A J Cleare

Summary

Affiliation: Institute of Psychiatry
Country: UK

Publications

  1. ncbi Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatry Res 69:89-95. 1997
  2. ncbi Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Int Clin Psychopharmacol 13:23-32. 1998
  3. ncbi Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine and the Institute of Psychiatry, London, UK
    Lancet 353:455-8. 1999
  4. ncbi Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry and Guy s King s and St Thomas School of Medicine, London, UK
    Psychopharmacology (Berl) 148:344-9. 2000
  5. doi Psychological and physiological effects of caring for patients with treatment-resistant depression
    L J Rane
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, London, UK
    Psychol Med 42:1825-33. 2012
  6. ncbi Peripheral hormonal responses to D-fenfluramine as a probe of central serotonergic function in humans
    K M Abel
    Department of Psychological Medicine, King s College School of Medicine and Dentistry and the Institute of Psychiatry, London, UK
    Psychopharmacology (Berl) 142:68-72. 1999
  7. doi Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?
    A D L Roberts
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Psychol Med 40:515-22. 2010
  8. doi Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system
    L A Carvalho
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology Laboratory King s College London, Institute of Psychiatry, London, UK
    J Affect Disord 148:136-40. 2013
  9. ncbi Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion
    A J Cleare
    Department of Psychological Medicine, Guy s, King s and St Thomas School of Medicine, 103 Denmark Hill, London SE3 8AF, UK
    Clin Endocrinol (Oxf) 55:113-9. 2001
  10. ncbi Serotonergic function and negative and depressive symptomatology in schizophrenia and major depression
    K M Abel
    Institute of Psychiatry, London, UK
    Psychoneuroendocrinology 22:539-48. 1997

Collaborators

Detail Information

Publications18

  1. ncbi Does central serotonergic function correlate inversely with aggression? A study using D-fenfluramine in healthy subjects
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Psychiatry Res 69:89-95. 1997
    ....
  2. ncbi Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Int Clin Psychopharmacol 13:23-32. 1998
    ..The presence of an oxytocin response to ipsapirone suggests that oxytocin is a potential marker for serotonergic function in neuroendocrine challenge studies, but this awaits further study...
  3. ncbi Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine and the Institute of Psychiatry, London, UK
    Lancet 353:455-8. 1999
    ..Reports of mild hypocortisolism in chronic fatigue syndrome led us to postulate that low-dose hydrocortisone therapy may be an effective treatment...
  4. ncbi Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression
    A J Cleare
    Department of Psychological Medicine, Institute of Psychiatry and Guy s King s and St Thomas School of Medicine, London, UK
    Psychopharmacology (Berl) 148:344-9. 2000
    ..We conclude that impaired 5-HT(1A) receptor function is associated with increased aggressiveness...
  5. doi Psychological and physiological effects of caring for patients with treatment-resistant depression
    L J Rane
    Section of Neurobiology of Mood Disorders, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, London, UK
    Psychol Med 42:1825-33. 2012
    ....
  6. ncbi Peripheral hormonal responses to D-fenfluramine as a probe of central serotonergic function in humans
    K M Abel
    Department of Psychological Medicine, King s College School of Medicine and Dentistry and the Institute of Psychiatry, London, UK
    Psychopharmacology (Berl) 142:68-72. 1999
    ..4 +/- 26.3 nmol/l; DEX+ = 0.0 nmol/l (all blunted) (df 7,1; P = 0.03). The completely blunted peripheral cortisol response indicates that DFEN cortisol responses are of central origin only...
  7. doi Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?
    A D L Roberts
    King s College London, Institute of Psychiatry, Department of Psychological Medicine, London, UK
    Psychol Med 40:515-22. 2010
    ..The clinical significance of this is unclear. We aimed to determine whether hypocortisolism exerted any effect on the response of CFS to cognitive behavioural therapy (CBT)...
  8. doi Lack of clinical therapeutic benefit of antidepressants is associated overall activation of the inflammatory system
    L A Carvalho
    Section of Perinatal Psychiatry and Stress, Psychiatry and Immunology Laboratory King s College London, Institute of Psychiatry, London, UK
    J Affect Disord 148:136-40. 2013
    ..Taking together, these data suggest that lack of clinical therapeutic benefit of antidepressants is associated with overall activation of the inflammatory system...
  9. ncbi Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion
    A J Cleare
    Department of Psychological Medicine, Guy s, King s and St Thomas School of Medicine, 103 Denmark Hill, London SE3 8AF, UK
    Clin Endocrinol (Oxf) 55:113-9. 2001
    ..Because both of these features may be related to leptin metabolism, we undertook a study of leptin in CFS...
  10. ncbi Serotonergic function and negative and depressive symptomatology in schizophrenia and major depression
    K M Abel
    Institute of Psychiatry, London, UK
    Psychoneuroendocrinology 22:539-48. 1997
    ..We wished to explore whether these symptoms could be distinguished biologically by directly comparing serotonergic function in these two illnesses...
  11. ncbi Plasma tryptophan and trait aggression
    J Wingrove
    Section of Clinical Psychopharmacology, Institute of Psychiatry, King s College, London, UK
    J Psychopharmacol 13:235-7. 1999
    ....
  12. pmc Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment
    S J Bull
    King s College London, Section and Laboratory of Stress, Psychiatry and Immunology, Institute of Psychiatry, London, UK
    Mol Psychiatry 14:1095-104. 2009
    ....
  13. ncbi The neuroendocrinology of chronic fatigue syndrome and fibromyalgia
    A J Parker
    Department of Psychological Medicine, Guy's, King's and St Thomas' School of Medicine and the Institute of Psychiatry, London
    Psychol Med 31:1331-45. 2001
    ..Longitudinal studies of populations at risk for CFS will help to resolve these issues...
  14. ncbi Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine, and The Institute of Psychiatry, London, United Kingdom
    J Clin Endocrinol Metab 85:1433-9. 2000
    ..Hydrocortisone treatment had no significant effect on any of these parameters. There is no evidence of GH deficiency in CFS. At the doses used, hydrocortisone treatment appears to have little impact on GH function...
  15. ncbi Urinary free cortisol in chronic fatigue syndrome
    A J Cleare
    Department of Psychological Medicine, Guy s King s and St Thomas School of Medicine and the Institute of Psychiatry, 103 Denmark Hill, London SE5 8AZ, UK
    Am J Psychiatry 158:641-3. 2001
    ..The authors measured 24-hour urinary free cortisol in a group of well-characterized patients with chronic fatigue syndrome...
  16. ncbi Predictors of fatigue following the onset of infectious mononucleosis
    B Candy
    Department of Psychological Medicine, Public Health Laboratory and Medical Microbiology, Guy s, King s and St Thomas School of Medicine and Institute of Psychiatry, London
    Psychol Med 33:847-55. 2003
    ..This study explored immunological, endocrine, behavioural and cognitive responses to the acute illness and assessed which components of these groups of risk factors predicted a chronic course...
  17. doi Discrepancy between subjective and objective severity in treatment-resistant depression: prediction of treatment outcome
    L J Rane
    King s College London, Institute of Psychiatry, Division of Psychological Medicine and Psychiatry, Section of Neurobiology of Mood Disorders, 103 Denmark Hill, London SE5 8AZ, UK
    J Psychiatr Res 44:1082-7. 2010
    ..Identifying predictors of outcome among patients with treatment-resistant depression (TRD) is challenging. We hypothesised that discrepancy between self-rated and observer-rated scales may be a simple way of making such a prediction...
  18. pmc Antinuclear autoantibodies (ANA) in Gulf War-related illness and chronic fatigue syndrome (CFS) patients
    A Skowera
    Department of Immunology, Guy s, King s and St Thomas School of Medicine, King s College London, London, UK
    Clin Exp Immunol 129:354-8. 2002
    ..None of the patients/or veterans we studied had ANA of the NE type. Our results show that multisymptom illness due to CFS or related to Gulf War service is not associated with antinuclear autoimmunity...