Research Topics
Genomes and Genes | Dave BurtSummaryAffiliation: Institute for Animal Health Country: UK Publications
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Detail Information
Publications
Development of a cDNA array for chicken gene expression analysisJoan Burnside
Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Room 229, Newark, DE 19711, USA
BMC Genomics 6:13. 2005..The application of microarray technology to functional genomic analysis in the chicken has been limited by the lack of arrays containing large numbers of genes...- Development of a chicken 5 K microarray targeted towards immune functionJacqueline Smith
Division of Genetics and Genomics, Roslin Institute, Roslin, Edinburgh, Midlothian, EH25 9PS, UK
BMC Genomics 7:49. 2006..The creation of an immune-related array is highly valuable in determining the host immune response in relation to infection with a wide variety of bacterial and viral diseases... 
Gene duplication and fragmentation in the zebra finch major histocompatibility complexChristopher N Balakrishnan
Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
BMC Biol 8:29. 2010....
Preliminary linkage map of the turkey (Meleagris gallopavo) based on microsatellite markersD W Burt
Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian, UK
Anim Genet 34:399-409. 2003..All primer information, polymerase chain reaction (PCR) conditions, allele sizes and genetic linkage maps can be viewed at http://roslin.thearkdb.org/. The DNA is also available on request through the Roslin Institute...- The chicken genome and the developmental biologistDavid W Burt
Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
Mech Dev 121:1129-35. 2004..In this paper we review progress in chicken genomics and discuss how the new tools and information on the chicken genome can help the developmental biologists now and in the future... - Genetics. Chicken genome--science nuggets to come soonDave Burt
Roslin Institute (Edinburgh, Midlothian EH25 9PS, UK
Science 300:1669. 2003 - Comparative mapping in farm animalsDavid W Burt
UK Centre for Functional Genomics in Farm Animanls, Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian, UK
Brief Funct Genomic Proteomic 1:159-68. 2002.... - Mapping quantitative trait loci and identification of genes that control fatness in poultryDavid W Burt
Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
Proc Nutr Soc 61:441-6. 2002..Progress in mapping quantitative trait loci for growth and fatness traits will be discussed, as an application of these new technologies and approaches in the study of avian physiology and genetics... - Origin and evolution of avian microchromosomesD W Burt
Department of Genomics and Bioinformatics, Roslin Institute, Roslin, Midlothian, United Kingdom
Cytogenet Genome Res 96:97-112. 2002..A "Fission-Fusion Model" of microchromosome evolution based on chromosome rearrangement and minimization of repeat content is discussed... - Chicken genomics charts a path to the genome sequenceDavid W Burt
Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian, EH25 9PS, UK
Brief Funct Genomic Proteomic 3:60-7. 2004..No other animal species have been phenotyped and selected so intensively as agricultural animals and thus there is much to be learned in basic and medical biology from this research... - Emergence of the chicken as a model organism: implications for agriculture and biologyD W Burt
Roslin Institute, Edinburgh, Midlothian EH25 9PS, United Kingdom
Poult Sci 86:1460-71. 2007..These advances are reviewed and their implications are discussed... - Avian genomics in the 21st centuryD W Burt
Department of Genomics and Genetics, Roslin Institute Edinburgh, Roslin, Midlothian, UK
Cytogenet Genome Res 117:6-13. 2007..The availability of new tools such as whole-genome gene expression arrays and SNP panels, coupled with information resources on the genes and proteins are likely to enhance this position... 
The chicken genomeD W Burt
Department of Genomics and Genetics, Roslin Institute, Edinburgh, UK
Genome Dyn 2:123-37. 2006..In this report these advances are reviewed and the implications of the chicken genome in current and future applications are discussed...- Chicken genome: current status and future opportunitiesDavid W Burt
Department of Genomics and Genetics, Roslin Institute Edinburgh, Midlothian EH25 9PS, United Kingdom
Genome Res 15:1692-8. 2005..Many of the features of the chicken genome and its biology make it an ideal organism for studies in development and evolution, along with applications in agriculture and medicine... - Quantitative trait loci for bone traits segregating independently of those for growth in an F2 broiler x layer crossP W A Sharman
Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, The King s Buildings, Edinburgh, UK
Cytogenet Genome Res 117:296-304. 2007.... - Quantitative trait loci affecting fatness in the chickenC O N Ikeobi
Roslin Institute, Edinburgh, Scotland, UK
Anim Genet 33:428-35. 2002..2-0.8 phenotypic standard deviations. The largest additive QTL (on chromosome 7) accounted for more than 20% of the mean weight of abdominal fat. Significant positive and negative QTL were identified from both lines... - Mapping of quantitative trait loci for body weight at three, six, and nine weeks of age in a broiler layer crossA Sewalem
Roslin Institute, Roslin, Midlothian EH25 9PS, Scotland
Poult Sci 81:1775-81. 2002..Interactions of the QTL with sex or family were unimportant. There was no evidence for imprinting or of two or more QTL at the same location for any of the traits... - Mapping of quantitative trait loci affecting organ weights and blood variables in a broiler layer crossP Navarro
Roslin Institute, Roslin, Midlothian
Br Poult Sci 46:430-42. 2005.... - Segregation of QTL for production traits in commercial meat-type chickensD J De Koning
Roslin Institute, Roslin, Midlothian EH25 9PS, UK
Genet Res 83:211-20. 2004..Future fine-mapping efforts could elucidate whether ancestral mutations are still segregating as a result of pleiotropic effects on fitness traits or whether this variation is due to new mutations... - qValue--a program to calculate comparative measures of genomic reorganisation from cytogenetic and/or linkage informationA S Law
Division of Molecular Biology, Roslin Institute Edinburgh, Midlothian, Scotland
Comput Appl Biosci 12:181-3. 1996..This provides a useful tool for the developing field of comparative genome mapping, particularly in the study of the evolution of the vertebrate genome... - Quantitative trait locus detection in commercial broiler lines using candidate regionsD J De Koning
Roslin Institute, Roslin, Midlothian EH25 9PS UK
J Anim Sci 81:1158-65. 2003..The results demonstrate the feasibility of QTL detection and the potential for marker-assisted selection within a commercial broiler line without altering the existing breeding scheme... - Two applications to facilitate the viewing of database search result files on the MacintoshA S Law
Division of Molecular Biology, Roslin Institute Edinburgh, Midlothian, UK
Comput Appl Biosci 13:623-4. 1997..AVAILABILITY: The programs can be obtained via anonymous ftp from ftp.ri.bbsrc.ac.uk from the directory/pub/software/MacBOB, or via WWW from the Roslin Institute Home Page (http://www.ri.bbsrc.ac.uk/)... - A chromosome-based model for estimating the number of conserved segments between pairs of species from comparative genetic mapsD Waddington
Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, Scotland
Genetics 154:323-32. 2000..The model is applied to data from two comparative maps for the chicken, one with human and one with mouse... - Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 geneB Houston
Bone Biology Group, Division of Integrative Biology, Roslin Institute, Roslin, Midlothian, UK
Anim Genet 33:451-4. 2002..Mapping of the PHOSPHO1 genes to regions of HSA17q21.3, MMU11 and GGA27 that exhibit conservation of synteny provides strong evidence that they are orthologous... - The dynamics of chromosome evolution in birds and mammalsD W Burt
Roslin Institute Edinburgh, Roslin, Midlothian, UK
Nature 402:411-3. 1999..The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates... - A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone indexI C Dunn
Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, Scotland
Anim Genet 38:45-9. 2007..Additive effects for tibiotarsal breaking strength represented 34% of the trait standard deviation and 7.6% of the phenotypic variance of the trait. These QTL for bone quality in poultry are directly relevant to commercial populations... - QTL analysis of body weight and conformation score in commercial broiler chickens using variance component and half-sib analysesS J Rowe
Roslin Institute, Roslin, Midlothian EH25 9PS, UK
Anim Genet 37:269-72. 2006..Results varied according to method of analysis and with common parent in the HS method... - Human chromosomes 3 and 21 are the products of an ancestral gene arrangement that is at least 300 million years oldJ Smith
Dept. of Molecular Biology, Roslin Institute, Roslin, Midlothian, EH25 9PS, UK
Mamm Genome 11:806-7. 2000 - Mapping of the leptin receptor gene (LEPR) to chicken chromosome 8I C Dunn
Roslin Institute, Midlothian, Scotland, U.K
Anim Genet 31:290. 2000 - Genetic mapping of the chicken prolactin receptor gene: a candidate gene for the control of broodinessI C Dunn
Roslin Institute, Edinburgh, Midlothian, Scotland
Br Poult Sci 39:S23-4. 1998 - Mapping the ABCA4, IMPDH2 and TIMP3 genes in chickenI R Paton
Department of Genomics and Bioinformatics, Roslin Institute, Roslin (Edinburgh, Midlothian, EH25 9PS, UK
Anim Genet 34:395-6. 2003 - A novel integral membrane protein is differentially expressed in the chick growth plate and maps to chromosome 1D H Lester
Division of Integrative Biology, Roslin Institute, Edinburgh, Midlothian, Scotland
Anim Genet 30:300-3. 1999..This gene was expressed in all other tissues examined. A polymorphism was identified by SSCP analysis and the gene was mapped to the centromeric region of the short arm of chicken chromosome 1, close to the locus for autosomal dwarfism... - Chicken syndecan-4 (SDC4) maps to linkage group E32E47W24I R Paton
Department of Genomics and Bioinformatics, Roslin Institute, Roslin (Edinburgh, Midlothian EH25 9PS, Scotland, UK
Anim Genet 34:237-8. 2003 - The chicken transforming growth factor-beta 3 gene: genomic structure, transcriptional analysis, and chromosomal locationD W Burt
Division of Molecular Biology, Roslin Institute Edinburgh, Midlothian, UK
DNA Cell Biol 14:111-23. 1995..Linkage to the TH locus showed that the TGFB3 locus was physically located on chicken chromosome 5... - Mapping of the prolactin gene to chicken chromosome 2Y W Miao
Roslin Institute, Midlothian, Scotland, U.K
Anim Genet 30:473. 1999 - Molecular cloning and primary structure of the chicken transforming growth factor-beta 2 geneD W Burt
Department of Cellular and Molecular Biology, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, UK
DNA Cell Biol 10:723-34. 1991..In contrast, the 3' untranslated region was highly conserved, suggesting that this region may play an important role in the expression of the TGF-beta 2 gene... - Molecular cloning and expression of bone morphogenetic protein-7 in the chick epiphyseal growth plateB Houston
Roslin Institute Edinburgh, Midlothian, UK
J Mol Endocrinol 13:289-301. 1994..These results point to a specific role for BMP-7 in the growth plate, possibly in osteoblast activation or as a chemotactic agent for the metaphyseal vessels... - Comparative analysis of human and chicken transforming growth factor-beta 2 and -beta 3 promotersD W Burt
Department of Cellular and Molecular Biology, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian
J Mol Endocrinol 7:175-83. 1991.... - ChickVD: a sequence variation database for the chicken genomeJing Wang
College of Life Sciences, Peking University, Beijing 100871, China
Nucleic Acids Res 33:D438-41. 2005..Our data can be queried by search engine and homology-based BLAST searches. ChickVD is publicly accessible at http://chicken.genomics.org.cn... - On reassessment of the chicken TGFB4 gene as TGFB1Jaroslava Halper
Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 7388, USA
Growth Factors 22:121-2. 2004..We, therefore, suggest that what was once called chicken "TGFB4" is actually TGFB1. Thus, in the evolutionary lineages of birds and mammals there are only three TGFB isoforms... - Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene lossNicholas D Temperley
Department of Genomics and Genetics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
BMC Genomics 9:62. 2008..This study takes advantage of the recently sequenced chicken genome to determine the complete chicken TLR repertoire and place it in context of vertebrate genomic evolution... - Genetic, ophthalmic, morphometric and histopathological analysis of the Retinopathy Globe Enlarged (rge) chickenChris F Inglehearn
Molecular Medicine Unit, St. James's University Hospital, University of Leeds, Leeds, UK
Mol Vis 9:295-300. 2003..Candidate disease loci include RP10 (IMPDH1) and uncharacterised Ushers (USH1E) and glaucoma (GLC1F) loci... - In-silico identification of chicken immune-related genesJacqueline Smith
Division of Genomics and Bioinformatics, Roslin Institute, EH25 9PS, Roslin Edinburgh, Midlothian, UK
Immunogenetics 56:122-33. 2004..The identification of these kinds of genes will allow further study of avian immunology and will pave the way for large-scale immune-related microarray experiments, giving new insight into functional and evolutionary studies... - Isolation and mapping the chicken zona pellucida genes: an insight into the evolution of orthologous genes in different speciesJacqueline Smith
Division of Genomics and Bioinformatics, Roslin Institute, Roslin Edinburgh, Midlothian EH25 9PS, Scotland, United Kingdom
Mol Reprod Dev 70:133-45. 2005..The presence of the ZPAX gene in the chicken has highlighted a pattern of probable gene loss by deletion in mouse and gene inactivation by deletion, and base substitution in human... - Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickensHemanth Tummala
Molecular Vision Group, School of Contemporary Sciences, University of Abertay, Dundee DD1 1HG, United Kingdom
Invest Ophthalmol Vis Sci 47:4714-8. 2006..It therefore seems likely that the defect underlying these human diseases also causes reduced embryonic viability in the rge chicken, making it a powerful model for studying the pathology involved in these associations... - Comparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomesErik Axelsson
Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
Genome Res 15:120-5. 2005..094) are significantly lower than those of macrochromosomes (average, 0.185; P = 0.025), suggesting that the proteins of genes on microchromosomes are under greater evolutionary constraint... - Comparative mapping of human Chromosome 19 with the chicken shows conserved synteny and gives an insight into chromosomal evolutionJacqueline Smith
Division of Genomics and Bioinformatics, Roslin Institute, Roslin Edinburgh, Midlothian EH25 9PS, UK
Mamm Genome 13:310-5. 2002..The ancestral nature of the chicken karyotype is demonstrated and may prove to be an excellent tool for studying genome evolution... - Identification of a non-mammalian leptin-like gene: characterization and expression in the tiger salamander (Ambystoma tigrinum)Timothy Boswell
Division of Genetics and Genomics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
Gen Comp Endocrinol 146:157-66. 2006..The characterization of a salamander leptin-like gene provides a basis for understanding how the structure and functions of leptin have altered during the evolution of tetrapod vertebrates... - Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolutionLadeana W Hillier
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 432:695-716. 2004..The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture... - Analysis of the rdd locus in chicken: a model for human retinitis pigmentosaDavid W Burt
Division of Genomics and Bioinformatics, Roslin Institute, Edinburgh, Midlothian, UK
Mol Vis 9:164-70. 2003..Linkage mapping places rdd in a region homologous to human chromosomes 9p and 5q. Candidate disease genes or loci include PDE6A, WGN1, and USH2C. This is the first use of genetic mapping in a chicken model of human disease... - A genetic variation map for chicken with 2.8 million single-nucleotide polymorphismsGane Ka-Shu Wong
Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
Nature 432:717-22. 2004..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases... - A comprehensive collection of chicken cDNAsPaul E Boardman
Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P.O. Box 88, M60 1QD, Manchester, United Kingdom
Curr Biol 12:1965-9. 2002..Using this dataset, we estimate that chickens have approximately 35,000 genes in total, suggesting that this number may be a characteristic feature of vertebrates... - Craniofacial development in the talpid3 chicken mutantPaul Buxton
Department of Craniofacial Development, GKT Dental Institute, Floor 27 Guy s Tower, Guy s Hospital, London SE1 9RT, UK
Differentiation 72:348-62. 2004..This gene expression analysis in the talpid(3) head also confirms and extends knowledge of the importance of Shh signaling and the balance between activation and repression of Shh targets in many aspects of craniofacial morphogenesis... - A genome-wide linkage study in families with major depression and co-morbid unexplained swellingCarl A Anderson
Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
Am J Med Genet B Neuropsychiatr Genet 147:356-62. 2008....