Dave Burt

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. pmc Development of a cDNA array for chicken gene expression analysis
    Joan Burnside
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Room 229, Newark, DE 19711, USA
    BMC Genomics 6:13. 2005
  2. pmc Development of a chicken 5 K microarray targeted towards immune function
    Jacqueline Smith
    Division of Genetics and Genomics, Roslin Institute, Roslin, Edinburgh, Midlothian, EH25 9PS, UK
    BMC Genomics 7:49. 2006
  3. pmc Gene duplication and fragmentation in the zebra finch major histocompatibility complex
    Christopher N Balakrishnan
    Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    BMC Biol 8:29. 2010
  4. ncbi request reprint Preliminary linkage map of the turkey (Meleagris gallopavo) based on microsatellite markers
    D W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Anim Genet 34:399-409. 2003
  5. ncbi request reprint The chicken genome and the developmental biologist
    David W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
    Mech Dev 121:1129-35. 2004
  6. ncbi request reprint Genetics. Chicken genome--science nuggets to come soon
    Dave Burt
    Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
    Science 300:1669. 2003
  7. ncbi request reprint Comparative mapping in farm animals
    David W Burt
    UK Centre for Functional Genomics in Farm Animanls, Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian, UK
    Brief Funct Genomic Proteomic 1:159-68. 2002
  8. ncbi request reprint Mapping quantitative trait loci and identification of genes that control fatness in poultry
    David W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Proc Nutr Soc 61:441-6. 2002
  9. ncbi request reprint Origin and evolution of avian microchromosomes
    D W Burt
    Department of Genomics and Bioinformatics, Roslin Institute, Roslin, Midlothian, United Kingdom
    Cytogenet Genome Res 96:97-112. 2002
  10. ncbi request reprint Chicken genomics charts a path to the genome sequence
    David W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian, EH25 9PS, UK
    Brief Funct Genomic Proteomic 3:60-7. 2004

Detail Information

Publications54

  1. pmc Development of a cDNA array for chicken gene expression analysis
    Joan Burnside
    Delaware Biotechnology Institute, University of Delaware, 15 Innovation Way, Room 229, Newark, DE 19711, USA
    BMC Genomics 6:13. 2005
    ..The application of microarray technology to functional genomic analysis in the chicken has been limited by the lack of arrays containing large numbers of genes...
  2. pmc Development of a chicken 5 K microarray targeted towards immune function
    Jacqueline Smith
    Division of Genetics and Genomics, Roslin Institute, Roslin, Edinburgh, Midlothian, EH25 9PS, UK
    BMC Genomics 7:49. 2006
    ..The creation of an immune-related array is highly valuable in determining the host immune response in relation to infection with a wide variety of bacterial and viral diseases...
  3. pmc Gene duplication and fragmentation in the zebra finch major histocompatibility complex
    Christopher N Balakrishnan
    Department of Organismic and Evolutionary Biology, Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA
    BMC Biol 8:29. 2010
    ....
  4. ncbi request reprint Preliminary linkage map of the turkey (Meleagris gallopavo) based on microsatellite markers
    D W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Anim Genet 34:399-409. 2003
    ..All primer information, polymerase chain reaction (PCR) conditions, allele sizes and genetic linkage maps can be viewed at http://roslin.thearkdb.org/. The DNA is also available on request through the Roslin Institute...
  5. ncbi request reprint The chicken genome and the developmental biologist
    David W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
    Mech Dev 121:1129-35. 2004
    ..In this paper we review progress in chicken genomics and discuss how the new tools and information on the chicken genome can help the developmental biologists now and in the future...
  6. ncbi request reprint Genetics. Chicken genome--science nuggets to come soon
    Dave Burt
    Roslin Institute Edinburgh, Midlothian EH25 9PS, UK
    Science 300:1669. 2003
  7. ncbi request reprint Comparative mapping in farm animals
    David W Burt
    UK Centre for Functional Genomics in Farm Animanls, Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Midlothian, UK
    Brief Funct Genomic Proteomic 1:159-68. 2002
    ....
  8. ncbi request reprint Mapping quantitative trait loci and identification of genes that control fatness in poultry
    David W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Proc Nutr Soc 61:441-6. 2002
    ..Progress in mapping quantitative trait loci for growth and fatness traits will be discussed, as an application of these new technologies and approaches in the study of avian physiology and genetics...
  9. ncbi request reprint Origin and evolution of avian microchromosomes
    D W Burt
    Department of Genomics and Bioinformatics, Roslin Institute, Roslin, Midlothian, United Kingdom
    Cytogenet Genome Res 96:97-112. 2002
    ..A "Fission-Fusion Model" of microchromosome evolution based on chromosome rearrangement and minimization of repeat content is discussed...
  10. ncbi request reprint Chicken genomics charts a path to the genome sequence
    David W Burt
    Department of Genomics and Bioinformatics, Roslin Institute Edinburgh, Roslin, Midlothian, EH25 9PS, UK
    Brief Funct Genomic Proteomic 3:60-7. 2004
    ..No other animal species have been phenotyped and selected so intensively as agricultural animals and thus there is much to be learned in basic and medical biology from this research...
  11. ncbi request reprint Emergence of the chicken as a model organism: implications for agriculture and biology
    D W Burt
    Roslin Institute, Edinburgh, Midlothian EH25 9PS, United Kingdom
    Poult Sci 86:1460-71. 2007
    ..These advances are reviewed and their implications are discussed...
  12. ncbi request reprint Avian genomics in the 21st century
    D W Burt
    Department of Genomics and Genetics, Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Cytogenet Genome Res 117:6-13. 2007
    ..The availability of new tools such as whole-genome gene expression arrays and SNP panels, coupled with information resources on the genes and proteins are likely to enhance this position...
  13. doi request reprint The chicken genome
    D W Burt
    Department of Genomics and Genetics, Roslin Institute, Edinburgh, UK
    Genome Dyn 2:123-37. 2006
    ..In this report these advances are reviewed and the implications of the chicken genome in current and future applications are discussed...
  14. ncbi request reprint Chicken genome: current status and future opportunities
    David W Burt
    Department of Genomics and Genetics, Roslin Institute Edinburgh, Midlothian EH25 9PS, United Kingdom
    Genome Res 15:1692-8. 2005
    ..Many of the features of the chicken genome and its biology make it an ideal organism for studies in development and evolution, along with applications in agriculture and medicine...
  15. ncbi request reprint Quantitative trait loci for bone traits segregating independently of those for growth in an F2 broiler x layer cross
    P W A Sharman
    Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, The King s Buildings, Edinburgh, UK
    Cytogenet Genome Res 117:296-304. 2007
    ....
  16. ncbi request reprint Quantitative trait loci affecting fatness in the chicken
    C O N Ikeobi
    Roslin Institute, Edinburgh, Scotland, UK
    Anim Genet 33:428-35. 2002
    ..2-0.8 phenotypic standard deviations. The largest additive QTL (on chromosome 7) accounted for more than 20% of the mean weight of abdominal fat. Significant positive and negative QTL were identified from both lines...
  17. ncbi request reprint Mapping of quantitative trait loci for body weight at three, six, and nine weeks of age in a broiler layer cross
    A Sewalem
    Roslin Institute, Roslin, Midlothian EH25 9PS, Scotland
    Poult Sci 81:1775-81. 2002
    ..Interactions of the QTL with sex or family were unimportant. There was no evidence for imprinting or of two or more QTL at the same location for any of the traits...
  18. ncbi request reprint Mapping of quantitative trait loci affecting organ weights and blood variables in a broiler layer cross
    P Navarro
    Roslin Institute, Roslin, Midlothian
    Br Poult Sci 46:430-42. 2005
    ....
  19. ncbi request reprint Segregation of QTL for production traits in commercial meat-type chickens
    D J De Koning
    Roslin Institute, Roslin, Midlothian EH25 9PS, UK
    Genet Res 83:211-20. 2004
    ..Future fine-mapping efforts could elucidate whether ancestral mutations are still segregating as a result of pleiotropic effects on fitness traits or whether this variation is due to new mutations...
  20. ncbi request reprint qValue--a program to calculate comparative measures of genomic reorganisation from cytogenetic and/or linkage information
    A S Law
    Division of Molecular Biology, Roslin Institute Edinburgh, Midlothian, Scotland
    Comput Appl Biosci 12:181-3. 1996
    ..This provides a useful tool for the developing field of comparative genome mapping, particularly in the study of the evolution of the vertebrate genome...
  21. ncbi request reprint Quantitative trait locus detection in commercial broiler lines using candidate regions
    D J De Koning
    Roslin Institute, Roslin, Midlothian EH25 9PS UK
    J Anim Sci 81:1158-65. 2003
    ..The results demonstrate the feasibility of QTL detection and the potential for marker-assisted selection within a commercial broiler line without altering the existing breeding scheme...
  22. ncbi request reprint Two applications to facilitate the viewing of database search result files on the Macintosh
    A S Law
    Division of Molecular Biology, Roslin Institute Edinburgh, Midlothian, UK
    Comput Appl Biosci 13:623-4. 1997
    ..MacBOB (Macintosh BLAST Output Browser) and MacBOB Filter are two Macintosh-based applications that greatly simplify the viewing of BLAST and FASTA search results files...
  23. pmc A chromosome-based model for estimating the number of conserved segments between pairs of species from comparative genetic maps
    D Waddington
    Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, Scotland
    Genetics 154:323-32. 2000
    ..The model is applied to data from two comparative maps for the chicken, one with human and one with mouse...
  24. ncbi request reprint Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene
    B Houston
    Bone Biology Group, Division of Integrative Biology, Roslin Institute, Roslin, Midlothian, UK
    Anim Genet 33:451-4. 2002
    ..Mapping of the PHOSPHO1 genes to regions of HSA17q21.3, MMU11 and GGA27 that exhibit conservation of synteny provides strong evidence that they are orthologous...
  25. ncbi request reprint The dynamics of chromosome evolution in birds and mammals
    D W Burt
    Roslin Institute Edinburgh, Roslin, Midlothian, UK
    Nature 402:411-3. 1999
    ..The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates...
  26. ncbi request reprint A QTL for osteoporosis detected in an F2 population derived from White Leghorn chicken lines divergently selected for bone index
    I C Dunn
    Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, Scotland
    Anim Genet 38:45-9. 2007
    ..Additive effects for tibiotarsal breaking strength represented 34% of the trait standard deviation and 7.6% of the phenotypic variance of the trait. These QTL for bone quality in poultry are directly relevant to commercial populations...
  27. ncbi request reprint QTL analysis of body weight and conformation score in commercial broiler chickens using variance component and half-sib analyses
    S J Rowe
    Roslin Institute, Roslin, Midlothian EH25 9PS, UK
    Anim Genet 37:269-72. 2006
    ..Results varied according to method of analysis and with common parent in the HS method...
  28. ncbi request reprint Human chromosomes 3 and 21 are the products of an ancestral gene arrangement that is at least 300 million years old
    J Smith
    Dept of Molecular Biology, Roslin Institute, Roslin, Midlothian, EH25 9PS, UK
    Mamm Genome 11:806-7. 2000
  29. ncbi request reprint Mapping of the leptin receptor gene (LEPR) to chicken chromosome 8
    I C Dunn
    Roslin Institute, Midlothian, Scotland, U K
    Anim Genet 31:290. 2000
  30. ncbi request reprint Genetic mapping of the chicken prolactin receptor gene: a candidate gene for the control of broodiness
    I C Dunn
    Roslin Institute, Edinburgh, Midlothian, Scotland
    Br Poult Sci 39:S23-4. 1998
  31. ncbi request reprint Mapping the ABCA4, IMPDH2 and TIMP3 genes in chicken
    I R Paton
    Department of Genomics and Bioinformatics, Roslin Institute, Roslin Edinburgh, Midlothian, EH25 9PS, UK
    Anim Genet 34:395-6. 2003
  32. ncbi request reprint A novel integral membrane protein is differentially expressed in the chick growth plate and maps to chromosome 1
    D H Lester
    Division of Integrative Biology, Roslin Institute, Edinburgh, Midlothian, Scotland
    Anim Genet 30:300-3. 1999
    ..This gene was expressed in all other tissues examined. A polymorphism was identified by SSCP analysis and the gene was mapped to the centromeric region of the short arm of chicken chromosome 1, close to the locus for autosomal dwarfism...
  33. ncbi request reprint Chicken syndecan-4 (SDC4) maps to linkage group E32E47W24
    I R Paton
    Department of Genomics and Bioinformatics, Roslin Institute, Roslin Edinburgh, Midlothian EH25 9PS, Scotland, UK
    Anim Genet 34:237-8. 2003
  34. ncbi request reprint The chicken transforming growth factor-beta 3 gene: genomic structure, transcriptional analysis, and chromosomal location
    D W Burt
    Division of Molecular Biology, Roslin Institute Edinburgh, Midlothian, UK
    DNA Cell Biol 14:111-23. 1995
    ..Linkage to the TH locus showed that the TGFB3 locus was physically located on chicken chromosome 5...
  35. ncbi request reprint Mapping of the prolactin gene to chicken chromosome 2
    Y W Miao
    Roslin Institute, Midlothian, Scotland, U K
    Anim Genet 30:473. 1999
  36. ncbi request reprint Molecular cloning and primary structure of the chicken transforming growth factor-beta 2 gene
    D W Burt
    Department of Cellular and Molecular Biology, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian, UK
    DNA Cell Biol 10:723-34. 1991
    ..In contrast, the 3' untranslated region was highly conserved, suggesting that this region may play an important role in the expression of the TGF-beta 2 gene...
  37. ncbi request reprint Molecular cloning and expression of bone morphogenetic protein-7 in the chick epiphyseal growth plate
    B Houston
    Roslin Institute Edinburgh, Midlothian, UK
    J Mol Endocrinol 13:289-301. 1994
    ..These results point to a specific role for BMP-7 in the growth plate, possibly in osteoblast activation or as a chemotactic agent for the metaphyseal vessels...
  38. ncbi request reprint Comparative analysis of human and chicken transforming growth factor-beta 2 and -beta 3 promoters
    D W Burt
    Department of Cellular and Molecular Biology, AFRC Institute of Animal Physiology and Genetics Research, Roslin, Midlothian
    J Mol Endocrinol 7:175-83. 1991
    ....
  39. pmc ChickVD: a sequence variation database for the chicken genome
    Jing Wang
    College of Life Sciences, Peking University, Beijing 100871, China
    Nucleic Acids Res 33:D438-41. 2005
    ..Our data can be queried by search engine and homology-based BLAST searches. ChickVD is publicly accessible at http://chicken.genomics.org.cn...
  40. ncbi request reprint On reassessment of the chicken TGFB4 gene as TGFB1
    Jaroslava Halper
    Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602 7388, USA
    Growth Factors 22:121-2. 2004
    ..We, therefore, suggest that what was once called chicken "TGFB4" is actually TGFB1. Thus, in the evolutionary lineages of birds and mammals there are only three TGFB isoforms...
  41. pmc Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss
    Nicholas D Temperley
    Department of Genomics and Genetics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    BMC Genomics 9:62. 2008
    ..This study takes advantage of the recently sequenced chicken genome to determine the complete chicken TLR repertoire and place it in context of vertebrate genomic evolution...
  42. ncbi request reprint Genetic, ophthalmic, morphometric and histopathological analysis of the Retinopathy Globe Enlarged (rge) chicken
    Chris F Inglehearn
    Molecular Medicine Unit, St James s University Hospital, University of Leeds, Leeds, UK
    Mol Vis 9:295-300. 2003
    ..To identify the locus responsible for rge (retinopathy globe enlarged) in chickens and further characterise the rge phenotype...
  43. ncbi request reprint In-silico identification of chicken immune-related genes
    Jacqueline Smith
    Division of Genomics and Bioinformatics, Roslin Institute, EH25 9PS, Roslin Edinburgh, Midlothian, UK
    Immunogenetics 56:122-33. 2004
    ..The identification of these kinds of genes will allow further study of avian immunology and will pave the way for large-scale immune-related microarray experiments, giving new insight into functional and evolutionary studies...
  44. ncbi request reprint Isolation and mapping the chicken zona pellucida genes: an insight into the evolution of orthologous genes in different species
    Jacqueline Smith
    Division of Genomics and Bioinformatics, Roslin Institute, Roslin Edinburgh, Midlothian EH25 9PS, Scotland, United Kingdom
    Mol Reprod Dev 70:133-45. 2005
    ..The presence of the ZPAX gene in the chicken has highlighted a pattern of probable gene loss by deletion in mouse and gene inactivation by deletion, and base substitution in human...
  45. ncbi request reprint Mutation in the guanine nucleotide-binding protein beta-3 causes retinal degeneration and embryonic mortality in chickens
    Hemanth Tummala
    Molecular Vision Group, School of Contemporary Sciences, University of Abertay, Dundee DD1 1HG, United Kingdom
    Invest Ophthalmol Vis Sci 47:4714-8. 2006
    ..To identify the gene defect that causes blindness and the predisposition to embryonic death in the retinopathy globe enlarged (rge) chicken...
  46. pmc Comparison of the chicken and turkey genomes reveals a higher rate of nucleotide divergence on microchromosomes than macrochromosomes
    Erik Axelsson
    Department of Evolutionary Biology, Evolutionary Biology Centre, Uppsala University, SE 752 36 Uppsala, Sweden
    Genome Res 15:120-5. 2005
    ..094) are significantly lower than those of macrochromosomes (average, 0.185; P = 0.025), suggesting that the proteins of genes on microchromosomes are under greater evolutionary constraint...
  47. ncbi request reprint Comparative mapping of human Chromosome 19 with the chicken shows conserved synteny and gives an insight into chromosomal evolution
    Jacqueline Smith
    Division of Genomics and Bioinformatics, Roslin Institute, Roslin Edinburgh, Midlothian EH25 9PS, UK
    Mamm Genome 13:310-5. 2002
    ..The ancestral nature of the chicken karyotype is demonstrated and may prove to be an excellent tool for studying genome evolution...
  48. ncbi request reprint Identification of a non-mammalian leptin-like gene: characterization and expression in the tiger salamander (Ambystoma tigrinum)
    Timothy Boswell
    Division of Genetics and Genomics, Roslin Institute Edinburgh, Roslin, Midlothian EH25 9PS, UK
    Gen Comp Endocrinol 146:157-66. 2006
    ..The characterization of a salamander leptin-like gene provides a basis for understanding how the structure and functions of leptin have altered during the evolution of tetrapod vertebrates...
  49. ncbi request reprint Analysis of the rdd locus in chicken: a model for human retinitis pigmentosa
    David W Burt
    Division of Genomics and Bioinformatics, Roslin Institute, Edinburgh, Midlothian, UK
    Mol Vis 9:164-70. 2003
    ..To identify the locus responsible for the blind mutation rdd (retinal dysplasia and degeneration) in chickens and to further characterise the rdd phenotype...
  50. pmc A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms
    Gane Ka Shu Wong
    Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
    Nature 432:717-22. 2004
    ..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases...
  51. ncbi request reprint A comprehensive collection of chicken cDNAs
    Paul E Boardman
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P O Box 88, M60 1QD, Manchester, United Kingdom
    Curr Biol 12:1965-9. 2002
    ..Using this dataset, we estimate that chickens have approximately 35,000 genes in total, suggesting that this number may be a characteristic feature of vertebrates...
  52. ncbi request reprint Craniofacial development in the talpid3 chicken mutant
    Paul Buxton
    Department of Craniofacial Development, GKT Dental Institute, Floor 27 Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Differentiation 72:348-62. 2004
    ..This gene expression analysis in the talpid(3) head also confirms and extends knowledge of the importance of Shh signaling and the balance between activation and repression of Shh targets in many aspects of craniofacial morphogenesis...
  53. ncbi request reprint A genome-wide linkage study in families with major depression and co-morbid unexplained swelling
    Carl A Anderson
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 147:356-62. 2008
    ....