Paul C Evans

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi Isolation and characterization of two novel A20-like proteins
    P C Evans
    Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem J 357:617-23. 2001
  2. ncbi A novel type of deubiquitinating enzyme
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:23180-6. 2003
  3. ncbi Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Biochem J 378:727-34. 2004
  4. ncbi The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones
    Carla Marques
    Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    FASEB J 20:741-3. 2006
  5. ncbi Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells
    Jason Partridge
    BHF Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    FASEB J 21:3553-61. 2007
  6. ncbi NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
    Karine Enesa
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London W12 ONN, United Kingdom
    J Biol Chem 283:7036-45. 2008
  7. ncbi Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms
    Karine Enesa
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, W12 ONN, United Kingdom
    J Biol Chem 283:18582-90. 2008
  8. ncbi Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs
    Paul C Evans
    British Heart Foundation Cardiovascular Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
    Expert Rev Mol Med 7:1-19. 2005
  9. ncbi Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008

Collaborators

Detail Information

Publications9

  1. ncbi Isolation and characterization of two novel A20-like proteins
    P C Evans
    Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem J 357:617-23. 2001
    ..In contrast, reporter gene experiments revealed a specific ability of Cezanne to down-regulate NF-kappa B. It is likely, therefore, that Cezanne participates in the regulation of inflammatory processes...
  2. ncbi A novel type of deubiquitinating enzyme
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 278:23180-6. 2003
    ..We also provide evidence for an additional ubiquitin binding site in the C-terminal part of the molecule. Our data provide the first demonstration of functional activity among OTU proteins...
  3. ncbi Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Biochem J 378:727-34. 2004
    ..A20 did not have a global effect on ubiquitinated cellular proteins, which indicates that its activity is target-specific. The biological significance of the catalytic domain is unknown...
  4. ncbi The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones
    Carla Marques
    Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    FASEB J 20:741-3. 2006
    ..Isopeptidases, the enzymes that reverse the actions of CHIP, also play an important role in determining the fate of denatured proteins...
  5. ncbi Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells
    Jason Partridge
    BHF Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    FASEB J 21:3553-61. 2007
    ..Thus modulation of NF-kappaB function may underlie the atheroprotective effects of laminar shear stress...
  6. ncbi NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling
    Karine Enesa
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London W12 ONN, United Kingdom
    J Biol Chem 283:7036-45. 2008
    ..Thus we conclude that Cezanne forms a novel negative feedback loop in pro-inflammatory signaling and that it suppresses NF-kappaB activation by targeting RIP1 signaling intermediaries for deubiquitination...
  7. ncbi Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms
    Karine Enesa
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, W12 ONN, United Kingdom
    J Biol Chem 283:18582-90. 2008
    ..We conclude that H(2)O(2) prolongs NF-kappaB activation in co-stimulated cells by suppressing the negative regulatory functions of Cezanne and IkappaBalpha...
  8. ncbi Regulation of pro-inflammatory signalling networks by ubiquitin: identification of novel targets for anti-inflammatory drugs
    Paul C Evans
    British Heart Foundation Cardiovascular Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London, W12 ONN, UK
    Expert Rev Mol Med 7:1-19. 2005
    ..Finally, the potential for ubiquitin modifications to be targeted by novel classes of anti-inflammatory drugs is discussed...
  9. ncbi Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008
    ..We conclude that MKP-1 induction is required for the antiinflammatory effects of shear stress. Thus, our findings reveal a novel molecular mechanism contributing to the spatial distribution of vascular inflammation and atherosclerosis...