P Hedden

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc Purification and kinetic studies of recombinant gibberellin dioxygenases
    Diane R Lester
    Institute for Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden
    BMC Plant Biol 5:19. 2005
  2. ncbi request reprint Manipulation of hormone biosynthetic genes in transgenic plants
    P Hedden
    Department of Agricultural Sciences, IACR Long Ashton Research Station, University of Bristol, Long Ashton, UK
    Curr Opin Biotechnol 11:130-7. 2000
  3. ncbi request reprint Gibberellin metabolism: new insights revealed by the genes
    P Hedden
    Crop Production and Improvement Dept, IACR Long Ashton Research Station, University of Bristol Dept of Agricultural Sciences, Long Ashton, Bristol, UK BS41 9AF
    Trends Plant Sci 5:523-30. 2000
  4. ncbi request reprint The genes of the Green Revolution
    Peter Hedden
    Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, BS41 9AF, Bristol, UK
    Trends Genet 19:5-9. 2003
  5. pmc Function and substrate specificity of the gibberellin 3beta-hydroxylase encoded by the Arabidopsis GA4 gene
    J Williams
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, United Kingdom
    Plant Physiol 117:559-63. 1998
  6. pmc Molecular cloning and functional expression of gibberellin 2- oxidases, multifunctional enzymes involved in gibberellin deactivation
    S G Thomas
    Institute of Arable Crops Research IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, United Kingdom
    Proc Natl Acad Sci U S A 96:4698-703. 1999
  7. pmc Isolation and expression of three gibberellin 20-oxidase cDNA clones from Arabidopsis
    A L Phillips
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, United Kingdom
    Plant Physiol 108:1049-57. 1995
  8. pmc The rice YABBY1 gene is involved in the feedback regulation of gibberellin metabolism
    Mingqiu Dai
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Plant Physiol 144:121-33. 2007
  9. ncbi request reprint Function and transcript analysis of gibberellin-biosynthetic enzymes in wheat
    Nigel E J Appleford
    Rothamsted Research, AL5 2JN Harpenden, Herts, UK
    Planta 223:568-82. 2006
  10. pmc Transgenic barley grain overexpressing thioredoxin shows evidence that the starchy endosperm communicates with the embryo and the aleurone
    Joshua H Wong
    Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:16325-30. 2002

Collaborators

  • T Lange
  • Ivo Rieu
  • Bob B Buchanan
  • Katrien M Devos
  • S Hake
  • Nicholas P Harberd
  • Miguel A Blázquez
  • Filip Vandenbussche
  • Bettina Tudzynski
  • Andrew L Phillips
  • Liesbeth De Grauwe
  • Nigel E J Appleford
  • Stefan Malonek
  • Paul Gaskin
  • Dominique Van Der Straeten
  • Christiane Bömke
  • Thomas Moritz
  • M Cecilia Rojas
  • Angela Hay
  • Claudia Troncoso
  • Gerrit T S Beemster
  • Susana Ubeda-Tomas
  • Wim H Vriezen
  • Mourad Baghour
  • Fan Gong
  • Qian Ma
  • Mingqiu Dai
  • Patrick Achard
  • Stephen J Powers
  • John R Lenton
  • Daniel J Evans
  • Stephen G Thomas
  • Joris J Benschop
  • Wayne L Morris
  • Jayne Griffiths
  • Andy Phillips
  • Martín Frigerio
  • Maria Cecilia Rojas
  • Sophie Jasinski
  • Sam Lievens
  • Diane R Lester
  • Isabel Desgagné-Penix
  • Maria C Rojas
  • Paul Hopkins
  • A L Phillips
  • Andrew Phillips
  • Miltos Tsiantis
  • Joshua H Wong
  • Jasper Dugardeyn
  • Rishikesh Bhalerao
  • Ranjan Swarup
  • Malcolm J Bennett
  • Laury Chaerle
  • Laurent Laplaze
  • S G Thomas
  • Andy L Phillips
  • Juliet Coates
  • Jan Decat
  • Kamal Swarup
  • José Cárcamo
  • Andrew Chapple
  • Mark D Wilkinson
  • Yongfeng Hu
  • Huw D Jones
  • Pascal Genschik
  • Ana M Vidal
  • Sophie Bertrand
  • Qifa Zhang
  • Dao Xiu Zhou
  • Yu Zhao
  • Stephen P Pearce
  • Marlon C Stone
  • Anton J M Peeters
  • Stephen J Croker
  • Jordi Bou
  • David Alabadi
  • Tai Ping Sun
  • J Williams
  • Rodolfo Zentella
  • Laurence J M Ducreux
  • Dennis Ward
  • Zhong Lin Zhang
  • Laura García-Cárcel
  • Kerstin Gühl
  • Niels Wagemaker
  • Laurentius A C J Voesenek
  • Kohji Murase
  • Steve Millam
  • José Pérez-Gómez
  • Mark A Taylor

Detail Information

Publications33

  1. pmc Purification and kinetic studies of recombinant gibberellin dioxygenases
    Diane R Lester
    Institute for Cell and Molecular Biology, Uppsala University, 751 24 Uppsala, Sweden
    BMC Plant Biol 5:19. 2005
    ..The activity of recombinant GA 2ODDs from many species has been characterised in detail, however little information relates to enzyme purification. Native GA 2ODDs displayed lability during purification...
  2. ncbi request reprint Manipulation of hormone biosynthetic genes in transgenic plants
    P Hedden
    Department of Agricultural Sciences, IACR Long Ashton Research Station, University of Bristol, Long Ashton, UK
    Curr Opin Biotechnol 11:130-7. 2000
    ..Furthermore, this technology is providing the means to introduce agriculturally useful traits into crops...
  3. ncbi request reprint Gibberellin metabolism: new insights revealed by the genes
    P Hedden
    Crop Production and Improvement Dept, IACR Long Ashton Research Station, University of Bristol Dept of Agricultural Sciences, Long Ashton, Bristol, UK BS41 9AF
    Trends Plant Sci 5:523-30. 2000
    ..A future challenge will be to dissect the complex, interacting pathways that mediate the regulation of gibberellin metabolism...
  4. ncbi request reprint The genes of the Green Revolution
    Peter Hedden
    Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, BS41 9AF, Bristol, UK
    Trends Genet 19:5-9. 2003
    ..We knew that the wheat Rht genes encode growth repressors that are normally suppressed by GA, and recent work shows that the rice sd1 gene encodes a defective enzyme in the GA-biosynthetic pathway...
  5. pmc Function and substrate specificity of the gibberellin 3beta-hydroxylase encoded by the Arabidopsis GA4 gene
    J Williams
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, United Kingdom
    Plant Physiol 117:559-63. 1998
    ..In contrast to the free acid, GA25 19,20-anhydride was 3beta-hydroxylated to give GA13. 2,3-Didehydro-GA9 and GA5 were converted by recombinant GA4 to the corresponding epoxides 2, 3-oxido-GA9 and GA6...
  6. pmc Molecular cloning and functional expression of gibberellin 2- oxidases, multifunctional enzymes involved in gibberellin deactivation
    S G Thomas
    Institute of Arable Crops Research IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, Long Ashton, Bristol BS41 9AF, United Kingdom
    Proc Natl Acad Sci U S A 96:4698-703. 1999
    ..These mechanisms would serve to maintain the concentrations of biologically active GAs in plant tissues...
  7. pmc Isolation and expression of three gibberellin 20-oxidase cDNA clones from Arabidopsis
    A L Phillips
    IACR Long Ashton Research Station, Department of Agricultural Sciences, University of Bristol, United Kingdom
    Plant Physiol 108:1049-57. 1995
    ....
  8. pmc The rice YABBY1 gene is involved in the feedback regulation of gibberellin metabolism
    Mingqiu Dai
    National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Plant Physiol 144:121-33. 2007
    ..Finally, either overexpression or cosuppression of YAB1 impaired GA-mediated repression of GA3ox2. These data together suggest that YAB1 is involved in the feedback regulation of GA biosynthesis in rice...
  9. ncbi request reprint Function and transcript analysis of gibberellin-biosynthetic enzymes in wheat
    Nigel E J Appleford
    Rothamsted Research, AL5 2JN Harpenden, Herts, UK
    Planta 223:568-82. 2006
    ..In contrast to TaGA20ox1, TaGA3ox2 is expressed in internodes, as well as nodes and the ear of the elongating stem. It is also highly expressed in developing and germinated embryos...
  10. pmc Transgenic barley grain overexpressing thioredoxin shows evidence that the starchy endosperm communicates with the embryo and the aleurone
    Joshua H Wong
    Department of Plant and Microbial Biology, University of California, 111 Koshland Hall, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 99:16325-30. 2002
    ....
  11. ncbi request reprint Characterization of the final two genes of the gibberellin biosynthesis gene cluster of Gibberella fujikuroi: des and P450-3 encode GA4 desaturase and the 13-hydroxylase, respectively
    Bettina Tudzynski
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlobetagarten 3, D 48149 Munster, Germany
    J Biol Chem 278:28635-43. 2003
    ..In common with the other five GA biosynthesis genes, expression of the desaturase gene is repressed by high amounts of nitrogen in the culture medium, whereas P450-3 is the only gene in the cluster not repressed by nitrogen...
  12. ncbi request reprint Reciprocal influence of ethylene and gibberellins on response-gene expression in Arabidopsis thaliana
    Liesbeth De Grauwe
    Unit Plant Hormone Signalling and Bio imaging, Department of Molecular Genetics, Ghent University, K L Ledeganckstraat 35, 9000 Ghent, Belgium
    Planta 226:485-98. 2007
    ..In this paper, we present a number of genes with an altered response-pattern as a direct consequence of cross-talk between ethylene and GA...
  13. ncbi request reprint New frontiers in plant development: from genes to phenotype
    Peter Hedden
    IACR Long Ashton Research Station, Dept of Agricultural Sciences, University of Bristol, Long Ashton, Bristol, UK
    Trends Plant Sci 7:381-3. 2002
  14. pmc The plant stress hormone ethylene controls floral transition via DELLA-dependent regulation of floral meristem-identity genes
    Patrick Achard
    Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UJ, UK
    Proc Natl Acad Sci U S A 104:6484-9. 2007
    ..Our findings establish a link between the CTR1/EIN3-dependent ethylene and GA-DELLA signaling pathways that enables adaptively significant regulation of plant life cycle progression in response to environmental adversity...
  15. ncbi request reprint Decreased shoot stature and grain alpha-amylase activity following ectopic expression of a gibberellin 2-oxidase gene in transgenic wheat
    Nigel E J Appleford
    Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom
    J Exp Bot 58:3213-26. 2007
    ..The marked decline in transcript abundance of both alpha-amylase gene families in aleurone was associated with a decreased content of bioactive GAs in grains of the semi-dwarf lines...
  16. ncbi request reprint Influence of electron transport proteins on the reactions catalyzed by Fusarium fujikuroi gibberellin monooxygenases
    Claudia Troncoso
    Laboratorio de Bioorgánica, Departamento de Quimica, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Phytochemistry 69:672-83. 2008
    ..Thus these partially oxidized GAs correspond to intermediates of the sequential oxidation of C-20 catalyzed by P450-2...
  17. ncbi request reprint The gibberellin biosynthetic genes AtGA20ox1 and AtGA20ox2 act, partially redundantly, to promote growth and development throughout the Arabidopsis life cycle
    Ivo Rieu
    Plant Science Department, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
    Plant J 53:488-504. 2008
    ..In addition, the effects of the mutations are mitigated by the homeostatic mechanism that acts on expression of other GA dioxygenase and GID1 receptor genes...
  18. ncbi request reprint Reduced gibberellin response affects ethylene biosynthesis and responsiveness in the Arabidopsis gai eto2-1 double mutant
    Liesbeth De Grauwe
    Unit Plant Hormone Signaling and Bio Imaging, Department of Molecular Genetics, Ghent University, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    New Phytol 177:128-41. 2008
    ....
  19. ncbi request reprint Ethylene-induced Arabidopsis hypocotyl elongation is dependent on but not mediated by gibberellins
    Filip Vandenbussche
    Unit of Plant Hormone Signaling and Bio imaging, Department of Molecular Genetics, Ghent University, Ledeganckstraat 35, B 9000 Ghent, Belgium
    J Exp Bot 58:4269-81. 2007
    ....
  20. doi request reprint Root growth in Arabidopsis requires gibberellin/DELLA signalling in the endodermis
    Susana Ubeda-Tomas
    Centre for Plant Integrative Biology, University of Nottingham, Loughborough, LE12 5RD, UK
    Nat Cell Biol 10:625-8. 2008
    ..Our results demonstrate that the endodermis represents the primary GA-responsive tissue regulating organ growth and that endodermal cell expansion is rate-limiting for elongation of other tissues and therefore of the root as a whole...
  21. pmc Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis
    Jayne Griffiths
    Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom
    Plant Cell 18:3399-414. 2006
    ..Furthermore, yeast three-hybrid assays showed that the GA-GID1 complex promotes the interaction between RGA and the F-box protein SLY1, a component of the SCF(SLY1) E3 ubiquitin ligase that targets the DELLA protein for degradation...
  22. pmc Transcriptional regulation of gibberellin metabolism genes by auxin signaling in Arabidopsis
    Martín Frigerio
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia, Consejo Superior de Investigaciones Cientificas, 46022 Valencia, Spain
    Plant Physiol 142:553-63. 2006
    ....
  23. ncbi request reprint Overexpression of a bacterial 1-deoxy-D-xylulose 5-phosphate synthase gene in potato tubers perturbs the isoprenoid metabolic network: implications for the control of the tuber life cycle
    Wayne L Morris
    Quality, Health and Nutrition, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    J Exp Bot 57:3007-18. 2006
    ..Additionally, compared with controls, in some dxs-expressing lines, tuber carotenoid content increased approximately 2-fold, with most of the increase accounted for by a 6-7-fold increase in phytoene...
  24. ncbi request reprint Constructing dwarf rice
    Peter Hedden
    Nat Biotechnol 21:873-4. 2003
  25. ncbi request reprint The NADPH-cytochrome P450 reductase gene from Gibberella fujikuroi is essential for gibberellin biosynthesis
    Stefan Malonek
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    J Biol Chem 279:25075-84. 2004
    ..In addition, expression of cpr-Gf is induced by benzoate. These results indicate that CPR-Gf is the main but not the only electron donor for several P450 monooxygenases from primary and secondary metabolism...
  26. ncbi request reprint Kaurenolides and fujenoic acids are side products of the gibberellin P450-1 monooxygenase in Gibberella fujikuroi
    M Cecilia Rojas
    Departamento de Quimica, Laboratorio de Bioorgánica, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Phytochemistry 65:821-30. 2004
    ..fujikuroi and are thus side products that probably result from stabilization of radical intermediates involved in GA14 synthesis...
  27. ncbi request reprint The auxin transport inhibitor response 3 (tir3) allele of BIG and auxin transport inhibitors affect the gibberellin status of Arabidopsis
    Isabel Desgagné-Penix
    Biology Department, University of Texas at San Antonio, San Antonio, TX 78249, USA
    Plant J 41:231-42. 2005
    ....
  28. ncbi request reprint Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex
    Stefan Malonek
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, D 48149 Munster, Germany
    Phytochemistry 66:1296-311. 2005
    ..The molecular phylogenetic studies for both genes have revealed good agreement with phylogenetic trees inferred from other genes. Furthermore, we discuss the role and evolutionary origin of the GA biosynthetic gene cluster...
  29. ncbi request reprint KNOX action in Arabidopsis is mediated by coordinate regulation of cytokinin and gibberellin activities
    Sophie Jasinski
    Plant Sciences Department, University of Oxford, South Parks Road, Oxford OX1 3RB, United Kingdom
    Curr Biol 15:1560-5. 2005
    ..We propose that KNOX proteins may act as general orchestrators of growth-regulator homeostasis at the shoot apex of Arabidopsis by simultaneously activating CK and repressing GA biosynthesis, thus promoting meristem activity...
  30. ncbi request reprint The gibberellin pathway mediates KNOTTED1-type homeobox function in plants with different body plans
    Angela Hay
    Plant and Microbial Biology Department, University of California, Berkeley 94720, USA
    Curr Biol 12:1557-65. 2002
    ..Less is known regarding downstream targets of KNOX function. Recent evidence, however, has suggested that growth regulators may mediate KNOX activity in a variety of plant species...
  31. pmc Gibberellins are involved in nodulation of Sesbania rostrata
    Sam Lievens
    Department of Plant Systems Biology, Flanders Interuniversity Institute for Biotechnology, Ghent University, B 9052 Gent, Belgium
    Plant Physiol 139:1366-79. 2005
    ..Moreover, GAs inhibited the root hair curling process. These results show that GAs are Nod factor downstream signals for nodulation in hydroponic growth...
  32. pmc Long-term submergence-induced elongation in Rumex palustris requires abscisic acid-dependent biosynthesis of gibberellin1
    Joris J Benschop
    Plant Ecophysiology, Institute of Environmental Biology, Utrecht University, Utrecht, Sorbonnelaan 16, 3584 CA, The Netherlands
    Plant Physiol 141:1644-52. 2006
    ..Exogenous abscisic acid repressed the transcript levels of RpGA20ox1 and RpGA3ox1 and thus inhibited the submergence-induced increase in GA1. Abscisic acid had no effect on the tissue responsiveness to GA...
  33. pmc Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola
    Christiane Bömke
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, 48149 Munster, Germany
    Appl Environ Microbiol 74:5325-39. 2008
    ..The close similarity between the two GA gene clusters, the identical gene functions, and the conserved intron positions suggest a common evolutionary origin despite the distant relatedness of the two fungi...