Affiliation: Institute of Cancer Research
- Bavetsias V, Large J, Sun C, Bouloc N, Kosmopoulou M, Matteucci M, et al. Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate. J Med Chem. 2010;53:5213-28 pubmed publisher..019 muM). Compound 51 is highly orally bioavailable, and in in vivo efficacy studies it inhibited the growth of SW620 colon carcinoma xenografts following oral administration with no observed toxicities as defined by body weight loss. ..