Genomes and Genes
Paul C Evans
Affiliation: Institute for Animal Health
- Isolation and characterization of two novel A20-like proteinsP C Evans
Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
Biochem J 357:617-23. 2001..In contrast, reporter gene experiments revealed a specific ability of Cezanne to down-regulate NF-kappa B. It is likely, therefore, that Cezanne participates in the regulation of inflammatory processes...
- A novel type of deubiquitinating enzymePaul C Evans
Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
J Biol Chem 278:23180-6. 2003..We also provide evidence for an additional ubiquitin binding site in the C-terminal part of the molecule. Our data provide the first demonstration of functional activity among OTU proteins...
- Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activityPaul C Evans
Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
Biochem J 378:727-34. 2004..A20 did not have a global effect on ubiquitinated cellular proteins, which indicates that its activity is target-specific. The biological significance of the catalytic domain is unknown...
- The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperonesCarla Marques
Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
FASEB J 20:741-3. 2006..Isopeptidases, the enzymes that reverse the actions of CHIP, also play an important role in determining the fate of denatured proteins...
- Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cellsJason Partridge
BHF Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
FASEB J 21:3553-61. 2007..Thus modulation of NF-kappaB function may underlie the atheroprotective effects of laminar shear stress...
- NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signalingKarine Enesa
British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London W12 ONN, United Kingdom
J Biol Chem 283:7036-45. 2008..Thus we conclude that Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination...
- Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanismsKarine Enesa
British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, W12 ONN, United Kingdom
J Biol Chem 283:18582-90. 2008..We conclude that H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha...
- Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugsPaul C Evans
British Heart Foundation Cardiovascular Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
Expert Rev Mol Med 7:1-19. 2005..Finally, the potential for ubiquitin modifications to be targeted by novel classes of anti-inflammatory drugs is discussed...
- Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosisMustafa Zakkar
British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
Circ Res 103:726-32. 2008..We conclude that MKP-1 induction is required for the antiinflammatory effects of shear stress. Thus, our findings reveal a novel molecular mechanism contributing to the spatial distribution of vascular inflammation and atherosclerosis...