K L Woodford Richens

Summary

Affiliation: Imperial Cancer Research Fund
Country: UK

Publications

  1. ncbi request reprint Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium
    K Woodford-Richens
    Molecular and Population Genetics, Imperial Cancer Research Fund, London, United Kingdom
    Cancer Res 60:2477-82. 2000
  2. pmc SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 98:9719-23. 2001
  3. pmc Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 159:1293-300. 2001

Collaborators

  • I P Tomlinson
  • R Poulsom
  • J C Kim
  • T Iwama
  • H S Wasan
  • K L Woodford-Richens
  • A J Rowan
  • S Bevan
  • K Woodford-Richens
  • R Salovaara
  • R S Houlston
  • N A Wright
  • S Halford
  • W F Bodmer
  • R R Roylance
  • P Gorman
  • D C Bicknell
  • L A Aaltonen
  • R Houlston
  • D Sheer
  • N Wright
  • S Hodgson
  • J Williamson
  • J Young
  • M Novelli
  • Y Thway
  • I Frayling
  • B Leggett

Detail Information

Publications3

  1. ncbi request reprint Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium
    K Woodford-Richens
    Molecular and Population Genetics, Imperial Cancer Research Fund, London, United Kingdom
    Cancer Res 60:2477-82. 2000
    ..SMAD4/DPC4 probably acts as a "gatekeeper" tumor suppressor in juvenile polyps, and there is no need to invoke a "landscaper hypothesis."..
  2. pmc SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 98:9719-23. 2001
    ..Thus, MSI(+) cancers may diverge first, followed by CIN(+) (chromosomal instability) cancers, leaving other cancers to follow a CIN(-)MSI(-) pathway...
  3. pmc Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 159:1293-300. 2001
    ..The morphology of polyps from SMAD4 mutation carriers is subtly different from other JPS polyps, notably including a more prominent epithelial component in the former...