Research Topics
| I T JohnsonSummaryAffiliation: Institute for Animal Health Country: UK Publications
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Detail Information
Publications
Identification of the Eph receptor pathway as a novel target for eicosapentaenoic acid (EPA) modification of gene expression in human colon adenocarcinoma cells (HT-29)Joanne F Doleman
Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
Nutr Metab (Lond) 7:56. 2010..The health benefits of polyunsaturated fatty acids (PUFAs), particularly those of the n-3 series are well documented. The mechanisms by which these effects are mediated are not fully clarified...- 2D-electrophoresis and multiplex immunoassay proteomic analysis of different body fluids and cellular components reveal known and novel markers for extended fastingFreek G Bouwman
Department of Human Biology, NUTRIM, Maastricht University, Maastricht, The Netherlands
BMC Med Genomics 4:24. 2011..Proteomic technologies applied for profiling human biofluids and blood cells are considered to reveal new biomarkers of exposure or provide insights into novel mechanisms of adaptation... - Ulcerative colitis and irritable bowel patients exhibit distinct abnormalities of the gut microbiotaSamah O Noor
Institute of Food Research, Norwich, UK
BMC Gastroenterol 10:134. 2010..Our aim was to investigate any quantitative differences in faecal bacterial compositions in UC and IBS patients compared to healthy controls, and to identify individual bacterial species that contribute to these differences... 
Glucosinolates: bioavailability and importance to healthIan T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
Int J Vitam Nutr Res 72:26-31. 2002....- Micronutrients and cancerI T Johnson
Institute of Food Research, Norwich Research Park, Colney, UK
Proc Nutr Soc 63:587-95. 2004..There seems little doubt that micronutrients contribute to the protective effects of plant foods against cancers of the lung and alimentary tract, but it has not been established that these benefits can be achieved using supplements... - Phytochemicals and cancerIan T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Proc Nutr Soc 66:207-15. 2007.... - New food components and gastrointestinal healthI T Johnson
Institute of Food Research, Norwich, Norfolk, UK
Proc Nutr Soc 60:481-8. 2001.... - Review article: nutrition, obesity and colorectal cancerI T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
Aliment Pharmacol Ther 26:161-81. 2007..The age-adjusted incidence of colorectal cancer is higher in prosperous industrialized countries than elsewhere. Dietary factors may account for 75% of sporadic colorectal cancer in the west, but the mechanisms remain obscure... - Environment, diet and CpG island methylation: epigenetic signals in gastrointestinal neoplasiaIan T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Food Chem Toxicol 46:1346-59. 2008.... - New approaches to the role of diet in the prevention of cancers of the alimentary tractI T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Mutat Res 551:9-28. 2004..The future challenge is to fully characterise and evaluate these effects at the cellular and molecular level, so at to exploit their full potential as protective mechanisms for the population as a whole... - Using smart card technology to monitor the eating habits of children in a school cafeteria: 3. The nutritional significance of beverage and dessert choicesN Lambert
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
J Hum Nutr Diet 18:271-9. 2005..The aim of this study was to continuously monitor the choice of beverages and desserts made by nearly 1000 children in a school cafeteria... - Using smart card technology to monitor the eating habits of children in a school cafeteria: 2. The nutrient contents of all meals chosen by a group of 8- to 11-year-old boys over 78 daysN Lambert
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
J Hum Nutr Diet 18:255-65; quiz 267-9. 2005..The aim of the study was to test the abilities of the newly created smart card system to track the nutrient contents of foods chosen over several months by individual diners in a school cafeteria... - Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosaN J Belshaw
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Br J Cancer 99:136-42. 2008..Methylation of the genes selected by the models may play a role in the earliest stages of the development of colorectal neoplasia... 
Can the rat be used as a valid model of human esophageal adenocarcinoma?A Hindmarsh
Department of Upper GI Surgery, Norfolk and Norwich University Hospital, Norwich, UK
Dis Esophagus 25:159-65. 2012....- Effects of cellular redox balance on induction of apoptosis by eicosapentaenoic acid in HT29 colorectal adenocarcinoma cells and rat colon in vivoP Latham
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Gut 49:97-105. 2001..The data suggest a mechanism whereby polyunsaturated fatty acids may influence the susceptibility of colorectal crypt cells to induction or progression of neoplasia... - Quercetin glucosides interact with the intestinal glucose transport pathwayJ M Gee
Nutrition Diet and Health Department, Institute of Food Research, Norwich Laboratory, Norfolk, UK
Free Radic Biol Med 25:19-25. 1998..These studies suggest that purified quercetin glucosides are capable of interacting with the sodium dependent glucose transport receptors in the mucosal epithelium and may therefore be absorbed by the small intestine in vivo... - Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteersE K Lund
Institute of Food Research, Norwich Research Park, Colney, United Kingdom
Am J Clin Nutr 69:250-5. 1999..Most dietary iron remains unabsorbed and hence may be available to participate in Fenton-driven free radical generation in conjunction with the colonic microflora, leading to the production of carcinogens or direct damage to colonocytes... - Polyphenolic compounds: interactions with the gut and implications for human healthJ M Gee
Institute of Food Research, Norwich Laboratory, Norwich Research Park, Colney, NR4 7UA, UK
Curr Med Chem 8:1245-55. 2001..Future research should therefore focus on the biological effects of flavonoids in the human body, using biomarkers to define their effects at each stage in the onset of neoplasia... - Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosaI T Johnson
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Food Chem Toxicol 40:1171-8. 2002..Further mechanistic and clinical studies are required to establish whether such dietary effects can be exploited to achieve preventive or therapeutic effects in humans... - Systematic review: Cyclo-oxygenase-2 in human oesophageal adenocarcinogenesisS Mehta
Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Aliment Pharmacol Ther 24:1321-31. 2006..Other non-cyclo-oxygenase-2 targets may account for the epidemiological data supporting the use of non-steroidal anti-inflammatory drugs in the chemoprevention of oesophageal adenocarcinoma... - Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitroA P Wilkinson
Nutrition and Consumer Sciences Division, Institute of Food Research, Colney, Norwich NR4 7UA, UK
Xenobiotica 33:255-64. 2003.... - Chronic exposure to high levels of dietary iron fortification increases lipid peroxidation in the mucosa of the rat large intestineE K Lund
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
J Nutr 131:2928-31. 2001..These results may be relevant to epidemiological evidence showing that dietary iron is associated with the risk of proximal colon cancer in humans... - Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cellsTracy K Smith
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Carcinogenesis 25:1409-15. 2004..AITC inhibits proliferation of cancer cells by causing mitotic block associated with disruption of alpha-tubulin in a manner analogous to a number of chemotherapeutic agents... - Involvement of KLF4 in sulforaphane- and iberin-mediated induction of p21(waf1/cip1)Maria H Traka
Phytochemicals and Health Programme, Institute of Food Research, Colney, England
Nutr Cancer 61:137-45. 2009..These results suggest that induction of p21(waf1/cip1) by SF or IB may be partly mediated by KLF4 in some colon cancer cells and tissues... - Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in ratsJennifer M Gee
Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, Norwich, Norfolk NR4 7UA, UK
Nutr Cancer 43:193-201. 2002..At low concentrations, dietary quercetin inhibits induction of aberrant crypts by a mechanism that does not involve increased crypt cell apoptosis... - Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosaNigel J Belshaw
Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
Carcinogenesis 31:1158-63. 2010.... - Methylation of the ESR1 CpG island in the colorectal mucosa is an 'all or nothing' process in healthy human colon, and is accelerated by dietary folate supplementation in the mouseN J Belshaw
Institute of Food Research, Colney Lane, Norwich NR4 7UA, UK
Biochem Soc Trans 33:709-11. 2005..Preliminary studies with a rodent model suggest the rate of age-dependent methylation of ESR1 is modifiable by dietary folate... - The procyanidin-mediated induction of apoptosis and cell-cycle arrest in esophageal adenocarcinoma cells is not dependent on p21(Cip1/WAF1)R Pierini
Institute of Food Research, Norwich Research Park, Colney Lane, Norwich NR4 7UA, UK
Cancer Lett 270:234-41. 2008..However, blocking the PA-induced up-regulation of p21 expression with siRNA did not alter PA-mediated changes in apoptosis and cell cycle, demonstrating that p21 is not responsible for the PA-induced effects... - Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivoTracy K Smith
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Carcinogenesis 24:491-5. 2003..We conclude that glucosinolate breakdown products derived from Brassica vegetables can exert a profound effect on the balance of colorectal cell proliferation and death in an animal model of colorectal neoplasia... - Use of DNA from human stools to detect aberrant CpG island methylation of genes implicated in colorectal cancerNigel J Belshaw
Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
Cancer Epidemiol Biomarkers Prev 13:1495-501. 2004.... - Effects of Brussels sprout juice on the cell cycle and adhesion of human colorectal carcinoma cells (HT29) in vitroTracy K Smith
Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, United Kingdom
J Agric Food Chem 53:3895-901. 2005.... - Development of a food frequency questionnaire for the assessment of quercetin and naringenin intakeS Ranka
Department of Surgery, Norfolk and Norwich University Hospital, Norwich, UK
Eur J Clin Nutr 62:1131-8. 2008..To measure the relationship between quercetin and naringenin intakes as estimated by food frequency questionnaire (FFQ), and the urinary excretion of quercetin and naringenin aglycones after their enzymatic hydrolysis in human volunteers... - Evidence for consistent patterns between flavonoid structures and cellular activitiesF Depeint
Institute of Food Research, Norwich Research Park, Colney, UK
Proc Nutr Soc 61:97-103. 2002..The present review also presents a summary of mechanistic data on a few elected compounds... - Flavonoids and intestinal cancersRoberto Pierini
Institute of Food Research, Norwich Research Park, Colney, Norwich NR4 7UA, UK
Br J Nutr 99:ES53-9. 2008.... - Using smart card technology to monitor the eating habits of children in a school cafeteria: 1. Developing and validating the methodologyN Lambert
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
J Hum Nutr Diet 18:243-54. 2005..The aim of the study was to test the feasibility of using smart card technology to track the eating behaviours of nearly a thousand children in a school cafeteria... - Systematic review: the chemoprevention of oesophageal adenocarcinomaS Mehta
Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University Hospital, Colney Lane, Norwich, UK
Aliment Pharmacol Ther 22:759-68. 2005..Dietary agents, however, have a more favourable side-effect profile and may prove to be an attractive alternative, although more work is needed to fully explore this prospect... - Nutrigenomic approaches for obesity researchR M Elliott
Institute of Food Research, Colney, Norwich, UK
Obes Rev 8:77-81. 2007 - Olive oil supplementation in healthy adults: effects in cell membrane fatty acid composition and platelet functionI M Vicario
Institute of Food Research Norwich Laboratory, Norwich Research Park, Colney, UK
Ann Nutr Metab 42:160-9. 1998..None of these changes in fatty acid composition in the different tissues were related to significant changes in serum cholesterol-related variables or in clotting factors or adenosine diphosphate-induced platelet aggregation... - Cyclo-oxygenase-2 expression in Barrett's oesophageal carcinogenesis: an immunohistochemical studyE Cheong
General Surgery Department, Norfolk and Norwich University Hospital, Colney, UK
Aliment Pharmacol Ther 17:379-86. 2003..These findings may be significant for an effective chemo-prevention strategy with selective cyclo-oxygenase-2 inhibitors... - Synthetic and naturally occurring COX-2 inhibitors suppress proliferation in a human oesophageal adenocarcinoma cell line (OE33) by inducing apoptosis and cell cycle arrestE Cheong
General Surgery Department, Norfolk and Norwich University Hospital, Colney, Norwich NR4 7UY, UK
Carcinogenesis 25:1945-52. 2004..Synthetic COX-2 inhibitors and the food-borne flavonoid quercetin suppress proliferation, induce apoptosis and cell cycle block in human oesophageal adenocarcinoma cells in vitro, and future studies should assess their effects in vivo... - Procyanidin effects on oesophageal adenocarcinoma cells strongly depend on flavan-3-ol degree of polymerizationRoberto Pierini
Institute of Food Research, Norwich Research Park, Colney, Norwich, UK
Mol Nutr Food Res 52:1399-407. 2008..As tested flavan-3-ol concentrations are achievable through diet, this study suggests that apple-derived PA may possess chemotherapeutic effects against OA... - Proteomic analysis reveals field-wide changes in protein expression in the morphologically normal mucosa of patients with colorectal neoplasiaAbigael C J Polley
Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
Cancer Res 66:6553-62. 2006.... - Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humansJennifer M Gee
Nutrition Division, Institute of Food Research, Norwich, United Kingdom
Nutrition 21:1036-43. 2005..There was no effect on plasma glucan-like peptide-1. CONCLUSION: Our observations are consistent with a role for fermentation products in the release of gastrointestinal peptides in the rat and, to a lesser extent, in humans... - Emerging diet-related surrogate end points for colorectal cancer: UK Food Standards Agency diet and colonic health workshop reportPeter Sanderson
Nutrition Division, Food Standards Agency, London, UK
Br J Nutr 91:315-23. 2004.... - Polyphenols: antioxidants and beyondAugustin Scalbert
Laboratoire des Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomique, Saint Genes Champanelle, France
Am J Clin Nutr 81:215S-217S. 2005.... - Cancers of the gut and Western illsIan T Johnson
Science 307:1839. 2005 - Absorption of quercetin-3-glucoside and quercetin-4'-glucoside in the rat small intestine: the role of lactase phlorizin hydrolase and the sodium-dependent glucose transporterAndrea J Day
Procter Department of Food Science, University of Leeds, Leeds LS2 9JT, UK
Biochem Pharmacol 65:1199-206. 2003..Evidently the mechanism of absorption of quercetin-4'-glucoside involves both an interaction with SGLT1 and luminal hydrolysis by LPH, whereas quercetin-3-glucoside appears to be absorbed only following hydrolysis by LPH... - Reduced Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels from arteries of Type 2 diabetic Zucker diabetic fatty ratsMatthew P Burnham
Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK
Am J Physiol Heart Circ Physiol 290:H1520-7. 2006..This altered function was related to a reduced Ca(2+)-dependent activation of the channel not involving beta(1) subunits... - Pea (Pisum sativum L.) protease inhibitors from the Bowman-Birk class influence the growth of human colorectal adenocarcinoma HT29 cells in vitroAlfonso Clemente
Department of Metabolic Biology, John Innes Centre, Norwich Research Park, Norwich NR4 7UH, United Kingdom
J Agric Food Chem 53:8979-86. 2005..The relative effectiveness of rTI1B and rTI2B may correlate with a variant amino acid sequence within their respective chymotrypsin inhibitory domain, in agreement with a chymotrypsin-like protease as a potential target... - Metabolism of the soybean isoflavone glycoside genistin in vitro by human gut bacteria and the effect of prebioticsToni E Steer
School of Food Biosciences, The University of Reading, Reading, Berks, UK
Br J Nutr 90:635-42. 2003..In particular, the use of FOS not only augmented this effect, but also conferred an additional benefit in selectively increasing numbers of purportedly beneficial bacteria such as bifidobacteria and lactobacilli... - Effect of n-3 polyunsaturated fatty acids on Barrett's epithelium in the human lower esophagusSamir P Mehta
Department of Upper Gastrointestinal Surgery and the Department of Histopathology, Norfolk and Norwich University Hospital, Norwich, United Kingdom
Am J Clin Nutr 87:949-56. 2008..One possible explanation is the suppression of eicosanoid production through inhibition of cyclooxygenase 2 (COX-2)...