Miguel Constancia

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
  2. ncbi Resourceful imprinting
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 432:53-7. 2004
  3. ncbi Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005
  4. ncbi Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 24:5650-6. 2004
  5. ncbi Regulation of supply and demand for maternal nutrients in mammals by imprinted genes
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    J Physiol 547:35-44. 2003
  6. ncbi Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth
    Emily Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    FASEB J 25:1737-45. 2011
  7. ncbi Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions
    Susana Lopes
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 12:295-305. 2003

Collaborators

Detail Information

Publications7

  1. ncbi Placental-specific IGF-II is a major modulator of placental and fetal growth
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 417:945-8. 2002
    ..We propose that the Igf2 gene, and perhaps other imprinted genes, control both the placental supply of, and the genetic demand for, maternal nutrients to the mammalian fetus...
  2. ncbi Resourceful imprinting
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK
    Nature 432:53-7. 2004
  3. ncbi Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005
    ..Thus, crosstalk between an imprinted growth demand gene (Igf2) and placental supply transporter genes (Slc38a4, Slc38a2, and Slc2a3) may be a component of the genetic control of nutrient supply and demand during mammalian development...
  4. ncbi Tandem repeat hypothesis in imprinting: deletion of a conserved direct repeat element upstream of H19 has no effect on imprinting in the Igf2-H19 region
    Annabelle Lewis
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Mol Cell Biol 24:5650-6. 2004
    ....
  5. ncbi Regulation of supply and demand for maternal nutrients in mammals by imprinted genes
    Wolf Reik
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    J Physiol 547:35-44. 2003
    ..These data and hypotheses are important, as deregulation of supply and demand affects fetal growth and has long term consequences for health in mammals both in the neonatal period and, as a result of fetal programming, in adulthood...
  6. ncbi Developmental adaptations to increased fetal nutrient demand in mouse genetic models of Igf2-mediated overgrowth
    Emily Angiolini
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge, UK
    FASEB J 25:1737-45. 2011
    ..Our findings are indicative of fetal-placental signaling mechanisms that limit total demand for maternal nutrients...
  7. ncbi Epigenetic modifications in an imprinting cluster are controlled by a hierarchy of DMRs suggesting long-range chromatin interactions
    Susana Lopes
    Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Hum Mol Genet 12:295-305. 2003
    ..These observations are likely to be relevant to other gene clusters in which epigenetic regulation plays a role, and in pathological situations in which epigenetic regulation is disrupted...