Affiliation: Imperial College
Zhao L, Sebkhi A, Ali O, Wojciak Stothard B, Mamanova L, Yang Q, et al
. Simvastatin and sildenafil combine to attenuate pulmonary hypertension. Eur Respir J. 2009;34:948-57 pubmed publisher
..These data suggest that simvastatin can be usefully combined with sildenafil in the treatment of pulmonary arterial hypertension to achieve greater therapeutic benefit. ..
Zhao L, Chen C, Hajji N, Oliver E, Cotroneo E, Wharton J, et al
. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012;126:455-67 pubmed publisher
..The effectiveness of HDAC inhibitors, valproic acid, and suberoylanilide hydroxamic acid, in models of pulmonary arterial hypertension supports a therapeutic strategy based on HDAC inhibition in pulmonary arterial hypertension. ..
Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al
. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res. 2015;116:1680-90 pubmed publisher
..These data suggest a major role for iron in pulmonary vascular homeostasis and support the clinical evaluation of iron replacement in patients with pulmonary hypertension. ..