Terry Jackson

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding
    T Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 81:1383-91. 2000
  2. pmc A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells
    Sarah Gold
    Pirbright Laboratory, Institute for Animal Health, Woking, United Kingdom
    PLoS ONE 5:e11360. 2010
  3. pmc The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus
    T Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 74:4949-56. 2000
  4. pmc Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection
    Terry Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 78:4533-40. 2004
  5. pmc Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus
    Terry Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, UK
    J Virol 76:935-41. 2002
  6. pmc Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus
    Stephen Berryman
    Mammalian Virology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 79:8519-34. 2005
  7. ncbi request reprint The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle
    Paul Monaghan
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 86:2769-80. 2005
  8. pmc Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen
    Claudine Porta
    The Pirbright Insitute, Pirbright, Woking, United Kingdom
    PLoS Pathog 9:e1003255. 2013
  9. pmc A dominant-negative mutant of rab5 inhibits infection of cells by foot-and-mouth disease virus: implications for virus entry
    Helen L Johns
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey, United Kingdom
    J Virol 83:6247-56. 2009
  10. pmc Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins
    Alison Burman
    Division of Microbiology, Institute for Animal Health, Pirbright, Surrey, GU24 ONF, United Kingdom
    J Virol 80:9798-810. 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding
    T Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 81:1383-91. 2000
    ....
  2. pmc A clathrin independent macropinocytosis-like entry mechanism used by bluetongue virus-1 during infection of BHK cells
    Sarah Gold
    Pirbright Laboratory, Institute for Animal Health, Woking, United Kingdom
    PLoS ONE 5:e11360. 2010
    ....
  3. pmc The epithelial integrin alphavbeta6 is a receptor for foot-and-mouth disease virus
    T Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 74:4949-56. 2000
    ..These studies establish a role for alphavbeta6 as a cellular receptor for FMDV...
  4. pmc Integrin alphavbeta8 functions as a receptor for foot-and-mouth disease virus: role of the beta-chain cytodomain in integrin-mediated infection
    Terry Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 78:4533-40. 2004
    ..These data suggest that the beta6 cytodomain is important for maintaining alphavbeta6 in a conformation required for productive infection by FMDV...
  5. pmc Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus
    Terry Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, UK
    J Virol 76:935-41. 2002
    ..In addition, data are presented suggesting that amino acid residues near the RGD motif may be important for differentiating between the binding specificities of alphavbeta1 and alphavbeta6...
  6. pmc Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus
    Stephen Berryman
    Mammalian Virology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 79:8519-34. 2005
    ..These findings are all consistent with FMDV infection proceeding via clathrin-dependent endocytosis...
  7. ncbi request reprint The alpha(v)beta6 integrin receptor for Foot-and-mouth disease virus is expressed constitutively on the epithelial cells targeted in cattle
    Paul Monaghan
    Institute for Animal Health, Pirbright Laboratory, Ash Road, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 86:2769-80. 2005
    ..Together, these data suggest that in cattle, alpha(v)beta6, rather than alpha(v)beta3, serves as the major receptor that determines the tropism of FMDV for the epithelia normally targeted by this virus...
  8. pmc Rational engineering of recombinant picornavirus capsids to produce safe, protective vaccine antigen
    Claudine Porta
    The Pirbright Insitute, Pirbright, Woking, United Kingdom
    PLoS Pathog 9:e1003255. 2013
    ..Similar strategies that will optimize host cell viability during expression of a foreign toxic gene and/or improve capsid stability could allow the production of safe vaccines for other pathogenic picornaviruses of humans and animals...
  9. pmc A dominant-negative mutant of rab5 inhibits infection of cells by foot-and-mouth disease virus: implications for virus entry
    Helen L Johns
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey, United Kingdom
    J Virol 83:6247-56. 2009
    ..However, our results suggest that infection may not be exclusive to EE and that a small amount of infection could occur from within PNRE...
  10. pmc Specificity of the VP1 GH loop of Foot-and-Mouth Disease virus for alphav integrins
    Alison Burman
    Division of Microbiology, Institute for Animal Health, Pirbright, Surrey, GU24 ONF, United Kingdom
    J Virol 80:9798-810. 2006
    ..Taken together, our data suggest that the integrin binding loop of FMDV has most likely evolved for binding to alphavbeta6 with a higher affinity than to alphavbeta3 and alphavbeta8...
  11. doi request reprint Integrin sub-unit expression in cell cultures used for the diagnosis of foot-and-mouth disease
    Donald P King
    Institute for Animal Health, Ash Road, Pirbright, Surrey, GU24 0NF, United Kingdom
    Vet Immunol Immunopathol 140:259-65. 2011
    ....
  12. pmc Foot-and-mouth disease virus replicates only transiently in well-differentiated porcine nasal epithelial cells
    Pradyot Dash
    Institute for Animal Health, Pirbright Laboratory, Pirbright, Woking, Surrey GU24 0NF, United Kingdom
    J Virol 84:9149-60. 2010
    ....
  13. pmc A role for endoplasmic reticulum exit sites in foot-and-mouth disease virus infection
    Rebecca Midgley
    The Pirbright Institute, Pirbright, Surrey GU24 0NF, UK
    J Gen Virol 94:2636-46. 2013
    ..Together, these observations argue for a role for Sar1 in FMDV infection and that initial virus replication takes place on membranes that are formed at ERESs. ..
  14. pmc An infectious recombinant foot-and-mouth disease virus expressing a fluorescent marker protein
    Julian Seago
    The Pirbright Institute, Woking, Surrey GU24 0NF, UK
    J Gen Virol 94:1517-27. 2013
    ..iLOV-FMDV therefore offers a unique tool to characterize FMDV infection in vitro, and its applications for in vivo studies are discussed...
  15. pmc Efficient production of foot-and-mouth disease virus empty capsids in insect cells following down regulation of 3C protease activity
    Claudine Porta
    Institute for Animal Health, Ash Road, Pirbright, Woking GU24 0NF, UK
    J Virol Methods 187:406-12. 2013
    ..Expression was independent of the insect host cell background and leads to capsids that are recognised as authentic by a range of anti-FMDV bovine sera suggesting their feasibility as an alternate vaccine...
  16. ncbi request reprint Utility of recombinant integrin alpha v beta6 as a capture reagent in immunoassays for the diagnosis of foot-and-mouth disease
    Nigel P Ferris
    Institute for Animal Health, Pirbright Laboratory, Woking, Surrey GU24 0NF, UK
    J Virol Methods 127:69-79. 2005
    ....
  17. pmc Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro
    Hannah Armer
    Institute for Animal Health, Woking, Surrey, United Kingdom
    J Virol 82:10556-66. 2008
    ..In contrast, infection of cells with another picornavirus, bovine enterovirus, did not affect gamma-tubulin distribution, and the microtubule network remained relatively unaffected...
  18. pmc Positively charged residues at the five-fold symmetry axis of cell culture-adapted foot-and-mouth disease virus permit novel receptor interactions
    Stephen Berryman
    Pirbright Institute, Pirbright, Surrey, United Kingdom
    J Virol 87:8735-44. 2013
    ..The introduction of lysine at VP1-110 may allow for cell culture adaptation of FMDV by design, which may prove useful for vaccine manufacture when cell culture adaptation proves intractable. ..
  19. pmc Arginine-glycine-aspartic acid-specific binding by foot-and-mouth disease viruses to the purified integrin alpha(v)beta3 in vitro
    T Jackson
    Pirbright Laboratory, Institute for Animal Health, Surrey, United Kingdom
    J Virol 71:8357-61. 1997
    ....
  20. pmc Characterization of epitope-tagged foot-and-mouth disease virus
    Julian Seago
    Pirbright Laboratory, Institute for Animal Health, Woking, Surrey, GU24 0NF, UK
    J Gen Virol 93:2371-81. 2012
    ..Tagged FMDV offers a feasible alternative to the current methods of vaccine concentration and purification, a potential to develop FMD vaccine conjugates and a unique tool for FMDV research...
  21. pmc Role of the cytoplasmic domain of the beta-subunit of integrin alpha(v)beta6 in infection by foot-and-mouth disease virus
    L C Miller
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey GU24 ONF, United Kingdom
    J Virol 75:4158-64. 2001
    ..The importance of endosomal acidification in alpha(v)beta6-mediated infection was confirmed by experiments showing that infection could be blocked by concanamycin A, a specific inhibitor of the vacuolar ATPase...
  22. pmc Foot-and-mouth disease virus exhibits an altered tropism in the presence of specific immunoglobulins, enabling productive infection and killing of dendritic cells
    L Robinson
    Pirbright Laboratory, Institute for Animal Health, Woking, Surrey, UK
    J Virol 85:2212-23. 2011
    ..Moreover, we propose that DC targeting could prove useful in the development of effective vaccines against FMDV...
  23. ncbi request reprint The ultrastructure of the developing replication site in foot-and-mouth disease virus-infected BHK-38 cells
    Paul Monaghan
    Institute for Animal Health, Ash Road, Pirbright, Woking, Surrey GU24 0NF, UK
    J Gen Virol 85:933-46. 2004
    ..With conventional fixation, FMDV particles were not seen; however, following high-pressure freezing and freeze-substitution, many clusters of virus-like particles were seen...
  24. pmc Foot-and-mouth disease virus induces autophagosomes during cell entry via a class III phosphatidylinositol 3-kinase-independent pathway
    Stephen Berryman
    Institute for Animal Health, Pirbright Laboratories, Woking, Surrey, United Kingdom
    J Virol 86:12940-53. 2012
    ..These results suggest that FMDV induces autophagosomes during cell entry to facilitate infection, but not to provide membranes for replication...
  25. ncbi request reprint Structure and receptor binding
    Terry Jackson
    Department of Molecular Biology, Institute for Animal Health, Pirbright, Surrey GU24 ONF, UK
    Virus Res 91:33-46. 2003
  26. ncbi request reprint Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity
    S Curry
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey, GU24 0NF, UK
    Structure 4:135-45. 1996
    ..Strains of the A22 subtype have been reported to change antigenically when adapted to different growth conditions. To investigate the structural basis of this phenomenon we have determined the structures of two variants of an A22 virus...
  27. pmc Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus
    S Curry
    Pirbright Laboratory, Institute for Animal Health, Surrey, United Kingdom
    J Virol 71:9743-52. 1997
    ..A comparison of the putative active sites in FMDV and poliovirus suggests a structural explanation for the sequence specificity of the cleavage reaction...
  28. pmc Efficient infection of cells in culture by type O foot-and-mouth disease virus requires binding to cell surface heparan sulfate
    T Jackson
    Pirbright Laboratory, Institute for Animal Health, Pirbright, Surrey, United Kingdom
    J Virol 70:5282-7. 1996
    ..The results show that entry of type O FMDV into cells is a complex process and suggest that the initial contact with the cell surface is made through heparan sulfate...
  29. pmc Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness
    Danielle DiCara
    Centre for Tumour Biology, Barts and the London Queen Mary s Medical and Dental School, Charterhouse Square, London EC1M 6BQ, United Kingdom
    J Virol 82:1537-46. 2008
    ..An ability to induce such stable complexes with its cellular receptor is likely to contribute significantly to the high infectiousness of FMDV...
  30. pmc Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host
    Jose I Núñez
    Centro de Biologia Molecular Severo Ochoa, Cantoblanco, 28049 Madrid, Spain
    J Virol 81:8497-506. 2007
    ..These observations illustrate how the appearance of minority variant viruses in an unnatural host can result in the dominance of these viruses on reinfection of the original host species...
  31. pmc Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9
    Cigdem H Williams
    Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, United Kingdom
    J Virol 78:6967-73. 2004
    ..Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections...
  32. ncbi request reprint Structure of Foot-and-mouth disease virus serotype A10 61 alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation
    Elizabeth E Fry
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Headington, Oxford OX3 7BN, UK
    J Gen Virol 86:1909-20. 2005
    ..Heparin bound at a similar site and in a similar conformation to that seen in the analogous complex with O(1)BFS, although the binding had a lower affinity and was more ionic...