Beata Wojciak-Stothard

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. doi request reprint Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia
    Beata Wojciak-Stothard
    Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, London, UK
    Circ Res 110:1423-34. 2012
  2. doi request reprint Endothelial cell migration under flow
    Beata Wojciak-Stothard
    Department of Experimental Medicine and Toxicology, Imperial College London, London, UK
    Methods Mol Biol 769:137-47. 2011
  3. ncbi request reprint Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells
    Beata Wojciak-Stothard
    British Heart Foundation Laboratories, Department of Medicine, University College London, 5 University St, WC1 E6JJ London, UK
    Am J Physiol Lung Cell Mol Physiol 288:L749-60. 2005
  4. doi request reprint The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis
    Lorna R Fiedler
    National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK
    Arterioscler Thromb Vasc Biol 29:2117-24. 2009
  5. doi request reprint Adenoviral-mediated overexpression of DDAH improves vascular tone regulation
    Belen Torondel
    The British Heart Foundation Laboratories, The Rayne Institute, Division of Medicine, University College London, London, UK
    Vasc Med 15:205-13. 2010
  6. ncbi request reprint Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension
    Beata Wojciak-Stothard
    British Heart Foundation Laboratories, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, UK
    Am J Physiol Lung Cell Mol Physiol 290:L1173-82. 2006
  7. ncbi request reprint The ADMA/DDAH pathway is a critical regulator of endothelial cell motility
    Beata Wojciak-Stothard
    BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, WC1 E6JJ, UK
    J Cell Sci 120:929-42. 2007
  8. pmc Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension
    Beata Wojciak-Stothard
    Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK B W S, V B A S, K H L, H T, R J E, C J R, J W, L Z, M R W Cardiovascular Pulmonary Research Group, University of Colorado Denver Health Sciences Center, Aurora D C I, C L, Z L, K R S Division of Nephrology, Department of Internal Medicine, St Louis University, St Louis MO J C E Laboratory of Cancer Biology and Genetics, Centre for Cancer Research, Bethesda, MD S H Y and National Pulmonary Hypertension Service and National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK L S H, J S R G
    Circulation 129:1770-80. 2014

Detail Information

Publications8

  1. doi request reprint Role of RhoB in the regulation of pulmonary endothelial and smooth muscle cell responses to hypoxia
    Beata Wojciak-Stothard
    Centre for Pharmacology and Therapeutics, Experimental Medicine, Imperial College London, London, UK
    Circ Res 110:1423-34. 2012
    ..RhoB, a protein homologous to RhoA and activated by hypoxia, regulates neoplastic growth and vasoconstriction but its role in the regulation of pulmonary vascular function is not known...
  2. doi request reprint Endothelial cell migration under flow
    Beata Wojciak-Stothard
    Department of Experimental Medicine and Toxicology, Imperial College London, London, UK
    Methods Mol Biol 769:137-47. 2011
    ..This chapter describes methods of generating laminar flow in vitro and studying endothelial cell alignment and motility under flow...
  3. ncbi request reprint Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells
    Beata Wojciak-Stothard
    British Heart Foundation Laboratories, Department of Medicine, University College London, 5 University St, WC1 E6JJ London, UK
    Am J Physiol Lung Cell Mol Physiol 288:L749-60. 2005
    ..Our results show that Rho GTPases act as mediators coupling cellular redox state to endothelial function...
  4. doi request reprint The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis
    Lorna R Fiedler
    National Heart and Lung Institute, Faculty of Medicine, Imperial College London, UK
    Arterioscler Thromb Vasc Biol 29:2117-24. 2009
    ..We hypothesized that ADMA/DDAH modifies endothelial responses to vascular endothelial growth factor (VEGF) by affecting activity of Rho GTPases, regulators of actin polymerization, and focal adhesion dynamics...
  5. doi request reprint Adenoviral-mediated overexpression of DDAH improves vascular tone regulation
    Belen Torondel
    The British Heart Foundation Laboratories, The Rayne Institute, Division of Medicine, University College London, London, UK
    Vasc Med 15:205-13. 2010
    ..Thus, therapeutic manipulation of DDAH expression or activity may represent a novel approach to improve vascular dysfunction in various cardiovascular diseases...
  6. ncbi request reprint Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension
    Beata Wojciak-Stothard
    British Heart Foundation Laboratories, Department of Medicine, University College London, 5 University St, London WC1E 6JJ, UK
    Am J Physiol Lung Cell Mol Physiol 290:L1173-82. 2006
    ..Activation of Rac1 and its effector PAK-1 as well as inhibition of RhoA restored the abnormal phenotype and permeability of hypertensive PAECs to normal...
  7. ncbi request reprint The ADMA/DDAH pathway is a critical regulator of endothelial cell motility
    Beata Wojciak-Stothard
    BHF Laboratories, Department of Medicine, University College London, 5 University Street, London, WC1 E6JJ, UK
    J Cell Sci 120:929-42. 2007
    ..These results are the first demonstration that metabolism of cardiovascular risk factor ADMA regulates endothelial cell motility, an important factor in angiogenesis and vascular repair...
  8. pmc Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension
    Beata Wojciak-Stothard
    Centre for Pharmacology and Therapeutics, Department of Medicine, Imperial College London, London, UK B W S, V B A S, K H L, H T, R J E, C J R, J W, L Z, M R W Cardiovascular Pulmonary Research Group, University of Colorado Denver Health Sciences Center, Aurora D C I, C L, Z L, K R S Division of Nephrology, Department of Internal Medicine, St Louis University, St Louis MO J C E Laboratory of Cancer Biology and Genetics, Centre for Cancer Research, Bethesda, MD S H Y and National Pulmonary Hypertension Service and National Heart and Lung Institute, Imperial College Healthcare NHS Trust, London, UK L S H, J S R G
    Circulation 129:1770-80. 2014
    ..CLIC4 regulates vasculogenesis through endothelial tube formation. Aberrant CLIC4 expression may contribute to the vascular pathology of pulmonary arterial hypertension...