D A Hughes

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes
    Joanna R Worley
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Cardiovasc Diabetol 6:21. 2007
  2. pmc Pro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trial
    Mark S Winterbone
    Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK
    Cardiovasc Diabetol 6:8. 2007
  3. pmc Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control
    Deepak Kejariwal
    Department of Gastroenterology, Norfolk and Norwich University Hospital Colney Lane, Norwich NR4 7UY, UK
    BMC Endocr Disord 8:12. 2008
  4. ncbi request reprint Effects of dietary antioxidants on the immune function of middle-aged adults
    D A Hughes
    Department of Nutrition, Diet and Health, Institute of Food Research, Norwich, UK
    Proc Nutr Soc 58:79-84. 1999
  5. ncbi request reprint Effects of carotenoids on human immune function
    D A Hughes
    Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, UK
    Proc Nutr Soc 58:713-8. 1999
  6. pmc Vitamin D and respiratory health
    D A Hughes
    Institute of Food Research, Norwich Research Park, University of East Anglia, Norwich, UK
    Clin Exp Immunol 158:20-5. 2009
  7. ncbi request reprint Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers
    D A Hughes
    Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk, NR4 7UA, UK
    J Infect Dis 182:S11-5. 2000
  8. ncbi request reprint Dietary carotenoids and human immune function
    D A Hughes
    Immunology Group, Nutrition, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Norwich, Norfolk, NR4 7UA, United Kingdom
    Nutrition 17:823-7. 2001
  9. ncbi request reprint n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro-inflammatory mediators in Type 2 diabetes mellitus
    M J Sampson
    Bertram Diabetes Research Unit, Norfolk, UK
    Diabet Med 18:51-8. 2001
  10. doi request reprint Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes
    J A Cross
    Institute of Food Research, Colney Lane, Norwich, UK
    Diabet Med 27:1264-70. 2010

Collaborators

  • A J Wright
  • P M Finglas
  • S Southon
  • Susan J Fairweather-Tait
  • Kamal Ivory
  • M J Sampson
  • J A Cross
  • Mike J Sampson
  • C Brennan
  • R C Temple
  • D Fowler
  • J C Hughes
  • Deepak Kejariwal
  • Joanna R Worley
  • Mark S Winterbone
  • J C Brown
  • I R Davies
  • B M Corridan
  • N C Dozio
  • H R Murphy
  • K Stanley
  • H Murphy
  • N J Levell
  • N Dozio
  • T Gray
  • Karolina M Stepien
  • Hugh Kennedy
  • Tracy Smith
  • Jackie C Hughes
  • Nicoletta Dozio
  • Jelena Gavrilovic
  • Shikha Saha
  • A P Sampson
  • A J James
  • V Morgan
  • P A Morrissey
  • T Richardson

Detail Information

Publications16

  1. pmc Low density lipoprotein from patients with Type 2 diabetes increases expression of monocyte matrix metalloproteinase and ADAM metalloproteinase genes
    Joanna R Worley
    School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK
    Cardiovasc Diabetol 6:21. 2007
    ..We hypothesised that plasma low density lipoprotein [LDL] from subjects with Type 2 diabetes would influence in vitro monocytic ADAM and matrix metalloproteinase [MMP] gene expression differently compared to control LDL...
  2. pmc Pro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trial
    Mark S Winterbone
    Institute of Food Research, Norwich Research Park, Norwich, NR4 7UA, UK
    Cardiovasc Diabetol 6:8. 2007
    ....
  3. pmc Lack of association of colonic epithelium telomere length and oxidative DNA damage in Type 2 diabetes under good metabolic control
    Deepak Kejariwal
    Department of Gastroenterology, Norfolk and Norwich University Hospital Colney Lane, Norwich NR4 7UY, UK
    BMC Endocr Disord 8:12. 2008
    ..We hypothesised that the colonic mucosa in Type 2 diabetes would be characterised by increased DNA damage and telomere shortening...
  4. ncbi request reprint Effects of dietary antioxidants on the immune function of middle-aged adults
    D A Hughes
    Department of Nutrition, Diet and Health, Institute of Food Research, Norwich, UK
    Proc Nutr Soc 58:79-84. 1999
    ..A further review, dealing more specifically with the effects of carotenoids on human immune function, will be presented at a forthcoming meeting of the Nutrition Society...
  5. ncbi request reprint Effects of carotenoids on human immune function
    D A Hughes
    Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, UK
    Proc Nutr Soc 58:713-8. 1999
    ..Finally, possible reasons for the failure of three major prospective studies to demonstrate a beneficial effect of beta-carotene supplementation on lung cancer risk will be discussed...
  6. pmc Vitamin D and respiratory health
    D A Hughes
    Institute of Food Research, Norwich Research Park, University of East Anglia, Norwich, UK
    Clin Exp Immunol 158:20-5. 2009
    ....
  7. ncbi request reprint Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers
    D A Hughes
    Diet, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk, NR4 7UA, UK
    J Infect Dis 182:S11-5. 2000
    ..These findings emphasize that it cannot be assumed that the effect of one carotenoid will be the same as another, even at the same level of intake...
  8. ncbi request reprint Dietary carotenoids and human immune function
    D A Hughes
    Immunology Group, Nutrition, Health and Consumer Science Division, Institute of Food Research, Norwich Research Park, Norwich, Norfolk, NR4 7UA, United Kingdom
    Nutrition 17:823-7. 2001
    ..Future studies comparing supplements with real foodstuffs, combined with postgenomic technologies, will help define optimal intakes for different sectors of the population...
  9. ncbi request reprint n-3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro-inflammatory mediators in Type 2 diabetes mellitus
    M J Sampson
    Bertram Diabetes Research Unit, Norfolk, UK
    Diabet Med 18:51-8. 2001
    ....
  10. doi request reprint Cord blood telomere length, telomerase activity and inflammatory markers in pregnancies in women with diabetes or gestational diabetes
    J A Cross
    Institute of Food Research, Colney Lane, Norwich, UK
    Diabet Med 27:1264-70. 2010
    ....
  11. ncbi request reprint n-3 polyunsaturated fatty acids inhibit the antigen-presenting function of human monocytes
    D A Hughes
    Diet, Health and Consumer Science Division, the Institute of Food Research, Norwich Research Park, Colney, Norwich, Norfolk, NR4 7UA, United Kingdom
    Am J Clin Nutr 71:357S-60S. 2000
    ....
  12. ncbi request reprint Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in type 2 diabetes
    M J Sampson
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7UA, UK
    Diabetologia 49:1726-31. 2006
    ....
  13. ncbi request reprint Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after antioxidant treatment in type 2 diabetes and control patients
    M J Sampson
    Bertram Diabetes Research Unit, Department of Diabetes and Endocrinology, Norfolk and Norwich University Hospital NHS Trust, Colney, Norwich, UK
    Arterioscler Thromb Vasc Biol 22:1187-93. 2002
    ....
  14. ncbi request reprint Reticulated platelets interfere with flow cytometric reticulocyte counts
    K Ivory
    Gastrointestinal Biology and Health, Institute of Food Research, Colney, Norwich, East Anglia, UK
    Int J Lab Hematol 29:352-60. 2007
    ..We conclude that it is necessary to exclude reticulated platelets from flow cytometric reticulocyte analysis...
  15. doi request reprint Absence of telomere shortening and oxidative DNA damage in the young adult offspring of women with pre-gestational type 1 diabetes
    J A Cross
    Institute of Food Research, Norwich, UK
    Diabetologia 52:226-34. 2009
    ..The aim of the present study was to test the hypothesis that fetal chromosomal telomere oxidative DNA damage resulting from maternal PGDM programmes the offspring towards a senescent phenotype that is detectable in young adulthood...
  16. ncbi request reprint Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans
    B M Corridan
    Nutritional Sciences, Department of Food Science and Technology, University College, Cork, Ireland
    Eur J Clin Nutr 55:627-35. 2001
    ....