Janine T Erler

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi request reprint The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer
    Ann Marie Baker
    Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:407-24. 2011
  2. pmc Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
    Thomas R Cox
    Cancer Research UK Tumour Cell Signalling Unit, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    Dis Model Mech 4:165-78. 2011
  3. pmc Three-dimensional context regulation of metastasis
    Janine T Erler
    Hypoxia and Metastasis Team, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    Clin Exp Metastasis 26:35-49. 2009
  4. pmc Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
    Ann Marie Baker
    Hypoxia and Metastasis Team, The Institute of Cancer Research, London, UK
    Cancer Res 73:583-94. 2013
  5. doi request reprint The rationale for targeting the LOX family in cancer
    Holly E Barker
    Hypoxia and Metastasis Team, The Institute of Cancer Research, London SW3 6JB, UK
    Nat Rev Cancer 12:540-52. 2012
  6. pmc LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
    Holly E Barker
    Section of Cell and Molecular Biology, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 71:1561-72. 2011
  7. pmc Contrasting effects of sunitinib within in vivo models of metastasis
    Jonathan C Welti
    Tumour Biology Team, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Angiogenesis 15:623-41. 2012

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer
    Ann Marie Baker
    Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    J Natl Cancer Inst 103:407-24. 2011
    ..Emerging evidence implicates lysyl oxidase (LOX), an extracellular matrix-modifying enzyme, in promoting metastasis of solid tumors. We investigated whether LOX plays an important role in the metastasis of colorectal cancer (CRC)...
  2. pmc Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
    Thomas R Cox
    Cancer Research UK Tumour Cell Signalling Unit, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    Dis Model Mech 4:165-78. 2011
    ..This can only be achieved through the use of appropriate in vitro and in vivo models to mimic disease, and with technologies that enable accurate monitoring, imaging and quantification of the ECM...
  3. pmc Three-dimensional context regulation of metastasis
    Janine T Erler
    Hypoxia and Metastasis Team, Section of Cell and Molecular Biology, The Institute of Cancer Research, London, UK
    Clin Exp Metastasis 26:35-49. 2009
    ..Thus, clarifying the molecular pathways by which ECM remodeling and tumor hypoxia intersect to promote tumor progression should identify novel therapeutic targets...
  4. pmc Lysyl oxidase plays a critical role in endothelial cell stimulation to drive tumor angiogenesis
    Ann Marie Baker
    Hypoxia and Metastasis Team, The Institute of Cancer Research, London, UK
    Cancer Res 73:583-94. 2013
    ..Finally, we validate our findings in a breast cancer model, showing the universality of these observations. Taken together, our findings have broad clinical and therapeutic implications for a wide variety of solid tumor types...
  5. doi request reprint The rationale for targeting the LOX family in cancer
    Holly E Barker
    Hypoxia and Metastasis Team, The Institute of Cancer Research, London SW3 6JB, UK
    Nat Rev Cancer 12:540-52. 2012
    ..We also discuss how targeting this family of proteins might lead to a new avenue of cancer therapeutics...
  6. pmc LOXL2-mediated matrix remodeling in metastasis and mammary gland involution
    Holly E Barker
    Section of Cell and Molecular Biology, The Institute of Cancer Research, London, United Kingdom
    Cancer Res 71:1561-72. 2011
    ..Our findings highlight the importance of LOXL2 in breast cancer progression and support the development of anti-LOXL2 therapeutics for the treatment of metastatic breast cancer...
  7. pmc Contrasting effects of sunitinib within in vivo models of metastasis
    Jonathan C Welti
    Tumour Biology Team, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK
    Angiogenesis 15:623-41. 2012
    ..These findings have relevance for understanding how anti-angiogenic agents may influence disease progression when used in the adjuvant or metastatic setting in cancer patients...