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Genomes and Genes | V M ArltSummaryAffiliation: Institute of Cancer Research Country: UK Publications
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Publications
Analyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathyV M Arlt
Division of Molecular Toxicology, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
Mutat Res 494:143-50. 2001..These results demonstrate that OTA-related DNA adducts do not play a key role in CHN or CHN-associated urothelial cancer...- Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cellsVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Int J Cancer 105:583-92. 2003..Consequently, polymorphisms in these genes could be important determinants of lung cancer risk from 3-NBA... - DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in ratsVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Biochem Biophys Res Commun 300:107-14. 2003..Therefore, 3-NBA-DNA adducts are useful biomarkers for exposure to 3-NBA and its metabolites and may help to identify enzymes involved in their metabolic activation... - Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferaseVolker M Arlt
Institute of Cancer Research, Section of Molecular Carcinogenesis, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Carcinogenesis 23:1937-45. 2002..Moreover, the yet-unidentified four major 3-NBA-derived adducts may be DNA adducts without an N-acetyl group... - Aristolochic acid as a probable human cancer hazard in herbal remedies: a reviewVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Mutagenesis 17:265-77. 2002..Therefore, all products containing botanicals known to or suspected of containing AA should be banned from the market world wide... - Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductaseVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
Cancer Res 63:2752-61. 2003..These results demonstrate for the first time the potential of human NADPH: p450 reductase and recombinant p450s to contribute to the metabolic activation of 3-NBA by nitroreduction... - DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined by (32)P-postlabelingV M Arlt
Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 93:450-4. 2001.... - Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancerVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
Carcinogenesis 28:2253-61. 2007.... - Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthroneVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom
Toxicol Sci 98:445-57. 2007.... - Different mechanisms involved in apoptosis following exposure to benzo[a]pyrene in F258 and Hepa1c1c7 cellsJørn A Holme
Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, N 0403 Oslo, Norway
Chem Biol Interact 167:41-55. 2007.... - Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effectsNina E Landvik
Division of Environmental Medicine, Norwegian Institute of Public Health, Nydalen, N 0403 Oslo, Norway
Toxicology 231:159-74. 2007..These results suggest that after exposure to 1,8-DNP more cells may survive with DNA damage, thereby increasing its mutagenic and carcinogenic potential... - ECNIS-sponsored workshop on biomarkers of exposure and cancer risk: DNA damage and DNA adduct detection and 6th GUM-32P-postlabelling workshop, German Cancer Research Center, Heidelberg, Germany, 29-30 September 2006Volker M Arlt
Institute of Cancer Research, Section of Molecular Carcinogenesis Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK
Mutagenesis 22:83-8. 2007.... - Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in ratsChristian A Bieler
Division of Molecular Toxicology, German Cancer Research Center, INF 280, 69120 Heidelberg, Germany
Carcinogenesis 28:1117-21. 2007..The correlation between DNA adducts in lung and blood suggests that persistent 3-NBA-DNA adducts in the blood may be useful biomarkers for human respiratory exposure to 3-NBA... 
Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2Sarah L Hockley
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, UK
BMC Genomics 7:260. 2006....- DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liverNan Mei
Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, FDA, Jefferson, AR 72079, USA
Mutat Res 602:83-91. 2006..Although the same treatment does not produce tumors in rat liver, it does induce DNA adducts and mutations in this tissue, albeit at lower levels than in kidney... - The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductaseMarie Stiborova
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
Drug Metab Dispos 34:1398-405. 2006.... - DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone: analysis by the (32)P-postlabeling methodTakaharu Kanno
Frontier Science Innovation Center, Osaka Prefecture University, Osaka, Japan
Mutat Res 634:184-91. 2007..Quantitative analyses revealed that the major adduct was dA3'p-N(6)-C2-ABA and its relative adduct labeling (RAL) value at 36.4 microM of 3-NBA was 200.8+/-86.1/10(8)nucleotide... - Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathyMarie Stiborova
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
Mutat Res 658:55-67. 2008.... 
Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53Maria L Simões
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey, UK
Toxicol Appl Pharmacol 232:86-98. 2008..These results strengthen the importance of TP53 in AA-induced cancer, and indicate that other alterations, e.g. to MYC oncogenic pathways, may also contribute...- Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experimentJóhannes Reynisson
School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom
Environ Mol Mutagen 49:659-67. 2008..Therefore, our data clearly indicate that the stability of the nitrenium ions is one critical determinant of the mutagenic potency of NBAs in Salmonella tester strains... - The influence of diesel exhaust on polycyclic aromatic hydrocarbon-induced DNA damage, gene expression, and tumor initiation in Sencar mice in vivoLauren A Courter
Department of Environmental and Molecular Toxicology, Oregon State University, Agricultural and Life Sciences 1007, Corvallis, OR 97331, USA
Cancer Lett 265:135-47. 2008..Therefore we validate microarray data as a source to uncover transcriptional signatures that may provide insights into molecular pathways affected following exposure to environmental complex mixtures such as diesel exhaust particulates... - The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicityMarie Stiborova
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
Toxicology 247:11-22. 2008..These results demonstrate that 3-NBA is capable to induce NQO1 and CYP1A1 in lungs and kidney of rats thereby enhancing its own genotoxic and carcinogenic potential... - Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null miceVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Carcinogenesis 29:656-65. 2008..7- to 2.6-fold) relative to WT mice. These data reveal an apparent paradox, whereby hepatic CYP enzymes appear to be more important for detoxification of BaP in vivo, despite being involved in its metabolic activation in vitro... - The 32P-postlabeling assay for DNA adductsDavid H Phillips
Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Nat Protoc 2:2772-81. 2007..It has a wide range of applications in human, animal and in vitro studies, and can be used for a wide variety of classes of compound and for the detection of adducts formed by complex mixtures. This protocol can be completed in 3 d... - Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouseMarie Stiborova
Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
Toxicol Appl Pharmacol 226:318-27. 2008.... - AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell linesSarah L Hockley
Section of Molecular Carcinogenesis, The Institute of Cancer Research, Surrey, UK
Chem Res Toxicol 20:1797-810. 2007..Promoter analysis identified candidate genes for direct transcriptional regulation by either AHR or p53. These analyses have further dissected and characterized the complex cellular response to BaP... - Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53Sarah L Hockley
Section of Molecular Carcinogenesis, The Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, UK
Carcinogenesis 29:202-10. 2008..Taken together, these results give further insight into the role of p53 in the response of human cells to BaP and BPDE and suggest that loss of this tumour suppressor can influence the metabolic activation of BaP... - Molecular mechanism of genotoxicity of the environmental pollutant 3-nitrobenzanthroneMarie Stiborova
Department of Biochemistry, Charles University, Albertov 2030, 12840 Prague 2, Czech Republic
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:191-7. 2005..The results suggest that both CYPs and peroxidases may play an important role in metabolism of 3-ABA to reactive species forming DNA adducts, participating in genotoxicity of this compound and its parental counterpart, 3-NBA... - Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenineVolker M Arlt
Institute of Cancer Research, Section of Molecular Carcinogenesis, Sutton, Surrey, United Kingdom
Int J Cancer 118:2139-46. 2006.... - Aristolochic acid (AA)-DNA adduct as marker of AA exposure and risk factor for AA nephropathy-associated cancerVolker M Arlt
Int J Cancer 111:977-80. 2004 - DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta MouseVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Surrey, United Kingdom
Environ Mol Mutagen 43:186-95. 2004..These results suggest that G:C-->T:A transversions induced by 3-NBA are caused by misreplication of adducted guanine residues through incorporation of adenine opposite the adduct (A-rule)... - DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathyGraham M Lord
Division of Renal Medicine and Transplantation, Hammersmith Hospital NHS Trust, London, England UK
Am J Kidney Dis 43:e11-7. 2004..The authors have analyzed DNA from a patient who had urothelial malignancy 6 years after presenting with AAN and later had a breast carcinoma that metastasized to the liver... - Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B lymphoblastoid MCL-5 cellsVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK
Mutagenesis 19:149-56. 2004..Environmental exposure to 3-NBA may be a health hazard for large sections of the population and the risks associated with such exposure require further assessment... - DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone in V79 cells expressing human cytochrome P450 enzymesChristian A Bieler
Division of Molecular Toxicology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
Cancer Lett 200:9-18. 2003..Our results suggest that nitroreduction is the major pathway in the human bioactivation of 3-NBA. Moreover, acetylation of the initially formed N-hydroxy arylamine intermediates may contribute to the high genotoxic potential of 3-NBA... - Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathyFrédéric Debellé
Laboratoire de Recherche sur le Métabolisme des Peptides L R M P, Faculte de Medecine, Universite Libre de Bruxelles, 1070, Brussels, Belgium
Arch Toxicol 77:218-26. 2003..These functional and histological data suggest that DXF does not enhance AA nephrotoxicity in a rat model for CHN. Further investigations are needed to clarify the mechanism by which DXF may enhance AA-DNA adduct formation... - Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failureJoelle L Nortier
Department of Nephrology, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, B 1070 Brussels, Belgium
Nephrol Dial Transplant 18:426-8. 2003 - Is aristolochic acid a risk factor for Balkan endemic nephropathy-associated urothelial cancer?Volker M Arlt
Int J Cancer 101:500-2. 2002 - 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2Volker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Chem Res Toxicol 17:1092-101. 2004..In summary, our results strongly suggest a genotoxic potential of 3-ABA for humans. Moreover, 3-ABA is not only a suitable biomarker of exposure to 3-NBA but may also directly contribute to the high genotoxic potential of 3-NBA... - 32P-postlabeling analysis of DNA adductsDavid H Phillips
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, UK
Methods Mol Biol 291:3-12. 2005.... - 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidenceVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK
Mutagenesis 20:399-410. 2005..For an accurate risk assessment more epidemiological studies on 3-NBA-exposed individuals and a broader monitoring of environmental levels of 3-NBA are required... - Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studiesCatherine Lebeau
Laboratory for Research on Peptide Metabolism, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
Nephrol Dial Transplant 20:2321-32. 2005..Clinical and in vitro findings have previously suggested that the proximal tubule was the target of AA... - Synthesis, characterization, and 32p-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-nitrobenzanthroneMartin R Osborne
Section of Molecular Carcinogenesis and Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton, Surrey SM2 5NG, United Kingdom
Chem Res Toxicol 18:1056-70. 2005..Therefore, a different approach to the synthesis of authentic standards is needed for the structural characterization of 3-NBA-derived DNA adducts formed in vivo... - Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessmentDavid H Phillips
Institute of Cancer Research, Brookes Lawley Building, Cotswold Road, Sutton SM2 5NG, UK
Mutagenesis 20:297-303. 2005..The confinement of ST2A2, the isozyme of hydroxysteroid sulfotransferase that can activate the compounds, mainly to rat liver is the possible reason for the formation of ducts in the liver but not in other organs of the rat... - Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidasesVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Brookes Lawley Building, Sutton, Surrey SM2 5NG, UK
Cancer Lett 234:220-31. 2006..Collectively, these results suggest that both CYPs and peroxidases may play an important role in metabolizing 3-ABA to reactive DNA adduct forming species... - DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in ratsChristian A Bieler
German Cancer Research Center, Division of Molecular Toxicology, Heidelberg, Germany
Int J Cancer 116:833-8. 2005..Therefore, 3-NBA-DNA adducts present in the blood are useful biomarkers for exposure to 3-NBA and may help to assess the effective biological dose in humans exposed to it... - Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosolsVolker M Arlt
Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, United Kingdom
Cancer Res 65:2644-52. 2005..Collectively, these results show the role of human hepatic NQO1 to reduce 3-NBA to species being further activated by NATs and SULTs... - Covalent binding of the anticancer drug ellipticine to DNA in V79 cells transfected with human cytochrome P450 enzymesEva Frei
Division of Molecular Toxicology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Biochem Pharmacol 64:289-95. 2002..The results presented here are the first report showing the formation of CYP-mediated covalent DNA adducts by ellipticine in cells in culture, and confirm the formation of covalent DNA adducts as a new mechanism of ellipticine action... - Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studiesGaëlle Gillerot
Division of Nephrology and Department of Pathology, Université Catholique de Louvain Medical School, Brussels, Belgium
Kidney Int 64:1883-92. 2003..Although the fibrotic process has been documented in extrarenal tissues, the involvement of the peritoneum, as well as the efficacy of peritoneal dialysis in AAN patients, remain uncertain... - Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathyStanley H Lo
Department of Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, SAR, China
Am J Kidney Dis 45:407-10. 2005..Physicians should be on the alert for herbal nephrotoxicity by possible replacement of nontoxic herbs by nephrotoxic herbs...