Jayne C Hope

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc DEC-205 expression on migrating dendritic cells in afferent lymph
    Daniel R Gliddon
    Institute for Animal Health, Compton, Newbury, Berks RG20 7NN, UK
    Immunology 111:262-72. 2004
  2. ncbi Bovine TB and the development of new vaccines
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Comp Immunol Microbiol Infect Dis 31:77-100. 2008
  3. ncbi Dendritic cells induce CD4+ and CD8+ T-cell responses to Mycobacterium bovis and M. avium antigens in Bacille Calmette Guérin vaccinated and nonvaccinated cattle
    J C Hope
    Institute for Animal Health, Compton, Newbury, RG20 7NN, UK
    Scand J Immunol 52:285-91. 2000
  4. ncbi Maturation of bovine dendritic cells by lipopeptides
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Vet Immunol Immunopathol 95:21-31. 2003
  5. pmc Vaccination of neonatal calves with Mycobacterium bovis BCG induces protection against intranasal challenge with virulent M. bovis
    J C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Clin Exp Immunol 139:48-56. 2005
  6. ncbi Development of detection methods for ruminant interleukin (IL)-4
    J C Hope
    Institute for Animal Health, Compton, Near Newbury, RG20 7NN, UK
    J Immunol Methods 301:114-23. 2005
  7. pmc Exposure to Mycobacterium avium induces low-level protection from Mycobacterium bovis infection but compromises diagnosis of disease in cattle
    J C Hope
    Institute for Animal Health, Compton, Newbury, UK
    Clin Exp Immunol 141:432-9. 2005
  8. ncbi Development of detection methods for ruminant interleukin (IL)-12
    J C Hope
    Institute for Animal Health, Compton, Near Newbury, UK
    J Immunol Methods 266:117-26. 2002
  9. ncbi Vaccines for bovine tuberculosis: current views and future prospects
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, RG207NN, UK
    Expert Rev Vaccines 4:891-903. 2005
  10. pmc Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish
    J C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Clin Vaccine Immunol 18:373-9. 2011

Detail Information

Publications44

  1. pmc DEC-205 expression on migrating dendritic cells in afferent lymph
    Daniel R Gliddon
    Institute for Animal Health, Compton, Newbury, Berks RG20 7NN, UK
    Immunology 111:262-72. 2004
    ..The observations imply that DCs in afferent lymph are all DEC-205high, but not a uniform population of homogeneous mature DCs...
  2. ncbi Bovine TB and the development of new vaccines
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Comp Immunol Microbiol Infect Dis 31:77-100. 2008
    ..In this review we discuss immune responses elicited by mycobacteria in cattle and the novel approaches emerging for the control of bovine TB based on our increasing knowledge of protective immune responses...
  3. ncbi Dendritic cells induce CD4+ and CD8+ T-cell responses to Mycobacterium bovis and M. avium antigens in Bacille Calmette Guérin vaccinated and nonvaccinated cattle
    J C Hope
    Institute for Animal Health, Compton, Newbury, RG20 7NN, UK
    Scand J Immunol 52:285-91. 2000
    ..The findings suggest that immunity to M. bovis induced by BCG vaccination in cattle may involve CD8+ memory T cells which produce IFN-gamma, as well as CD4+ memory T cells...
  4. ncbi Maturation of bovine dendritic cells by lipopeptides
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Vet Immunol Immunopathol 95:21-31. 2003
    ....
  5. pmc Vaccination of neonatal calves with Mycobacterium bovis BCG induces protection against intranasal challenge with virulent M. bovis
    J C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Clin Exp Immunol 139:48-56. 2005
    ..Overall, vaccination of neonatal calves with BCG induced significant protection against disease and has potential as a strategy for the reduction of the incidence of bovine tuberculosis...
  6. ncbi Development of detection methods for ruminant interleukin (IL)-4
    J C Hope
    Institute for Animal Health, Compton, Near Newbury, RG20 7NN, UK
    J Immunol Methods 301:114-23. 2005
    ....
  7. pmc Exposure to Mycobacterium avium induces low-level protection from Mycobacterium bovis infection but compromises diagnosis of disease in cattle
    J C Hope
    Institute for Animal Health, Compton, Newbury, UK
    Clin Exp Immunol 141:432-9. 2005
    ..The implication is that responses to M. avium, although providing some immunity, may mask diagnosis of M. bovis infection, even when specific antigens are employed, potentially contributing to disease transmission in the field...
  8. ncbi Development of detection methods for ruminant interleukin (IL)-12
    J C Hope
    Institute for Animal Health, Compton, Near Newbury, UK
    J Immunol Methods 266:117-26. 2002
    ..The ability to detect ruminant IL-12 by three methods: ELISA, bioassay with neutralising mAb and cytoplasmic staining, will permit studies of the role of this important cytokine in the immunology and pathogenesis of animal diseases...
  9. ncbi Vaccines for bovine tuberculosis: current views and future prospects
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, RG207NN, UK
    Expert Rev Vaccines 4:891-903. 2005
    ..These strategies are also highly applicable to the fight against tuberculosis in humans...
  10. pmc Identification of surrogates and correlates of protection in protective immunity against Mycobacterium bovis infection induced in neonatal calves by vaccination with M. bovis BCG Pasteur and M. bovis BCG Danish
    J C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    Clin Vaccine Immunol 18:373-9. 2011
    ..In addition, we show that measurement of antigen-specific T lymphocyte populations may provide a reliable means for identifying protective vaccine candidates...
  11. ncbi NK-like CD8(+) cells in immunologically naïve neonatal calves that respond to dendritic cells infected with Mycobacterium bovis BCG
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    J Leukoc Biol 71:184-94. 2002
    ..The presence of mycobacteria-reactive, IFN-gamma-secreting CD8(+) NK cells in neonatal calves may have important consequences for the induction of a Th1-biased immune response...
  12. ncbi Isolation and purification of afferent lymph dendritic cells that drain the skin of cattle
    Jayne C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Nat Protoc 1:982-7. 2006
    ..This technique, although technically demanding, facilitates studies of DCs and other cells that traffic in the lymph in both the steady state and following antigenic exposure...
  13. ncbi Differences in the induction of CD8+ T cell responses by subpopulations of dendritic cells from afferent lymph are related to IL-1 alpha secretion
    J C Hope
    Institute for Animal Health, Newbury, Berkshire, United Kingdom
    J Leukoc Biol 69:271-9. 2001
    ..We conclude that the failure to stimulate CD8+ T cell proliferation results from the lack of IL-1alpha synthesis by this population, which may have important consequences in vivo...
  14. ncbi Interaction of antigen presenting cells with mycobacteria
    J C Hope
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Vet Immunol Immunopathol 100:187-95. 2004
    ..These studies indicate that infection of bovine antigen presenting cells by mycobacterial species results in the induction of both innate and adaptive immune responses that are critical for the outcome of infection...
  15. pmc Workshop cluster 1+ gammadelta T-cell receptor T cells from calves express high levels of interferon-gamma in response to stimulation with interleukin-12 and -18
    Sally J Price
    Institute for Animal Health, Compton, Newbury, Berkshire, United Kingdom
    Immunology 120:57-65. 2007
    ..The high numbers of WC1(+)gammadelta T cells in neonatal calves, and their inherent ability to respond to inflammatory cytokines, could be a key factor in the enhanced responses seen in calves to BCG vaccination...
  16. pmc Enhanced secretion of interferon-gamma by bovine gammadelta T cells induced by coculture with Mycobacterium bovis-infected dendritic cells: evidence for reciprocal activating signals
    Sally J Price
    Institute for Animal Health, Compton, Newbury, Berkshire, UK
    Immunology 126:201-8. 2009
    ..These interactions are likely to form a critical part of the T helper type 1-conditioning response of DCs to M. bovis...
  17. ncbi Development of an ELISA for bovine IL-10
    L S Kwong
    Institute for Animal Health, Compton, Near Newbury, Berkshire RG20 7NN, UK
    Vet Immunol Immunopathol 85:213-23. 2002
    ....
  18. doi Natural killer cell number and phenotype in bovine peripheral blood is influenced by age
    Elizabeth M Graham
    Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom
    Vet Immunol Immunopathol 132:101-8. 2009
    ..However, the proportion of NKp46(+) and CD3(-)CD2(+) cells that expressed perforin was not significantly different in any age group tested...
  19. doi Development of a simple, sensitive, rapid test which discriminates BCG-vaccinated from Mycobacterium bovis-infected cattle
    P Sopp
    Institute for Animal Health, Compton, Newbury, Berkshire RG207NN, United Kingdom
    Vaccine 26:5470-6. 2008
    ....
  20. ncbi Masking of two in vitro immunological assays for Mycobacterium bovis (BCG) in calves acutely infected with non-cytopathic bovine viral diarrhoea virus
    B Charleston
    Institute for Animal Health, Compton, Newbury, Berkshire
    Vet Rec 149:481-4. 2001
    ..The implication is that acute infections of cattle with non-cytopathic BVDV may temporarily compromise diagnostic tests for M. bovis infections and result in a failure to identify cattle with tuberculosis...
  21. pmc Flow cytometric detection of gamma interferon can effectively discriminate Mycobacterium bovis BCG-vaccinated cattle from M. bovis-infected cattle
    P Sopp
    Institute for Animal Health, Compton, Newbury, Berkshire RG207NN, United Kingdom
    Clin Vaccine Immunol 13:1343-8. 2006
    ..bovis-infected animals. This assay could allow an accurate diagnosis of M. bovis and allow the discrimination of BCG-vaccinated cattle from infected cattle...
  22. ncbi The effect of repeated tuberculin skin testing of cattle on immune responses and disease following experimental infection with Mycobacterium bovis
    M Thom
    Institute for Animal Health, Compton, Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 102:399-412. 2004
    ..An antibody response was not evident as a result of repeat skin testing prior to infection but was seen in both groups of calves following skin testing performed 7 weeks after infection...
  23. ncbi Differential effects of bovine viral diarrhoea virus on monocytes and dendritic cells
    E J Glew
    Institute for Animal Health, Compton, Newbury, Berkshire, RG20 7NN UK
    J Gen Virol 84:1771-80. 2003
    ..We conclude that the prevention of cell death in DCs is not associated with enhanced production of IFN-alpha/beta, as proposed for influenza virus, but is by a distinct mechanism...
  24. pmc Alpha/beta and gamma interferons are induced by infection with noncytopathic bovine viral diarrhea virus in vivo
    B Charleston
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, United Kingdom
    J Virol 76:923-7. 2002
    ..The results of this study indicate that the immunosuppression caused by ncpBVDV is not associated with low interferon responses or elevated levels of TGF-beta...
  25. ncbi The effect of tuberculin testing on the development of cell-mediated immune responses during Mycobacterium bovis infection
    M L Thom
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Vet Immunol Immunopathol 114:25-36. 2006
    ..These observations may offer the potential for further diagnostic assays that could complement the TT and IFNgamma test...
  26. ncbi Co-stimulation and modulation of the ensuing immune response
    C J Howard
    Institute for Animal Health, Compton, Near Newbury RG20 7NN, UK
    Vet Immunol Immunopathol 87:123-30. 2002
    ..A model is proposed that takes these observations into account in which SIRPalpha(-) DC would be expected to promote a Th1 biased response and the SIRPalpha(+) DC a more balanced one...
  27. ncbi Dendritic cells, implications on function from studies of the afferent lymph veiled cell
    C J Howard
    Institute for Animal Health, Near Newbury RG20 7NN, Compton, UK
    Vet Immunol Immunopathol 77:1-13. 2000
    ..By deliberately targeting functionally distinct subsets of either precursor or mature dendritic cells in vivo, it should become feasible to achieve an appropriately biased immune response...
  28. pmc Exposure to Mycobacterium avium primes the immune system of calves for vaccination with Mycobacterium bovis BCG
    C J Howard
    Institute for Animal Health, Compton, Newbury, UK
    Clin Exp Immunol 130:190-5. 2002
    ..They suggest that M. avium infection primes the immune system of calves and that the detection of an immune response specific for M. bovis BCG is masked by reactivity to antigens also present in M. avium...
  29. ncbi The role of dendritic cells in shaping the immune response
    C J Howard
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Anim Health Res Rev 5:191-5. 2004
    ..Dendritic cells also interact with the innate immune system, inducing responses that potentially bias the subsequent adaptive response...
  30. doi Production and characterization of two monoclonal antibodies to bovine tumour necrosis factor alpha (TNF-alpha) and their cross-reactivity with ovine TNF-alpha
    L S Kwong
    Institute for Animal Health, Compton, Near Newbury, RG20 7NN, UK
    Vet Immunol Immunopathol 135:320-4. 2010
    ..These mAbs have generated the capability to study the role of TNF-alpha in host immune protection and disease pathogenesis in ruminants...
  31. ncbi Contribution of in vivo and ex vivo studies to understanding the role of antigen-presenting cells and T cell subsets in immunity to cattle diseases
    C J Howard
    Institute for Animal Health, Compton, Newbury, Berkshire RG20 7NN, UK
    Anim Health Res Rev 5:1-13. 2004
    ..Here the case is made for how studies in cattle have aided our understanding of immunity to several infections that can be exploited for the rational design of effective vaccination and control strategies...
  32. doi Characterisation of antibodies to bovine Toll-like receptor (TLR)-2 and cross-reactivity with ovine TLR2
    Lai Shan Kwong
    Institute for Animal Health, High Street, Compton, Newbury, Berkshire RG207NN, United Kingdom
    Vet Immunol Immunopathol 139:313-8. 2011
    ..The identification of antibodies specific for bovine and ovine TLR2 will facilitate studies of the role of this important PRR in the initiation of immune responses to important pathogens...
  33. pmc Anaplasma marginale major surface protein 2 CD4+-T-cell epitopes are evenly distributed in conserved and hypervariable regions (HVR), whereas linear B-cell epitopes are predominantly located in the HVR
    Jeffrey R Abbott
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    Infect Immun 72:7360-6. 2004
    ..The pattern of recognition of epitope clusters by T cells and of HVR epitopes by B cells is consistent with the influence of protein structure on epitope recognition...
  34. pmc DNA vaccine construct incorporating intercellular trafficking and intracellular targeting motifs effectively primes and induces memory B- and T-cell responses in outbred animals
    Waithaka Mwangi
    Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Clin Vaccine Immunol 14:304-11. 2007
    ..These results demonstrate that DNA vaccines targeting key intercellular and intracellular events significantly enhance priming and expansion and support the feasibility of single-dose DNA immunization in outbred populations...
  35. pmc Characterization of a phenotypically unique population of CD13+ dendritic cells resident in the spleen
    Yan Zhuang
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, 99164 7040, USA
    Clin Vaccine Immunol 13:1064-9. 2006
    ..Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses...
  36. pmc Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists
    Dirk Werling
    Institute of Veterinary Virology, University of Bern, CH 3012 Bern, Switzerland
    Immunology 111:41-52. 2004
    ..Collectively, our results point to profound differences in pathogen-derived signal-response coupling occurring commensurate with distinct functions carried out by Mphi or DC...
  37. ncbi CpG ODN 2006 and IL-12 are comparable for priming Th1 lymphocyte and IgG responses in cattle immunized with a rickettsial outer membrane protein in alum
    Yan Zhang
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, 99164 7040, USA
    Vaccine 21:3307-18. 2003
    ..No differences in IL-10 mRNA expression were detected among the groups. These results indicate that CpG ODN 2006 is an effective vaccine adjuvant for stimulating both antibody and IFN-gamma mediated cellular immune responses in cattle...
  38. ncbi Rapid and long-term disappearance of CD4+ T lymphocyte responses specific for Anaplasma marginale major surface protein-2 (MSP2) in MSP2 vaccinates following challenge with live A. marginale
    Jeffrey R Abbott
    Program in Vector borne Disease, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, 99164, USA
    J Immunol 174:6702-15. 2005
    ..marginale organisms. These results suggest that loss of memory T cell responses following A. marginale infection is due to a mechanism other than induction of T regulatory cells, such as peripheral deletion of MSP2-specific T cells...
  39. pmc Escherichia coli and Staphylococcus aureus elicit differential innate immune responses following intramammary infection
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, USDA Agricultural Research Service ANRI, BARC East, Bldg 1040, Room 2, Beltsville, MD 20705 2350, USA
    Clin Diagn Lab Immunol 11:463-72. 2004
    ..coli and S. aureus and suggest that the limited cytokine response to S. aureus may contribute to the well-known ability of the bacterium to establish chronic intramammary infection...
  40. ncbi DNA-encoded fetal liver tyrosine kinase 3 ligand and granulocyte macrophage-colony-stimulating factor increase dendritic cell recruitment to the inoculation site and enhance antigen-specific CD4+ T cell responses induced by DNA vaccination of outbred anim
    Waithaka Mwangi
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 169:3837-46. 2002
    ..These results support use of these growth factors in DNA vaccination and specifically indicate their applicability for vaccine testing in outbred animals...
  41. pmc Bovine NK cells can produce gamma interferon in response to the secreted mycobacterial proteins ESAT-6 and MPP14 but not in response to MPB70
    Ingrid Olsen
    National Veterinary Institute, P O Box 8156 Dep, 0033 Oslo, Norway
    Infect Immun 73:5628-35. 2005
    ....
  42. ncbi NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics
    Anne K Storset
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Oslo, Norway
    Eur J Immunol 34:669-76. 2004
    ..Together, these data indicate that bovine NKp46 is anactivating receptor and demonstrate the existence of a subset of leukocytes in cattle that, in terms of surface markers, morphology and function, represent NK cells...
  43. ncbi The bovine innate immune response during experimentally-induced Pseudomonas aeruginosa mastitis
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, USDA Agricultural Research Service, ANRI, BARC East, Bldg 1040, Room 2, Beltsville, MD 20705 2350, USA
    Vet Immunol Immunopathol 107:201-15. 2005
    ..aeruginosa that is characterized by the induction of pro-inflammatory cytokines, complement activation, and increased levels of accessory molecules involved in Gram-negative bacterial recognition...
  44. ncbi Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis
    Douglas D Bannerman
    Bovine Functional Genomics Laboratory, Beltsville Agricultural Research Center, USDA Agricultural Research Service, Beltsville, MD 20705, USA
    Vet Res 35:681-700. 2004
    ..marcescens infection. Together, these data demonstrate the variability of the innate immune response to two distinct mastitis pathogens...