Jonathan Houseley

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK
    Nucleic Acids Res 39:8778-91. 2011
  2. pmc Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e12271. 2010
  3. pmc Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 26:4996-5006. 2007
  4. pmc Yeast Trf5p is a nuclear poly(A) polymerase
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Edinburgh EH9 3JR, UK
    EMBO Rep 7:205-11. 2006
  5. pmc Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae
    Christophe Dez
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 25:1534-46. 2006
  6. doi request reprint A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, Institute for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Mol Cell 32:685-95. 2008
  7. doi request reprint The nuclear RNA surveillance machinery: the link between ncRNAs and genome structure in budding yeast?
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK
    Biochim Biophys Acta 1779:239-46. 2008
  8. ncbi request reprint RNA-quality control by the exosome
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK
    Nat Rev Mol Cell Biol 7:529-39. 2006
  9. doi request reprint The many pathways of RNA degradation
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR, UK
    Cell 136:763-76. 2009
  10. ncbi request reprint RNA degradation by the exosome is promoted by a nuclear polyadenylation complex
    John LaCava
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Cell 121:713-24. 2005

Collaborators

  • Alain Jacquier
  • Christophe Dez
  • David Tollervey
  • John LaCava
  • Elizabeth Thompson
  • Elisabeth Petfalski
  • Cosmin Saveanu

Detail Information

Publications10

  1. pmc Repeat expansion in the budding yeast ribosomal DNA can occur independently of the canonical homologous recombination machinery
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK
    Nucleic Acids Res 39:8778-91. 2011
    ..Our data suggest that a novel mode of break-induced replication occurs in repetitive DNA that is dependent on high homology but does not require the canonical homologous recombination machinery...
  2. pmc Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 5:e12271. 2010
    ..Particularly, the native ability of reverse transcriptase enzymes to template switch during transcription could produce apparently trans-spliced sequences...
  3. pmc Trf4 targets ncRNAs from telomeric and rDNA spacer regions and functions in rDNA copy number control
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 26:4996-5006. 2007
    ..Co-transcriptional RNA binding by Trf4 may link RNA and DNA metabolism and direct immediate IGS1-R degradation by the exosome following transcription termination...
  4. pmc Yeast Trf5p is a nuclear poly(A) polymerase
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Swann Building, King s Buildings, Edinburgh EH9 3JR, UK
    EMBO Rep 7:205-11. 2006
    ..Trf5p co-purified with Mtr4p and Air1p, indicating that it forms a complex, designated TRAMP5, that has functions that partially overlap with the TRAMP complex...
  5. pmc Surveillance of nuclear-restricted pre-ribosomes within a subnucleolar region of Saccharomyces cerevisiae
    Christophe Dez
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK
    EMBO J 25:1534-46. 2006
    ..Localization of pre-ribosomes to this focus was lost in sda1-2 strains lacking Trf4p or Rrp6p. We designate this nucleolar focus the No-body and propose that it represents a site of pre-ribosome surveillance...
  6. doi request reprint A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, Institute for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Mol Cell 32:685-95. 2008
    ..These chromatin modifications act principally through the Rpd3S complex to aid glucose repression of GAL1-10 at physiologically relevant sugar concentrations...
  7. doi request reprint The nuclear RNA surveillance machinery: the link between ncRNAs and genome structure in budding yeast?
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, UK
    Biochim Biophys Acta 1779:239-46. 2008
    ..Less well-understood observations link both the TRAMP and exosome complexes to chromatin structure and DNA repair, and we will speculate on the potential significance of these activities...
  8. ncbi request reprint RNA-quality control by the exosome
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, EH9 3JR, UK
    Nat Rev Mol Cell Biol 7:529-39. 2006
    ..Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes...
  9. doi request reprint The many pathways of RNA degradation
    Jonathan Houseley
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, EH9 3JR, UK
    Cell 136:763-76. 2009
    ..Because RNA degradation is ubiquitous in all cells, it is clear that it must be carefully controlled to accurately recognize target RNAs. How this is achieved is perhaps the most pressing question in the field...
  10. ncbi request reprint RNA degradation by the exosome is promoted by a nuclear polyadenylation complex
    John LaCava
    Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3JR, UK
    Cell 121:713-24. 2005
    ..We speculate that this function was maintained in eukaryotic nuclei, while cytoplasmic mRNA poly(A) tails acquired different roles in translation...