N A Wright

Summary

Affiliation: Imperial College School of Medicine
Country: UK

Publications

  1. ncbi Migration of the ductular elements of gut-associated glands gives clues to the histogenesis of structures associated with responses to acid hypersecretory state: the origins of "gastric metaplasia" in the duodenum of the specialized mucosa of ba
    N A Wright
    Department of Histopathology, Royal Postgraduate Medical School, London, United Kingdom
    Yale J Biol Med 69:147-53. 1996
  2. ncbi Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer
    N A Wright
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    FEBS Lett 408:121-3. 1997
  3. ncbi Bone marrow contributes to renal parenchymal turnover and regeneration
    R Poulsom
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    J Pathol 195:229-35. 2001
  4. ncbi Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice
    S Bamba
    Histopathology Unit, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    J Pathol 209:265-73. 2006
  5. ncbi Recipes for adult stem cell plasticity: fusion cuisine or readymade?
    M R Alison
    Histopathology Unit, Cancer Research UK, London WC2A 3PX, UK
    J Clin Pathol 57:113-20. 2004
  6. ncbi The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse
    S L Preston
    Histopathology Unit, London Research Institute, Cancer Research UK, London, UK
    J Pathol 214:294-301. 2008
  7. ncbi Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus
    S J Leedham
    Histopathology Unit, Cancer Research UK, London, UK
    Gut 57:1041-8. 2008
  8. ncbi The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment
    T H Yen
    Histopathology Unit, Cancer Research UK, London Research Institute, London, UK
    Cell Prolif 40:143-56. 2007
  9. ncbi Glicentin, an active enteroglucagon, has a significant trophic role on the small intestine but not on the colon in the rat
    M Sasaki
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, UK
    Aliment Pharmacol Ther 15:1681-6. 2001
  10. ncbi Gastrointestinal stem cells and cancer: bridging the molecular gap
    S J Leedham
    Histopathology Unit, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stem Cell Rev 1:233-41. 2005

Collaborators

Detail Information

Publications32

  1. ncbi Migration of the ductular elements of gut-associated glands gives clues to the histogenesis of structures associated with responses to acid hypersecretory state: the origins of "gastric metaplasia" in the duodenum of the specialized mucosa of ba
    N A Wright
    Department of Histopathology, Royal Postgraduate Medical School, London, United Kingdom
    Yale J Biol Med 69:147-53. 1996
    ..It is suggested that Barrett's epithelium arises directly from the epithelium of the cardiac esophageal glands, and that these three ductal epithelia are the origins of these three important adaptive phenomena to gastric hypersecretion...
  2. ncbi Rolling in the clover: trefoil factor family (TFF)-domain peptides, cell migration and cancer
    N A Wright
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    FEBS Lett 408:121-3. 1997
    ..Knockout mice lacking TFF1 or TFF3 show significant pathology, with the former developing gastric tumours. A recent Conference Philippe Laudat agreed upon a new nomenclature for these peptides...
  3. ncbi Bone marrow contributes to renal parenchymal turnover and regeneration
    R Poulsom
    Histopathology Unit, Imperial Cancer Research Fund, London, UK
    J Pathol 195:229-35. 2001
    ..These data indicate that bone marrow cells contribute to both normal turnover of renal epithelia and regeneration after damage, and it is suggested that this could be exploited therapeutically...
  4. ncbi Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice
    S Bamba
    Histopathology Unit, London Research Institute, Cancer Research UK, London WC2A 3PX, UK
    J Pathol 209:265-73. 2006
    ..The contribution of BM-derived cells to colonic SEMFs was significantly increased in the inflamed mucosa compared with non-inflamed mucosa...
  5. ncbi Recipes for adult stem cell plasticity: fusion cuisine or readymade?
    M R Alison
    Histopathology Unit, Cancer Research UK, London WC2A 3PX, UK
    J Clin Pathol 57:113-20. 2004
    ....
  6. ncbi The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse
    S L Preston
    Histopathology Unit, London Research Institute, Cancer Research UK, London, UK
    J Pathol 214:294-301. 2008
    ....
  7. ncbi Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus
    S J Leedham
    Histopathology Unit, Cancer Research UK, London, UK
    Gut 57:1041-8. 2008
    ..The histogenesis of Barrett's metaplasia and neo-squamous islands has never been demonstrated. We investigated the oesophageal gland squamous ducts as the source of both epithelial sub-types...
  8. ncbi The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment
    T H Yen
    Histopathology Unit, Cancer Research UK, London Research Institute, London, UK
    Cell Prolif 40:143-56. 2007
    ....
  9. ncbi Glicentin, an active enteroglucagon, has a significant trophic role on the small intestine but not on the colon in the rat
    M Sasaki
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, UK
    Aliment Pharmacol Ther 15:1681-6. 2001
    ..Glicentin had no effects on proliferation or fission in the colon. CONCLUSIONS: Glicentin is trophic to the rat small intestine, but not the colon...
  10. ncbi Gastrointestinal stem cells and cancer: bridging the molecular gap
    S J Leedham
    Histopathology Unit, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Stem Cell Rev 1:233-41. 2005
    ..This model has been used to suggest that short-range interaction between adjacent initiated crypts, not random polyp collision, is responsible for tumor polyclonality...
  11. ncbi Stem cell in gastrointestinal structure and neoplastic development
    M Brittan
    Histopathology Unit, Cancer Research UK, Lincoln's Inn Fields, London, UK
    Gut 53:899-910. 2004
  12. ncbi Intestinal stem cells
    S J Leedham
    Histopathology Unit, Cancer Research UK, London, WC2A 3PX, UK
    J Cell Mol Med 9:11-24. 2005
    ..The derangement of these pathways within stem cells plays an integral part in the development of malignancy within the intestinal tract...
  13. ncbi Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration
    L Gutierrez-Gonzalez
    Histopathology Unit, Cancer Research UK, London Research Institute, London, UK
    Dig Liver Dis 40:510-22. 2008
    ..These changes start to explain the principles of the development of intestinal metaplasia and suggest that the regulation of these genes is of importance in the development of gastric cancer...
  14. ncbi Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair
    C Albera
    Tissue Engineering and Regenerative Medicine Centre, Imperial College, London, UK
    Tissue Eng 11:1115-21. 2005
    ..This finding could provide new therapeutic opportunities for a range of pulmonary diseases by providing means to repair the lung and a novel route for gene therapy...
  15. ncbi The new stem cell biology: something for everyone
    S L Preston
    Department of Histopathology, Barts and the London School of Medicine and Dentistry, Turner Street, London E1 2AD, UK
    Mol Pathol 56:86-96. 2003
    ..This review sets out to provide a critical evaluation of the current literature in the adult stem cell field...
  16. ncbi Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 159:1293-300. 2001
    ..The morphology of polyps from SMAD4 mutation carriers is subtly different from other JPS polyps, notably including a more prominent epithelial component in the former...
  17. ncbi Expansion of a mutated clone: from stem cell to tumour
    S J Leedham
    Histopathology Department, Cancer Research UK, London, UK
    J Clin Pathol 61:164-71. 2008
    ..This model has been used to suggest that short-range interaction between adjacent initiated crypts, not random polyp collision, is responsible for tumour polyclonality...
  18. ncbi Human tumour clonality assessment--flawed but necessary
    S J Leedham
    Histopathology Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London, UK
    J Pathol 215:351-4. 2008
    ..However it is only through clonality and mutation burden assessments that phylogenetic tress become established. Here, we review the advantages, disadvantages and use of different clonality markers...
  19. ncbi Stem cells and cancer: an intimate relationship
    J Burkert
    Histopathology Unit, Cancer Research UK, and ICMS, Queen Mary s School of Medicine and Dentistry, London WC2A 3PX, UK
    J Pathol 209:287-97. 2006
    ....
  20. ncbi Hepatic and renal differentiation from blood-borne stem cells
    S J Forbes
    Histopathology Unit, Cancer Research UK, London, UK
    Gene Ther 9:625-30. 2002
    ..However, there are technical barriers to be overcome before the theoretical benefits of this exiting new area becomes a practical prospect...
  21. ncbi Side populations of gastrointestinal cancers are not enriched in stem cells
    J Burkert
    Cancer Research UK, London Research Institute, London, UK
    J Pathol 214:564-73. 2008
    ..These findings stand in contrast to the observations made in many other tissues and harbour important implications for the future search for intestinal cancer stem cell markers...
  22. ncbi APC and the three-hit hypothesis
    S Segditsas
    1Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, UK
    Oncogene 28:146-55. 2009
    ....
  23. ncbi Lectins can reverse the distal intestinal atrophy associated with elemental diets in mice
    M Sasaki
    Department of Histopathology, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Aliment Pharmacol Ther 16:633-42. 2002
    ..CONCLUSIONS: Lectins have significant trophic effects on the small intestine and colon of mice fed elemental diets, and these actions vary between different sites in the gastrointestinal tract...
  24. ncbi Localization of intestinal trefoil-factor mRNA in rat stomach and intestine by hybridization in situ
    R Chinery
    Histopathology Unit, Imperial Cancer Research Fund, London, U K
    Biochem J 285:5-8. 1992
    ..We hypothesize that concerted expression occurs of particular trefoil peptides with specific mucins, and that this organization reflects a functional relationship between mucins and trefoil peptides...
  25. ncbi Characterization of monoclonal antibodies raised to C-terminal peptides of pS2: a major trefoil peptide and motility factor expressed in adenocarcinomas and regions of mucosal injury
    R Williams
    Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Hum Pathol 27:1259-66. 1996
    ....
  26. ncbi From gene mutations to tumours--stem cells in gastrointestinal carcinogenesis
    S J Leedham
    Histopathology Unit, Cancer Research UK, London, UK
    Cell Prolif 38:387-405. 2005
    ..It is likely that short-range interaction between adjacent initiated crypts is responsible for polyclonality...
  27. ncbi Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon
    M Brittan
    Histopathology Unit, Cancer Research UK, London, UK
    Gut 50:752-7. 2002
    ....
  28. ncbi Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms
    N A Wright
    Histopathology Unit, Cancer Research UK, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Gut 51:306-8. 2002
  29. ncbi The gastrointestinal stem cell
    M Brittan
    Histopathology Unit, Cancer Research UK, London, UK
    Cell Prolif 37:35-53. 2004
    ....
  30. ncbi Circulating mesenchymal stem cells
    C A Roufosse
    Department of Histopathology, Imperial College of Science, Medicine and Technology, Hammersmith Campus, DuCane Road, London W12 0NN, UK
    Int J Biochem Cell Biol 36:585-97. 2004
    ..Variations in the methods of cell purification, culture and characterisation may explain the inconsistent results obtained in different studies...
  31. ncbi Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission
    W M Wong
    Histopathology Unit, Imperial Cancer Research Fund, Lincoln s Inn Fields, London WC2A 3PX, UK
    Gut 50:212-7. 2002
    ..The histogenesis of human colorectal hyperplastic polyps and colorectal adenomas is poorly understood even now...
  32. ncbi T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment
    L Dianda
    Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 150:91-7. 1997
    ....