John Ashburner

..We propose that the analysis of VBCT maps can provide results that are complementary to other anatomical analyses such as voxel-based morphometry...

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..Thirdly, the method is robust and can be generalized across different centres. This suggests an important role for computer based diagnostic image analysis for clinical practice...

..g. grey and white matter) are registered simultaneously with the current template estimate. In order to generalise the resulting template to a broader range of subjects, a template blurriness prior is included within the model...

..We illustrate MVB using simulated and real data, with a special focus on model comparison; where models can differ in the form of the mapping (i.e., neuronal representation) within one region, or in the (combination of) regions per se...

..UNICORT is easy to apply, as it is computationally efficient and its basic framework is implemented as part of the tissue segmentation in SPM8...

..Although the original work was aimed at the PBAIC, many techniques described in this paper can be generally applied to any fMRI decoding works to increase the prediction accuracy...

..This has important implications for users of both structural and functional imaging techniques in the study of patients with structural brain damage...

..In contrast, the overall form of the brain may be more accurately modeled using multivariate approaches. Such models of anatomical variability may prove accurate enough for computer assisted diagnoses...

..We therefore propose that used together, these techniques can separate the underlying grey matter changes, highlighting the utility of combining these complementary methods...

..The algorithm was evaluated using freely available manually labelled datasets, and found to compare favourably with other inter-subject registration algorithms evaluated using the same data...

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..Karl Friston began the SPM project around 1991. The rest is history...

..In the present study, we examined the prognostic and diagnostic potential of the structural neural correlates of depression...

..Similar analyses in other multi-scanner data-sets could be used to justify the pooling of data when needed, such as in studies of rare disorders or in multi-center designs...

..A strategy for optimising the model parameters is described, along with the requisite partial derivatives of the objective function...

..Knowledge of some basic linear algebra and probability theory should make the review easier to follow, although it may still have something to offer to those readers whose mathematics may be more limited...

..Finally, we also consider, briefly, dynamic models and how these inform the regularisation of free energy ascent schemes, like EM and ReML...

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..The finding suggests the possibility that the heterogeneous manifestations of ASD can be aetiologically characterised into distinct subtypes through genetic-morphological analysis...

..In addition, the Bayesian approach returns the posterior distribution which allows for some characterisation of the error component. The method is applied to the estimation of parametric images of neuroreceptor radioligand studies...

..We believe that this method can be used to examine pathophysiological concepts in a number of basal ganglia-related disorders...

..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD...

..The resulting DT maps exhibit considerably higher geometric fidelity, as assessed by comparison to an image volume acquired using a conventional 3D MR technique...

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..However, we suggest that the variance between successively measured field maps introduces additional unwanted variance in the voxel time-series and is therefore not adequate to correct for time-varying distortions...