide-specific phospholipase C isozymes
    Pann Ghill Suh
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Korea
    BMB Rep 41:415-34. 2008
    ..In this review, we discuss the structural organization, enzymatic properties and molecular diversity of PLC splicing variants and study functional and physiological roles of each isozyme...