Richard O Williams

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
  2. ncbi request reprint Pathogenesis and therapy of rheumatoid arthritis
    R O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, W6 8LH London, UK
    Ernst Schering Found Symp Proc . 2006
  3. ncbi request reprint Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases
    Richard O Williams
    The Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Curr Opin Pharmacol 7:412-7. 2007
  4. pmc Analysing the effect of novel therapies on cytokine expression in experimental arthritis
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
    Int J Exp Pathol 86:267-78. 2005
  5. pmc Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
  6. doi request reprint ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis
    Clare A Notley
    Imperial College London, London, UK
    Arthritis Rheum 62:171-8. 2010
  7. doi request reprint Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 149:386-92. 2010
  8. doi request reprint CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis
    Egle Simelyte
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:1038-43. 2008
  9. pmc Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    Clare A Notley
    Kennedy Institute of Rheumatology Division, Imperial College London, London, W6 8LH, England, UK
    J Exp Med 205:2491-7. 2008
  10. pmc Impact of cAMP on the T-cell response to type II collagen
    Patricia Ozegbe
    The Kennedy Institute of Rheumatology Division, Imperial College London, UK
    Immunology 111:35-40. 2004

Detail Information

Publications36

  1. pmc Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Arthritis Res Ther 9:R113. 2007
    ....
  2. ncbi request reprint Pathogenesis and therapy of rheumatoid arthritis
    R O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, W6 8LH London, UK
    Ernst Schering Found Symp Proc . 2006
    ..Anti-TNFalpha therapy is now accepted as a fully-validated treatment modality for rheumatoid arthritis...
  3. ncbi request reprint Cytokine inhibitors in rheumatoid arthritis and other autoimmune diseases
    Richard O Williams
    The Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Curr Opin Pharmacol 7:412-7. 2007
    ..Cytokines driving angiogenesis are also important in disease chronicity and thus might be valid therapeutic targets...
  4. pmc Analysing the effect of novel therapies on cytokine expression in experimental arthritis
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
    Int J Exp Pathol 86:267-78. 2005
    ..In this review, we outline the various techniques used to detect cytokines in experimental arthritis and describe how these techniques have been used to quantify changes in cytokine expression following therapeutic intervention...
  5. pmc Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
    Fiona E McCann
    The Kennedy Institute of Rheumatology, Imperial College London, 65 Aspenlea Road, London, W6 8LH, UK
    Arthritis Res Ther 12:R107. 2010
    ..We assessed the anti-inflammatory effects of a novel PDE4 inhibitor, apremilast, in human synovial cells from rheumatoid arthritis (RA) patients, as well as two murine models of arthritis...
  6. doi request reprint ANTI-CD3 therapy expands the numbers of CD4+ and CD8+ Treg cells and induces sustained amelioration of collagen-induced arthritis
    Clare A Notley
    Imperial College London, London, UK
    Arthritis Rheum 62:171-8. 2010
    ..To assess the therapeutic potential of anti-CD3 monoclonal antibodies (mAb) for rheumatoid arthritis, using collagen-induced arthritis as an animal model...
  7. doi request reprint Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 149:386-92. 2010
    ..They also suggest that, unlike post-operative pain, induction of pain in OA may not necessarily be driven by classical inflammatory processes...
  8. doi request reprint CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis
    Egle Simelyte
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:1038-43. 2008
    ....
  9. pmc Blockade of tumor necrosis factor in collagen-induced arthritis reveals a novel immunoregulatory pathway for Th1 and Th17 cells
    Clare A Notley
    Kennedy Institute of Rheumatology Division, Imperial College London, London, W6 8LH, England, UK
    J Exp Med 205:2491-7. 2008
    ....
  10. pmc Impact of cAMP on the T-cell response to type II collagen
    Patricia Ozegbe
    The Kennedy Institute of Rheumatology Division, Imperial College London, UK
    Immunology 111:35-40. 2004
    ..The cAMP-elevating agents could directly influence the activity of T cells but, in addition, influenced the ability of antigen-presenting cells to support T helper type 1 responses...
  11. doi request reprint Indoleamine 2,3 dioxygenase-mediated tryptophan catabolism regulates accumulation of Th1/Th17 cells in the joint in collagen-induced arthritis
    Gabriel Criado
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 60:1342-51. 2009
    ..The aim of this study was to investigate the regulation of collagen-induced arthritis by tryptophan catabolism mediated by IDO...
  12. doi request reprint Protocol for the induction of arthritis in C57BL/6 mice
    Julia J Inglis
    Kennedy Institute of Rheumatology Division, Imperial College London, 1 Aspenlea Road, London W6 8LH, UK
    Nat Protoc 3:612-8. 2008
    ..The incidence of arthritis varies from 50 to 80% and is milder than the classical collagen-induced arthritis model. This procedure takes approximately 3 months to complete...
  13. ncbi request reprint Anti-TNF therapy: where have we got to in 2005?
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College, 1 Aspenlea Road, London W6 8LH, UK
    J Autoimmun 25:26-8. 2005
    ..There are still many limitations, but the prospects for the future are intriguing...
  14. ncbi request reprint Collagen-induced arthritis in mice: a major role for tumor necrosis factor-alpha
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
    Methods Mol Biol 361:265-84. 2007
    ..Three anti-TNFalpha biologics(infliximab, etanercept, and adalimumab) are now approved for use and TNFalpha blockade therefore represents an important advance in our ability to treat rheumatoid arthritis...
  15. doi request reprint SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis
    Stefan K Drexler
    Imperial College London, London, UK
    Arthritis Rheum 62:2249-61. 2010
    ..Therefore, the purpose of this study was to investigate the involvement of SIGIRR in regulating inflammation in disease-relevant models...
  16. ncbi request reprint Down-regulation of Th1-mediated pathology in experimental arthritis by stimulation of the Th2 arm of the immune response
    Claudia Mauri
    Center for Rheumatology Research, Windeyer Institute of Medical Sciences, University College London, London, UK
    Arthritis Rheum 48:839-45. 2003
    ....
  17. ncbi request reprint Collagen-induced arthritis in mice
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, UK
    Methods Mol Med 136:191-9. 2007
    ....
  18. ncbi request reprint The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis
    Marc Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College, 1 Aspenlea Road, Hammersmith, London W6 8LH, UK
    Best Pract Res Clin Rheumatol 18:59-80. 2004
    ..The development of anti-TNF therapy is a key step forward in rheumatology as it is the first new therapy for based on investigating the molecular mechanisms of this disease. This chapter reviews how this discovery was made...
  19. doi request reprint The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity
    Ling Weng
    Kennedy Institute of Rheumatology, Imperial College, London, UK
    Ann Rheum Dis 69:1519-26. 2010
    ..In the present work it is demonstrated that partial myeloablation induces a relative expansion of T(regs) that is sufficient to mediate immunological tolerance...
  20. doi request reprint Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
    Julia J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London, UK
    Arthritis Rheum 58:3110-9. 2008
    ..However, up to 40% of individuals with radiologic damage are asymptomatic. The purpose of this study was to assess the role of the endogenous opioid system in delaying the onset of pain in a murine model of osteoarthritis (OA)...
  21. ncbi request reprint Collagen-induced arthritis as a model for rheumatoid arthritis
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College London, London, UK
    Methods Mol Med 98:207-16. 2004
    ....
  22. doi request reprint IL-17 induces hyperalgesia via TNF-dependent neutrophil infiltration
    Kay E McNamee
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Pain 152:1838-45. 2011
    ..The subsequent production of keratinocyte chemoattractant then triggers neutrophil chemotaxis to the plantar tissue, releasing algesic mediators locally to sensitise the nerve...
  23. doi request reprint What have we learnt from targeted anti-TNF therapy?
    M Feldmann
    Kennedy Institute of Rheumatology Division, Imperial College, 65 Aspenlea Road, London W6 8LH, UK
    Ann Rheum Dis 69:i97-99. 2010
    ..Focus will be on the TNF-dependent cytokine cascade and what it means, and potential new approaches to treatment. Finally, an entertaining challenge: might many or even all unmet clinical needs be dealt with through cytokine analysis?..
  24. ncbi request reprint Therapeutic effect of vasoactive intestinal peptide in collagen-induced arthritis
    Richard O Williams
    Kennedy Institute of Rheumatology, London, UK
    Arthritis Rheum 46:271-3. 2002
  25. ncbi request reprint Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases
    Peter C Taylor
    The Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Road, London W68LH, UK
    Curr Opin Biotechnol 15:557-63. 2004
    ..Better understanding of these pathogenic pathways will inform the development of new therapeutic approaches leading to more complete and sustained disease remissions...
  26. doi request reprint Kynurenine metabolism in health and disease
    Lukasz R Kolodziej
    The Kennedy Institute of Rheumatology Division, Imperial College London, Charing Cross Hospital Campus, UK
    Amino Acids 41:1173-83. 2011
    ..In addition, the involvement of kynurenine and its metabolites in the biology of different T cell subsets (including Th17 cells and regulatory T cells) and neuronal cells is discussed...
  27. ncbi request reprint Cutting edge: A-kinase anchor proteins are involved in maintaining resting T cells in an inactive state
    Richard O Williams
    Kennedy Institute of Rheumatology Division, Imperial College of Science, Technology, and Medicine, London, United Kingdom
    J Immunol 168:5392-6. 2002
    ..It was concluded that AKAPs, through their association with PKA, are involved in maintaining T cell homeostasis and in regulating the sensitivity of T cells to incoming cAMP signals...
  28. doi request reprint Effector T cells in rheumatoid arthritis: lessons from animal models
    Saba Alzabin
    Imperial College London, Kennedy Institute of Rheumatology, London, United Kingdom
    FEBS Lett 585:3649-59. 2011
    ..This understanding will aid in the design of more effective therapeutic strategies for rheumatoid arthritis and other autoimmune disorders...
  29. ncbi request reprint Plasmid DNA as a safe gene delivery vehicle for treatment of chronic inflammatory disease
    Felix I L Clanchy
    Research Associate Kennedy Institute of Rheumatology, Imperial College London, Faculty of Medicine, 65 Aspenlea Road, London, W6 8LH, UK
    Expert Opin Biol Ther 8:1507-19. 2008
    ....
  30. pmc Remission of collagen-induced arthritis is associated with high levels of transforming growth factor-beta expression in the joint
    L Marinova-Mutafchieva
    Division of Neurosciences and Mental Health, Imperial College London, UK
    Clin Exp Immunol 146:287-93. 2006
    ..Of the anti-inflammatory cytokines studied, TGF-beta1 and TGF-beta2 predominate during the time of disease remission, suggesting that these cytokines are involved in regulating disease activity...
  31. ncbi request reprint The anti-allergic drug, N-(3',4'-dimethoxycinnamonyl) anthranilic acid, exhibits potent anti-inflammatory and analgesic properties in arthritis
    J J Inglis
    Kennedy Institute of Rheumatology, Imperial College London, London W6 8LH, UK
    Rheumatology (Oxford) 46:1428-32. 2007
    ....
  32. ncbi request reprint Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapies
    A M Malfait
    Kennedy Institute of Rheumatology, Imperial College School of Medicine, London, UK
    Arthritis Rheum 44:1215-24. 2001
    ..CONCLUSION: Chronic relapsing homologous collagen-induced arthritis is a valuable model for identifying remission-inducing antiarthritic drugs and has predictive value with respect to their joint-protective potency...
  33. ncbi request reprint Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis
    L Marinova-Mutafchieva
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, Charing Cross Hospital Campus, Arthritis Research Campaign Bldg, 1 Aspenlea Road, London W68LH, UK
    Arthritis Rheum 46:507-13. 2002
    ..To determine the involvement of mesenchymal progenitor cells in the induction of collagen-induced arthritis (CIA)...
  34. ncbi request reprint Immunotherapy for rheumatoid arthritis
    P C Taylor
    The Kennedy Institute Division, Imperial College School of Medicine, 1 Aspenlea Road, W6 8LH, London, UK
    Curr Opin Immunol 13:611-6. 2001
    ..Thus, for patients with RA, anti-TNF therapies set a new standard for symptom control and joint protection...
  35. ncbi request reprint Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy
    R O Williams
    Kennedy Institute of Rheumatology Division, Imperial College School of Medicine, London, United Kingdom
    J Immunol 165:7240-5. 2000
    ..Combined anti-TNF-alpha/anti-CD4 treatment almost completely blocked the expression of IL-1beta, thereby confirming the ability of this form of combination therapy to prevent IL-1ss-mediated pathology...
  36. pmc RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: a different interpretation of redundancy
    Shlomo Nedvetzki
    The Lautenberg Center for General and Tumor Immunology, Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Proc Natl Acad Sci U S A 101:18081-6. 2004
    ..This model enlightens several aspects of molecular redundancy, which is widely discussed in many scientific circles, but the processes are still ill defined...