L Zhao

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Comparison of 18F-FDG uptake by right ventricular myocardium in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease
    Wei Fang
    Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Pulm Circ 2:365-72. 2012
  2. pmc Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid
    Lan Zhao
    Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Du Cane Rd, London W12 ONN, UK
    Circulation 126:455-67. 2012
  3. pmc Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
    Cong Wang
    Beijing Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, PR China
    Respir Res 10:123. 2009
  4. doi request reprint Simvastatin and sildenafil combine to attenuate pulmonary hypertension
    L Zhao
    Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK
    Eur Respir J 34:948-57. 2009
  5. ncbi request reprint Sildenafil inhibits hypoxia-induced pulmonary hypertension
    L Zhao
    Section on Clinical Pharmacology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Circulation 104:424-8. 2001
  6. ncbi request reprint Genetic determination of cardiac mass in normotensive rats: results from an F344xWKY cross
    A Sebkhi
    Section on Clinical Pharmacology, Division of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, UK
    Hypertension 33:949-53. 1999
  7. doi request reprint Identification of three novel HLA-DQA1 alleles: DQA1*01:08, DQA1*01:09 and DQA1*03:03:02
    H Yan
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Tissue Antigens 80:551-3. 2012
  8. ncbi request reprint Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate
    L Zhao
    Section on Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Science, Technology, and Medicine, London, UK
    Circulation 103:442-7. 2001
  9. doi request reprint Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction
    B N Francis
    Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, DuCane Road, London, W12 ONN, UK
    Eur Respir J 36:323-30. 2010
  10. ncbi request reprint NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension
    L Zhao
    Section on Clinical Pharmacology, Imperial College School of Science, Technology, and Medicine, Hammersmith Hospital, London, UK
    Circulation 99:605-7. 1999

Collaborators

Detail Information

Publications13

  1. pmc Comparison of 18F-FDG uptake by right ventricular myocardium in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with congenital heart disease
    Wei Fang
    Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Pulm Circ 2:365-72. 2012
    ..Increased RV FDG uptake is a marker of poor prognosis in IPAH and is reduced in patients receiving effective therapy. It could prove useful in the early clinical assessment of novel therapies for PAH...
  2. pmc Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid
    Lan Zhao
    Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, Du Cane Rd, London W12 ONN, UK
    Circulation 126:455-67. 2012
    ..Little is known about the contribution of histone deacetylase (HDAC) activity to the development of pulmonary arterial hypertension, a condition characterized by profound structural remodeling of pulmonary arteries and arterioles...
  3. pmc Inhibition of SOC/Ca2+/NFAT pathway is involved in the anti-proliferative effect of sildenafil on pulmonary artery smooth muscle cells
    Cong Wang
    Beijing Institute of Respiratory Medicine, Beijing Chao Yang Hospital, Capital Medical University, Beijing, PR China
    Respir Res 10:123. 2009
    ....
  4. doi request reprint Simvastatin and sildenafil combine to attenuate pulmonary hypertension
    L Zhao
    Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, London, UK
    Eur Respir J 34:948-57. 2009
    ..These data suggest that simvastatin can be usefully combined with sildenafil in the treatment of pulmonary arterial hypertension to achieve greater therapeutic benefit...
  5. ncbi request reprint Sildenafil inhibits hypoxia-induced pulmonary hypertension
    L Zhao
    Section on Clinical Pharmacology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Circulation 104:424-8. 2001
    ..The eNOS-NO-cGMP pathway contributes to the response to sildenafil, but other biochemical sources of cGMP also play a role. Sildenafil has beneficial pulmonary hemodynamic effects even when eNOS activity is impaired...
  6. ncbi request reprint Genetic determination of cardiac mass in normotensive rats: results from an F344xWKY cross
    A Sebkhi
    Section on Clinical Pharmacology, Division of Medicine, Imperial College of Science, Technology, and Medicine, Hammersmith Hospital, London, UK
    Hypertension 33:949-53. 1999
    ..The prostaglandin synthase 1 gene is located within the QTL...
  7. doi request reprint Identification of three novel HLA-DQA1 alleles: DQA1*01:08, DQA1*01:09 and DQA1*03:03:02
    H Yan
    Department of Pulmonary Medicine, Peking University People s Hospital, Beijing, China
    Tissue Antigens 80:551-3. 2012
    ..Three novel alleles DQA1*01:08, 01:09 and 03:03:02 are described. All are single-nucleotide substitutions...
  8. ncbi request reprint Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate
    L Zhao
    Section on Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Science, Technology, and Medicine, London, UK
    Circulation 103:442-7. 2001
    ..Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2 strains were used to examine the genetic basis for the differential response...
  9. doi request reprint Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction
    B N Francis
    Experimental Medicine and Toxicology, Imperial College London, Hammersmith Hospital, DuCane Road, London, W12 ONN, UK
    Eur Respir J 36:323-30. 2010
    ..Its effects are mediated via nitric oxide, hydrogen peroxide and its antioxidant properties, and are attenuated by oxidant stress. Pharmacological administration of BH(4) may have therapeutic potential in pulmonary hypertension...
  10. ncbi request reprint NPR-A-Deficient mice show increased susceptibility to hypoxia-induced pulmonary hypertension
    L Zhao
    Section on Clinical Pharmacology, Imperial College School of Science, Technology, and Medicine, Hammersmith Hospital, London, UK
    Circulation 99:605-7. 1999
    ....
  11. ncbi request reprint [Comparison of effects of 5 and 20 Hz magnetic field on cerebral ischemia in rats]
    L Zhao
    Institute of Space Medico-Engineering, Beijing, China
    Space Med Med Eng (Beijing) 14:41-4. 2001
    ..Conclusion: Magnetic field stimulation influences cerebral ischemic reaction with frequency-dependency...
  12. ncbi request reprint [Changes of early components of auditory ERPs during HDT-simulated weightlessness]
    L Zhao
    Institute of Space Medico-Engineering, Beijing, China
    Space Med Med Eng (Beijing) 14:395-9. 2001
    ..Conclusion. These data provided further evidence showing that the early activity process of brain was also affected by simulated weightlessness...
  13. doi request reprint HLA-DQ association and allele competition in Chinese narcolepsy
    F Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Tissue Antigens 80:328-35. 2012
    ....