Research Topics
| Hans J CoolsSummaryAffiliation: Institute for Animal Health Country: UK Publications
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Detail Information
Publications
Overexpression of the sterol 14α-demethylase gene (MgCYP51) in Mycosphaerella graminicola isolates confers a novel azole fungicide sensitivity phenotypeHans J Cools
Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire, UK
Pest Manag Sci 68:1034-40. 2012..Although additional mechanisms, including increased MgCYP51 expression and enhanced active efflux, have been proposed, the genetic changes underlying these mechanisms are unknown...
Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal cropsH J Cools
Plant Pathogen Interactions Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
Biochem Soc Trans 34:1219-22. 2006..Nonetheless, the biological potential for resistance exists, and the question remains as to whether widespread triazole resistance can develop in an important cereal pathogen...
Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivityHans J Cools
Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, United Kingdom
Appl Environ Microbiol 77:3830-7. 2011....- Heterologous expression of mutated eburicol 14alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein functionH J Cools
Centre for Sustainable Pest and Disease Management, Department of Plant Pathology and Microbiology, Rothamsted Research, Hertfordshire, United Kingdom
Appl Environ Microbiol 76:2866-72. 2010..In addition, we also provide functional evidence underlying the order in which CYP51 alterations in the Western European M. graminicola population emerged... - Are azole fungicides losing ground against Septoria wheat disease? Resistance mechanisms in Mycosphaerella graminicolaHans J Cools
Fungicide Resistance Group, Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire, AL5 2JQ, UK
Pest Manag Sci 64:681-4. 2008..Hans J. Cools and Bart A. Fraaije ask the question: can widespread resistance to all azoles develop in this pathogen?.. - Sterol content analysis suggests altered eburicol 14alpha-demethylase (CYP51) activity in isolates of Mycosphaerella graminicola adapted to azole fungicidesTim P Bean
Department of Plant Pathology and Microbiology, Centre for Sustainable Pest and Disease Management, Rothamsted Research, Harpenden, Hertfordshire, UK
FEMS Microbiol Lett 296:266-73. 2009..Together with CYP51 gene expression studies, these data suggest that mutations in the CYP51 gene impact on the activity of the CYP51 protein... - Risk assessment studies on succinate dehydrogenase inhibitors, the new weapons in the battle to control Septoria leaf blotch in wheatBart A Fraaije
Rothamsted Research, Plant Pathology and Microbiology Department, Harpenden, Hertfordshire AL5 2JQ, UK
Mol Plant Pathol 13:263-75. 2012.... - Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 functionJieru Fan
Department of Plant Pathology, China Agricultural University, Beijing, 100193, China Department of Biological Chemistry and Crop Protection, Rothamsted Research, Harpenden, AL5 2JQ, UK
New Phytol 198:821-35. 2013..FgCYP51C does not encode a sterol 14α-demethylase, but is required for full virulence on host wheat ears. This is the first example of the functional diversification of a fungal CYP51... - Transcriptome profiling of the response of Mycosphaerella graminicola isolates to an azole fungicide using cDNA microarraysHans J Cools
Plant Pathogen Interactions Division, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK
Mol Plant Pathol 8:639-51. 2007..This represents the first study investigating the response of a plant pathogenic fungus to a fungicide using cDNA microarray technology... - Update on mechanisms of azole resistance in Mycosphaerella graminicola and implications for future controlHans J Cools
Department of Plant Pathology and Microbiology, Rothamsted Research, Harpenden, Hertfordshire, UK
Pest Manag Sci 69:150-5. 2013..The prospects for azole fungicides in controlling European M. graminicola populations in the future are discussed in the context of these new findings...