Jonathan Weber

Summary

Affiliation: Imperial College
Country: UK

Publications

  1. pmc Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters
    Astrid Gall
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Retrovirology 10:8. 2013
  2. pmc Mouse DNA contamination in human tissue tested for XMRV
    Mark J Robinson
    Section of Infectious Diseases, Jefferiss Research Trust Laboratories, Imperial College London, St Mary s Campus, London, W2 1PG, UK
    Retrovirology 7:108. 2010
  3. pmc Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial
    Graham P Taylor
    Department of GU Medicine and Communicable Diseases, Faculty of Medicine, Imperial College, London, UK
    Retrovirology 3:63. 2006
  4. pmc The development of vaginal microbicides for the prevention of HIV transmission
    Jonathan Weber
    Wright Fleming Institute, Imperial College London, United Kingdom
    PLoS Med 2:e142. 2005
  5. doi request reprint Postexposure prophylaxis, preexposure prophylaxis or universal test and treat: the strategic use of antiretroviral drugs to prevent HIV acquisition and transmission
    Jonathan Weber
    Faculty of Medicine, Imperial College London, St Mary s Hospital, London, UK
    AIDS 24:S27-39. 2010
  6. doi request reprint Data linkage reduces loss to follow-up in an observational HIV cohort study
    Teresa Hill
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    J Clin Epidemiol 63:1101-9. 2010
  7. doi request reprint Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC Study
    Tristan J Barber
    St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
    Antivir Ther 16:805-14. 2011
  8. doi request reprint Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study
    R J C Gilson
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    HIV Med 11:152-60. 2010
  9. ncbi request reprint Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort
    Sarah Fidler
    Imperial College, St Mary s Hospital, London, UK
    AIDS 21:1283-91. 2007
  10. ncbi request reprint Comparative potency of three antiretroviral therapy regimes in primary HIV infection
    Sarah Fidler
    Department of GUM and Communicable Diseases, Wright Fleming Institute, Jefferiss Trust Laboratories, London, UK
    AIDS 20:247-52. 2006

Detail Information

Publications37

  1. pmc Restriction of V3 region sequence divergence in the HIV-1 envelope gene during antiretroviral treatment in a cohort of recent seroconverters
    Astrid Gall
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK
    Retrovirology 10:8. 2013
    ....
  2. pmc Mouse DNA contamination in human tissue tested for XMRV
    Mark J Robinson
    Section of Infectious Diseases, Jefferiss Research Trust Laboratories, Imperial College London, St Mary s Campus, London, W2 1PG, UK
    Retrovirology 7:108. 2010
    ..To control for contamination, PCR assays to detect either mouse mitochondrial DNA (mtDNA) or intracisternal A particle (IAP) long terminal repeat DNA were run on all samples, owing to their very high copy number in mouse cells...
  3. pmc Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial
    Graham P Taylor
    Department of GU Medicine and Communicable Diseases, Faculty of Medicine, Imperial College, London, UK
    Retrovirology 3:63. 2006
    ..We therefore conducted a randomised, double blind, placebo controlled study of six months combination therapy with these nucleoside analogues in sixteen patients...
  4. pmc The development of vaginal microbicides for the prevention of HIV transmission
    Jonathan Weber
    Wright Fleming Institute, Imperial College London, United Kingdom
    PLoS Med 2:e142. 2005
  5. doi request reprint Postexposure prophylaxis, preexposure prophylaxis or universal test and treat: the strategic use of antiretroviral drugs to prevent HIV acquisition and transmission
    Jonathan Weber
    Faculty of Medicine, Imperial College London, St Mary s Hospital, London, UK
    AIDS 24:S27-39. 2010
    ..Specifically, we consider the evidences for and against targeting HIV-uninfected individuals compared with enhanced HIV testing and treatment of HIV-infected individuals in terms of impact on viral transmission...
  6. doi request reprint Data linkage reduces loss to follow-up in an observational HIV cohort study
    Teresa Hill
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    J Clin Epidemiol 63:1101-9. 2010
    ..To ascertain the degree of loss to follow-up in a cohort and to identify its predictors...
  7. doi request reprint Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC Study
    Tristan J Barber
    St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
    Antivir Ther 16:805-14. 2011
    ..We analysed the influence of gender on use and outcomes of first-line HAART in a UK cohort...
  8. doi request reprint Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study
    R J C Gilson
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    HIV Med 11:152-60. 2010
    ..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes...
  9. ncbi request reprint Slower CD4 cell decline following cessation of a 3 month course of HAART in primary HIV infection: findings from an observational cohort
    Sarah Fidler
    Imperial College, St Mary s Hospital, London, UK
    AIDS 21:1283-91. 2007
    ..To investigate the effect of a short course of HAART during primary HIV infection (PHI) on rate of CD4 cell and viral load change...
  10. ncbi request reprint Comparative potency of three antiretroviral therapy regimes in primary HIV infection
    Sarah Fidler
    Department of GUM and Communicable Diseases, Wright Fleming Institute, Jefferiss Trust Laboratories, London, UK
    AIDS 20:247-52. 2006
    ..To best achieve the most rapid reduction in primary viraemia we compared three different ART regimens in PHI...
  11. pmc Duration of HIV-1 viral suppression on cessation of antiretroviral therapy in primary infection correlates with time on therapy
    Wolfgang Stöhr
    Medical Research Council Clinical Trials Unit, London, United Kingdom
    PLoS ONE 8:e78287. 2013
    ..A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection (PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored...
  12. pmc Plasma HIV viral rebound following protocol-indicated cessation of ART commenced in primary and chronic HIV infection
    Elizabeth Hamlyn
    Kings College Hospital National Health Service Foundation Trust, London, United Kingdom
    PLoS ONE 7:e43754. 2012
    ..We compared plasma viral load (pVL) rebound after stopping ART initiated in primary (PHI) and chronic HIV infection (CHI)...
  13. pmc Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men
    Emma C Thomson
    Department of Hepatology, Wright Fleming Institute, Faculty of Medicine, Imperial College London, London, UK
    Gut 60:837-45. 2011
    ..The aim of this study was to characterise the natural history of primary HCV in this setting and to assess host and viral factors which predict spontaneous clearance...
  14. ncbi request reprint Changes in viral load in people with virological failure who remain on the same HAART regimen
    Alessandro Cozzi-Lepri
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
    Antivir Ther 8:127-36. 2003
    ..To assess the rate of change in viral load and CD4 count over time in HIV-infected patients experiencing virological failure on a HAART regimen...
  15. doi request reprint The effect of transmitted HIV-1 drug resistance on pre-therapy viral load
    Linda Harrison
    HIV and Infections Group, MRC Clinical Trials Unit, London, UK
    AIDS 24:1917-22. 2010
    ..Reduced replication capacity of viruses expressing drug resistant mutations implies that patients with transmitted drug resistance (TDR) could have lower HIV RNA viral load than those infected with wild-type virus...
  16. pmc Factors influencing lopinavir and atazanavir plasma concentration
    Wolfgang Stöhr
    MRC Clinical Trials Unit, London, UK
    J Antimicrob Chemother 65:129-37. 2010
    ..The aim of this study was to evaluate which demographic factors and concomitant drugs are associated with lopinavir and atazanavir plasma concentration...
  17. doi request reprint The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
    C A Sabin
    Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
    HIV Med 10:35-43. 2009
    ....
  18. doi request reprint Primary HIV infection: to treat or not to treat?
    Sarah Fidler
    Department of GUM and HIV, Division of Medicine, Imperial College, UK
    Curr Opin Infect Dis 21:4-10. 2008
    ..The aim of this article is to review new data on the use of antiretroviral therapy in primary HIV infection...
  19. ncbi request reprint HIV-1-specific CD4+ responses in primary HIV-1 infection predict disease progression
    John Frater
    aNuffield Department of Clinical Medicine, John Radcliffe Hospital bPeter Medawar Building for Pathogen Research cInstitute for Emerging Infections, The Oxford Martin School dOxford National Institute of Health Research Biomedical Research Centre, Oxford eMedical Research Council Clinical Trials Unit fMRC Tropical Epidemiology Group, London School of Hygiene and Tropical Medicine, London, UK gMwanza Intervention Trials Unit, Mwanza, Tanzania hDivision of Medicine, Wright Fleming Institute, Imperial College, London, UK Fiona Ewings and Jacob Hurst contributed equally to the writing of this article
    AIDS 28:699-708. 2014
    ..The SPARTAC trial randomized 366 participants in primary HIV infection (PHI) to different short-course therapies. The aim of this study was to investigate how early immune responses in PHI impacted clinical progression in SPARTAC...
  20. doi request reprint Reductions in HIV transmission risk behaviour following diagnosis of primary HIV infection: a cohort of high-risk men who have sex with men
    Julie Fox
    Department of Genitourinary Medicine and Infectious Disease, Clinical Trials Centre, Winston ChurchillBuilding, Imperial College London, St Mary s Hospital Campus, London W2 1PG, UK
    HIV Med 10:432-8. 2009
    ..We explored the potential impact on HIV transmission-risk behaviour of PHI diagnosis in men who have sex with men (MSM)...
  21. doi request reprint Late diagnosis in the HAART era: proposed common definitions and associations with mortality
    Caroline A Sabin
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    AIDS 24:723-7. 2010
    ....
  22. doi request reprint Clinical epidemiology of HIV-associated end-stage renal failure in the UK
    Loveleen Bansi
    University College London Medical School, London, UK
    AIDS 23:2517-21. 2009
    ..To describe the clinical epidemiology of HIV-associated end-stage renal failure (HIV/ESRF) from 1998 to 2007 in the United Kingdom...
  23. ncbi request reprint Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection
    Sarah Fidler
    Wright Fleming Institute, Department of GUM and Communicable Diseases, Faculty of Medicine, Imperial College, St Mary s Hospital, London, UK
    AIDS 16:2049-54. 2002
    ..We sought to investigate whether a short course of antiretroviral therapy (SCART) at PHI was sufficient to preserve HIV-specific cellular immunity...
  24. pmc PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
    Sheena McCormack
    MRC Clinical Trials Unit, London, UK
    Lancet 376:1329-37. 2010
    ..PRO2000 vaginal gel was efficacious against HIV-1 transmission in studies in macaques; we aimed to assess efficacy and safety of 2% and 0·5% PRO2000 gels against vaginal HIV-1 transmission in women in sub-Saharan Africa...
  25. pmc Glucopyranosyl lipid A adjuvant significantly enhances HIV specific T and B cell responses elicited by a DNA-MVA-protein vaccine regimen
    Paul F McKay
    Imperial College London, Department of Infectious Diseases, Division of Medicine, Norfolk Place, London, United Kingdom
    PLoS ONE 9:e84707. 2014
    ....
  26. pmc DNA extraction columns contaminated with murine sequences
    Otto Erlwein
    Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Imperial College London, London, United Kingdom
    PLoS ONE 6:e23484. 2011
    ..Thus, DNA purification columns can present problems when used to detect minute amounts of DNA targets by highly sensitive amplification techniques...
  27. ncbi request reprint Risk of AIDS and death at given HIV-RNA and CD4 cell count, in relation to specific antiretroviral drugs in the regimen
    Christian Holkmann Olsen
    Copenhagen HIV Programme, Section 044, Pavilion 1, DK 2650 Hvidovre, Denmark
    AIDS 19:319-30. 2005
    ..It is unknown whether the relationship between the HIV-RNA/CD4 cell count and risk of clinical disease continues to hold true for newer antiretroviral drugs approved without data from clinical endpoint trials...
  28. pmc Resistance to HIV drugs in UK may be lower in some areas
    Julie M Fox
    BMJ 332:179-80. 2006
  29. ncbi request reprint Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda
    Pontiano Kaleebu
    Medical Research Council Programme on AIDS, Uganda Virus Research Institute, Entebbe, Uganda
    J Infect Dis 185:1244-50. 2002
    ..001), compared with subtype A, after adjusting for CD4 cell count at enrollment. In Africa, envelope subtype D is associated with faster disease progression, compared with subtype A...
  30. ncbi request reprint Relation between chemokine receptor use, disease stage, and HIV-1 subtypes A and D: results from a rural Ugandan cohort
    Pontiano Kaleebu
    Medical Research Council Uganda Virus Research Institute Research Unit on AIDS, Entebbe, Uganda
    J Acquir Immune Defic Syndr 45:28-33. 2007
    ..To determine whether there are differences in coreceptor use in subjects infected with HIV-1 envelope subtypes A and D that could explain the differences in progression rates between these subtypes in a rural Ugandan cohort...
  31. ncbi request reprint Factors associated with the development of opportunistic infections in HIV-1-infected adults with high CD4+ cell counts: a EuroSIDA study
    Daria Podlekareva
    Hvidovre University Hospital, Kettegaard Alle 30, DK 2650 Hvidovre, Denmark
    J Infect Dis 194:633-41. 2006
    ..Limited data exist on factors predicting the development of opportunistic infections (OIs) at higher-than-expected CD4(+) cell counts in human immunodeficiency virus (HIV) type 1-infected adults...
  32. pmc Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study
    Patricia Cane
    BMJ 331:1368. 2005
    ..To examine whether the level of primary resistance to HIV drugs is increasing in the United Kingdom...
  33. doi request reprint Increasing incidence of acute hepatitis C in individuals diagnosed with primary HIV in the United Kingdom
    Julie Fox
    AIDS 22:666-8. 2008
  34. ncbi request reprint Long-term persistence of HIV-1 vaccine-induced CD4+CD45RA-CD62L-CCR7- memory T-helper cells
    Sunita S Balla-Jhagjhoorsingh
    Department of Virology, Biomedical Primate Research Centre, 2280 GH Rijswijk, The Netherlands
    AIDS 18:837-48. 2004
    ..To determine in chimpanzees if candidate HIV-1 subunit protein vaccines were capable of eliciting long-lasting T-cell memory responses in the absence of viral infection, and to determine the specific characteristics of these responses...
  35. ncbi request reprint EV01: a phase I trial in healthy HIV negative volunteers to evaluate a clade C HIV vaccine, NYVAC-C undertaken by the EuroVacc Consortium
    Pierre Alexandre Bart
    Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Vaccine 26:3153-61. 2008
    ..Half of the 10 assessed responded in the ELISpot assay under stringent criteria, which informed the sample size for a DNA-NYVAC-C comparison to NYVAC-C alone...
  36. ncbi request reprint EV02: a Phase I trial to compare the safety and immunogenicity of HIV DNA-C prime-NYVAC-C boost to NYVAC-C alone
    Sheena McCormack
    MRC Clinical Trials Unit, 222 Euston Road, London NW1 2DA, UK
    Vaccine 26:3162-74. 2008
    ..Of the 9 individuals with responses to envelope and other peptides, 8 were in the DNA-C group. These promising results suggest that DNA-C was an effective priming agent, that merits further investigation...
  37. pmc Discordances between interpretation algorithms for genotypic resistance to protease and reverse transcriptase inhibitors of human immunodeficiency virus are subtype dependent
    Joke Snoeck
    Rega Institute for Medical Research, Minderbroedersstraat 10, 3000 Leuven, Belgium
    Antimicrob Agents Chemother 50:694-701. 2006
    ..It is not yet known whether therapy response is subtype dependent, but the advice given to clinicians based on a genotypic interpretation algorithm differs according to the subtype...