Douglas Young

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Bovine tuberculosis and brucellosis prevalence in cattle from selected milk cooperatives in Arsi zone, Oromia region, Ethiopia
    Rea Tschopp
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    BMC Vet Res 9:163. 2013
  2. doi request reprint Creativity in tuberculosis research and discovery
    Douglas Younga
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    Tuberculosis (Edinb) 92:S14-6. 2012
  3. pmc Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis
    Katalin A Wilkinson
    National Institute for Medical Research, Mill Hill, London, UK
    BMC Microbiol 9:93. 2009
  4. pmc Bovine tuberculosis at a cattle-small ruminant-human interface in Meskan, Gurage region, Central Ethiopia
    Rea Tschopp
    Swiss Tropical and Public Health Institute, PO Box, CH 4002, Basel, Switzerland
    BMC Infect Dis 11:318. 2011
  5. doi request reprint Animal models of tuberculosis
    Douglas Young
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 39:2011-4. 2009
  6. ncbi request reprint Prospects for molecular epidemiology of leprosy
    Douglas Young
    CMMI, Flowers Building, Imperial College London, UK
    Lepr Rev 74:11-7. 2003
  7. doi request reprint Systems biology of persistent infection: tuberculosis as a case study
    Douglas Young
    Centre for Integrative Systems Biology at Imperial College, Imperial College London, London SW7 2AZ, UK
    Nat Rev Microbiol 6:520-8. 2008
  8. ncbi request reprint The development and impact of tuberculosis vaccines
    Douglas Young
    Imperial College, University of London, South Kensington Campus, London SW7 2AZ, United Kingdom
    Cell 124:683-7. 2006
  9. doi request reprint Detection and treatment of subclinical tuberculosis
    Brian D Robertson
    Rapporteur, Imperial College London, MRC Centre for Molecular Bacteriology and Infection, Flowers Building, South Kensington Campus, London SW7 2AZ, UK
    Tuberculosis (Edinb) 92:447-52. 2012
  10. pmc Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis
    Kristine Arnvig
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    RNA Biol 9:427-36. 2012

Collaborators

Detail Information

Publications19

  1. pmc Bovine tuberculosis and brucellosis prevalence in cattle from selected milk cooperatives in Arsi zone, Oromia region, Ethiopia
    Rea Tschopp
    Armauer Hansen Research Institute, Addis Ababa, Ethiopia
    BMC Vet Res 9:163. 2013
    ....
  2. doi request reprint Creativity in tuberculosis research and discovery
    Douglas Younga
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    Tuberculosis (Edinb) 92:S14-6. 2012
    ..Current trends towards improved experimental and computational approaches for studying biological complexity will be an important element in the developing science of TB vaccinology...
  3. pmc Genetic determination of the effect of post-translational modification on the innate immune response to the 19 kDa lipoprotein of Mycobacterium tuberculosis
    Katalin A Wilkinson
    National Institute for Medical Research, Mill Hill, London, UK
    BMC Microbiol 9:93. 2009
    ..We also reintroduced the 19 kDa gene in two modified forms that lacked motifs for acylation (Delta19::19NA) and O-glycosylation (Delta19::19NOG)...
  4. pmc Bovine tuberculosis at a cattle-small ruminant-human interface in Meskan, Gurage region, Central Ethiopia
    Rea Tschopp
    Swiss Tropical and Public Health Institute, PO Box, CH 4002, Basel, Switzerland
    BMC Infect Dis 11:318. 2011
    ..The aim of this study was to assess BTB prevalence at an intensive contact interface in Meskan Woreda (district) in cattle, small ruminants and suspected TB-lymphadenitis (TBLN) human patients...
  5. doi request reprint Animal models of tuberculosis
    Douglas Young
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    Eur J Immunol 39:2011-4. 2009
    ..There clearly are major differences between experimental infection of mice and natural infection of humans, but this overarching dogma is inconducive to fruitful research...
  6. ncbi request reprint Prospects for molecular epidemiology of leprosy
    Douglas Young
    CMMI, Flowers Building, Imperial College London, UK
    Lepr Rev 74:11-7. 2003
  7. doi request reprint Systems biology of persistent infection: tuberculosis as a case study
    Douglas Young
    Centre for Integrative Systems Biology at Imperial College, Imperial College London, London SW7 2AZ, UK
    Nat Rev Microbiol 6:520-8. 2008
    ..In this article, we use Mycobacterium tuberculosis as an example of how systems-biology approaches have begun to make strides in uncovering important facets of the host-pathogen interaction...
  8. ncbi request reprint The development and impact of tuberculosis vaccines
    Douglas Young
    Imperial College, University of London, South Kensington Campus, London SW7 2AZ, United Kingdom
    Cell 124:683-7. 2006
    ..But developing a new effective vaccine will require innovation in scientific research, a proactive approach to clinical trials of new vaccine candidates, and application of vaccines as part of an integrated approach to disease control...
  9. doi request reprint Detection and treatment of subclinical tuberculosis
    Brian D Robertson
    Rapporteur, Imperial College London, MRC Centre for Molecular Bacteriology and Infection, Flowers Building, South Kensington Campus, London SW7 2AZ, UK
    Tuberculosis (Edinb) 92:447-52. 2012
    ..The Working Group met in Cape Town on 26th February 2012, following presentation of results from the GC11 Grand Challenges in Global Health project to discover drugs for latent TB...
  10. pmc Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis
    Kristine Arnvig
    Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK
    RNA Biol 9:427-36. 2012
    ..We have reviewed emerging information on the presence and abundance of different types of non-coding RNA in M. tuberculosis and consider their potential contribution to the adaptive responses that underlie disease pathogenesis...
  11. ncbi request reprint Mycobacterium tuberculosis and its ability to resist immunity
    Douglas Young
    Imperial College London, South Kensington Campus, London, UK
    Novartis Found Symp 281:169-77; discussion 177-80, 208-9. 2007
    ..We explore here the hypothesis that genetic diversity of Mycobacterium tuberculosis provides an opportunity to tilt this balance in favour of the pathogen through variations in innate immune signalling...
  12. pmc Natural killer cells are recruited during pulmonary tuberculosis and their ex vivo responses to mycobacteria vary between healthy human donors in association with KIR haplotype
    Damien Portevin
    Division of Mycobacterial Research, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Cell Microbiol 14:1734-44. 2012
    ..tuberculosis infection...
  13. ncbi request reprint Chronic bacterial infections: living with unwanted guests
    Douglas Young
    Centre for Molecular Microbiology and Infection, Imperial College of Science, Technology and Medicine, London SW7 2AZ, UK
    Nat Immunol 3:1026-32. 2002
    ..Bacteria appear to adapt their immediate environment to favor survival and may hijack essential immunoregulatory mechanisms designed to minimize immune pathology or the inappropriate activation of immune effectors...
  14. pmc Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages
    Damien Portevin
    Mycobacterial Research Division, MRC National Institute for Medical Research, London, United Kingdom
    PLoS Pathog 7:e1001307. 2011
    ..In addition to the lineage effects, the large strain-to-strain variation in innate immune responses elicited by MTBC will need to be considered in tuberculosis vaccine development...
  15. pmc Natural killer cell cytokine response to M. bovis BCG Is associated with inhibited proliferation, increased apoptosis and ultimate depletion of NKp44(+)CD56(bright) cells
    Damien Portevin
    Division of Mycobacterial Research, MRC National Institute for Medical Research, Mill Hill, London, United Kingdom
    PLoS ONE 8:e68864. 2013
    ..Therefore, IFN-γ production by CD56(bright) cells constitutes the main effector mechanism of NK cells that would contribute to the benefits observed for M. bovis BCG as an immunotherapeutic agent. ..
  16. ncbi request reprint Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium
    Siouxsie Wiles
    Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College London, London SW7 2AZ, UK
    Cell Microbiol 6:963-72. 2004
    ..A bioluminescent eae (encoding the outer membrane adhesin intimin) C. rodentium mutant failed to establish long-term colonization, although low levels of bacteria could be recovered for up to 3 days post challenge from the caecum...
  17. ncbi request reprint The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2
    Martin Lopez
    Department of Medicine, Division of Infectious Diseases, University of British Columbia, Faculty of Medicine and Science, The Research Institute of the Vancouver Hospital and Health Sciences Center, Vancouver, British Columbia, Canada
    J Immunol 170:2409-16. 2003
    ....
  18. ncbi request reprint Systems biology could help us harness useful microbes
    Douglas Young
    Nature 442:627. 2006
  19. ncbi request reprint Conquistadors and Mycobacterium bovis
    Douglas Young
    Tuberculosis (Edinb) 83:277-8. 2003