Research Topics
Species | Chris D EllsonSummaryAffiliation: Institute for Animal Health Country: UK Publications
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Detail Information
Publications
The PX domain: a new phosphoinositide-binding moduleChris D Ellson
The Inositide Laboratory, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
J Cell Sci 115:1099-105. 2002..Additionally, phosphoinositide binding to the PX domains of p40(phox) and p47(phox) appears to play a critical role in the active assembly of the neutrophil oxidase complex...
Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approachHerve Guillou
The Babraham Institute, Cambridge, UK
J Lipid Res 48:726-32. 2007....
Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophilsSabine Suire
The Babraham Institute, Babraham, Cambs CB22 3AT, UK
Nat Cell Biol 8:1303-9. 2006..We conclude that Gbetagammas, p101 and the Ras-RBD interaction all have important roles in the regulation of PI(3)Kgamma in vivo and that they can simultaneously, but differentially, control distinct PI(3)Kgamma effectors...
The role of phosphoinositides and phosphorylation in regulation of NADPH oxidaseOlga Perisic
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
Adv Enzyme Regul 44:279-98. 2004
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidaseSarah A Bissonnette
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J Biol Chem 283:2108-19. 2008..We present a model where p40(phox) translocates p67(phox) to the region of the cytochrome and subsequently switches the oxidase to an activated state dependent upon PtdIns(3)P and SH3 domain engagement...
