Louis Chesler

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. pmc Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma
    Louis Chesler
    Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5NG, United Kingdom
    Semin Cancer Biol 21:245-55. 2011
  2. pmc Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction
    Louis Chesler
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA
    Neoplasia 10:1268-74. 2008
  3. pmc Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    Fredrik J Swartling
    University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
    Cancer Cell 21:601-13. 2012
  4. pmc Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma
    Louis Chesler
    Department of Pediatrics, Neurology, University of California San Francisco Medical School, San Francisco, California 94143, USA
    Cancer Res 67:9435-42. 2007
  5. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
  6. doi request reprint Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma
    Yann Jamin
    Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 15 Cotswold Road, Sutton, Surrey SM2 5NG, England
    Radiology 266:130-40. 2013
  7. pmc Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    Louis Chesler
    Department of Neurology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 66:8139-46. 2006
  8. doi request reprint The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo
    Amir Faisal
    Cancer Research UK, Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom
    Mol Cancer Ther 10:2115-23. 2011
  9. pmc Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells
    Gary E Meyer
    Department of Pediatrics, University of California, San Francisco, California 94143, USA
    J Cell Biochem 102:1529-41. 2007
  10. pmc CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
    Mike I Walton
    Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, United Kingdom
    Clin Cancer Res 18:5650-61. 2012

Collaborators

Detail Information

Publications12

  1. pmc Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma
    Louis Chesler
    Division of Clinical Studies and Cancer Therapeutics, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey SM2 5NG, United Kingdom
    Semin Cancer Biol 21:245-55. 2011
    ..We review the potential of these models to contribute both to an understanding of the developmental nature of neuroblastoma and to improved therapy for this disease...
  2. pmc Chemotherapy-induced apoptosis in a transgenic model of neuroblastoma proceeds through p53 induction
    Louis Chesler
    Department of Pediatrics, University of California, San Francisco, San Francisco, CA 94143, USA
    Neoplasia 10:1268-74. 2008
    ....
  3. pmc Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    Fredrik J Swartling
    University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
    Cancer Cell 21:601-13. 2012
    ..These differences were regulated in part by the transcription factor SOX9, activated in the SHH subclass of human medulloblastoma. Our results demonstrate context-dependent transformation of NSCs in response to a common oncogenic signal...
  4. pmc Malignant progression and blockade of angiogenesis in a murine transgenic model of neuroblastoma
    Louis Chesler
    Department of Pediatrics, Neurology, University of California San Francisco Medical School, San Francisco, California 94143, USA
    Cancer Res 67:9435-42. 2007
    ....
  5. pmc Pleiotropic role for MYCN in medulloblastoma
    Fredrik J Swartling
    University of California at San Francisco, San Francisco, California 94158, USA
    Genes Dev 24:1059-72. 2010
    ..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis...
  6. doi request reprint Evaluation of clinically translatable MR imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of neuroblastoma
    Yann Jamin
    Division of Radiotherapy and Imaging, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, 15 Cotswold Road, Sutton, Surrey SM2 5NG, England
    Radiology 266:130-40. 2013
    ..To evaluate noninvasive and clinically translatable magnetic resonance (MR) imaging biomarkers of therapeutic response in the TH-MYCN transgenic mouse model of aggressive, MYCN-amplified neuroblastoma...
  7. pmc Inhibition of phosphatidylinositol 3-kinase destabilizes Mycn protein and blocks malignant progression in neuroblastoma
    Louis Chesler
    Department of Neurology, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Res 66:8139-46. 2006
    ....
  8. doi request reprint The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivo
    Amir Faisal
    Cancer Research UK, Cancer Therapeutics Unit, The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom
    Mol Cancer Ther 10:2115-23. 2011
    ..The potent preclinical activity of CCT137690 suggests that this inhibitor may benefit patients with MYCN-amplified neuroblastoma...
  9. pmc Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells
    Gary E Meyer
    Department of Pediatrics, University of California, San Francisco, California 94143, USA
    J Cell Biochem 102:1529-41. 2007
    ..In addition, NDGA inhibits the growth of xenografted human neuroblastoma tumors in nude mice. These results indicate that NDGA may be useful in the treatment of neuroblastoma and may function in part via disruption of IGF-IR signaling...
  10. pmc CCT244747 is a novel potent and selective CHK1 inhibitor with oral efficacy alone and in combination with genotoxic anticancer drugs
    Mike I Walton
    Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, Sutton, United Kingdom
    Clin Cancer Res 18:5650-61. 2012
    ..We have therefore discovered a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor, CCT244747, and present its preclinical pharmacology and therapeutic activity...
  11. pmc The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma
    Teeara Berry
    Division of Clinical Studies, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Cancer Cell 22:117-30. 2012
    ..Our findings demonstrate a pathogenic role for ALK(F1174L) in neuroblastomas overexpressing MYCN and suggest a strategy for improving targeted therapy for ALK-positive neuroblastoma...
  12. doi request reprint Phase I study of vincristine, irinotecan, and ¹³¹I-metaiodobenzylguanidine for patients with relapsed or refractory neuroblastoma: a new approaches to neuroblastoma therapy trial
    Steven G DuBois
    Department of Pediatrics, UCSF School of Medicine, San Francisco, California 94143, USA
    Clin Cancer Res 18:2679-86. 2012
    ..Irinotecan is a known radiosensitizer with activity in neuroblastoma. This phase I study aimed to determine the recommended phase 2 dose of MIBG together with fixed doses of vincristine and irinotecan...