K L Woodford Richens

Summary

Affiliation: Imperial Cancer Research Fund
Country: UK

Publications

  1. ncbi Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium
    K Woodford-Richens
    Molecular and Population Genetics, Imperial Cancer Research Fund, London, United Kingdom
    Cancer Res 60:2477-82. 2000
  2. ncbi SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 98:9719-23. 2001
  3. ncbi Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 159:1293-300. 2001

Collaborators

  • I P Tomlinson
  • R Poulsom
  • J C Kim
  • T Iwama
  • H S Wasan
  • K L Woodford-Richens
  • A J Rowan
  • S Bevan
  • K Woodford-Richens
  • R Salovaara
  • R S Houlston
  • D C Bicknell
  • S Halford
  • R R Roylance
  • P Gorman
  • W F Bodmer
  • L A Aaltonen
  • N A Wright
  • R Houlston
  • B Leggett
  • J Williamson
  • Y Thway
  • M Novelli
  • I Frayling
  • S Hodgson
  • J Young
  • N Wright
  • D Sheer

Detail Information

Publications3

  1. ncbi Allelic loss at SMAD4 in polyps from juvenile polyposis patients and use of fluorescence in situ hybridization to demonstrate clonal origin of the epithelium
    K Woodford-Richens
    Molecular and Population Genetics, Imperial Cancer Research Fund, London, United Kingdom
    Cancer Res 60:2477-82. 2000
    ..SMAD4/DPC4 probably acts as a "gatekeeper" tumor suppressor in juvenile polyps, and there is no need to invoke a "landscaper hypothesis."..
  2. ncbi SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Proc Natl Acad Sci U S A 98:9719-23. 2001
    ..Thus, MSI(+) cancers may diverge first, followed by CIN(+) (chromosomal instability) cancers, leaving other cancers to follow a CIN(-)MSI(-) pathway...
  3. ncbi Comprehensive analysis of SMAD4 mutations and protein expression in juvenile polyposis: evidence for a distinct genetic pathway and polyp morphology in SMAD4 mutation carriers
    K L Woodford-Richens
    Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, United Kingdom
    Am J Pathol 159:1293-300. 2001
    ..The morphology of polyps from SMAD4 mutation carriers is subtly different from other JPS polyps, notably including a more prominent epithelial component in the former...