Nathalie Juge

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Plant protein inhibitors of cell wall degrading enzymes
    Nathalie Juge
    Institut Méditerranéen de Recherche en Nutrition, Faculté des Sciences de St Jérôme, F 13397 Marseilles Cedex 20, France
    Trends Plant Sci 11:359-67. 2006
  2. ncbi request reprint XIP-I, a xylanase inhibitor protein from wheat: a novel protein function
    Nathalie Juge
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Biochim Biophys Acta 1696:203-11. 2004
  3. ncbi request reprint The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase
    Sandra Tribolo
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    J Mol Biol 370:964-75. 2007
  4. pmc Substrate (aglycone) specificity of human cytosolic beta-glucosidase
    Jean Guy Berrin
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
    Biochem J 373:41-8. 2003
  5. ncbi request reprint Probing the determinants of substrate specificity of a feruloyl esterase, AnFaeA, from Aspergillus niger
    Craig B Faulds
    Institute of Food Research, Colney, Norwich, UK
    FEBS J 272:4362-71. 2005
  6. ncbi request reprint The activity of barley alpha-amylase on starch granules is enhanced by fusion of a starch binding domain from Aspergillus niger glucoamylase
    Nathalie Juge
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Biochim Biophys Acta 1764:275-84. 2006
  7. ncbi request reprint Functional importance of Asp37 from a family 11 xylanase in the binding to two proteinaceous xylanase inhibitors from wheat
    Tariq A Tahir
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    FEMS Microbiol Lett 239:9-15. 2004
  8. ncbi request reprint Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    Kitti Németh
    Institute of Food Research, Colney Lane, Norwich NR4 7 UA, UK
    Eur J Nutr 42:29-42. 2003
  9. ncbi request reprint Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor
    Giles O Elliott
    Institute of Food Research, Norwich Research Park, Norwich, UK
    FEBS Lett 519:66-70. 2002
  10. ncbi request reprint Cross-inhibitory activity of cereal protein inhibitors against alpha-amylases and xylanases
    Ana I Sancho
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Biochim Biophys Acta 1650:136-44. 2003

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Plant protein inhibitors of cell wall degrading enzymes
    Nathalie Juge
    Institut Méditerranéen de Recherche en Nutrition, Faculté des Sciences de St Jérôme, F 13397 Marseilles Cedex 20, France
    Trends Plant Sci 11:359-67. 2006
    ....
  2. ncbi request reprint XIP-I, a xylanase inhibitor protein from wheat: a novel protein function
    Nathalie Juge
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Biochim Biophys Acta 1696:203-11. 2004
    ....
  3. ncbi request reprint The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase
    Sandra Tribolo
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    J Mol Biol 370:964-75. 2007
    ..In particular, Val168, Trp345, Phe225, Phe179, Phe334 and Phe433 were identified as likely to be important in determining substrate specificity in hCBG, and site-directed mutagenesis supported a key role for some of these residues...
  4. pmc Substrate (aglycone) specificity of human cytosolic beta-glucosidase
    Jean Guy Berrin
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
    Biochem J 373:41-8. 2003
    ..Taken together with the three-dimensional model, these mutation studies identified the amino-acid residues in the aglycone-binding subsite of hCBG that are essential for flavonoid glucoside binding and catalysis...
  5. ncbi request reprint Probing the determinants of substrate specificity of a feruloyl esterase, AnFaeA, from Aspergillus niger
    Craig B Faulds
    Institute of Food Research, Colney, Norwich, UK
    FEBS J 272:4362-71. 2005
    ..The role of Tyr80 and Trp260 in AnFaeA are discussed in light of the three-dimensional structure...
  6. ncbi request reprint The activity of barley alpha-amylase on starch granules is enhanced by fusion of a starch binding domain from Aspergillus niger glucoamylase
    Nathalie Juge
    Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
    Biochim Biophys Acta 1764:275-84. 2006
    ..9 for rAMY1. Remarkably, at low concentration (2 nM), AMY1-SBD hydrolysed barley starch granules 15-fold faster than rAMY1, while higher amounts of AMY-SBD caused molecular overcrowding of the starch granule surface...
  7. ncbi request reprint Functional importance of Asp37 from a family 11 xylanase in the binding to two proteinaceous xylanase inhibitors from wheat
    Tariq A Tahir
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    FEMS Microbiol Lett 239:9-15. 2004
    ..The results are consistent with a competitive inhibition mode and underline the strategic importance of Asp37 in the inhibition mechanism...
  8. ncbi request reprint Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans
    Kitti Németh
    Institute of Food Research, Colney Lane, Norwich NR4 7 UA, UK
    Eur J Nutr 42:29-42. 2003
    ..Hence, first-pass metabolism (small intestine-liver) appears to involve a critical deglycosylation step for which the mechanisms are not known...
  9. ncbi request reprint Functional identification of the cDNA coding for a wheat endo-1,4-beta-D-xylanase inhibitor
    Giles O Elliott
    Institute of Food Research, Norwich Research Park, Norwich, UK
    FEBS Lett 519:66-70. 2002
    ..This is the first full-length cDNA sequence that encodes a novel class of protein which inhibits the activity of endo-1,4-beta-D-xylanases...
  10. ncbi request reprint Cross-inhibitory activity of cereal protein inhibitors against alpha-amylases and xylanases
    Ana I Sancho
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Biochim Biophys Acta 1650:136-44. 2003
    ..Taken together, the data demonstrate for the first time the dual target enzyme specificity of BASI and XIP-I inhibitors for xylanase and alpha-amylase...
  11. ncbi request reprint Emergence of a subfamily of xylanase inhibitors within glycoside hydrolase family 18
    Anne Durand
    Institute of Food Research IFR, Norwich, UK
    FEBS J 272:1745-55. 2005
    ..This study provides new information which will lead to a better understanding of the biological significance of a number of GH18 'inactivated' chitinases...
  12. ncbi request reprint Specific characterization of substrate and inhibitor binding sites of a glycosyl hydrolase family 11 xylanase from Aspergillus niger
    Tariq A Tahir
    Institute of Food Research IFR, Norwich Research Park, United Kingdom
    J Biol Chem 277:44035-43. 2002
    ..A close inspection of the three-dimensional structure of A. niger xylanase suggests that the binding site of XIP-I is located at the conserved "thumb" hairpin loop of family 11 xylanases...
  13. ncbi request reprint A family 11 xylanase from the pathogen Botrytis cinerea is inhibited by plant endoxylanase inhibitors XIP-I and TAXI-I
    Alexandre Brutus
    Institut Méditerranéen de Recherche en Nutrition, Laboratoire de Biochimie et Biologie de la Nutrition, UMR Université Paul Cézanne Aix Marseille III, INRA 1111, Service 342, Faculté des Sciences et Techniques Saint Jérôme, Marseille Cedex, France
    Biochem Biophys Res Commun 337:160-6. 2005
    ..1+/-0.1 and 6.0+/-0.2 nM, respectively, whereas no inhibition was detected with TAXI-II. We also showed that XynBc1 mRNAs accumulated during early stages of plant tissue infection...
  14. doi request reprint Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of Lactobacillus reuteri
    Donald A MacKenzie
    Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
    Microbiology 156:3368-78. 2010
    ..reuteri, and further demonstrated that MUB and MUB-like proteins, although present in many L. reuteri isolates, show a high genetic heterogeneity among strains...
  15. pmc Mining the "glycocode"--exploring the spatial distribution of glycans in gastrointestinal mucin using force spectroscopy
    A Patrick Gunning
    1Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    FASEB J 27:2342-54. 2013
    ..Gunning, A. P., Kirby, A. R., Fuell, C., Pin, C., Tailford L. E., Juge, N. Mining the "glycocode"-exploring the spatial distribution of glycans in gastrointestinal mucin using force spectroscopy...
  16. ncbi request reprint The inhibition specificity of recombinant Penicillium funiculosum xylanase B towards wheat proteinaceous inhibitors
    Alexandre Brutus
    Laboratoire de Biochimie et Biologie de la Nutrition, Institut Méditerranéen de Recherche en Nutrition, Umr Université Aix Marseille III INRA 1111, Service 342, Faculté des Sciences et Techniques Saint Jérôme, 13397 Marseille Cedex 20, France
    Biochim Biophys Acta 1701:121-8. 2004
    ..7+/-8.5 and 2.9+/-0.3 nM, respectively, whereas no inhibition was detected with TAXI-II. Physical interaction of both TAXI-I and XIP-I with XYNB was observed using titration curves across a pH range 3-9...
  17. pmc Genome sequence of the vertebrate gut symbiont Lactobacillus reuteri ATCC 53608
    Darren Heavens
    The Genome Analysis Centre, Norwich Research Park, Norwich NR4 7UH, UK
    J Bacteriol 193:4015-6. 2011
    ..Here we describe the draft genome of L. reuteri ATCC 53608, isolated from a pig. The genome sequence provides important insights into the evolutionary changes underlying host specialization...
  18. ncbi request reprint Structural properties of porcine intestine acylpeptide hydrolase
    Anne Durand
    Institut Méditerranéen de Recherche en Nutrition, Umr Université Aix Marseille III INRA 1111, Faculté des Sciences et Techniques de St Jérôme, Case 342, 13397 Marseille Cedex 20, France
    J Protein Chem 22:183-91. 2003
    ..The putative role of this domain in the specificity mechanism of APH enzymes is also discussed...
  19. doi request reprint Microbial adhesins to gastrointestinal mucus
    Nathalie Juge
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Trends Microbiol 20:30-9. 2012
    ..This review focuses on the current knowledge of microbial adhesins to gastrointestinal mucus and mucus components...
  20. ncbi request reprint Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides
    Jean Guy Berrin
    Nutrition, Health and Consumer Sciences Division, Institute of Food Research, Norwich, UK
    Eur J Biochem 269:249-58. 2002
    ..These data indicate that human CBG hydrolyses a broad range of dietary glucosides and may play a critical role in xenobiotic metabolism...
  21. pmc Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity
    Donald A MacKenzie
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, United Kingdom
    J Biol Chem 284:32444-53. 2009
    ..This hitherto undetected activity is consistent with the current model that antibody responses against commensal flora are of broad specificity and low affinity...
  22. ncbi request reprint Potential physiological role of plant glycosidase inhibitors
    Daniela Bellincampi
    Dipartimento di Biologia Vegetale, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, 00185 Rome, Italy
    Biochim Biophys Acta 1696:265-74. 2004
    ..Results recently obtained with plant transformation technology indicate that this class of inhibitors has potential biotechnological applications...
  23. ncbi request reprint The dual nature of the wheat xylanase protein inhibitor XIP-I: structural basis for the inhibition of family 10 and family 11 xylanases
    Francoise Payan
    Architecture et Fonction de Macromolecules Biologiques, UMR 6098, CNRS et Universités d Aix Marseille I et II, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    J Biol Chem 279:36029-37. 2004
    ..The biological role of the xylanase inhibitors is discussed in light of the present structural data...
  24. ncbi request reprint Involvement of individual subsites and secondary substrate binding sites in multiple attack on amylose by barley alpha-amylase
    Birte Kramhøft
    Department of Chemistry, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK 2500 Copenhagen Valby, Denmark
    Biochemistry 44:1824-32. 2005
    ..Accordingly, the degree of multiple attack as well as the profile of products can be manipulated by structural changes in the active site or by introduction of extra substrate binding sites...
  25. pmc Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat
    Ruth Flatman
    Institute of Food Research, Colney Lane, Norwich NR4 7UA, U K
    Biochem J 365:773-81. 2002
    ..niger and A. nidulans xylanase are due to a 200-fold lower dissociation rate k(off) for the latter, with only a small difference in association rate k(on)...
  26. doi request reprint Factors affecting xylanase functionality in the degradation of arabinoxylans
    Jean Guy Berrin
    Biosciences FRE 3005 CNRS, Universite Paul Cezanne Aix Marseille III, Av Escadrille Normandie Niemen, 13397, Marseille Cedex 20, France
    Biotechnol Lett 30:1139-50. 2008
    ....
  27. ncbi request reprint Understanding the structural basis for substrate and inhibitor recognition in eukaryotic GH11 xylanases
    Maria Vardakou
    Institute for Cell and Molecular Biosciences, Newcastle University, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    J Mol Biol 375:1293-305. 2008
    ..Finally, the crystal structure of NpXyn11A shows that the resistance of the enzyme to XIP-I is not due solely to insertions in the loop connecting beta strands 11 and 12, as suggested previously, but is highly complex...
  28. pmc Structural analysis of xylanase inhibitor protein I (XIP-I), a proteinaceous xylanase inhibitor from wheat (Triticum aestivum, var. Soisson)
    Francoise Payan
    Architecture et Fonction des Macromolecules Biologiques, UMR6098, CNRS and Universities Aix Marseille I and II, 31 Chemin Joseph Aiguier, France
    Biochem J 372:399-405. 2003
    ..The structural differences in the inhibitor cleft structure probably account for the lack of activity of XIP-I towards chitin...
  29. ncbi request reprint The crystal structure of feruloyl esterase A from Aspergillus niger suggests evolutive functional convergence in feruloyl esterase family
    Juan A Hermoso
    Grupo de Cristalografia Macromolecular y Biologia Estructural, Instituto Química Física Rocasolano C S I C, Serrano 119, 28006 Madrid, Spain
    J Mol Biol 338:495-506. 2004
    ....
  30. ncbi request reprint Potential role of glycosidase inhibitors in industrial biotechnological applications
    Jens Frisbaek Sørensen
    Section Enzyme Development, Danisco Cultor A S, Edwin Rahrsvej 38, DK 8220 Brabrand, Denmark
    Biochim Biophys Acta 1696:275-87. 2004
    ..They will also allow careful selection of raw material and reaction conditions, and future development of new genetic varieties low in inhibitors. These are all new and very promising concepts for the food and feed sector...
  31. ncbi request reprint Occurrence of proteinaceous endoxylanase inhibitors in cereals
    Hans Goesaert
    KU Leuven, Laboratory of Food Chemistry, Kasteelpark Arenberg 20, B 3001 Louvain, Belgium
    Biochim Biophys Acta 1696:193-202. 2004
    ..Lower inhibitor levels are present in durum wheat and barley, while maize contains solely XIP-type inhibitors. No inhibitors have been isolated from rice, oats and buckwheat...
  32. ncbi request reprint Substrate and product hydrolysis specificity in family 11 glycoside hydrolases: an analysis of Penicillium funiculosum and Penicillium griseofulvum xylanases
    Jean Guy Berrin
    Biosciences FRE 3005 CNRS, Universite Paul Cezanne Aix Marseille III, Av Escadrille Normandie Niemen, 13397 Marseille Cedex 20, France
    Appl Microbiol Biotechnol 74:1001-10. 2007
    ..In contrast to PfXynC, PgXynA was found insensitive to the wheat xylanase inhibitor protein XIP-I...