S Bahn

Summary

Affiliation: Institute for Animal Health
Country: UK

Publications

  1. ncbi request reprint Oligodendrocyte dysfunction in schizophrenia and bipolar disorder
    Dmitri Tkachev
    Department of Neurobiology, Babraham Institute, Cambridge, UK
    Lancet 362:798-805. 2003
  2. ncbi request reprint Gene expression profiling in the post-mortem human brain--no cause for dismay
    S Bahn
    Department of Neurobiology, Babraham Institute, CB2 4AT, Cambridge, UK
    J Chem Neuroanat 22:79-94. 2001
  3. ncbi request reprint Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
    Sabine Bahn
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK
    Lancet 359:310-5. 2002
  4. doi request reprint Identification of a biological signature for schizophrenia in serum
    E Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 17:494-502. 2012
  5. doi request reprint Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients
    M K Chan
    Department of Chemical Engineering and Biotechnology, Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 16:1189-202. 2011
  6. pmc Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients
    D Martins-de-Souza
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    Transl Psychiatry 2:e87. 2012
  7. pmc Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients
    E Schwarz
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    Transl Psychiatry 2:e82. 2012
  8. doi request reprint Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients
    M Herberth
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 16:848-59. 2011
  9. ncbi request reprint Gene expression profiling in the adult Down syndrome brain
    H E Lockstone
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Genomics 90:647-60. 2007
  10. doi request reprint Sex-specific serum biomarker patterns in adults with Asperger's syndrome
    E Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 16:1213-20. 2011

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Oligodendrocyte dysfunction in schizophrenia and bipolar disorder
    Dmitri Tkachev
    Department of Neurobiology, Babraham Institute, Cambridge, UK
    Lancet 362:798-805. 2003
    ..Here, we investigated oligodendrocyte-specific and myelination-associated gene expression in schizophrenia and bipolar affective disorder...
  2. ncbi request reprint Gene expression profiling in the post-mortem human brain--no cause for dismay
    S Bahn
    Department of Neurobiology, Babraham Institute, CB2 4AT, Cambridge, UK
    J Chem Neuroanat 22:79-94. 2001
    ..The combination of laser-capture microdissection with high throughput profiling techniques offers opportunities to obtain precise genetic fingerprints of individual neurons allowing comparisons of normal and pathological states...
  3. ncbi request reprint Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study
    Sabine Bahn
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK
    Lancet 359:310-5. 2002
    ..We did a study to investigate abnormalities in gene expression in human neuronal stem cells and progenitor cells from Down's syndrome and control post-mortem human fetal tissue...
  4. doi request reprint Identification of a biological signature for schizophrenia in serum
    E Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 17:494-502. 2012
    ..This study lays the groundwork for development of a diagnostic test that can be used as an aid for distinguishing SCZ subjects from healthy controls and from those affected by related psychiatric illnesses with overlapping symptoms...
  5. doi request reprint Evidence for disease and antipsychotic medication effects in post-mortem brain from schizophrenia patients
    M K Chan
    Department of Chemical Engineering and Biotechnology, Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 16:1189-202. 2011
    ..Most of these markers were altered specifically in SCZ as determined by analysis of the same brain region from BPD patients...
  6. pmc Identification of proteomic signatures associated with depression and psychotic depression in post-mortem brains from major depression patients
    D Martins-de-Souza
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    Transl Psychiatry 2:e87. 2012
    ..These findings suggest that it may be possible to contribute to the disease understanding by distinguishing different subtypes of MDD based on distinct brain proteomic profiles...
  7. pmc Identification of blood-based molecular signatures for prediction of response and relapse in schizophrenia patients
    E Schwarz
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    Transl Psychiatry 2:e82. 2012
    ..This study provides the groundwork for the development of novel objective clinical tests that can help psychiatrists in the clinical management of schizophrenia...
  8. doi request reprint Impaired glycolytic response in peripheral blood mononuclear cells of first-onset antipsychotic-naive schizophrenia patients
    M Herberth
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 16:848-59. 2011
    ..Moreover, these results highlight the importance of using cells for functional discovery and show that it may not be sufficient to measure protein expression levels in static states...
  9. ncbi request reprint Gene expression profiling in the adult Down syndrome brain
    H E Lockstone
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Genomics 90:647-60. 2007
    ....
  10. doi request reprint Sex-specific serum biomarker patterns in adults with Asperger's syndrome
    E Schwarz
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 16:1213-20. 2011
    ..We conclude that to understand the etiology and development of autism spectrum conditions, stratification by sex is essential...
  11. doi request reprint Expression profiling of fibroblasts identifies cell cycle abnormalities in schizophrenia
    L Wang
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    J Proteome Res 9:521-7. 2010
    ....
  12. doi request reprint Global proteomic profiling reveals altered proteomic signature in schizophrenia serum
    Y Levin
    Institute of Biotechnology, University of Cambridge, Tennis Court Road, Cambridge, UK
    Mol Psychiatry 15:1088-100. 2010
    ..The results of this large-scale study are presented along with enzyme-linked immunosorbent assay-based validation data...
  13. pmc Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders
    A Ernst
    Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK
    Transl Psychiatry 3:e263. 2013
    ..The overlap of these findings with effects seen in type 2 diabetes, schizophrenia, major depressive disorder and Alzheimer's disease might contribute to a common endophenotype seen in metabolic and neurological disorders...
  14. doi request reprint Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder
    M J Lan
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 14:269-79. 2009
    ..These findings promise to provide new insight into the pathophysiology of bipolar disorder and may be used to direct research into novel therapeutic strategies...
  15. ncbi request reprint Indexing-based differential display--studies on post-mortem Alzheimer's brains
    M Ryan
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK
    Brain Res Mol Brain Res 88:199-202. 2001
    ..Differential display results were confirmed by semi-quantitative RT-PCR on a larger number of brains...
  16. doi request reprint [Serum-based biomarkers for psychiatric disorders]
    S Bahn
    Department of Chemical Engineering and Biotechnology, Cambridge Centre for Neuropsychiatric Research, University of Cambridge, UK
    Nervenarzt 82:1395-6, 1398, 1400 passim. 2011
    ..We also describe here the development of the first ever molecular blood-test for schizophrenia, and its reception in the market place, as a case in point...
  17. ncbi request reprint Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes
    M M Ryan
    Cambridge Centre for Neuropsychiatric Research, Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 11:965-78. 2006
    ..Overall, our results suggest that dysregulation of the ubiquitin pathway and synaptic function may be central to the disease process...
  18. ncbi request reprint Independent protein-profiling studies show a decrease in apolipoprotein A1 levels in schizophrenia CSF, brain and peripheral tissues
    J T J Huang
    Institute of Biotechnology, University of Cambridge, Cambridge, UK
    Mol Psychiatry 13:1118-28. 2008
    ..05; -51%, P=0.05). These results show that apoA1 is consistently downregulated in the central nervous system as well as peripheral tissues of schizophrenia patients and may be linked to the underlying disease mechanism...
  19. pmc Disease biomarkers in cerebrospinal fluid of patients with first-onset psychosis
    Jeffrey T J Huang
    Institute of Biotechnology, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 3:e428. 2006
    ..The identification of biological markers (so-called biomarkers) of psychosis is a fundamental step towards a better understanding of the pathogenesis of psychosis and holds the potential for more objective testing methods...
  20. pmc Systematic analysis of gene expression in human brains before and after death
    Henriette Franz
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz, D 04103 Leipzig, Germany
    Genome Biol 6:R112. 2005
    ..The vast majority of human samples available for research are obtained from deceased individuals. This raises questions about how well gene expression patterns in such samples reflect those of living individuals...
  21. ncbi request reprint Quantitative polymerase chain reaction: validation of microarray results from postmortem brain studies
    Michael L Mimmack
    Department of Neurobiology, The Babraham Institute, Babraham, Cambridge CB2 4AT, United Kingdom
    Biol Psychiatry 55:337-45. 2004
    ....
  22. pmc Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22
    Michael L Mimmack
    Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 99:4680-5. 2002
    ....
  23. ncbi request reprint Increased MAP kinase activity in Alzheimer's and Down syndrome but not in schizophrenia human brain
    Jane E Swatton
    Neurobiology Programme, The Babraham Institute, Babraham, Cambridge, CB2 4AT, UK
    Eur J Neurosci 19:2711-9. 2004
    ..These data also question the significance of GSK-3 alpha beta, as much previous work carried out in vitro has placed this kinase as a favoured candidate for involvement in the pathological phosphorylation of tau...