Research Topics
| J P WebsterSummaryAffiliation: Imperial College Country: UK Publications
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Publications
Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stabilizer and anti-parasite medication on Toxoplasma gondii's ability to alter host behaviourJ P Webster
Department of Zoology, University of Oxford South Parks Road, Oxford OX1 3SY, UK
Proc Biol Sci 273:1023-30. 2006..gondii drugs in preventing such behavioural alterations. Our results have important implications regarding the aetiology and treatment of such disorders...- Simultaneous infection of Schistosoma mansoni and S. rodhaini in Biomphalaria glabrata: impact on chronobiology and cercarial behaviourAlice Norton
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, The Natural History Museum, London, SW7 5BD, UK
Parasit Vectors 1:43. 2008..abstract:.. - Parasitological impact of 2-year preventive chemotherapy on schistosomiasis and soil-transmitted helminthiasis in UgandaYaobi Zhang
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, UK
BMC Med 5:27. 2007..Annual treatment with praziquantel and albendazole was given to schoolchildren in endemic areas and to adults in selected communities where local prevalence of Schistosoma mansoni in schoolchildren was high... - Integrated monitoring and evaluation and environmental risk factors for urogenital schistosomiasis and active trachoma in Burkina Faso before preventative chemotherapy using sentinel sitesArtemis Koukounari
Schistosomiasis Control Initiative, Department of Infectious Diseases Epidemiology, St Mary s Campus, Faculty of Medicine, Imperial College London, UK
BMC Infect Dis 11:191. 2011.... - The impact of single versus mixed schistosome species infections on liver, spleen and bladder morbidity within Malian children pre- and post-praziquantel treatmentArtemis Koukounari
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, UK
BMC Infect Dis 10:227. 2010..Mixed infections might generate synergistic or antagonistic interactions and thereby clinically affect individuals and/or impact parasite epidemiology... - Is host-schistosome coevolution going anywhere?Joanne P Webster
Department of Zoology, University of Oxford, Oxford, UK
BMC Evol Biol 7:91. 2007..glabrata genotypes, or a mixed population of the two. All parasite lines were also passaged through their obligatory mammalian definitive host at each generation... - The effect of Toxoplasma gondii on animal behavior: playing cat and mouseJoanne P Webster
Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, St Mary s Campus, Norfolk Place, London, UK
Schizophr Bull 33:752-6. 2007..This article reviews evidence of behavioral alterations in animal hosts and considers what these may elucidate about the potential mechanisms involved and what implications such alterations could have on animal and human health... 
Parasitic manipulation: where else should we go?Joanne P Webster
Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, Norfolk Place St Mary s Campus, London W2 1PG, UK
Behav Processes 68:275-7. 2005
Evaluation and application of potential schistosome-associated morbidity markers within large-scale mass chemotherapy programmesJ P Webster
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, St Mary s Campus, Norfolk Place, London, W2 1PG, UK
Parasitology 136:1789-99. 2009....- Do hosts and parasites coevolve? Empirical support from the Schistosoma systemJ P Webster
Department of Zoology, University of Oxford, Oxford OX1 3PS, United Kingdom
Am Nat 164:S33-51. 2004.... - Schistosome genomes: a wealth of informationJoanne P Webster
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Trends Parasitol 26:103-6. 2010..We comment on these breakthroughs and their potential applications in the study and control of schistosomes... - Toxoplasma gondii-altered host behaviour: clues as to mechanism of actionJoanne P Webster
Department of Infectious Disease Epidemiology, Imperial College, Faculty of Medicine, London, W2 1PG, UK
Folia Parasitol (Praha) 57:95-104. 2010..Here we consider what the available data to date may reveal about the potential mechanisms involved, the future research that needs to be performed, and the subsequent implications for animal and human health... - Specificity of the Toxoplasma gondii-altered behaviour to definitive versus non-definitive host predation riskP H L Lamberton
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
Parasitology 135:1143-50. 2008..Drug treatment of infected rats prevented any such host-specificity from being displayed. We discuss our results in terms of their potential implications both for T. gondii epidemiology and the evolution of parasite-altered behaviour... - Population genetics of Schistosoma haematobium: development of novel microsatellite markers and their application to schistosomiasis control in MaliC M Gower
Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine St Mary s Campus, Norfolk Place, London W2 1PG, UK
Parasitology 138:978-94. 2011.... - Population genetics of the schistosome intermediate host Biomphalaria pfeifferi in the Zimbabwean highveld: implications for co-evolutionary theoryJ P Webster
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, UK
Ann Trop Med Parasitol 95:203-14. 2001..These results are discussed with reference to the population biology of B. pfeifferi and to host-parasite co-evolution... - Development and application of an ethically and epidemiologically advantageous assay for the multi-locus microsatellite analysis of Schistosoma mansoniC M Gower
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College St Mary s Campus, Norfolk Place, London W2 1PG, UK
Parasitology 134:523-36. 2007.... - Use of circulating cathodic antigen (CCA) dipsticks for detection of intestinal and urinary schistosomiasisJ Russell Stothard
Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
Acta Trop 97:219-28. 2006..At approximately 2.6 US dollars per dipstick, they are presently too expensive to be cost-effective for wide scale use in disease mapping surveys unless Lot Quality Assurance Sampling (LQAS) strategies are developed... - Spatio-temporal genetic variability in the schistosome intermediate host Biomphalaria pfeifferiJ P Webster
Wellcome Trust Centre for the Epidemiology of Infectious Disease WTCEID, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, UK
Ann Trop Med Parasitol 95:515-27. 2001.... - Molecular epidemiology of Schistosoma mansoni in Uganda: DNA barcoding reveals substantial genetic diversity within Lake Albert and Lake Victoria populationsJ R Stothard
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, SW7 5BD, UK
Parasitology 136:1813-24. 2009..While it appears plausible that locally evolved heritable traits could spread through most of the Lake Albert populations, it seems unlikely they could quickly homogenise into Lake Victoria or amongst populations therein... - Transmission of Schistosoma japonicum in marshland and hilly regions of China: parasite population genetic and sibship structureDa Bing Lu
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
PLoS Negl Trop Dis 4:e781. 2010..Such results suggest a different transmission process within the hilly region from within the marshlands. Moreover, this is the first time that the sibling relationship analysis was applied to the transmission dynamics for S. japonicum... - The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008A Fenwick
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College, St Mary s Campus, Norfolk Place, London W2 1PG, UK
Parasitology 136:1719-30. 2009..SCI and partners are now actively striving to raise further funds to expand the coverage of integrated control of neglected tropical diseases (NTDs) in sub-Saharan Africa... - Coevolution and compatibility in the snail-schistosome systemJ P Webster
Wellcome Trust Centre for the Epidemiology of Infectious Disease WTCEID, University of Oxford, UK
Parasitology 123:S41-56. 2001.... - Inter-specific parasite competition: mixed infections of Schistosoma mansoni and S. rodhaini in the definitive hostA J Norton
Department of Infectious Disease Epidemiology, Imperial College Faculty of Medicine, London W2 1PG, UK
Parasitology 135:473-84. 2008..rodhaini. Inter-specific competition was also implicated as increased parasite virulence to the host. The potential effects of such interactions on parasite and host ecology and evolution in nature are discussed... - Trade-offs in the evolution of virulence in an indirectly transmitted macroparasiteC M Davies
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, UK
Proc Biol Sci 268:251-7. 2001..This is the first report of a trade-off in parasite reproductive success across hosts in an indirectly transmitted macroparasite... - Morbidity due to Schistosoma mansoni: an epidemiological assessment of distended abdomen syndrome in Ugandan school children with observations before and 1-year after anthelminthic chemotherapyJulie Balen
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK
Trans R Soc Trop Med Hyg 100:1039-48. 2006..g. malnutrition and malaria. At 1-year follow-up, ACR scores showed an overall trend of regression towards the mean, potentially indicative of amelioration following chemotherapy, but geographic overdispersion still remained... - Field evaluation of the Meade Readiview handheld microscope for diagnosis of intestinal schistosomiasis in Ugandan school childrenJ Russell Stothard
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, London, United Kingdom
Am J Trop Med Hyg 73:949-55. 2005..It could play an important role in the collection of prevalence data to better guide anthelmintic drug delivery and also empower the diagnostic capacity of peripheral health centers where compound microscopes are few or absent... - Population genetics of multi-host parasites--the case for molecular epidemiological studies of Schistosoma japonicum using larval stages from naturally infected hostsJ Shrivastava
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College St Mary s Hospital Campus, Norfolk Place, London W2 1PG, UK
Parasitology 131:617-26. 2005..Our results thus advocate the use of natural life-cycle stages to obtain an accurate and ethical representation of the population genetic structure of S. japonicum and other multi-host pathogens... - Bayesian spatial analysis and disease mapping: tools to enhance planning and implementation of a schistosomiasis control programme in TanzaniaArchie C A Clements
Schistosomiasis Control Initiative, Imperial College London, London, UK
Trop Med Int Health 11:490-503. 2006..CONCLUSION: Bayesian geostatistical analysis is a powerful and statistically robust tool for identifying high prevalence areas in a heterogeneous and imperfectly known environment... - Fitness of indirectly transmitted pathogens: restraint and constraintCharlotte M Gower
Peter Medawar Building for Pathogen Research, and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom
Evolution Int J Org Evolution 58:1178-84. 2004.... - Mixed strain schistosome infections of snails and the evolution of parasite virulenceC M Davies
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford
Parasitology 124:31-8. 2002..Reduced host survival was consistent with an adaptive conditional parasite response... - Genetic consequences of mass human chemotherapy for Schistosoma mansoni: population structure pre- and post-praziquantel treatment in TanzaniaAlice J Norton
Department of Infectious Disease Epidemiology, Imperial College, Faculty of Medicine, London, United Kingdom
Am J Trop Med Hyg 83:951-7. 2010..Such unique results illustrate the importance of genetic monitoring and examination of long lived multi-cellular parasites such as these under novel or increased chemotherapeutic selective pressures... - Contrasting reservoirs for Schistosoma japonicum between marshland and hilly regions in Anhui, China--a two-year longitudinal parasitological surveyDa Bing Lu
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, Norfolk Place, London W2 1PG, UK
Parasitology 137:99-110. 2010..Such results may have implications for the current human- and bovine-oriented control policy for this medically and veterinarily important disease, particularly within the hilly regions of mainland China... - An insight into the genetic variation of Schistosoma japonicum in mainland China using DNA microsatellite markersJaya Shrivastava
Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
Mol Ecol 14:839-49. 2005..These results highlight the suitability of microsatellites for population genetic studies of S. japonicum and suggest that there may be different strains of S. japonicum circulating in mainland China... - Parasite genetic differentiation by habitat type and host species: molecular epidemiology of Schistosoma japonicum in hilly and marshland areas of Anhui Province, ChinaJames W Rudge
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK
Mol Ecol 18:2134-47. 2009..japonicum control, particularly in hilly regions where control of infection among wild rodent populations could be challenging... - Sensitivities and specificities of diagnostic tests and infection prevalence of Schistosoma haematobium estimated from data on adults in villages northwest of Accra, GhanaArtemis Koukounari
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, United Kingdom
Am J Trop Med Hyg 80:435-41. 2009..Furthermore, microscopy and hematuria dipsticks were indicated through these models as the most appropriate techniques for detection of S. haematobium infection... - Intraspecific competition and the evolution of virulence in a parasitic trematodeCharlotte M Gower
Department of Zoology, University of Oxford, South Parks Road, Oxford, OX1 3SY, United Kingdom
Evolution 59:544-53. 2005..Moreover, since the less virulent strain investigated here had a competitive advantage, we suggest that a high frequency of multiple infections could favor the evolution of less, rather than more, virulent parasites in this system... - Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogsJames W Rudge
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
PLoS Negl Trop Dis 2:e340. 2008..japonicum transmission in the Philippines remain to be determined. We examined the population genetics of S. japonicum in the Philippines in order to elucidate transmission patterns across host species and geographic areas... - Morbidity indicators of Schistosoma mansoni: relationship between infection and anemia in Ugandan schoolchildren before and after praziquantel and albendazole chemotherapyArtemis Koukounari
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
Am J Trop Med Hyg 75:278-86. 2006..834 g/dL after treatment was found. Our results suggest that anemia is associated with schistosomiasis and hookworm in Ugandan children and that such anemia shows a significant improvement after chemotherapy... - Bovine tuberculosis (Mycobacterium bovis) in British farmland wildlife: the importance to agricultureFiona Mathews
Wildlife Conservation Research Unit, Department of Zoology, University of Oxford, Tubney House, Abingdon Road, Tubney, OXON OX13 5QL, UK
Proc Biol Sci 273:357-65. 2006.... - Assessment of ultrasound morbidity indicators of schistosomiasis in the context of large-scale programs illustrated with experiences from Malian childrenArtemis Koukounari
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, UK
Am J Trop Med Hyg 75:1042-52. 2006..mansoni infection. We conclude that ultrasonography should be included in large-scale control interventions, where logistics allow, but cautiously... - Schistosoma haematobium infection and morbidity before and after large-scale administration of praziquantel in Burkina FasoArtemis Koukounari
Schistosomiasis Control Initiative, Department of Infectious Disease Epidemiology, Imperial College London, London, W2 1PG, United Kingdom
J Infect Dis 196:659-69. 2007..In sub-Saharan Africa, 112 million people are infected with Schistosoma haematobium, with the most intense infections in children 5-15 years old... - Schistosomiasis: challenges for control, treatment and drug resistanceAlan Fenwick
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, UK
Curr Opin Infect Dis 19:577-82. 2006..Despite shifts in global health policy towards the implementation of mass chemotherapeutic control programmes at the national scale in sub-Saharan Africa, however, many challenges still exist... - Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: a mathematical modelling studyMichael D French
Schistosomiasis Control Initiative, Imperial College London, London, United Kingdom
PLoS Negl Trop Dis 4:e897. 2010..In doing this we aim to elucidate the benefits of MDA in reducing community transmission... - In vitro praziquantel test capable of detecting reduced in vivo efficacy in Schistosoma mansoni human infectionsPoppy H L Lamberton
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, London, United Kingdom
Am J Trop Med Hyg 83:1340-7. 2010..After only a few treatments, uncleared parasites were identified to be phenotypically different from drug-sensitive parasites, emphasizing the urgent need for monitoring of these repeatedly PZQ-treated populations... - Predation of beetles (Tenebrio molitor) infected with tapeworms (Hymenolepis diminuta): a note of caution for the manipulation hypothesisJ P Webster
Wellcome Trust Centre for the Epidemiology of Infectious Disease, University of Oxford, UK
Parasitology 120:313-8. 2000..We discuss this in terms of the historical and evolutionary contexts under which such altered behaviours could evolve and their implications for the Manipulation Hypothesis... - Dose-dependent schistosome-induced mortality and morbidity risk elevates host reproductive effortL Blair
Department of Zoology, University of Oxford, Oxford, UK
J Evol Biol 20:54-61. 2007..These results uniquely suggest an exposure-dose-dependent post-patent fecundity compensation occurring in relation to the risk of future parasite-associated mortality... - Genetic diversity of schistosomes and snails: implications for controlDavid Rollinson
Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
Parasitology 136:1801-11. 2009.... - Isolation and characterization of the first polymorphic microsatellite markers for Schistosoma haematobium and their application in multiplex reactions of larval stagesR Golan
Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College, London, Norfolk Place, London W2 1PG, UK, Wolfson Wellcome Biomedical Laboratories, Department of Zoology, Natural History Museum, Cromwell Road, London SW7 5BD, UK
Mol Ecol Resour 8:647-9. 2008..Three primers also amplified Schistosoma mansoni and two Schistosoma japonicum. The results suggest these primers are useful for population genetic analyses of S. haematobium... - Parasites of wild brown rats (Rattus norvegicus) on UK farmsJ P Webster
University of Oxford, Department of Zoology
Parasitology 111:247-55. 1995..The study suggests that wild brown rats, serving as vectors of disease, represent a serious risk to the health of humans and domestic animals in the UK... - Extensive genetic variation revealed in adjacent populations of the schistosome intermediate host Biomphalaria pfeifferi from a single river systemJ I Hoffman
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford
Ann Trop Med Parasitol 92:693-8. 1998..The most genetically polymorphic snail populations were those collected within and downstream from human water-contact sites... - Parasite infection, host resistance and mate choice: battle of the genders in a simultaneous hermaphroditeJoanne P Webster
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3SY, UK
Proc Biol Sci 270:1481-5. 2003..Such recognition and discrimination has implications for the maintenance of sex and the evolution of recognition systems... - Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviourJ P Webster
Wellcome Trust Centre for the Epidemiology of Infectious Disease, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3FY, UK
Microbes Infect 3:1037-45. 2001.... - Biological and biomedical implications of the co-evolution of pathogens and their hostsMark E J Woolhouse
Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
Nat Genet 32:569-77. 2002.... - Progress towards countrywide control of schistosomiasis and soil-transmitted helminthiasis in UgandaNarcis B Kabatereine
Vector Control Division, Ministry of Health, Kampala, Uganda
Trans R Soc Trop Med Hyg 100:208-15. 2006..As a way forward, it is suggested that the Ministry of Health should integrate deworming into the existing health infrastructure so that every time a child is reached for any health service, the child is also de-wormed... - Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildrenNarcis B Kabatereine
Vector Control Division, Ministry of Health, Kampala, Uganda
Bull World Health Organ 85:91-9. 2007..We aimed to assess the health impact of a national control programme targeting schistosomiasis and intestinal nematodes in Uganda, which has provided population-based anthelmintic chemotherapy since 2003...