Margaret Ashcroft

Summary

Affiliation: Institute of Cancer Research
Country: UK

Publications

  1. ncbi Phosphorylation of HDM2 by Akt
    Margaret Ashcroft
    CRC, Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Oncogene 21:1955-62. 2002
  2. pmc Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression
    Julia I Bárdos
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Mol Cell Biol 24:2905-14. 2004
  3. ncbi Negative and positive regulation of HIF-1: a complex network
    Julia I Bárdos
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK, Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK
    Biochim Biophys Acta 1755:107-20. 2005
  4. ncbi Hypoxia-inducible factor-1 and oncogenic signalling
    Julia I Bárdos
    Cell Growth Regulation and Angiogenesis Laboratory, Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, UK
    Bioessays 26:262-9. 2004
  5. ncbi Targeting the molecular basis for tumour hypoxia
    Veronica A Carroll
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
    Expert Rev Mol Med 7:1-16. 2005
  6. pmc Akt2: a role in breast cancer metastasis
    Noan Minh Chau
    Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK
    Breast Cancer Res 6:55-7. 2004
  7. ncbi Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors
    Noan Minh Chau
    Cell Growth Regulation and Angiogenesis Team, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer Res 65:4918-28. 2005
  8. ncbi Proceedings of the Oxygen Homeostasis/Hypoxia Meeting
    Bennett Kaufman
    TRI Inc, Rockville, Maryland, USA
    Cancer Res 64:3350-6. 2004
  9. ncbi Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway
    Veronica A Carroll
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, United Kingdom
    Cancer Res 66:6264-70. 2006
  10. doi Regulation of angiogenic factors by HDM2 in renal cell carcinoma
    Veronica A Carroll
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, Surrey, United Kingdom
    Cancer Res 68:545-52. 2008

Collaborators

Detail Information

Publications10

  1. ncbi Phosphorylation of HDM2 by Akt
    Margaret Ashcroft
    CRC, Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
    Oncogene 21:1955-62. 2002
    ..Tryptic peptide and mutational analyses revealed evidence for an Akt phosphorylation site in HDM2 additional to the two consensus sites...
  2. pmc Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1alpha expression
    Julia I Bárdos
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
    Mol Cell Biol 24:2905-14. 2004
    ..Our study has important implications for the role of the PI-3K-Akt/PKB-HDM2 pathway in tumor progression and angiogenesis...
  3. ncbi Negative and positive regulation of HIF-1: a complex network
    Julia I Bárdos
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK, Centre for Cancer Therapeutics, The Institute of Cancer Research, 15 Cotswold Road, Sutton SM2 5NG, UK
    Biochim Biophys Acta 1755:107-20. 2005
    ..Our understanding of the key signalling pathways that regulate HIF-1 has significantly progressed in recent years and has highlighted the potential for targeting the HIF-1 pathway as a basis for the development of new cancer therapies...
  4. ncbi Hypoxia-inducible factor-1 and oncogenic signalling
    Julia I Bárdos
    Cell Growth Regulation and Angiogenesis Laboratory, Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, UK
    Bioessays 26:262-9. 2004
    ..A better understanding of this regulation may provide a basis for the development of new cancer therapies...
  5. ncbi Targeting the molecular basis for tumour hypoxia
    Veronica A Carroll
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
    Expert Rev Mol Med 7:1-16. 2005
    ..Efforts are currently under way to develop targeted cancer therapeutics to hypoxia-activated pathways, and in particular to the transcription factor HIF...
  6. pmc Akt2: a role in breast cancer metastasis
    Noan Minh Chau
    Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK
    Breast Cancer Res 6:55-7. 2004
    ..However, the precise contribution of the Akt kinase family members, Akt1, Akt2 and Akt3, in mediating these processes is unclear. The possibility that they have distinct functions in tumour progression is particularly interesting...
  7. ncbi Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors
    Noan Minh Chau
    Cell Growth Regulation and Angiogenesis Team, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, United Kingdom
    Cancer Res 65:4918-28. 2005
    ..Our cell-based assay approach has successfully identified novel compounds that differentially target hypoxia and/or growth factor-mediated induction of HIF-1alpha...
  8. ncbi Proceedings of the Oxygen Homeostasis/Hypoxia Meeting
    Bennett Kaufman
    TRI Inc, Rockville, Maryland, USA
    Cancer Res 64:3350-6. 2004
  9. ncbi Role of hypoxia-inducible factor (HIF)-1alpha versus HIF-2alpha in the regulation of HIF target genes in response to hypoxia, insulin-like growth factor-I, or loss of von Hippel-Lindau function: implications for targeting the HIF pathway
    Veronica A Carroll
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, United Kingdom
    Cancer Res 66:6264-70. 2006
    ..Our data have important implications for how we target the HIF pathway therapeutically...
  10. doi Regulation of angiogenic factors by HDM2 in renal cell carcinoma
    Veronica A Carroll
    Cell Growth Regulation and Angiogenesis Laboratory, Cancer Research UK Centre for Cancer Therapeutics, Surrey, United Kingdom
    Cancer Res 68:545-52. 2008
    ..This study identifies a novel role for the HDM2 oncoprotein in the regulation of angiogenic factors in renal cell carcinoma...