M J Berridge

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. doi request reprint Calcium signalling and Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Neurochem Res 36:1149-56. 2011
  2. ncbi request reprint Unlocking the secrets of cell signaling
    Michael J Berridge
    The Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB2 4AT, United Kingdom
    Annu Rev Physiol 67:1-21. 2005
  3. ncbi request reprint Conformational coupling: a physiological calcium entry mechanism
    Michael Berridge
    Calcium Group, Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    Sci STKE 2004:pe33. 2004
  4. ncbi request reprint The versatility and universality of calcium signalling
    M J Berridge
    The Babraham Institute, Laboratory of Molecular Signalling, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    Nat Rev Mol Cell Biol 1:11-21. 2000
  5. ncbi request reprint Remodelling Ca2+ signalling systems and cardiac hypertrophy
    M J Berridge
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem Soc Trans 34:228-31. 2006
  6. ncbi request reprint Calcium signalling: dynamics, homeostasis and remodelling
    Michael J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Mol Cell Biol 4:517-29. 2003
  7. ncbi request reprint The endoplasmic reticulum: a multifunctional signaling organelle
    Michael J Berridge
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB2 4AT, Babraham, UK
    Cell Calcium 32:235-49. 2002
  8. ncbi request reprint Calcium microdomains: organization and function
    Michael J Berridge
    Babraham Institute, Babraham, Cambridge, UK
    Cell Calcium 40:405-12. 2006
  9. pmc Smooth muscle cell calcium activation mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB22 4AT, UK
    J Physiol 586:5047-61. 2008
  10. doi request reprint Inositol trisphosphate and calcium signalling mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochim Biophys Acta 1793:933-40. 2009

Collaborators

  • M D Bootman
  • P Lipp
  • H L Roderick
  • Tony J Collins
  • K W Young
  • C C Petersen
  • L Missiaen
  • A Holmes
  • F Ciccolini
  • Jen Liou
  • Nael Nadif Kasri
  • E N Olson
  • Robert Lefkowitz
  • John Doyle
  • Rui Chen
  • R J Bram
  • Clark W Distelhorst
  • W A Catterall
  • Melanie Cobb
  • Lauren Mackenzie
  • Stuart J Conway
  • S C Tovey
  • Andrew Proven
  • Claire M Peppiatt
  • Alfred G Gilman
  • L Mackenzie
  • L K Bobanovic
  • Stephen J Capper
  • Jeffrey K Horton
  • Jeong T Seo
  • Paul C Sternweis
  • Jan Thuring
  • Madhusudan Natarajan
  • Robert S Sinkovits
  • Stephen B Milne
  • Anthony J Pawson
  • James E Ferrell
  • H Alex Brown
  • Tobias Meyer
  • Henry R Bourne
  • Robert Hsueh
  • Jeffrey S Forrester
  • Keng Mean Lin
  • Bruce A Harris
  • Heping Han
  • Joan S Brugge
  • Won Do Heo
  • Martha L Gray
  • Rama Ranganathan
  • Mika Laine
  • Tony Hunter
  • Wen Hong Li
  • Mary Verghese
  • Temple F Smith
  • Yan Ni
  • Paul C Simpson
  • Roger Y Tsien
  • David Botstein
  • Lewis C Cantley
  • Shankar Subramaniam
  • James T Stull
  • Pavlina Ivanova
  • Ronald Taussig
  • Stephen Michnick
  • Iain Fraser
  • Peter N Devreotes
  • Paul W Sternberg
  • Hongjun Shu
  • Sangdun Choi
  • Adam P Arkin
  • Deirdre Brekken
  • Jason G Cyster
  • Brian Saunders
  • Donald Hilgemann
  • Yingming Zhao
  • Joshua Li
  • Dianne DeCamp
  • Yuhong Ning
  • Arthur Weiss
  • Harold Varmus
  • Gilberto R Sambrano
  • Marc C Mumby
  • David Fruman
  • Timothy D O'Connell
  • Melvin I Simon
  • Shaun R Coughlin
  • Grischa Chandy
  • Nancy O'Rourke
  • Michael Gold
  • William E Seaman

Detail Information

Publications37

  1. doi request reprint Calcium signalling and Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge, CB22 3AT, UK
    Neurochem Res 36:1149-56. 2011
    ..Further dysregulation in Ca(2+) signalling will then go on to induce the neurodegeneration that characterizes the later stages of dementia...
  2. ncbi request reprint Unlocking the secrets of cell signaling
    Michael J Berridge
    The Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB2 4AT, United Kingdom
    Annu Rev Physiol 67:1-21. 2005
    ....
  3. ncbi request reprint Conformational coupling: a physiological calcium entry mechanism
    Michael Berridge
    Calcium Group, Laboratory of Molecular Signalling, The Babraham Institute, Babraham Research Campus, Cambridge, CB2 4AT, UK
    Sci STKE 2004:pe33. 2004
    ....
  4. ncbi request reprint The versatility and universality of calcium signalling
    M J Berridge
    The Babraham Institute, Laboratory of Molecular Signalling, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    Nat Rev Mol Cell Biol 1:11-21. 2000
    ..Exceeding its normal spatial and temporal boundaries can result in cell death through both necrosis and apoptosis...
  5. ncbi request reprint Remodelling Ca2+ signalling systems and cardiac hypertrophy
    M J Berridge
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem Soc Trans 34:228-31. 2006
    ..It is a change in the properties of the Ca2+ transient that seems to carry the information responsible for the remodelling of the cardiac gene transcription programme that leads first to hypertrophy and then to congestive heart failure...
  6. ncbi request reprint Calcium signalling: dynamics, homeostasis and remodelling
    Michael J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Nat Rev Mol Cell Biol 4:517-29. 2003
    ..Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease...
  7. ncbi request reprint The endoplasmic reticulum: a multifunctional signaling organelle
    Michael J Berridge
    Laboratory of Molecular Signaling, The Babraham Institute, Cambridge CB2 4AT, Babraham, UK
    Cell Calcium 32:235-49. 2002
    ..Conversely, the presenilins that appear to increase the Ca(2+) content of the ER lumen make cells more susceptible to apoptosis...
  8. ncbi request reprint Calcium microdomains: organization and function
    Michael J Berridge
    Babraham Institute, Babraham, Cambridge, UK
    Cell Calcium 40:405-12. 2006
    ..Control of cardiac cell contraction and gene transcription provides another example of how the parallel processing of Ca(2+) signalling can occur through microdomains of intracellular Ca(2+)...
  9. pmc Smooth muscle cell calcium activation mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB22 4AT, UK
    J Physiol 586:5047-61. 2008
    ....
  10. doi request reprint Inositol trisphosphate and calcium signalling mechanisms
    Michael J Berridge
    The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochim Biophys Acta 1793:933-40. 2009
    ....
  11. doi request reprint Calcium hypothesis of Alzheimer's disease
    Michael J Berridge
    The Babraham Institute, Cambridge CB22 3AT, UK
    Pflugers Arch 459:441-9. 2010
    ..The alteration in Ca(2+) signaling will also contribute to the neurodegeneration that characterizes the later stages of dementia...
  12. ncbi request reprint Calcium signal transduction and cellular control mechanisms
    Michael J Berridge
    The Babraham Institute, The Babraham Campus, Cambridge CB2 4AT, UK
    Biochim Biophys Acta 1742:3-7. 2004
  13. ncbi request reprint The organisation and functions of local Ca(2+) signals
    M D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 114:2213-22. 2001
    ..Furthermore, local Ca(2+) signals are the triggers and building blocks for larger global signals that propagate throughout cells...
  14. ncbi request reprint Calcium signalling--an overview
    M D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    Semin Cell Dev Biol 12:3-10. 2001
    ..By mixing and matching components from the toolkit, cells can obtain Ca2+ signals that suit their physiology...
  15. pmc Predetermined recruitment of calcium release sites underlies excitation-contraction coupling in rat atrial myocytes
    L Mackenzie
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    J Physiol 530:417-29. 2001
    ..While the subsarcolemmal Ca2+ response can be considered as stereotypic, the central bulk of the cell grades its response in direct proportion to cellular Ca2+ load and Ca2+ influx...
  16. ncbi request reprint Calcium puffs are generic InsP(3)-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses
    S C Tovey
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 114:3979-89. 2001
    ..Therefore, Ca(2+) puffs underlie inositol 1,4,5-trisphosphate signalling in diverse cell types and are focal points for regulation of cellular responses...
  17. ncbi request reprint 2-Aminoethoxydiphenyl borate (2-APB) antagonises inositol 1,4,5-trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry channels
    Claire M Peppiatt
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Cell Calcium 34:97-108. 2003
    ..Our data suggest that 2-APB has multiple cellular targets, a use-dependent action, is difficult to reverse and may affect Ca(2+) signalling in cell types where InsP(3) and SOC are not active...
  18. ncbi request reprint Elementary and global aspects of calcium signalling
    M J Berridge
    Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK
    J Exp Biol 200:315-9. 1997
    ....
  19. ncbi request reprint Nuclear calcium signalling
    M D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, United Kingdom
    Cell Mol Life Sci 57:371-8. 2000
    ..Clearly, the many Ca2+ signalling mechanisms that may impinge on Ca2+(nuc) will remain a topic of controversy and debate for some time...
  20. ncbi request reprint The 1996 Massry Prize. Inositol trisphosphate and calcium: two interacting second messengers
    M J Berridge
    Babraham Institute Laboratory of Molecular Signalling, Cambridge, UK
    Am J Nephrol 17:1-11. 1997
    ..This highly versatile signalling system has been adapted to regulate a wide range of cellular processes including fertilization, development, proliferation and apoptosis...
  21. ncbi request reprint Mitochondrial Ca(2+) uptake depends on the spatial and temporal profile of cytosolic Ca(2+) signals
    T J Collins
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    J Biol Chem 276:26411-20. 2001
    ..Furthermore, in addition to the characteristics of Ca(2+) signals, Ca(2+) uniporter desensitization and proximity of mitochondria to InsP(3) receptors modulate mitochondrial Ca(2+) responses...
  22. ncbi request reprint Inositol 1,4,5-trisphosphate supports the arrhythmogenic action of endothelin-1 on ventricular cardiac myocytes
    Andrew Proven
    Calcium Group, Laboratory of Molecular Signalling, Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 119:3363-75. 2006
    ..We propose that Ins(1,4,5)P3 receptors support the development of both inotropy and spontaneous pro-arrhythmic Ca2+ signals in ventricular myocytes stimulated with a Gq-coupled agonist...
  23. pmc The role of inositol 1,4,5-trisphosphate receptors in Ca(2+) signalling and the generation of arrhythmias in rat atrial myocytes
    Lauren Mackenzie
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    J Physiol 541:395-409. 2002
    ....
  24. pmc Mitochondria are morphologically and functionally heterogeneous within cells
    Tony J Collins
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    EMBO J 21:1616-27. 2002
    ..Our data indicate that mitochondria within individual cells are morphologically heterogeneous and unconnected, allowing them to have distinct functional properties...
  25. ncbi request reprint 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    FASEB J 16:1145-50. 2002
    ..These data indicate that although it must be used with caution, 2-APB can be useful in probing certain aspects of Ca2+ signaling...
  26. pmc Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT United Kingdom
    Proc Natl Acad Sci U S A 99:7320-2. 2002
  27. ncbi request reprint Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release
    S C Tovey
    Laboratory of Molecular Signalling, Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom
    Biochem Biophys Res Commun 276:97-100. 2000
    ..With low ATP concentrations, only local Ca(2+) release events were observed. CAML did not affect the characteristics of these local Ca(2+) signals, suggesting that it does not directly affect Ca(2+) release channels...
  28. ncbi request reprint Cardiac calcium signalling
    M J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem Soc Trans 31:930-3. 2003
    ..Calcium regulates three different aspects of cardiac contraction. It drives pacemaker activity, excitation-contraction coupling and the transcriptional events that remodel the Ca(2+) signalling system in both health and disease...
  29. ncbi request reprint The spatial pattern of atrial cardiomyocyte calcium signalling modulates contraction
    Lauren Mackenzie
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham Hall, Babraham, Cambridge, CB2 4AT, UK
    J Cell Sci 117:6327-37. 2004
    ..These data indicate how calcium signals and their consequences are determined by the interplay of multiple subcellular calcium management systems...
  30. ncbi request reprint Calcium signalling: more messengers, more channels, more complexity
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, CB2 4AT, Cambridge, UK
    Curr Biol 12:R563-5. 2002
    ..Recent studies have expanded the number of channel types and messengers that lead to Ca(2+) signals within cells. Furthermore, we are beginning to understand the complex interplay between different sources of Ca(2+)...
  31. pmc Molecular cloning and immunolocalization of a novel vertebrate trp homologue from Xenopus
    L K Bobanovic
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK
    Biochem J 340:593-9. 1999
    ..Lett. 248, 195-198] we suggest that Xtrp may underlie capacitative calcium entry in Xenopus tissues...
  32. ncbi request reprint The versatility and complexity of calcium signalling
    M J Berridge
    Laboratory of Molecular Signalling, The Babraham Institute, Cambridge, UK
    Novartis Found Symp 239:52-64; discussion 64-7, 150-9. 2001
    ..The Ca2+ signal stimulates gene transcription and thus initiates the cell cycle processes that culminate in cell division...
  33. ncbi request reprint Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation
    Francesca Ciccolini
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    J Neurosci 23:103-11. 2003
    ..Thus, spontaneous Ca(2+) signals are an intrinsic property of differentiating neurosphere-derived precursors. Their frequency may specify neuronal morphology and acquisition of neurotransmitter phenotype...
  34. ncbi request reprint Calcium-induced calcium release
    H Llewelyn Roderick
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    Curr Biol 13:R425. 2003
  35. pmc Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
    Rui Chen
    Department of Medicine, Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA
    J Cell Biol 166:193-203. 2004
    ..We suggest that this functional interaction of Bcl-2 with InsP3Rs inhibits InsP3R activation and thereby regulates InsP3-induced calcium release from the ER...
  36. pmc Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins
    Nael Nadif Kasri
    Laboratorium voor Fysiologie, KU Leuven, Campus Gasthuisberg O N, Leuven, Belgium
    EMBO J 23:312-21. 2004
    ..We also show that phosphorylation of CaBP1 at a casein kinase 2 consensus site regulates its inhibition of IICR. Our data suggest that CaBPs are endogenous regulators of InsP(3)Rs tuning the sensitivity of cells to InsP(3)...
  37. ncbi request reprint Overview of the Alliance for Cellular Signaling
    Alfred G Gilman
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 420:703-6. 2002
    ..One goal is to catalyse complementary research in individual laboratories; to facilitate this, all alliance data are freely available for use by the entire research community...